JP2012180311A - 持久力向上剤 - Google Patents
持久力向上剤 Download PDFInfo
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- JP2012180311A JP2012180311A JP2011044977A JP2011044977A JP2012180311A JP 2012180311 A JP2012180311 A JP 2012180311A JP 2011044977 A JP2011044977 A JP 2011044977A JP 2011044977 A JP2011044977 A JP 2011044977A JP 2012180311 A JP2012180311 A JP 2012180311A
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- Prior art keywords
- endurance
- ceramide
- fatigue
- exercise
- improver
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Abstract
【解決手段】セラミドシリアチンを有効成分とする持久力向上剤。
【選択図】なし
Description
(1)セラミドシリアチンを有効成分とする持久力向上剤。
(2)セラミドシリアチンを有効成分とする抗疲労剤。
抽出手段は、具体的には、固液抽出、液液抽出、浸漬、煎出、浸出、還流抽出、超音波抽出、マイクロ波抽出、攪拌等の手段を用いることができる。
斯くして得られる抽出物は、抽出液や画分をそのまま用いてもよく、適宜な溶媒で希釈した希釈液として用いてもよく、或いは濃縮物や乾燥物としてもよい。
また、セラミドシリアチンは、持久力向上剤、抗疲労剤(以下、「持久力向上剤等」)として使用することができ、さらにこれらの剤を製造するために使用することができる。このとき、当該持久力向上剤等には、当該セラミドシリアチンを単独で、又はこれ以外に、必要に応じて適宜選択した担体等の、配合すべき後述の対象物において許容されるものを使用してもよい。なお、当該製剤は配合すべき対象物に応じて常法により製造することができる。
このような種々の剤型の医薬製剤を調製するには、本発明の持久力向上剤等を単独で、又は他の薬学的に許容される賦形剤、結合剤、増量剤、崩壊剤、界面活性剤、滑沢剤、分散剤、緩衝剤、保存剤、嬌味剤、香料、被膜剤、担体、希釈剤等を適宜組み合わせて用いることができる。
種々の形態の食品を調製するには、本発明の持久力向上剤等を単独で、又は他の食品材料や、溶剤、軟化剤、油、乳化剤、防腐剤、香科、安定剤、着色剤、酸化防止剤、保湿剤、増粘剤等を適宜組み合わせて用いることができる。当該食品中のセラミドシリアチンの含有量は、一般的に0.01〜100質量%とするのが好ましく、0.1〜100質量%とするのがより好ましく、更に好ましくは1〜100質量%とするのが好ましい。
尚、飼料を製造する場合には、本発明の持久力向上剤等の他に、牛、豚、羊等の肉類、蛋白質、穀物類、ぬか類、粕類、糖類、野菜、ビタミン類、ミネラル類等一般に用いられる飼料原料、更に一般的に飼料に使用されるゲル化剤、保型剤、pH調整剤、調味料、防腐剤、栄養補強剤等を組み合わせて用いることができる。
また、飼料中の、本発明のセラミドシリアチンの含有量は、その使用形態により異なるが、通常0.0001〜20質量%であり、0.001〜10質量%が好ましく、0.01〜5質量%がより好ましい。
また、上記製剤は、1週間に週3日以上、特に5日以上投与又は摂取するのが好ましく、毎日投与又は摂取するのが更に好ましい。また、投与又は摂取する継続期間は、2週間以上とするのが好ましく、4週間以上とするのが更に好ましい。
投与又は摂取対象者としては、それを必要としている者であれば特に限定されないが、本発明の持久力向上剤等は持久力の向上等を図ることができることから、特に、運動愛好者やアスリート、運動不足者、中高年者、ベッドレスト者における投与又は摂取が有効である。
