JP2012500191A - 異形成の検出方法 - Google Patents
異形成の検出方法 Download PDFInfo
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- JP2012500191A JP2012500191A JP2011522522A JP2011522522A JP2012500191A JP 2012500191 A JP2012500191 A JP 2012500191A JP 2011522522 A JP2011522522 A JP 2011522522A JP 2011522522 A JP2011522522 A JP 2011522522A JP 2012500191 A JP2012500191 A JP 2012500191A
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- WVDDGKGOMKODPV-ZQBYOMGUSA-N phenyl(114C)methanol Chemical compound O[14CH2]C1=CC=CC=C1 WVDDGKGOMKODPV-ZQBYOMGUSA-N 0.000 description 1
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- PYWVYCXTNDRMGF-UHFFFAOYSA-N rhodamine B Chemical compound [Cl-].C=12C=CC(=[N+](CC)CC)C=C2OC2=CC(N(CC)CC)=CC=C2C=1C1=CC=CC=C1C(O)=O PYWVYCXTNDRMGF-UHFFFAOYSA-N 0.000 description 1
- 229940043267 rhodamine b Drugs 0.000 description 1
- 238000007363 ring formation reaction Methods 0.000 description 1
- KZUNJOHGWZRPMI-UHFFFAOYSA-N samarium atom Chemical compound [Sm] KZUNJOHGWZRPMI-UHFFFAOYSA-N 0.000 description 1
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- GZCRRIHWUXGPOV-UHFFFAOYSA-N terbium atom Chemical compound [Tb] GZCRRIHWUXGPOV-UHFFFAOYSA-N 0.000 description 1
- 125000005931 tert-butyloxycarbonyl group Chemical group [H]C([H])([H])C(OC(*)=O)(C([H])([H])[H])C([H])([H])[H] 0.000 description 1
- WGTODYJZXSJIAG-UHFFFAOYSA-N tetramethylrhodamine chloride Chemical compound [Cl-].C=12C=CC(N(C)C)=CC2=[O+]C2=CC(N(C)C)=CC=C2C=1C1=CC=CC=C1C(O)=O WGTODYJZXSJIAG-UHFFFAOYSA-N 0.000 description 1
- 150000004905 tetrazines Chemical class 0.000 description 1
- MPLHNVLQVRSVEE-UHFFFAOYSA-N texas red Chemical compound [O-]S(=O)(=O)C1=CC(S(Cl)(=O)=O)=CC=C1C(C1=CC=2CCCN3CCCC(C=23)=C1O1)=C2C1=C(CCC1)C3=[N+]1CCCC3=C2 MPLHNVLQVRSVEE-UHFFFAOYSA-N 0.000 description 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 description 1
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- ZGYICYBLPGRURT-UHFFFAOYSA-N tri(propan-2-yl)silicon Chemical compound CC(C)[Si](C(C)C)C(C)C ZGYICYBLPGRURT-UHFFFAOYSA-N 0.000 description 1
- LENZDBCJOHFCAS-UHFFFAOYSA-N tris Chemical compound OCC(N)(CO)CO LENZDBCJOHFCAS-UHFFFAOYSA-N 0.000 description 1
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Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/0019—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules
- A61K49/0021—Fluorescence in vivo characterised by the fluorescent group, e.g. oligomeric, polymeric or dendritic molecules the fluorescent group being a small organic molecule
- A61K49/0032—Methine dyes, e.g. cyanine dyes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K49/00—Preparations for testing in vivo
- A61K49/001—Preparation for luminescence or biological staining
- A61K49/0013—Luminescence
- A61K49/0017—Fluorescence in vivo
