JP2012505884A5 - - Google Patents
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- Publication number
- JP2012505884A5 JP2012505884A5 JP2011532093A JP2011532093A JP2012505884A5 JP 2012505884 A5 JP2012505884 A5 JP 2012505884A5 JP 2011532093 A JP2011532093 A JP 2011532093A JP 2011532093 A JP2011532093 A JP 2011532093A JP 2012505884 A5 JP2012505884 A5 JP 2012505884A5
- Authority
- JP
- Japan
- Prior art keywords
- dosage form
- proton pump
- pump inhibitor
- unit dosage
- pharmaceutical composition
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000002552 dosage form Substances 0.000 claims 22
- 229940126409 proton pump inhibitor Drugs 0.000 claims 18
- 239000000612 proton pump inhibitor Substances 0.000 claims 18
- 239000008194 pharmaceutical composition Substances 0.000 claims 14
- 229940127218 antiplatelet drug Drugs 0.000 claims 12
- 239000002702 enteric coating Substances 0.000 claims 12
- 238000009505 enteric coating Methods 0.000 claims 12
- 239000000651 prodrug Substances 0.000 claims 11
- 229940002612 prodrug Drugs 0.000 claims 11
- 150000003839 salts Chemical class 0.000 claims 11
- 239000005552 B01AC04 - Clopidogrel Substances 0.000 claims 7
- GKTWGGQPFAXNFI-HNNXBMFYSA-N clopidogrel Chemical compound C1([C@H](N2CC=3C=CSC=3CC2)C(=O)OC)=CC=CC=C1Cl GKTWGGQPFAXNFI-HNNXBMFYSA-N 0.000 claims 7
- 229960003009 clopidogrel Drugs 0.000 claims 7
- 239000011162 core material Substances 0.000 claims 7
- 239000012453 solvate Substances 0.000 claims 7
- 208000012671 Gastrointestinal haemorrhages Diseases 0.000 claims 6
- 206010061459 Gastrointestinal ulcer Diseases 0.000 claims 6
- 208000030304 gastrointestinal bleeding Diseases 0.000 claims 6
- 239000000203 mixture Substances 0.000 claims 6
- 208000010110 spontaneous platelet aggregation Diseases 0.000 claims 6
- 208000024891 symptom Diseases 0.000 claims 6
- SUBDBMMJDZJVOS-UHFFFAOYSA-N 5-methoxy-2-{[(4-methoxy-3,5-dimethylpyridin-2-yl)methyl]sulfinyl}-1H-benzimidazole Chemical compound N=1C2=CC(OC)=CC=C2NC=1S(=O)CC1=NC=C(C)C(OC)=C1C SUBDBMMJDZJVOS-UHFFFAOYSA-N 0.000 claims 4
- 239000003814 drug Substances 0.000 claims 4
- 238000009472 formulation Methods 0.000 claims 4
- 239000000463 material Substances 0.000 claims 4
- 229960000381 omeprazole Drugs 0.000 claims 4
- 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 3
- 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 3
- 208000018522 Gastrointestinal disease Diseases 0.000 claims 2
- 239000011230 binding agent Substances 0.000 claims 2
- 230000002401 inhibitory effect Effects 0.000 claims 2
- 239000004014 plasticizer Substances 0.000 claims 2
- 239000000843 powder Substances 0.000 claims 2
- 239000004094 surface-active agent Substances 0.000 claims 2
- 239000002775 capsule Substances 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 238000000034 method Methods 0.000 claims 1
- 238000002360 preparation method Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/254,640 | 2008-10-20 | ||
| US12/254,640 US9532945B2 (en) | 2006-04-04 | 2008-10-20 | Oral dosage forms including an antiplatelet agent and an enterically coated acid inhibitor |
| PCT/US2009/005671 WO2010047756A1 (en) | 2008-10-20 | 2009-10-19 | Oral dosage forms including an antiplatelet agents and an enterically coated acid inhibitor |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015112067A Division JP2015180670A (ja) | 2008-10-20 | 2015-06-02 | 抗血小板薬と腸溶性コーティング酸阻害剤とを含む経口剤形 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012505884A JP2012505884A (ja) | 2012-03-08 |
| JP2012505884A5 true JP2012505884A5 (OSRAM) | 2012-12-06 |
Family
ID=41461113
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011532093A Pending JP2012505884A (ja) | 2008-10-20 | 2009-10-19 | 抗血小板薬と腸溶性コーティング酸阻害剤とを含む経口剤形 |
| JP2015112067A Pending JP2015180670A (ja) | 2008-10-20 | 2015-06-02 | 抗血小板薬と腸溶性コーティング酸阻害剤とを含む経口剤形 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015112067A Pending JP2015180670A (ja) | 2008-10-20 | 2015-06-02 | 抗血小板薬と腸溶性コーティング酸阻害剤とを含む経口剤形 |
Country Status (3)
| Country | Link |
|---|---|
| US (1) | US9532945B2 (OSRAM) |
| JP (2) | JP2012505884A (OSRAM) |
| WO (1) | WO2010047756A1 (OSRAM) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101460154B (zh) * | 2006-04-04 | 2015-07-01 | Kg艾克维泽生公司 | 包含抗血小板剂和抑酸剂的口服剂型 |
| US9532945B2 (en) | 2006-04-04 | 2017-01-03 | Kg Acquisition Llc | Oral dosage forms including an antiplatelet agent and an enterically coated acid inhibitor |
