JP2012508753A5 - - Google Patents
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- Publication number
- JP2012508753A5 JP2012508753A5 JP2011536450A JP2011536450A JP2012508753A5 JP 2012508753 A5 JP2012508753 A5 JP 2012508753A5 JP 2011536450 A JP2011536450 A JP 2011536450A JP 2011536450 A JP2011536450 A JP 2011536450A JP 2012508753 A5 JP2012508753 A5 JP 2012508753A5
- Authority
- JP
- Japan
- Prior art keywords
- xaa
- peptide
- peptide immunogen
- item
- sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 80
- 230000002163 immunogen Effects 0.000 claims description 55
- 239000002671 adjuvant Substances 0.000 claims description 8
- 229940035032 monophosphoryl lipid a Drugs 0.000 claims description 8
- 238000006467 substitution reaction Methods 0.000 claims description 8
- DRHZYJAUECRAJM-DWSYSWFDSA-N (2s,3s,4s,5r,6r)-6-[[(3s,4s,4ar,6ar,6bs,8r,8ar,12as,14ar,14br)-8a-[(2s,3r,4s,5r,6r)-3-[(2s,3r,4s,5r,6s)-5-[(2s,3r,4s,5r)-4-[(2s,3r,4r)-3,4-dihydroxy-4-(hydroxymethyl)oxolan-2-yl]oxy-3,5-dihydroxyoxan-2-yl]oxy-3,4-dihydroxy-6-methyloxan-2-yl]oxy-5-[(3s,5s, Chemical compound O([C@H]1[C@H](O)[C@H](O[C@H]([C@@H]1O[C@H]1[C@@H]([C@@H](O)[C@@H](O)[C@@H](CO)O1)O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@H]5CC(C)(C)CC[C@@]5([C@@H](C[C@@]4(C)[C@]3(C)CC[C@H]2[C@@]1(C=O)C)O)C(=O)O[C@@H]1O[C@H](C)[C@@H]([C@@H]([C@H]1O[C@H]1[C@@H]([C@H](O)[C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@](O)(CO)CO3)O)[C@H](O)CO2)O)[C@H](C)O1)O)O)OC(=O)C[C@@H](O)C[C@H](OC(=O)C[C@@H](O)C[C@@H]([C@@H](C)CC)O[C@H]1[C@@H]([C@@H](O)[C@H](CO)O1)O)[C@@H](C)CC)C(O)=O)[C@@H]1OC[C@@H](O)[C@H](O)[C@H]1O DRHZYJAUECRAJM-DWSYSWFDSA-N 0.000 claims description 6
- 102000001189 Cyclic Peptides Human genes 0.000 claims description 6
- 108010069514 Cyclic Peptides Proteins 0.000 claims description 6
- 241000193996 Streptococcus pyogenes Species 0.000 claims description 6
- 150000001413 amino acids Chemical class 0.000 claims description 6
- 201000010099 disease Diseases 0.000 claims description 6
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 6
- 230000001404 mediated effect Effects 0.000 claims description 6
- 241000712461 unidentified influenza virus Species 0.000 claims description 6
- 229960005486 vaccine Drugs 0.000 claims description 6
- 241001647372 Chlamydia pneumoniae Species 0.000 claims description 4
- 108010049048 Cholera Toxin Proteins 0.000 claims description 4
- 102000009016 Cholera Toxin Human genes 0.000 claims description 4
- 108010053187 Diphtheria Toxin Proteins 0.000 claims description 4
- 102000016607 Diphtheria Toxin Human genes 0.000 claims description 4
- 102000002812 Heat-Shock Proteins Human genes 0.000 claims description 4
- 108010004889 Heat-Shock Proteins Proteins 0.000 claims description 4
- 108010081690 Pertussis Toxin Proteins 0.000 claims description 4
- -1 aminoalkyl glucosan phosphate compound Chemical class 0.000 claims description 4
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims description 4
- 229920001184 polypeptide Polymers 0.000 claims description 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims description 4
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims description 2
- YYGNTYWPHWGJRM-UHFFFAOYSA-N (6E,10E,14E,18E)-2,6,10,15,19,23-hexamethyltetracosa-2,6,10,14,18,22-hexaene Chemical compound CC(C)=CCCC(C)=CCCC(C)=CCCC=C(C)CCC=C(C)CCC=C(C)C YYGNTYWPHWGJRM-UHFFFAOYSA-N 0.000 claims description 2
