JP2012507268A5 - - Google Patents

Download PDF

Info

Publication number
JP2012507268A5
JP2012507268A5 JP2011533565A JP2011533565A JP2012507268A5 JP 2012507268 A5 JP2012507268 A5 JP 2012507268A5 JP 2011533565 A JP2011533565 A JP 2011533565A JP 2011533565 A JP2011533565 A JP 2011533565A JP 2012507268 A5 JP2012507268 A5 JP 2012507268A5
Authority
JP
Japan
Prior art keywords
meteef1a
metap2
concentration
activity
compound
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2011533565A
Other languages
English (en)
Japanese (ja)
Other versions
JP5347028B2 (ja
JP2012507268A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/EP2009/007102 external-priority patent/WO2010051882A1/en
Publication of JP2012507268A publication Critical patent/JP2012507268A/ja
Publication of JP2012507268A5 publication Critical patent/JP2012507268A5/ja
Application granted granted Critical
Publication of JP5347028B2 publication Critical patent/JP5347028B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2011533565A 2008-11-06 2009-10-05 バイオマーカーとしてのEEF1Aの使用およびMetAP2阻害剤をスクリーニングするための方法 Active JP5347028B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08019432.7 2008-11-06
EP08019432 2008-11-06
PCT/EP2009/007102 WO2010051882A1 (en) 2008-11-06 2009-10-05 Use of eef1a as biomarker and a method of screening metap2 inhibitors

Publications (3)

Publication Number Publication Date
JP2012507268A JP2012507268A (ja) 2012-03-29
JP2012507268A5 true JP2012507268A5 (enExample) 2012-11-22
JP5347028B2 JP5347028B2 (ja) 2013-11-20

Family

ID=41409225

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011533565A Active JP5347028B2 (ja) 2008-11-06 2009-10-05 バイオマーカーとしてのEEF1Aの使用およびMetAP2阻害剤をスクリーニングするための方法

Country Status (8)

Country Link
US (1) US9151743B2 (enExample)
EP (1) EP2344665B1 (enExample)
JP (1) JP5347028B2 (enExample)
AU (1) AU2009313167C1 (enExample)
CA (1) CA2742737C (enExample)
ES (1) ES2402564T3 (enExample)
IL (1) IL212664A0 (enExample)
WO (1) WO2010051882A1 (enExample)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2015069489A1 (en) 2013-11-06 2015-05-14 Merck Patent Gmbh Predictive biomarker for hypoxia-activated prodrug therapy
KR101712982B1 (ko) * 2015-07-31 2017-03-07 고려대학교 산학협력단 비알콜성지방간 조절인자 14-3-3 단백질
WO2018148638A1 (en) * 2017-02-10 2018-08-16 Zafgen, Inc. Pharmaceutical compositions of metap-2 inhibitors
CN108611352B (zh) * 2018-04-20 2020-08-07 华南农业大学 一种拟禾本科根结线虫翻译延长因子Mg-eEF1A及其防治植物病害的应用
CA3170118A1 (en) * 2020-02-06 2021-08-12 The Regents Of The University Of California Elongation factor 1-alpha inhibitors and uses thereof
CN116395718B (zh) * 2023-04-12 2024-12-17 中国科学院长春应用化学研究所 一种弱碱性钠盐纳米药物、其制备方法及其应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO1998056372A1 (en) * 1997-06-09 1998-12-17 Massachusetts Institute Of Technology TYPE 2 METHIONINE AMINOPEPTIDASE (MetAP2) INHIBITORS AND USES THEROF
EP1337854A2 (en) * 2000-11-14 2003-08-27 Novartis AG Method for screening anti-proliferative compounds and inhibiting tumor growth
US20020182701A1 (en) * 2001-08-30 2002-12-05 Saint Louis University Dominant negative variants of methionine aminopeptidase 2 (MetAP2) and clinical uses thereof
US20030232383A1 (en) 2001-11-02 2003-12-18 Sylvia Daunert Novel reagentless sensing system for measuring carbohydrates based on the galactose/glucose binding protein

Similar Documents

Publication Publication Date Title
Inoue et al. New BRAF knockin mice provide a pathogenetic mechanism of developmental defects and a therapeutic approach in cardio-facio-cutaneous syndrome
EP3046627B1 (en) Modulation of efferocytosis pathways for treatment of atherosclerotic disease
KR102266302B1 (ko) 심혈관 질환 또는 문제 위험 예측용 방법 및 키트
CN104569436B (zh) Adamts1作为主动脉夹层临床筛查分子标记物的应用
JP2012507268A5 (enExample)
Badri et al. Blood pressure homeostasis is maintained by a P311–TGF-β axis
Kuster et al. Altered C10 domain in cardiac myosin binding protein-C results in hypertrophic cardiomyopathy
Salah et al. MCP-1 promotes detrimental cardiac physiology, pulmonary edema, and death in the cpk model of polycystic kidney disease
CN114752669A (zh) 一种环状rna在制备脑卒中诊断产品中的应用
ES2665849T3 (es) Biomarcador para el diagnóstico de envejecimiento o amiotrofia
Ablooglu et al. Intrinsic endothelial hyperresponsiveness to inflammatory mediators drives acute episodes in models of Clarkson disease
Tanios et al. CXCR4: a potential marker for inflammatory activity in abdominal aortic aneurysm wall
JP2019200077A (ja) 肝細胞癌の診断マーカー
JP2011519030A (ja) ヒトおよび動物における生物学的老化、再生能、発癌リスク、加齢性疾患を発症するリスクおよび慢性疾患の予後を測定するための、dna損傷およびテロメア機能不全を測定するためのマーカー
Hofbauer et al. Arterial hypertension enhances neutrophil extracellular trap formation via an angiotensin-II-dependent pathway
TWI359271B (en) Pharmaceutical composition for insulin resistance
US20230192882A1 (en) Use Of Biomarker Or Biomarkers Combinations In Preparing A Diagnostic Reagent For Fulminant Myocarditis And A Drug For Fulminant Myocarditis
Amer et al. Rosuvastatin restores liver tissue-resident NK cell activation in aged mice by improving mitochondrial function
Xu et al. Serum CIAPIN1 is lower in septic patients with cardiac dysfunction
Wang et al. PIN1, a perspective on genetic biomarker for nonalcoholic fatty liver disease (NAFLD)
Chen et al. Interleukin-6-634C> G polymorphism in hypertensive patients with and without left ventricular hypertrophy
JP7525591B2 (ja) 心機能不全を予測及び処置するための方法
JP2012127879A (ja) 腎症の進行度の判定方法並びに線維化抑制剤。
Yamada et al. CTRP7 as a Molecular Biomarker for Predicting Responsiveness to Pulmonary Vasodilators: Insights from Human and Animal Studies in Pulmonary Arterial Hypertension
MASS 2022 NATIONAL CONGRESS OF THE ITALIAN SOCIETY OF HYPERTENSION (SIIA)