JP2012503668A5 - - Google Patents
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- Publication number
- JP2012503668A5 JP2012503668A5 JP2011529222A JP2011529222A JP2012503668A5 JP 2012503668 A5 JP2012503668 A5 JP 2012503668A5 JP 2011529222 A JP2011529222 A JP 2011529222A JP 2011529222 A JP2011529222 A JP 2011529222A JP 2012503668 A5 JP2012503668 A5 JP 2012503668A5
- Authority
- JP
- Japan
- Prior art keywords
- formulation
- lung
- droplets
- microns
- particles
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000000203 mixture Substances 0.000 claims 16
- 238000009472 formulation Methods 0.000 claims 11
- 210000004072 lung Anatomy 0.000 claims 4
- 239000002245 particle Substances 0.000 claims 4
- 208000002815 pulmonary hypertension Diseases 0.000 claims 4
- 230000008021 deposition Effects 0.000 claims 2
- 150000003839 salts Chemical class 0.000 claims 2
- 229960005032 treprostinil Drugs 0.000 claims 2
- PAJMKGZZBBTTOY-ZFORQUDYSA-N treprostinil Chemical compound C1=CC=C(OCC(O)=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 PAJMKGZZBBTTOY-ZFORQUDYSA-N 0.000 claims 2
- 239000006199 nebulizer Substances 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 229960001726 treprostinil sodium Drugs 0.000 claims 1
- IQKAWAUTOKVMLE-ZSESPEEFSA-M treprostinil sodium Chemical compound [Na+].C1=CC=C(OCC([O-])=O)C2=C1C[C@@H]1[C@@H](CC[C@@H](O)CCCCC)[C@H](O)C[C@@H]1C2 IQKAWAUTOKVMLE-ZSESPEEFSA-M 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10001708P | 2008-09-25 | 2008-09-25 | |
| US61/100,017 | 2008-09-25 | ||
| PCT/US2009/058217 WO2010036798A1 (en) | 2008-09-25 | 2009-09-24 | Deep lung pulmonary delivery of treprostinil |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015044671A Division JP2015129177A (ja) | 2008-09-25 | 2015-03-06 | 肺深部へのトレプロスチニルの肺送達 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012503668A JP2012503668A (ja) | 2012-02-09 |
| JP2012503668A5 true JP2012503668A5 (Direct) | 2012-11-08 |
Family
ID=42060085
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011529222A Pending JP2012503668A (ja) | 2008-09-25 | 2009-09-24 | 肺深部へのトレプロスチニルの肺送達 |
| JP2015044671A Pending JP2015129177A (ja) | 2008-09-25 | 2015-03-06 | 肺深部へのトレプロスチニルの肺送達 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015044671A Pending JP2015129177A (ja) | 2008-09-25 | 2015-03-06 | 肺深部へのトレプロスチニルの肺送達 |
Country Status (7)
| Country | Link |
|---|---|
| US (1) | US20120177693A1 (Direct) |
| EP (1) | EP2330893A4 (Direct) |
| JP (2) | JP2012503668A (Direct) |
| KR (1) | KR20110081204A (Direct) |
| CN (1) | CN102164487A (Direct) |
| CA (1) | CA2737350A1 (Direct) |
| WO (1) | WO2010036798A1 (Direct) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080200449A1 (en) | 2006-05-15 | 2008-08-21 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
| DE102006026786A1 (de) | 2006-06-07 | 2007-12-13 | Joachim Kern | Dosierinhalator |
| KR20180079458A (ko) | 2009-06-12 | 2018-07-10 | 맨카인드 코포레이션 | 한정된 비표면적을 갖는 디케토피페라진 마이크로입자 |
| DE102009031274A1 (de) * | 2009-06-30 | 2011-01-13 | Justus-Liebig-Universität Giessen | Liposomen zur pulmonalen Applikation |
| EP2338520A1 (de) | 2009-12-21 | 2011-06-29 | Ludwig Maximilians Universität | Konjugat mit Zielfindungsligand und dessen Verwendung |
| JP5681276B2 (ja) | 2010-03-15 | 2015-03-04 | ユナイテッド セラピューティクス コーポレイション | 肺高血圧症のための治療 |