- 241000304886 Bacilli Species 0.000 claims description 2
- 241000588832 Bordetella pertussis Species 0.000 claims description 2
- 108010059574 C5a peptidase Proteins 0.000 claims description 2
- 241000272470 Circus Species 0.000 claims description 2
- 150000008574 D-amino acids Chemical class 0.000 claims description 2
- 241000588724 Escherichia coli Species 0.000 claims description 2
- 229920001503 Glucan Polymers 0.000 claims description 2
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 2
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims description 2
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 2
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 2
- 101710154606 Hemagglutinin Proteins 0.000 claims description 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims description 2
- 108091006905 Human Serum Albumin Proteins 0.000 claims description 2
- 108060003951 Immunoglobulin Proteins 0.000 claims description 2
- 102000006992 Interferon-alpha Human genes 0.000 claims description 2
- 108010047761 Interferon-alpha Proteins 0.000 claims description 2
- 102000008070 Interferon-gamma Human genes 0.000 claims description 2
- 108010074328 Interferon-gamma Proteins 0.000 claims description 2
- 102000014150 Interferons Human genes 0.000 claims description 2
- 108010050904 Interferons Proteins 0.000 claims description 2
- 102000003814 Interleukin-10 Human genes 0.000 claims description 2
- 108090000174 Interleukin-10 Proteins 0.000 claims description 2
- 102000003816 Interleukin-13 Human genes 0.000 claims description 2
- 108090000176 Interleukin-13 Proteins 0.000 claims description 2
- 108010002350 Interleukin-2 Proteins 0.000 claims description 2
- 108090000978 Interleukin-4 Proteins 0.000 claims description 2
- 108010002616 Interleukin-5 Proteins 0.000 claims description 2
- 102000000743 Interleukin-5 Human genes 0.000 claims description 2
- 108090001005 Interleukin-6 Proteins 0.000 claims description 2
- 102000004889 Interleukin-6 Human genes 0.000 claims description 2
- 108010002586 Interleukin-7 Proteins 0.000 claims description 2
- 102000000704 Interleukin-7 Human genes 0.000 claims description 2
- 108090001007 Interleukin-8 Proteins 0.000 claims description 2
- 102000004890 Interleukin-8 Human genes 0.000 claims description 2
- 108090000542 Lymphotoxin-alpha Proteins 0.000 claims description 2
- 102000004083 Lymphotoxin-alpha Human genes 0.000 claims description 2
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims description 2
- 101710093908 Outer capsid protein VP4 Proteins 0.000 claims description 2
- 101710135467 Outer capsid protein sigma-1 Proteins 0.000 claims description 2
- 108010058846 Ovalbumin Proteins 0.000 claims description 2
- 229910019142 PO4 Inorganic materials 0.000 claims description 2
- 101710176177 Protein A56 Proteins 0.000 claims description 2
- 102000007056 Recombinant Fusion Proteins Human genes 0.000 claims description 2
- 108010008281 Recombinant Fusion Proteins Proteins 0.000 claims description 2
- BHEOSNUKNHRBNM-UHFFFAOYSA-N Tetramethylsqualene Natural products CC(=C)C(C)CCC(=C)C(C)CCC(C)=CCCC=C(C)CCC(C)C(=C)CCC(C)C(C)=C BHEOSNUKNHRBNM-UHFFFAOYSA-N 0.000 claims description 2
