JP2012067089A - Fungicidal composition - Google Patents

Abstract

PROBLEM TO BE SOLVED: To provide a fungicidal composition having little irritation to worker's fingers, suppressing metal corrosion, keeping its concentration for long hours even in the case of low ethanol concentration, and maintaining sufficient bactericidal effect, when being used in a food production environment.SOLUTION: This liquid fungicidal composition contains one or more kinds of components selected from a group comprising ethanol, lactic acid, sodium lactate, glycerol fatty acid ester, glycerol, diglycerol, polyglycerol, propylene glycol, sorbitol and maltitol, wherein the ethanol concentration is 15-55 wt.%, pH of the composition is 3.0-5.0, and the acidity of the composition is 0.03-0.5.

Description

  The present invention relates to a bactericidal composition, specifically, a low volatility ethanol bactericidal composition having low skin irritation and low metal corrosivity. The present invention also relates to a disinfectant composition-containing sheet obtained by impregnating a nonwoven fabric with the disinfectant composition.

  One of the causes of microbial contamination leading to food poisoning and food spoilage is secondary contamination that occurs through tools, workers' hands, etc. in the processing process. In order to prevent cross-contamination, it is necessary to sterilize the production environment, production tools and tools, and the fingers of workers to kill microorganisms. As a sterilization method, a method of spraying a bactericide composition containing ethanol as a main component directly on a manufacturing tool / tool or a finger of an operator, or a method of wiping by impregnating a nonwoven fabric or the like is used.

  However, a bactericidal composition containing ethanol at a high concentration has a high bactericidal effect, but has a high flammability and a safety problem. Also, such a bactericidal composition is highly irritating and has been a cause of rough hands when used in a method of spraying directly on the fingers of workers. On the other hand, a bactericidal composition containing ethanol at a low concentration has a problem that sterilization becomes insufficient although it is difficult to cause irritation to fingers. In particular, when a non-woven fabric is impregnated with a bactericide composition, ethanol contained in the non-woven fabric evaporates over time, and the ethanol concentration further decreases, so that sufficient sterilizing power can be maintained. There was a problem of disappearing.

  Against the background as described above, a preparation in which an organic acid having a bacteriostatic effect, an organic acid salt, a glycerin fatty acid ester and the like are added to a relatively low concentration of ethanol to enhance the bactericidal effect has been proposed. For example, Patent Document 1 contains a lower alcohol, an organic acid and an alkali metal salt thereof, an inorganic acid and an alkali metal salt thereof, and a nonionic surfactant in a specific ratio, and the pH of the composition stock solution is adjusted to 8 to 12. A conditioned disinfectant is disclosed. However, this disinfectant has a problem that the pH is in the alkaline region, and when the concentration of alcohol or organic acid is low, a sufficient disinfecting effect cannot be obtained. Furthermore, the bactericidal composition containing a large amount of organic acid has been a cause of metal corrosion such as rust when used in metallic manufacturing equipment.

  Therefore, there is a demand for a bactericidal composition that has little effect on manufacturing tools and workers' fingers, maintains ethanol concentration for a long period of time even when impregnated into a nonwoven fabric, etc., and can maintain a sufficient bactericidal effect against microorganisms. It was rare.

JP 2009-173641 A

  An object of the present invention is to provide a bactericidal composition that can suppress metal corrosion, reduce irritation to workers' fingers, maintain ethanol concentration for a long time, and maintain a sufficient bactericidal effect when used in a food production environment. There is to do.

  By adding a specific ratio of one or more components selected from the group consisting of glycerin, diglycerin, polyglycerin, propylene glycol, sorbitol, and maltitol, lactic acid, sodium lactate, and glycerin fatty acid ester to ethanol in a specific ratio. The inventors have found that a liquid disinfectant composition that suppresses metal corrosion, alleviates irritation on fingers, suppresses volatilization of ethanol, and maintains a sufficient disinfecting effect, and has completed the present invention.

That is, the present invention relates to a liquid fungicide composition containing at least one component selected from the group consisting of ethanol, lactic acid, sodium lactate, glycerin fatty acid ester, and glycerin, diglycerin, polyglycerin, propylene glycol, sorbitol, and maltitol. The ethanol concentration is 15 to 55% by weight, the pH of the composition is 3.0 to 5.0, and the acidity of the composition is 0.03 to 0.5. A liquid disinfectant composition is provided.
The present invention also provides a disinfectant composition-containing sheet obtained by impregnating a nonwoven fabric with the liquid disinfectant composition.

FIG. 1 shows the results of a metal corrosion test.

