JP2012500832A5 - - Google Patents
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- Publication number
- JP2012500832A5 JP2012500832A5 JP2011524427A JP2011524427A JP2012500832A5 JP 2012500832 A5 JP2012500832 A5 JP 2012500832A5 JP 2011524427 A JP2011524427 A JP 2011524427A JP 2011524427 A JP2011524427 A JP 2011524427A JP 2012500832 A5 JP2012500832 A5 JP 2012500832A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- itac
- seq
- variable domain
- chain variable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
Links
- 101001124191 Homo sapiens Neuropilin-2 Proteins 0.000 claims 4
- 102000015227 human neuropilin-2 Human genes 0.000 claims 4
- 239000003446 ligand Substances 0.000 claims 3
- 210000004881 tumor cell Anatomy 0.000 claims 3
- 230000006907 apoptotic process Effects 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 210000002569 neuron Anatomy 0.000 claims 2
- FWMNVWWHGCHHJJ-SKKKGAJSSA-N 4-amino-1-[(2r)-6-amino-2-[[(2r)-2-[[(2r)-2-[[(2r)-2-amino-3-phenylpropanoyl]amino]-3-phenylpropanoyl]amino]-4-methylpentanoyl]amino]hexanoyl]piperidine-4-carboxylic acid Chemical compound C([C@H](C(=O)N[C@H](CC(C)C)C(=O)N[C@H](CCCCN)C(=O)N1CCC(N)(CC1)C(O)=O)NC(=O)[C@H](N)CC=1C=CC=CC=1)C1=CC=CC=C1 FWMNVWWHGCHHJJ-SKKKGAJSSA-N 0.000 claims 1
- 102000004213 Neuropilin-2 Human genes 0.000 claims 1
- 108090000770 Neuropilin-2 Proteins 0.000 claims 1
- 230000000259 anti-tumor effect Effects 0.000 claims 1
- 210000004027 cell Anatomy 0.000 claims 1
Claims (6)
- ヒトニューロピリン-2を発現する腫瘍細胞へのその結合が、該腫瘍細胞のアポトーシスを誘導することを特徴とする抗ヒトニューロピリン-2抗体。
- i) それぞれ配列番号２及び配列番号４の配列で規定される、ITAC-B1抗体の重鎖の可変ドメインと軽鎖の可変ドメインとを含む抗体；
ii) それぞれ配列番号６及び配列番号８の配列で規定される、ITAC-B2抗体の重鎖の可変ドメインと軽鎖の可変ドメインとを含む抗体
から選択される請求項１に記載の抗ヒトニューロピリン-2抗体。 - 請求項１又は２に記載の抗体の重鎖のCDR3と軽鎖のCDR3とを少なくとも含むことを特徴とするヒトニューロピリン-2のリガンド。
- ITAC-B1又はITAC-B2抗体の重鎖及び軽鎖のCDR2及び/又はCDR1も含むことを特徴とする請求項３に記載のヒトニューロピリン-2のリガンド。
- 請求項１若しくは２に記載の抗体又は請求項３若しくは４に記載のリガンドを含む抗腫瘍医薬品。
- ヒトニューロピリン-2を発現する腫瘍細胞のアポトーシスを、該細胞のp53発現を増加させることにより誘導することを特徴とする請求項５に記載の医薬品。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| FR0804725 | 2008-08-27 | ||
| FR0804725A FR2935385B1 (fr) | 2008-08-27 | 2008-08-27 | Induction de l'expression de p53 par neutralisation de la neuropiline-2 pour le traitement des cancers |
| PCT/FR2009/001035 WO2010023382A1 (fr) | 2008-08-27 | 2009-08-26 | Induction de l'expression de p53 par neutralisation de la neuropiline-2 pour le traitement des cancers |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012500832A JP2012500832A (ja) | 2012-01-12 |
| JP2012500832A5 true JP2012500832A5 (ja) | 2012-08-30 |
Family
ID=40481948
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011524427A Ceased JP2012500832A (ja) | 2008-08-27 | 2009-08-26 | 癌の治療のためのニューロピリン−２の中和によるｐ５３発現の誘導 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8722043B2 (ja) |
| EP (1) | EP2331576B1 (ja) |
| JP (1) | JP2012500832A (ja) |
| CN (1) | CN102498130A (ja) |
| AR (1) | AR073218A1 (ja) |
| AU (1) | AU2009286594A1 (ja) |
| CA (1) | CA2735169A1 (ja) |
| FR (1) | FR2935385B1 (ja) |
| TW (1) | TW201012476A (ja) |
| WO (1) | WO2010023382A1 (ja) |
Families Citing this family (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN105378075B (zh) | 2013-03-15 | 2022-04-05 | Atyr 医药公司 | 组氨酰-trna合成酶-fc缀合物 |
| ES2811274T3 (es) | 2014-04-18 | 2021-03-11 | Univ Leland Stanford Junior | Anticuerpos monoclonales humanizados y quiméricos para CD99 |
| JP2020517638A (ja) | 2017-04-20 | 2020-06-18 | エータイアー ファーマ， インコーポレイテッド | 肺の炎症を治療するための組成物および方法 |
| AU2019247511A1 (en) | 2018-04-06 | 2020-10-22 | Atyr Pharma, Inc. | Compositions and methods comprising anti-NRP2 antibodies |
| CA3156803A1 (en) | 2019-10-03 | 2021-04-08 | Atyr Pharma, Inc. | Compositions and methods comprising anti-nrp2 antibodies |
| CN111281968A (zh) * | 2020-02-14 | 2020-06-16 | 杭州憶盛医疗科技有限公司 | 一种抗神经组织肿瘤药及其制备方法 |
Family Cites Families (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU1633999A (en) * | 1997-12-09 | 1999-06-28 | Children's Medical Center Corporation | Soluble inhibitors of vascular endothelial growth factor and use thereof |
| EP1037925A2 (en) * | 1997-12-09 | 2000-09-27 | Children's Medical Center Corporation | Antagonists of neuropilin receptor functional and use thereof |
-
2008
- 2008-08-27 FR FR0804725A patent/FR2935385B1/fr not_active Expired - Fee Related
-
2009
- 2009-08-26 CN CN2009801421927A patent/CN102498130A/zh active Pending
- 2009-08-26 TW TW098128632A patent/TW201012476A/zh unknown
- 2009-08-26 US US13/060,889 patent/US8722043B2/en not_active Expired - Fee Related
- 2009-08-26 AU AU2009286594A patent/AU2009286594A1/en not_active Abandoned
- 2009-08-26 EP EP09737035.7A patent/EP2331576B1/fr not_active Not-in-force
- 2009-08-26 CA CA2735169A patent/CA2735169A1/fr not_active Abandoned
- 2009-08-26 JP JP2011524427A patent/JP2012500832A/ja not_active Ceased
- 2009-08-26 WO PCT/FR2009/001035 patent/WO2010023382A1/fr active Application Filing
- 2009-08-27 AR ARP090103308A patent/AR073218A1/es not_active Application Discontinuation
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