JP2012031152A5 - - Google Patents
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- Publication number
- JP2012031152A5 JP2012031152A5 JP2011141877A JP2011141877A JP2012031152A5 JP 2012031152 A5 JP2012031152 A5 JP 2012031152A5 JP 2011141877 A JP2011141877 A JP 2011141877A JP 2011141877 A JP2011141877 A JP 2011141877A JP 2012031152 A5 JP2012031152 A5 JP 2012031152A5
- Authority
- JP
- Japan
- Prior art keywords
- substituted
- unsubstituted
- benzimidazol
- methyl
- group
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- -1 unsaturated nitrogen-containing aliphatic compounds Chemical class 0.000 claims 28
- 150000003839 salts Chemical class 0.000 claims 23
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 21
- 125000004432 carbon atom Chemical group C* 0.000 claims 18
- 150000001875 compounds Chemical class 0.000 claims 14
- 125000001931 aliphatic group Chemical group 0.000 claims 9
- 125000000217 alkyl group Chemical group 0.000 claims 9
- 125000000623 heterocyclic group Chemical group 0.000 claims 9
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims 9
- QDKWLJJOYIFEBS-UHFFFAOYSA-N 1-fluoro-4-$l^{1}-oxidanylbenzene Chemical group [O]C1=CC=C(F)C=C1 QDKWLJJOYIFEBS-UHFFFAOYSA-N 0.000 claims 8
- 125000004433 nitrogen atom Chemical group N* 0.000 claims 7
- 239000003814 drug Substances 0.000 claims 6
- 229910052757 nitrogen Chemical group 0.000 claims 6
- 125000000753 cycloalkyl group Chemical group 0.000 claims 5
- JUJWROOIHBZHMG-UHFFFAOYSA-N Pyridine Chemical group C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 4
- 229910052799 carbon Inorganic materials 0.000 claims 4
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 3
- 125000003118 aryl group Chemical group 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- 125000006618 5- to 10-membered aromatic heterocyclic group Chemical group 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- 125000000304 alkynyl group Chemical group 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000005843 halogen group Chemical group 0.000 claims 2
- 239000003112 inhibitor Substances 0.000 claims 2
- 210000005036 nerve Anatomy 0.000 claims 2
- 125000004430 oxygen atom Chemical group O* 0.000 claims 2
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Chemical group COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 2
- 229920006395 saturated elastomer Polymers 0.000 claims 2
- 230000001953 sensory effect Effects 0.000 claims 2
- 125000004434 sulfur atom Chemical group 0.000 claims 2
- ZYUAASICHDTDEK-AWEZNQCLSA-N (2s)-2-[[1-ethyl-6-(4-methylphenoxy)benzimidazol-2-yl]methylamino]propanamide Chemical compound C1=C2N(CC)C(CN[C@@H](C)C(N)=O)=NC2=CC=C1OC1=CC=C(C)C=C1 ZYUAASICHDTDEK-AWEZNQCLSA-N 0.000 claims 1
- 208000001294 Nociceptive Pain Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 125000003545 alkoxy group Chemical group 0.000 claims 1
- 150000001721 carbon Chemical class 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 206010013990 dysuria Diseases 0.000 claims 1
- 125000004438 haloalkoxy group Chemical group 0.000 claims 1
- 125000001188 haloalkyl group Chemical group 0.000 claims 1
- 125000005842 heteroatom Chemical group 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 208000004296 neuralgia Diseases 0.000 claims 1
- 208000021722 neuropathic pain Diseases 0.000 claims 1
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000003449 preventive effect Effects 0.000 claims 1
- 229910052717 sulfur Inorganic materials 0.000 claims 1
- 229940124597 therapeutic agent Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2011141877A JP5667934B2 (ja) | 2010-06-28 | 2011-06-27 | 新規２環性複素環化合物からなる医薬 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2010146560 | 2010-06-28 | ||
| JP2010146560 | 2010-06-28 | ||
| JP2011141877A JP5667934B2 (ja) | 2010-06-28 | 2011-06-27 | 新規２環性複素環化合物からなる医薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2012031152A JP2012031152A (ja) | 2012-02-16 |
| JP2012031152A5 true JP2012031152A5 (cg-RX-API-DMAC7.html) | 2014-06-19 |
| JP5667934B2 JP5667934B2 (ja) | 2015-02-12 |
Family
ID=45845001
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011141877A Active JP5667934B2 (ja) | 2010-06-28 | 2011-06-27 | 新規２環性複素環化合物からなる医薬 |
Country Status (1)
| Country | Link |
|---|---|
| JP (1) | JP5667934B2 (cg-RX-API-DMAC7.html) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP6002785B2 (ja) * | 2012-02-03 | 2016-10-05 | ファイザー・インク | ナトリウムチャネルモジュレーターとしてのベンゾイミダゾールおよびイミダゾピリジン誘導体 |
| KR102114389B1 (ko) * | 2018-05-02 | 2020-05-25 | 이화여자대학교 산학협력단 | 신규 소듐채널 저해 화합물, 이의 제조방법, 및 이를 포함하는 소듐채널 관련 질환의 예방 또는 치료용 약학적 조성물 |
| HRP20241414T1 (hr) * | 2018-05-08 | 2024-12-20 | Nippon Shinyaku Co., Ltd. | Azabenzimidazolski spojevi i farmaceutski proizvod |
| JP7391848B2 (ja) * | 2018-07-19 | 2023-12-05 | 住友ファーマ株式会社 | 外用製剤 |
| US20240100022A1 (en) * | 2020-12-23 | 2024-03-28 | Sumitomo Pharma Co., Ltd. | Oral solid preparation |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2425185A1 (en) * | 2000-10-06 | 2002-04-11 | Stephane De Lombaert | Benzimidazole and indole derivatives as crf receptor modulators |
| EP2234486A4 (en) * | 2007-12-19 | 2011-09-14 | Scripps Research Inst | BENZIMIDAZOLES AND ANALOGS AS INHIBITORS OF RHO-KINASE |
| CA2748251C (en) * | 2008-12-26 | 2016-08-02 | Dainippon Sumitomo Pharma Co., Ltd. | Bicyclic heterocyclic compound for use as a sensory neuron specific sodium channel inhibitor |
-
2011
- 2011-06-27 JP JP2011141877A patent/JP5667934B2/ja active Active
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