- 102000009843 Thyroglobulin Human genes 0.000 claims description 2
- 108010034949 Thyroglobulin Proteins 0.000 claims description 2
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 2
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 2
- UZQJVUCHXGYFLQ-AYDHOLPZSA-N [(2s,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-4-[(2r,3r,4s,5r,6r)-4-[(2s,3r,4s,5r,6r)-3,5-dihydroxy-6-(hydroxymethyl)-4-[(2s,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxan-2-yl]oxy-3,5-dihydroxy-6-(hydroxymethyl)oxan-2-yl]oxy-3,5-dihydroxy-6-(hy Chemical compound O([C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1[C@H](O)[C@@H](CO)O[C@H]([C@@H]1O)O[C@H]1CC[C@]2(C)[C@H]3CC=C4[C@@]([C@@]3(CC[C@H]2[C@@]1(C=O)C)C)(C)CC(O)[C@]1(CCC(CC14)(C)C)C(=O)O[C@H]1[C@@H]([C@@H](O[C@H]2[C@@H]([C@@H](O[C@H]3[C@@H]([C@@H](O[C@H]4[C@@H]([C@@H](O[C@H]5[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O5)O)[C@H](O)[C@@H](CO)O4)O)[C@H](O)[C@@H](CO)O3)O)[C@H](O)[C@@H](CO)O2)O)[C@H](O)[C@@H](CO)O1)O)[C@@H]1O[C@H](CO)[C@@H](O)[C@H](O)[C@H]1O UZQJVUCHXGYFLQ-AYDHOLPZSA-N 0.000 claims description 2
- 229940037003 alum Drugs 0.000 claims description 2
- WNROFYMDJYEPJX-UHFFFAOYSA-K aluminium hydroxide Chemical compound [OH-].[OH-].[OH-].[Al+3] WNROFYMDJYEPJX-UHFFFAOYSA-K 0.000 claims description 2
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims description 2
- 239000000427 antigen Substances 0.000 claims description 2
- 102000036639 antigens Human genes 0.000 claims description 2
- 108091007433 antigens Proteins 0.000 claims description 2
- 230000001580 bacterial effect Effects 0.000 claims description 2
- 239000003085 diluting agent Substances 0.000 claims description 2
- PRAKJMSDJKAYCZ-UHFFFAOYSA-N dodecahydrosqualene Natural products CC(C)CCCC(C)CCCC(C)CCCCC(C)CCCC(C)CCCC(C)C PRAKJMSDJKAYCZ-UHFFFAOYSA-N 0.000 claims description 2
- 239000002158 endotoxin Substances 0.000 claims description 2
- 239000000185 hemagglutinin Substances 0.000 claims description 2
- 208000002672 hepatitis B Diseases 0.000 claims description 2
- 102000018358 immunoglobulin Human genes 0.000 claims description 2
- 206010022000 influenza Diseases 0.000 claims description 2
- 229940079322 interferon Drugs 0.000 claims description 2
- 229960003130 interferon gamma Drugs 0.000 claims description 2
- 229920006008 lipopolysaccharide Polymers 0.000 claims description 2
- 201000004792 malaria Diseases 0.000 claims description 2
- 239000011159 matrix material Substances 0.000 claims description 2
- 230000000813 microbial effect Effects 0.000 claims description 2
- 229940092253 ovalbumin Drugs 0.000 claims description 2
- 239000000546 pharmaceutical excipient Substances 0.000 claims description 2
- 239000010452 phosphate Substances 0.000 claims description 2
- 239000000244 polyoxyethylene sorbitan monooleate Substances 0.000 claims description 2
- 235000010482 polyoxyethylene sorbitan monooleate Nutrition 0.000 claims description 2
- 229920000053 polysorbate 80 Polymers 0.000 claims description 2
- 229940068968 polysorbate 80 Drugs 0.000 claims description 2
- 102000004169 proteins and genes Human genes 0.000 claims description 2
- 108090000623 proteins and genes Proteins 0.000 claims description 2
- 239000001397 quillaja saponaria molina bark Substances 0.000 claims description 2
- 150000003839 salts Chemical class 0.000 claims description 2