The present invention relates to a liquid disinfectant composition containing at least one component selected from the group consisting of ethanol, lactic acid, sodium lactate, glycerin fatty acid ester, and glycerin, diglycerin, polyglycerin, propylene glycol, sorbitol and maltitol The ethanol concentration is 15 to 55% by weight, the pH of the composition is 3.0 to 5.0, and the acidity of the composition is 0.03 to 0.5. A liquid disinfectant composition is provided.
The present invention also includes ethanol 15-55 wt%, lactic acid 0.05-0.9 wt%, sodium lactate 0.01-0.35 wt%, glycerin fatty acid ester 0.01-0.5 wt%, and glycerin. A liquid bactericidal composition containing 0.1 to 3.0% by weight of one or more components selected from the group consisting of diglycerin, polyglycerin, propylene glycol, sorbitol and maltitol, A liquid fungicide composition having a pH of 3.0 to 5.0 and an acidity of the composition of 0.03 to 0.5 is provided.

  Although it does not limit as liquid sterilizer composition of this invention, For example, ethanol 17-45 weight%, lactic acid 0.1-0.4 weight%, sodium lactate 0.02-0.3 weight%, glycerin A liquid bactericidal composition containing 0.04 to 0.2% by weight of a fatty acid ester and 0.2 to 0.6% by weight of glycerin, wherein the pH of the composition is 3.3 to 4.6 And the liquid disinfectant composition whose acidity of this composition is 0.05-0.35 is mentioned.

Ethanol, which is a constituent component of the liquid bactericidal composition of the present invention, is not particularly limited, and may be industrial ethanol or denatured ethanol containing a food fragrance or the like as a denaturant in an arbitrary ratio.
The ratio of ethanol in the liquid bactericidal composition of the present invention is not particularly limited when the composition is not used for a sterilized object, for example, when stored in the form of a high concentration liquid. When used with respect to the sterilization object, the proportion of ethanol in the liquid bactericidal composition of the present invention may be 15 to 55% by weight with respect to the total weight of the composition, and 16 to 50% by weight. Is preferable, 17 to 45 weight% is more preferable, and 40 to 45 weight% is further more preferable. When the ratio of ethanol is less than 15% by weight, the bactericidal effect tends to be insufficient, and depending on the type and content of the glycerin fatty acid ester to be blended, it may be precipitated during storage. On the other hand, when the ratio of ethanol exceeds 55% by weight, irritation to fingers is increased, and the risk of ignition is increased, and handling is required.

As one or more components selected from the group consisting of glycerin, diglycerin, polyglycerin, propylene glycol, sorbitol, and maltitol, which are constituents of the liquid bactericidal composition of the present invention, the effect of suppressing ethanol volatilization From this point, glycerin is preferable.
The ratio of one or more components selected from the group consisting of glycerin, diglycerin, polyglycerin, propylene glycol, sorbitol and maltitol in the liquid fungicide composition of the present invention is not particularly limited. Is preferably 0.1 to 3.0% by weight, more preferably 0.15 to 1.0% by weight, and 0.2 to 0.6% by weight based on the total weight of the composition. Further preferred. When the ratio of one or more components selected from the group consisting of glycerin, diglycerin, polyglycerin, propylene glycol, sorbitol and maltitol is less than 0.1% by weight, the effect of suppressing the volatilization of ethanol tends to decrease. is there. When it exceeds 3.0% by weight, stickiness occurs during use, and there is a tendency to hinder work.

  The proportion of lactic acid in the liquid bactericidal composition of the present invention is not particularly limited, but when used for an object to be sterilized, it is preferably 0.05 to 0.9% by weight based on the total weight of the composition. 0.07 to 0.6% by weight is more preferable, and 0.1 to 0.4% by weight is even more preferable. When the ratio of lactic acid is less than 0.05% by weight, a sufficient bactericidal effect tends to be not obtained. When it exceeds 0.9% by weight, the pH is lowered and the acidity is increased, so that irritation to fingers is increased and metal corrosion tends to occur.

  The proportion of sodium lactate in the liquid bactericidal composition of the present invention is not particularly limited, but when used for the sterilization object, 0.01 to 0.35 wt% is the total weight of the composition. Preferably, 0.015-0.33 weight% is more preferable, and 0.02-0.3 weight% is further more preferable. When the proportion of sodium lactate is less than 0.01% by weight, irritation to fingers tends to be strong, and when it exceeds 0.35% by weight, acidity tends to decrease and a sufficient bactericidal effect tends not to be obtained. .