- A61K49/005—Fluorescence in vivo characterised by the carrier molecule carrying the fluorescent agent
- A61K49/0056—Peptides, proteins, polyamino acids
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- General Health & Medical Sciences (AREA)
- Epidemiology (AREA)
- Biomedical Technology (AREA)
- Animal Behavior & Ethology (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Investigating Or Analysing Materials By Optical Means (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8907308P | 2008-08-15 | 2008-08-15 | |
| US61/089,073 | 2008-08-15 | ||
| GBGB0814960.1A GB0814960D0 (en) | 2008-08-15 | 2008-08-15 | Method for detecting dysplasia |
| GB0814960.1 | 2008-08-15 | ||
| PCT/EP2009/060571 WO2010018230A2 (en) | 2008-08-15 | 2009-08-14 | Method for detecting dysplasia |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2012500191A true JP2012500191A (ja) | 2012-01-05 |
| JP2012500191A5 JP2012500191A5 (enExample) | 2013-05-23 |
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Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011522522A Pending JP2012500191A (ja) | 2008-08-15 | 2009-08-14 | 異形成の検出方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110268660A1 (enExample) |
| EP (1) | EP2326352A2 (enExample) |
| JP (1) | JP2012500191A (enExample) |
| CN (1) | CN102123738A (enExample) |
| GB (1) | GB0814960D0 (enExample) |
| WO (1) | WO2010018230A2 (enExample) |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023526277A (ja) * | 2020-05-13 | 2023-06-21 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 核酸リガンドコンジュゲートおよび細胞への送達のためのその使用 |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20140276107A1 (en) * | 2011-10-14 | 2014-09-18 | Photocure Asa | Photodynamic diagnosis |
| US20130116404A1 (en) | 2011-11-08 | 2013-05-09 | Case Western Reserve University | Targeted non-invasive imaging probes of egfr expressing cells |
| JP7181875B2 (ja) | 2016-09-22 | 2022-12-01 | ユニバーシティー オブ ロード アイランド ボード オブ トラスティーズ | ｐＨトリガーポリペプチドにコンジュゲートしたフルオロフォアを含む蛍光化合物 |
| US11702462B2 (en) | 2017-07-19 | 2023-07-18 | Rutgers, The State University Of New Jersey | Gene transfer systems for stem cell engineering |
| WO2019183633A1 (en) | 2018-03-23 | 2019-09-26 | Case Western Reserve Univeristy | Psma targeted conjugate compounds and uses thereof |
| KR20230098281A (ko) * | 2020-10-27 | 2023-07-03 | 위스콘신 얼럼나이 리서어치 화운데이션 | 조합 면역요법을 위한 모듈형 덴드론 미셀 |
| US20250332265A1 (en) | 2021-11-09 | 2025-10-30 | Case Western Reserve University | Psma targeted conjugate compounds and uses thereof |
| CN115010850B (zh) * | 2022-06-08 | 2023-09-15 | 上海大学 | 具有交联稳定结构的近红外光热聚合物功能材料、其制备方法及其应用 |
Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005058371A1 (en) * | 2003-12-18 | 2005-06-30 | Amersham Health As | Optical imaging contrast agents |