- 229930182490 saponin Natural products 0.000 claims description 2
- 150000007949 saponins Chemical class 0.000 claims description 2
- 229940031439 squalene Drugs 0.000 claims description 2
- TUHBEKDERLKLEC-UHFFFAOYSA-N squalene Natural products CC(=CCCC(=CCCC(=CCCC=C(/C)CCC=C(/C)CC=C(C)C)C)C)C TUHBEKDERLKLEC-UHFFFAOYSA-N 0.000 claims description 2
- 229940076156 streptococcus pyogenes Drugs 0.000 claims description 2
- 229960000814 tetanus toxoid Drugs 0.000 claims description 2
- 229960002175 thyroglobulin Drugs 0.000 claims description 2
- 231100000419 toxicity Toxicity 0.000 claims description 2
- 230000001988 toxicity Effects 0.000 claims description 2
- 239000003053 toxin Substances 0.000 claims description 2
- 231100000765 toxin Toxicity 0.000 claims description 2
- 241000124008 Mammalia Species 0.000 description 3
- 238000000034 method Methods 0.000 description 3
- 125000004122 cyclic group Chemical group 0.000 description 2
- 239000003102 growth factor Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US11388008P | 2008-11-12 | 2008-11-12 | |
| US61/113,880 | 2008-11-12 | ||
| PCT/US2009/064115 WO2010056796A1 (en) | 2008-11-12 | 2009-11-12 | Human m2e peptide immunogens |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014106974A Division JP2014148549A (ja) | 2008-11-12 | 2014-05-23 | ヒトＭ２ｅペプチド免疫原 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012508753A JP2012508753A (ja) | 2012-04-12 |
| JP2012508753A5 true JP2012508753A5 (enExample) | 2013-04-25 |
| JP5693460B2 JP5693460B2 (ja) | 2015-04-01 |
Family
ID=41682556
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011536450A Expired - Fee Related JP5693460B2 (ja) | 2008-11-12 | 2009-11-12 | ヒトＭ２ｅペプチド免疫原 |
| JP2014106974A Pending JP2014148549A (ja) | 2008-11-12 | 2014-05-23 | ヒトＭ２ｅペプチド免疫原 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014106974A Pending JP2014148549A (ja) | 2008-11-12 | 2014-05-23 | ヒトＭ２ｅペプチド免疫原 |
Country Status (7)
| Country | Link |
|---|---|
| US (3) | US8329188B2 (enExample) |
| EP (1) | EP2346529B1 (enExample) |
| JP (2) | JP5693460B2 (enExample) |
| AU (1) | AU2009314091B2 (enExample) |
| CA (1) | CA2743306A1 (enExample) |
| TW (1) | TW201029663A (enExample) |
| WO (1) | WO2010056796A1 (enExample) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US10004799B2 (en) | 2007-08-27 | 2018-06-26 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| TW201029663A (en) * | 2008-11-12 | 2010-08-16 | Theraclone Sciences Inc | Human M2e peptide immunogens |
| WO2011019932A2 (en) * | 2009-08-14 | 2011-02-17 | Theraclone Sciences, Inc. | Compositions and methods for the therapy and diagnosis of influenza |
| EP2661442A4 (en) * | 2011-01-06 | 2014-08-20 | Bionor Immuno As | MONOMER AND MULTIMERS IMMUNOGENIC PEPTIDES |
| CA3207612A1 (en) * | 2012-01-26 | 2013-08-01 | Longhorn Vaccines And Diagnostics, Llc | Composite antigenic sequences and vaccines |
| IL298382A (en) * | 2020-05-20 | 2023-01-01 | Bicycletx Ltd | Nectin-4-specific bicyclic peptide ligands and their uses |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4033940A (en) * | 1975-11-12 | 1977-07-05 | Armour Pharmaceutical Company | Cyclization of peptides |
| US4102877A (en) * | 1976-07-28 | 1978-07-25 | Merck & Co., Inc. | Cyclization of peptides |
