JP2012017335A - Lipolysis promoter - Google Patents
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- JP2012017335A JP2012017335A JP2011203897A JP2011203897A JP2012017335A JP 2012017335 A JP2012017335 A JP 2012017335A JP 2011203897 A JP2011203897 A JP 2011203897A JP 2011203897 A JP2011203897 A JP 2011203897A JP 2012017335 A JP2012017335 A JP 2012017335A
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Abstract
Description
本発明は体脂肪の分解を促進し、全身もしくは局所の脂肪を減少させ、肥満の予防・改善に有効な脂肪分解促進剤に関する。 The present invention promotes the degradation of body fat, reducing fat systemic or topical relates to effective lipolysis promoting agent for the prevention and improvement of obesity.
肥満は、消費エネルギーに対して過剰な摂取エネルギーが脂肪細胞に中性脂肪として蓄積して生じるものであり、動脈硬化等の様々な疾病を引き起こす要因となるのみならず美容上好ましくないため、その予防改善が強く求められている。しかしながら、近年、我が国をはじめ先進諸国では肥満者の割合は年々増加している。その理由に過食、運動不足、ストレス等が挙げられるが、食事制限、運動療法は強い意志と長い期間継続することが必要なため続けられない人が多い。 Obesity is caused by excessive intake of energy consumed and accumulated as neutral fat in fat cells, which is not only a factor that causes various diseases such as arteriosclerosis, but is not cosmetically desirable. There is a strong need for preventive improvements. However, in recent years, the proportion of obese people has been increasing year by year in Japan and other developed countries. Reasons include overeating, lack of exercise, and stress, but many people cannot continue because dietary restrictions and exercise therapy require a strong will and long duration.
このような背景から肥満の予防・改善に有効な脂肪分解促進剤の開発が種々成されている。例えば、ハトムギ、大麦、決明子、蕃石榴及びプアール茶よりなる群から選択される少なくとも1種以上の素材からの抽出エキスを有効成分とする脂肪分解促進剤が脂肪細胞中に蓄積する脂肪の分解を促進して、肥満の抑制や予防に寄与し得ることが知られている(例えば、特許文献1参照)。また、ゲンノショウコエキス、シャクヤクエキス、センブリエキス、タイムエキスからなる群より選ばれる一種、または二種以上を含有する脂肪分解促進剤が全身もしくは局所の脂肪組織の減少を促進することによる肥満体質の改善、または同組織の増大を防止することによる肥満の抑制もしくは防止に有効なことも知られている(例えば、特許文献2参照)。また更に、オレンジリーフ、オレンジフラワー、フキタンポポ葉及びカラマスルートからなる群から選択される少なくとも1種を有効成分として含有してなる脂肪分解促進剤が肥満の抑制または防止、肥満体質の改善、局所あるいは全身の脂肪組織の減量に有用なことも知られている(例えば、特許文献3参照)。また更に、コショウ科の植物を有効成分として含有することを特徴とする脂肪分解促進剤が脂肪組織において明らかな脂肪分解促進作用を有し、肥満の抑制、防止及び改善に優れた効果を有することも知られている(例えば、特許文献4参照)。また更に、アザミ族の植物を有効成分として含有することを特徴とする脂肪分解促進剤が脂肪組織において明らかな脂肪分解促進作用を有し、肥満の抑制、防止及び改善に優れた効果を有することも知られている(例えば、特許文献5参照)。また更に、バナナ果皮またはその抽出物を含有する脂肪分解促進剤が蓄積した脂肪の分解を促進し、十分に肥満を抑制、防止、改善できることも知られている(例えば、特許文献6参照)。しかしながら、これら脂肪分解促進剤は必ずしも十分な効果を持つとは言えず、また中には副作用が懸念されているものもあった。 From such a background, various developments of a lipolysis promoter effective for the prevention and improvement of obesity have been made. For example, a lipolysis accelerator containing as an active ingredient an extract extracted from at least one material selected from the group consisting of pearl barley, barley, seiko, garnet cocoon, and puar tea can decompose fat accumulated in fat cells. It is known that it can promote and contribute to the suppression and prevention of obesity (see, for example, Patent Document 1). In addition, improvement of obesity by improving lipolysis of systemic or local adipose tissue by using a lipolysis accelerator containing one or more selected from the group consisting of genochocolate extract, peonies extract, assembly extract, and thyme extract It is also known that it is effective in suppressing or preventing obesity by preventing the increase of the same tissue (see, for example, Patent Document 2). Furthermore, a lipolysis promoter comprising as an active ingredient at least one selected from the group consisting of orange leaf, orange flower, dandelion leaf and caramaroot is an inhibitor of obesity, improves obesity, Or it is also known that it is useful for weight loss of the whole body adipose tissue (for example, refer to patent documents 3). Furthermore, a lipolysis promoter characterized by containing a plant of the family Pepperaceae as an active ingredient has a clear lipolysis promoting action in adipose tissue, and has an excellent effect in suppressing, preventing and improving obesity Is also known (see, for example, Patent Document 4). Furthermore, a lipolysis promoter characterized by containing a plant of thistle family as an active ingredient has an obvious lipolysis promoting action in adipose tissue, and has an excellent effect in suppressing, preventing and improving obesity Is also known (see, for example, Patent Document 5). Furthermore, it is also known that the fat decomposition accelerator containing banana peel or an extract thereof accelerates the decomposition of accumulated fat and can sufficiently suppress, prevent and improve obesity (see, for example, Patent Document 6). However, it cannot be said that these lipolysis promoters have sufficient effects, and some of them are concerned about side effects.