| US20100305163A1 (en) * | 2009-05-20 | 2010-12-02 | Pramod Dattatray Yedurkar | Pharmaceutical formulations comprising nsaid and proton pump inhibitor drugs |
| WO2011025673A1 (en) * | 2009-08-26 | 2011-03-03 | Aptapharma, Inc. | Multilayer minitablets |
| WO2011036533A1 (en) * | 2009-09-23 | 2011-03-31 | Glenmark Pharmaceuticals Limited | Pharmaceutical composition comprising prasugrel and triflusal |
| US20120231076A1 (en) * | 2009-10-06 | 2012-09-13 | Ratiopharm Gmbh | Pharmaceutical compositions comprising rivaroxaban |
| US10610528B2 (en) | 2009-12-08 | 2020-04-07 | Intelgenx Corp. | Solid oral film dosage forms and methods for making same |
| US20110136815A1 (en) | 2009-12-08 | 2011-06-09 | Horst Zerbe | Solid oral film dosage forms and methods for making same |
| US20110263606A1 (en) * | 2010-04-26 | 2011-10-27 | Horst Zerbe | Solid oral dosage forms comprising tadalafil |
| KR101900966B1 (ko) | 2010-10-26 | 2018-09-20 | 캡슈겔 벨지엄 엔브이 | 벌크한 장용성 캡슐 쉘 |
| US9233103B2 (en) | 2011-03-25 | 2016-01-12 | Takeda Pharmaceuticals U.S.A., Inc. | Methods for treating heartburn, gastric bleeding or hemorrhage in patients receiving clopidogrel therapy |
| EA029341B1 (ru) * | 2011-09-14 | 2018-03-30 | Поузен Инк. | Способы предоставления антитромбоцитарной терапии |
| EP3065720A1 (en) | 2013-11-04 | 2016-09-14 | Capsugel Belgium NV | Methods and systems for improved bioavailability of active pharmaceutical ingredients including esomeprazole |
| UY39094A (es) * | 2020-02-27 | 2021-07-30 | Hk Inno N Corp | Composición farmacéutica que comprende compuesto derivado de bencimidazol |
| CN115260086A (zh) * | 2022-09-28 | 2022-11-01 | 吉林大学 | 一种氟代内标物及其应用和制备方法 |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4704295A (en) * | 1983-09-19 | 1987-11-03 | Colorcon, Inc. | Enteric film-coating compositions |
| GB2189698A (en) | 1986-04-30 | 1987-11-04 | Haessle Ab | Coated omeprazole tablets |
| US5635477A (en) * | 1991-09-30 | 1997-06-03 | The Dupont Merck Pharmaceutical Company | Cyclic compounds useful as inhibitors of platelet glycoprotein IIB/IIIA |
| US5576328A (en) | 1994-01-31 | 1996-11-19 | Elf Sanofi | Method for the secondary prevention of ischemic events |
| SE9402431D0 (sv) * | 1994-07-08 | 1994-07-08 | Astra Ab | New tablet formulation |
| SE9600070D0 (sv) | 1996-01-08 | 1996-01-08 | Astra Ab | New oral pharmaceutical dosage forms |
| FR2751540B1 (fr) | 1996-07-26 | 1998-10-16 | Sanofi Sa | Composition pharmaceutique antithrombotique |
| SE9704870D0 (sv) * | 1997-12-22 | 1997-12-22 | Astra Ab | New pharmaceutical formulation I |
| US6733778B1 (en) | 1999-08-27 | 2004-05-11 | Andrx Pharmaceuticals, Inc. | Omeprazole formulation |
| US6761895B2 (en) | 2000-04-17 | 2004-07-13 | Yamanouchi Pharmaceutical Co., Ltd. | Drug delivery system for averting pharmacokinetic drug interaction and method thereof |
| US6544556B1 (en) | 2000-09-11 | 2003-04-08 | Andrx Corporation | Pharmaceutical formulations containing a non-steroidal antiinflammatory drug and a proton pump inhibitor |
| US7029701B2 (en) | 2000-09-11 | 2006-04-18 | Andrx Pharmaceuticals, Llc | Composition for the treatment and prevention of ischemic events |
| SE0101932D0 (sv) * | 2001-05-31 | 2001-05-31 | Astrazeneca Ab | Pharmaceutical combinations |
| US6930099B2 (en) | 2001-09-07 | 2005-08-16 | Advanced Medical Instruments | Composition for the treatment and prevention of endothelial dysfunction |
| AU2003270861A1 (en) | 2002-10-02 | 2004-04-23 | Bristol-Myers Squibb Company | Novel combination of a factor xa inhibitor and clopidogrel |
| AU2005213472A1 (en) | 2004-02-10 | 2005-08-25 | Santarus, Inc. | Combination of proton pump inhibitor, buffering agent, and nonsteroidal anti-inflammatory agent |
| US20060177504A1 (en) | 2005-02-08 | 2006-08-10 | Renjit Sundharadas | Combination pain medication |
| CN101460154B (zh) | 2006-04-04 | 2015-07-01 | Kg艾克维泽生公司 | 包含抗血小板剂和抑酸剂的口服剂型 |
| US9532945B2 (en) | 2006-04-04 | 2017-01-03 | Kg Acquisition Llc | Oral dosage forms including an antiplatelet agent and an enterically coated acid inhibitor |
-
2008
- 2008-10-20 US US12/254,640 patent/US9532945B2/en active Active
-
2009
- 2009-10-19 WO PCT/US2009/005671 patent/WO2010047756A1/en not_active Ceased
- 2009-10-19 JP JP2011532093A patent/JP2012505884A/ja active Pending
-
2015
- 2015-06-02 JP JP2015112067A patent/JP2015180670A/ja active Pending
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