The glycerin fatty acid ester, which is a constituent of the liquid fungicide composition of the present invention, may be any glycerin fatty acid ester used as a food emulsifier, but monoglycerin caprylate and / or monoglycerin caprate is preferred.
The ratio of the glycerin fatty acid ester in the liquid fungicide composition of the present invention is not particularly limited, but when used for a sterilization object, 0.01 to 0.5% by weight based on the total weight of the composition. Is preferable, 0.02 to 0.3% by weight is more preferable, and 0.04 to 0.2% by weight is further preferable. When the proportion of glycerin fatty acid ester is less than 0.01% by weight, there is a tendency that sufficient sterilization effect cannot be obtained, and when it exceeds 0.5% by weight, odor is generated and the liquid germicide composition is deposited during storage. The tendency to do becomes large.

  The pH of the liquid bactericidal composition of the present invention is not particularly limited when the composition is not used for an object to be sterilized, for example, when stored in the form of a high-concentration liquid. The pH of the liquid bactericidal composition of the present invention when used for an object to be sterilized may be 3.0 to 5.0, preferably 3.2 to 4.8, and preferably 3.3 to 4. 6 is more preferable. When the pH is less than 3.0, the bactericidal effect is increased, but the influence on the irritation of fingers is increased, and depending on the type of metal, there is a tendency to cause corrosion such as rust. When pH exceeds 5.0, there exists a tendency for a bactericidal effect to fall.

  The acidity of the liquid disinfectant composition of the present invention is not particularly limited when the composition is not used for an object to be sterilized, for example, when stored in the form of a high-concentration liquid. The acidity of the liquid disinfectant composition of the present invention when used for an object to be sterilized may be 0.03 to 0.5, preferably 0.04 to 0.4, and 0.05 to 0.00. 35 is more preferable. If the acidity is less than 0.03, the bactericidal effect tends to decrease. When the acidity exceeds 0.5, the bactericidal effect increases, but the influence on finger irritation increases, and depending on the type of metal, corrosion such as rust tends to occur.

The acidity of the liquid fungicide composition of the present invention is measured by the following titration test. 5 ml of sample, 15 ml of water and 10 ml of 0.1N NaOH are added to a 100 ml stoppered flask in this order, and the flask is sealed and left at room temperature for 30 minutes to prepare the test solution. The test solution is titrated with 0.1N HCl using phenolphthalein (1000 ppm) as an indicator to obtain the test titer (ml). A titration test similar to the above is performed except that the sample is replaced with water to obtain a blank test titer (ml). The acidity is calculated from the resulting drop constant using the following formula:
Acidity = (Blank test drop constant [ml] −Main test drop constant [ml]) / 5 [ml].

One or more components selected from the group consisting of ethanol, lactic acid, sodium lactate, glycerin fatty acid ester, and glycerin, diglycerin, polyglycerin, propylene glycol, sorbitol and maltitol, constituting the liquid bactericidal composition of the present invention The remainder other than is water.
Therefore, the method for producing the liquid disinfectant composition of the present invention is not particularly limited, and for example, it can be produced by simply mixing each component and water. Further, if the ratio of each component in the liquid germicide composition and the pH and acidity of the composition are within the above ranges, for example, the liquid germicide composition obtained by mixing each component with water is diluted with water. Or may be made by further mixing with water.

  As a method of using the liquid disinfectant composition of the present invention, the composition is filled in a spray container or the like, and directly sprayed on a manufacturing tool / tool or operator's finger, or the nonwoven fabric is impregnated with the composition. There is a method of wiping off as a disinfectant composition-containing sheet, or a method of transferring the composition to a cleaning container or the like and immersing a manufacturing instrument / tool or operator's fingers.

  When the nonwoven fabric is impregnated with a liquid disinfectant composition, examples of the raw material for the nonwoven fabric include cotton, pulp, polyester, polypropylene, nylon, polyethylene, rayon, nylon, acrylic, vinylon, and the like. From the viewpoint of quick drying, those using pulp, rayon and acrylic are preferred.

  The liquid disinfectant composition of the present invention is used for sterilization of cooking machines and utensils, work tables, refrigerators, trays, tables, workers' hands, etc. in food processing factories, restaurants, school and hotel kitchens, etc. I can do it.

  Hereinafter, the present invention will be further described by examples. However, the present invention is not limited to the following examples.