イカミール(イカ肉質乾燥物、日本化学飼料より入手)1Kgをとり、ヘキサン−エタノール(1:1)混液3Lを加え、室温下で3時間攪拌抽出した。ろ過後、ろ過残渣に再度ヘキサン−エタノール(1:1)混液3Lを加え、室温下で3時間攪拌抽出した。抽出液は、併せて減圧濃縮した後、ヘキサン500mL、ラヂオライトデラックスW−50(昭和化学工業)50gを加え溶解した後、ろ過し、減圧濃縮した。これによりイカミール抽出物97gを得た。
得られたイカミール抽出物のうち、40gをとり、アセトン800mLを加え、氷冷下にホモミキサー(TKオートホモミキサー、特殊機化工業社製)にて分散した。その後、遠心分離により、アセトン可溶画分を除去した。同様の操作をさらに2回繰り返した後、沈殿物をヘキサンに溶解し回収した。これを濃縮、乾燥し、アセトン不溶画分1(10g)を得た。
さらに、本アセトン不溶画分1に0.4mol/LのKOH−MeOH溶液 200mLを加え、37℃で4時間攪拌し、加水分解反応を行った。反応終了後、クロロホルム400mLおよび0.9%食塩水を加え、抽出操作を行った。得られるクロロホルム層を減圧濃縮し、アルカリ安定画分7.6gを得た。
得られたアルカリ安定画分には、再度、アセトン100mLを加え、氷冷下にホモミキサー(TKオートホモミキサー、特殊機化工業社製)にて分散した。その後、遠心分離により、アセトン可溶画分を除去した。同様の操作をさらに2回繰り返した後、沈殿物をヘキサンに溶解し回収した。これを濃縮、乾燥し、アセトン不溶画分2(2.0g)を得た。最後に、アセトン不溶画分2をクロロホルムに溶解した後、シリカゲルカラムクロマト(Silica−gel 60《Merck社製》 100g使用、カラムサイズ:30x290mm)に供した。クロロホルム50mL、クロロホルム−メタノール(8/2)1000mLで展開した後、クロロホルム−メタノール(8/2)500mLおよびクロロホルム−メタノール(65/35)1500mLでの溶出分を併せて濃縮し、セラミドシリアチン精製品0.6g(収率:0.3%)を得た。
<方法>セラミドシリアチンは、上記製造例1より調製したものを用いた。
1週間の予備飼育後、9週齢の雄性BALB/cマウス(日本チャールスリバー)を体重と遊泳持久力(後記方法により、マウス用流水プール(京大松元式運動量測定流水槽:流路断面積=0.405m2)を用いて限界遊泳時間を測定)が等しくなるように2群(Cont群、CAPEn群)に分けた(各群8匹)。群分け後、Cont群のマウスにはコントロール食(10質量%(以下、単に「%」とする)脂質、20%カゼイン、55.5%ポテトスターチ、8.1%セルロース、0.2%メチオニン、2.2%ビタミン(商品名:ビタミン混合AIN−76、オリエンタルバイオサービス)、4%ミネラル(商品名:ミネラル混合AIN−76、オリエンタルバイオサービス)含有)を、また、CAEPn群のマウスには、セラミドシリアチンを含む試験食(10%脂質、20%カゼイン、55.25%ポテトスターチ、8.1%セルロース、0.2%メチオニン、2.2%ビタミン、4%ミネラル、0.25%セラミドシリアチン含有)を13週間給餌した。給餌期間中、Cont群およびCAEPn群のマウスにおいては、限界遊泳時間(7L/minの流量でマウスが泳げなくなった時点)を週に1度測定した。尚、この間、マウスを運動に慣らすため、週2回の遊泳トレーニング(6L/min、30min)を施した。
Claims (2)
- セラミドシリアチンを有効成分とする持久力向上剤。
- セラミドシリアチンを有効成分とする抗疲労剤。
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JP2017137439A (ja) * | 2016-02-04 | 2017-08-10 | 株式会社双葉紙器 | セラミドとセラミド誘導体との製造方法 |
WO2019026230A1 (ja) * | 2017-08-03 | 2019-02-07 | 株式会社双葉紙器 | セラミドの製造方法 |
WO2019049964A1 (ja) * | 2017-09-07 | 2019-03-14 | 株式会社ジェヌインR&D | 抗疲労経口組成物 |
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JP7164118B2 (ja) | 2017-09-07 | 2022-11-01 | 株式会社ジェヌインR&D | 抗疲労経口組成物 |
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