| US4816567A (en) * | 1983-04-08 | 1989-03-28 | Genentech, Inc. | Recombinant immunoglobin preparations |
| IL85035A0 (en) * | 1987-01-08 | 1988-06-30 | Int Genetic Eng | Polynucleotide molecule,a chimeric antibody with specificity for human b cell surface antigen,a process for the preparation and methods utilizing the same |
| US5057540A (en) * | 1987-05-29 | 1991-10-15 | Cambridge Biotech Corporation | Saponin adjuvant |
| DE3920358A1 (de) | 1989-06-22 | 1991-01-17 | Behringwerke Ag | Bispezifische und oligospezifische, mono- und oligovalente antikoerperkonstrukte, ihre herstellung und verwendung |
| IL101715A (en) | 1991-05-02 | 2005-06-19 | Amgen Inc | Recombinant dna-derived cholera toxin subunit analogs |
| CA2103059C (en) * | 1991-06-14 | 2005-03-22 | Paul J. Carter | Method for making humanized antibodies |
| DK1136556T3 (da) | 1991-11-25 | 2005-10-03 | Enzon Inc | Fremgangsmåde til fremstilling af multivalente antigen-bindende proteiner |
| WO1993013302A1 (de) | 1991-12-23 | 1993-07-08 | Michael Zoche | Motor mit einer vorrichtung zur entölung |
| US6207646B1 (en) * | 1994-07-15 | 2001-03-27 | University Of Iowa Research Foundation | Immunostimulatory nucleic acid molecules |
| US5641870A (en) * | 1995-04-20 | 1997-06-24 | Genentech, Inc. | Low pH hydrophobic interaction chromatography for antibody purification |
| US6090388A (en) * | 1998-06-20 | 2000-07-18 | United Biomedical Inc. | Peptide composition for prevention and treatment of HIV infection and immune disorders |
| PT1117435E (pt) | 1998-09-30 | 2008-02-21 | Us Gov Univ Health Sciences | Holotoxina da cólera mutante como adjuvante |
| MXPA03011135A (es) | 2001-06-07 | 2004-09-08 | Wyeth Corp | Formas mutantes de holotoxina de colera como adyuvante. |
| EP1404368B1 (en) | 2001-06-07 | 2009-12-09 | Wyeth Holdings Corporation | Mutant forms of cholera holotoxin as an adjuvant |
| US7361352B2 (en) * | 2001-08-15 | 2008-04-22 | Acambis, Inc. | Influenza immunogen and vaccine |
| EP1819732A2 (en) * | 2004-12-06 | 2007-08-22 | Kirin Beer Kabushiki Kaisha | Human monoclonal antibodies to influenza m2 protein and methods of making and using same |
| EP1928914A2 (en) | 2005-09-15 | 2008-06-11 | Crucell Holland B.V. | Method for preparing immunoglobulin libraries |
| PT2220116E (pt) * | 2007-11-12 | 2012-12-07 | Theraclone Sciences Inc | Composições e métodos para a terapia e o diagnóstico da gripe |
| TW201029663A (en) * | 2008-11-12 | 2010-08-16 | Theraclone Sciences Inc | Human M2e peptide immunogens |
-
2009
- 2009-11-12 TW TW98138409A patent/TW201029663A/zh unknown
- 2009-11-12 WO PCT/US2009/064115 patent/WO2010056796A1/en not_active Ceased
- 2009-11-12 JP JP2011536450A patent/JP5693460B2/ja not_active Expired - Fee Related
- 2009-11-12 CA CA 2743306 patent/CA2743306A1/en not_active Abandoned
- 2009-11-12 AU AU2009314091A patent/AU2009314091B2/en not_active Ceased
- 2009-11-12 EP EP09752676.8A patent/EP2346529B1/en not_active Not-in-force
- 2009-11-12 US US12/617,243 patent/US8329188B2/en not_active Expired - Fee Related
-
2012
- 2012-06-14 US US13/523,710 patent/US8932597B2/en not_active Expired - Fee Related
-
2014
- 2014-05-23 JP JP2014106974A patent/JP2014148549A/ja active Pending
-
2015
- 2015-01-12 US US14/594,461 patent/US20150125423A1/en not_active Abandoned
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