| CN1676166A (zh) * | 2004-03-31 | 2005-10-05 | 上海新世界基因技术开发有限公司 | 与人表皮生长因子受体egfr特异性结合的配体寡肽 |
| WO2007042289A2 (en) * | 2005-10-11 | 2007-04-19 | Ablynx N.V. | Nanobodies™ and polypeptides against egfr and igf-ir |
| WO2007115571A2 (en) * | 2006-04-07 | 2007-10-18 | Enkam Pharmaceuticals A/S | Erbb receptor-derived peptide fragments |
| JP2008526802A (ja) * | 2005-01-07 | 2008-07-24 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 増殖性疾患の診断のためのシアニン染料の使用 |
| WO2009062399A1 (en) * | 2007-11-05 | 2009-05-22 | Shanghai Jiaotong University | Peptide ligand directed drug delivery |
-
2008
- 2008-08-15 GB GBGB0814960.1A patent/GB0814960D0/en not_active Ceased
-
2009
- 2009-08-14 JP JP2011522522A patent/JP2012500191A/ja active Pending
- 2009-08-14 CN CN2009801324664A patent/CN102123738A/zh active Pending
- 2009-08-14 WO PCT/EP2009/060571 patent/WO2010018230A2/en not_active Ceased
- 2009-08-14 US US13/058,345 patent/US20110268660A1/en not_active Abandoned
- 2009-08-14 EP EP09781872A patent/EP2326352A2/en not_active Withdrawn
Patent Citations (6)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2005058371A1 (en) * | 2003-12-18 | 2005-06-30 | Amersham Health As | Optical imaging contrast agents |
| CN1676166A (zh) * | 2004-03-31 | 2005-10-05 | 上海新世界基因技术开发有限公司 | 与人表皮生长因子受体egfr特异性结合的配体寡肽 |
| JP2008526802A (ja) * | 2005-01-07 | 2008-07-24 | バイエル・シエーリング・ファーマ アクチエンゲゼルシャフト | 増殖性疾患の診断のためのシアニン染料の使用 |
| WO2007042289A2 (en) * | 2005-10-11 | 2007-04-19 | Ablynx N.V. | Nanobodies™ and polypeptides against egfr and igf-ir |
| WO2007115571A2 (en) * | 2006-04-07 | 2007-10-18 | Enkam Pharmaceuticals A/S | Erbb receptor-derived peptide fragments |
| WO2009062399A1 (en) * | 2007-11-05 | 2009-05-22 | Shanghai Jiaotong University | Peptide ligand directed drug delivery |
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| JPN5011012014; ＦＩＬＩＰＥ Ｍ Ｉ: 'ＧＲＯＷＴＨ ＦＡＣＴＯＲＳ ＡＮＤ ＯＮＣＯＧＥＮＥＳ ＩＮ ＢＡＲＲＥＴＴ'Ｓ ＯＥＳＯＰＨＡＧＵＳ ＡＮＤ ＧＡＳＴＲＩＣ ＭＥＴＡＰＬＡＳＩＡ' ＥＮＤＯＳＣＯＰＹ Ｖ２５ Ｎ９, 199311, Ｐ６３７-６４１ * |
| JPN5011012015; ＳＹＭＭＡＮＳ Ｐ Ｊ: 'Ｐ５３ ＥＸＰＲＥＳＳＩＯＮ ＩＮ ＢＡＲＲＥＴＴ'Ｓ ＯＥＳＯＰＨＡＧＵＳ，ＤＹＳＰＬＡＳＩＡ， ＡＮＤ ＡＤＥＮＯＣＡＲＣＩＮＯＭＡ ＵＳＩＮＧ ＡＮＴＩＢＯＤＹ ＤＯ-７' ＴＨＥ ＪＯＵＲＮＡＬ ＯＦ ＰＡＴＨＯＬＯＧＹ Ｖ１７３ Ｎ３, 199407, Ｐ２２１-２２６ * |
| JPN6013041106; Ｔｈｅ ＦＡＳＥＢ Ｊｏｕｒｎａｌ Ｖｏｌ．１９, 2005, ｐ．１９７８-１９８５ * |
| JPN6013041109; Ｊｏｕｒｎａｌ ｏｆ Ｍｏｌｅｃｕｌａｒ Ｂｉｏｌｏｇｙ Ｖｏｌ．３７６, 200801, ｐ．１３８８-１４０２ * |
Cited By (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2023526277A (ja) * | 2020-05-13 | 2023-06-21 | ザ・ユニヴァーシティ・オヴ・ノース・キャロライナ・アト・チャペル・ヒル | 核酸リガンドコンジュゲートおよび細胞への送達のためのその使用 |
Also Published As
| Publication number | Publication date |
|---|---|
| EP2326352A2 (en) | 2011-06-01 |
| WO2010018230A2 (en) | 2010-02-18 |
| GB0814960D0 (en) | 2008-09-24 |
| CN102123738A (zh) | 2011-07-13 |
| WO2010018230A3 (en) | 2010-04-08 |
| US20110268660A1 (en) | 2011-11-03 |
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