| EA033717B1 (ru) * | 2011-01-13 | 2019-11-19 | Scipharm Sarl | Способ ex vivo предварительной обработки гемопоэтических стволовых клеток и фармацевтическая композиция для улучшения приживления гемопоэтических стволовых клеток |
| JP6523247B2 (ja) | 2013-03-15 | 2019-05-29 | マンカインド コーポレイション | 微結晶性ジケトピペラジン粒子の製造方法および乾燥粉末組成物の製造方法 |
| BR122019026637B1 (pt) | 2013-07-18 | 2023-09-26 | Mannkind Corporation | Formulações farmacêuticas de pó seco e método para a fabricação de uma formulação de pó seco |
| HRP20210351T1 (hr) | 2013-10-25 | 2021-04-30 | Insmed Incorporated | Spojevi prostaciklina |
| TWI685348B (zh) * | 2014-05-08 | 2020-02-21 | 美國禮來大藥廠 | 速效胰島素組合物 |
| US10343979B2 (en) | 2014-11-18 | 2019-07-09 | Insmed Incorporated | Methods of manufacturing treprostinil and treprostinil derivative prodrugs |
| EP4079291A1 (en) * | 2016-01-29 | 2022-10-26 | MannKind Corporation | Dry powder inhaler |
| IL310250B2 (en) | 2016-05-05 | 2025-09-01 | Liquidia Tech Inc | Terpostinil in dry powder form for the treatment of pulmonary hypertension |
| US10799653B2 (en) | 2017-01-09 | 2020-10-13 | United Therapeutics Corporation | Aerosol delivery device and method for manufacturing and operating the same |
| TWI696471B (zh) * | 2018-05-07 | 2020-06-21 | 國邑藥品科技股份有限公司 | 用於控制曲前列環素的釋放之醫藥組成物 |
| CN114072136B (zh) | 2019-04-29 | 2024-11-29 | 英斯梅德股份有限公司 | 曲前列素前药的干粉组合物及其使用方法 |
| US20210022994A1 (en) | 2019-07-22 | 2021-01-28 | Lupin Holdings, B.V. | Sustained release trepostinil-compound microparticle compositions |
| WO2021211916A1 (en) | 2020-04-17 | 2021-10-21 | United Therapeutics Corporation | Treprostinil for use in the treatment of intersitial lung disease |
Family Cites Families (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6521212B1 (en) * | 1999-03-18 | 2003-02-18 | United Therapeutics Corporation | Method for treating peripheral vascular disease by administering benzindene prostaglandins by inhalation |
| US20040063912A1 (en) * | 2002-03-15 | 2004-04-01 | The Brigham And Women's Hospital, Inc. | Central airway administration for systemic delivery of therapeutics |
| US7550133B2 (en) * | 2002-11-26 | 2009-06-23 | Alexza Pharmaceuticals, Inc. | Respiratory drug condensation aerosols and methods of making and using them |
| US20040265238A1 (en) * | 2003-06-27 | 2004-12-30 | Imtiaz Chaudry | Inhalable formulations for treating pulmonary hypertension and methods of using same |
| RU2007106714A (ru) * | 2004-07-26 | 2008-09-10 | Байер Шеринг Фарма Аг (De) | Лечение легочной гипертензии путем ингаляции илопростата с препаратом микрочастиц |
| US20080200449A1 (en) * | 2006-05-15 | 2008-08-21 | United Therapeutics Corporation | Treprostinil administration using a metered dose inhaler |
-
2009
- 2009-09-24 WO PCT/US2009/058217 patent/WO2010036798A1/en not_active Ceased
- 2009-09-24 CN CN2009801379417A patent/CN102164487A/zh active Pending
- 2009-09-24 CA CA2737350A patent/CA2737350A1/en not_active Abandoned
- 2009-09-24 EP EP09816849A patent/EP2330893A4/en not_active Withdrawn
- 2009-09-24 KR KR1020117008976A patent/KR20110081204A/ko not_active Ceased
- 2009-09-24 US US13/120,015 patent/US20120177693A1/en not_active Abandoned
- 2009-09-24 JP JP2011529222A patent/JP2012503668A/ja active Pending
-
2015
- 2015-03-06 JP JP2015044671A patent/JP2015129177A/ja active Pending
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