Examples 1-3 and Comparative Examples 1-7
Test method for bactericidal activity : The following test bacteria were cultured in a BHI (Brain Heart Infusion) broth medium at 30 ° C. for 24 hours, and the bacterial solution was appropriately diluted to prepare a bacterial count of 10 ⁶ CFU / ml. . 0.1 mL of the bacterial solution was mixed with 10 mL of the liquid bactericidal composition shown in Table 1 and stirred, and then held at 25 ° C. for 0.5 minutes. After the sensitization time, the mixture was stirred again, and 10 μL was taken from each mixture and inoculated into 10 mL of BHI broth medium. This was cultured at 30 ° C. for 48 hours. The sterilization effect of each composition was determined by comparing the turbidity of the medium visually with reference to a BHI broth medium that had not been inoculated with bacteria.
Test bacteria: Escherichia-coli NBRC 3972

  The results are shown in Table 2. The liquid bactericidal compositions of Examples 1 to 3 had an excellent bactericidal effect with respect to the liquid bactericidal compositions of Comparative Examples 1 to 5. “−” In the table indicates that the medium was not turbid and sterilized, and “+” indicates that the medium was turbid and was not sterilized.

Table 1

Table 2

Ethanol volatilization measurement test test method: 30 g of each liquid germicide composition shown in Table 3 is put into a 100 mL beaker, placed in a constant temperature and humidity chamber with a temperature of 30 ° C. and a relative humidity of 55%, and the weight is measured every 30 minutes. did.
Table 3

The results are shown in Table 4 and FIG. The liquid bactericidal composition of Example 1 had a smaller weight change than the liquid bactericidal composition of Comparative Example 6, and was excellent in the ethanol retention effect.
Table 4

Metal Corrosion Test Test Method: 5 cm long, 3 cm wide, 0.1 cm thick iron pieces were immersed in 50 mL of each liquid disinfectant composition having the composition shown in Table 5, stored at room temperature for 4 weeks, and examined for changes in weight. It was. The change in weight was calculated from the weight difference between the iron piece before the start of the test and the iron piece after immersion by the following formula.
Weight change rate (%) =
(Iron piece weight after immersion-Iron piece weight before immersion) / Iron piece weight before immersion x 100
Table 5

The results are shown in Table 6. The iron piece treated with the liquid disinfectant composition of Example 1 had a small weight change rate, and the metal corrosivity was suppressed as compared with the liquid disinfectant compositions of Comparative Examples 7 and 8.
Table 6

Appearance observation The appearance of the iron piece after the metal corrosion test was observed. The surface of the iron piece after the test using the liquid fungicide composition of Example 1 was not changed compared to the iron piece before the test, whereas the liquid fungicide composition of Comparative Example 7 was used. White precipitates adhered to the iron piece surface, and when the liquid bactericidal composition of Comparative Example 8 was used, the iron piece surface changed to black.

Claims (6)

  A liquid disinfectant composition containing one or more components selected from the group consisting of ethanol, lactic acid, sodium lactate, glycerin fatty acid ester, and glycerin, diglycerin, polyglycerin, propylene glycol, sorbitol and maltitol, A liquid disinfectant having a concentration of the ethanol of 15 to 55% by weight, a pH of the composition of 3.0 to 5.0, and an acidity of the composition of 0.03 to 0.5 Composition.   15-55% by weight of ethanol, 0.05-0.9% by weight of lactic acid, 0.01-0.35% by weight of sodium lactate, 0.01-0.5% by weight of glycerin fatty acid ester, and glycerin, diglycerin, poly A liquid disinfectant composition containing 0.1 to 3.0% by weight of one or more components selected from the group consisting of glycerin, propylene glycol, sorbitol and maltitol, wherein the pH of the composition is 3.0 The liquid disinfectant composition which is -5.0, and the acidity of this composition is 0.03-0.5.   A liquid disinfectant composition containing one or more components selected from the group consisting of ethanol, lactic acid, sodium lactate, glycerin fatty acid ester, and glycerin, diglycerin, polyglycerin, propylene glycol, sorbitol and maltitol, The liquid disinfectant composition which becomes the liquid disinfectant composition according to claim 2 by diluting the composition with water or mixing with water.   The liquid disinfectant composition according to any one of claims 1 to 3, wherein one or more components selected from the group consisting of glycerin, diglycerin, polyglycerin, propylene glycol, sorbitol and maltitol are glycerin.   The liquid sterilizer composition according to any one of claims 1 to 4, wherein the glycerin fatty acid ester is a monoglycerin caprylate and / or a monoglycerin caprate.   A disinfectant composition-containing sheet obtained by impregnating a nonwoven fabric with the liquid disinfectant composition according to any one of claims 1 to 5.

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