以上のような背景から、肥満の予防・改善に十分な効果があり、且つ、安全に使用できる脂肪分解促進剤の更なる開発が望まれている。 From the background as described above, further development of a lipolysis promoter that is sufficiently effective in preventing and improving obesity and that can be used safely is desired.
本発明者らは肥満の要因である脂肪細胞の増加・膨大に注目し、脂肪細胞中の中性脂肪の分解を促進することにより、肥満を予防・改善できると考え、種々の植物について鋭意研究を行った結果、メース(Myristica fragarance)、カリフォルニアンポピー(Escholzia california)、ミクリ(Sparganium stoloniferum)、ブラッドルート(Sanguinaria canadensis)、オレゴンマウンテングレープ(Mahonia Aquifolium)、セキショウ(Acorus gramineus)、バナナ(musa paradiciaca)の実部位、エニシダ(Cytisus scoparius)、ゴールデンシール(Hydrastis canadensis)、パイルワート(Ficaria ranunculoides)、ヒューミトリー(Fumaria officinalis)、イコジャ(unonopsis floribunda)、クレソン(Nasturtium officinale)、ブラッククミン(Nigella sativa)、ネトル(Urtica dioica)、ナズナ(Capsella bursa-pastoris)、ケンジン(Polygonum bistorta)に脂肪細胞における中性脂質の分解を促進する効果があることを発見し、本発明を完成させた。 The present inventors pay attention to the increase and enormous number of fat cells that are the cause of obesity, and believe that obesity can be prevented and ameliorated by promoting the degradation of neutral fat in fat cells. the results of, mace (Myristica fragarance), mosquito Rifo CALIFORNIA down poppy (Escholzia california), Mikuri (Sparganium stoloniferum), Blood root (Sanguinaria canadensis), Oregon Mountain grape (Mahonia Aquifolium), Sekishou (Acorus gramineus), banana (musa Paradiciaca fruit part, Cytisus scoparius, Golden seal (Hydrastis canadensis), Pilewort (Ficaria ranunculoides), Humitry (Fumaria officinalis), Ikoja (unonopsis floribunda), Watercress (Nasturtium officinale), Black cumin (ella satin) Nettle (Urtica dioica), Nazuna (Capsella bursa-pastoris), Ke The present invention was completed by discovering that N. ginseng (Polygonum bistorta) has an effect of promoting the degradation of neutral lipids in adipocytes.
すなわち、本発明は、メース(Myristica fragarance)、カリフォルニアンポピー(Escholzia california)、ミクリ(Sparganium stoloniferum)、ブラッドルート(Sanguinaria canadensis)、オレゴンマウンテングレープ(Mahonia Aquifolium)、セキショウ(Acorus gramineus)、バナナ(musa paradiciaca)の実部位、エニシダ(Cytisus scoparius)、ゴールデンシール(Hydrastis canadensis)、パイルワート(Ficaria ranunculoides)、ヒューミトリー(Fumaria officinalis)、イコジャ(unonopsis floribunda)、クレソン(Nasturtium officinale)、ブラッククミン(Nigella sativa)、ネトル(Urtica dioica)、ナズナ(Capsella bursa-pastoris)、ケンジン(Polygonum bistorta)からなる群より選択される一種、又は二種以上の植物体及び/又はその抽出物を有効成分として含有する脂肪分解促進剤である。 That is, the present invention is, mace (Myristica fragarance), mosquito Rifo CALIFORNIA emissions Poppy (Escholzia california), Mikuri (Sparganium stoloniferum), Blood Root (Sanguinaria canadensis), Oregon Mountain grape (Mahonia aquifolium), Sekishou (Acorus gramineus), banana ( Real part of musa paradiciaca, Cytisus scoparius, Golden seal (Hydrastis canadensis), Pilewort (Ficaria ranunculoides), Humitry (Fumaria officinalis), Ikoja (unonopsis floribunda), Watercress (Nasturtium officinale), Black mint , Nettle (Urtica dioica), nazuna (Capsella bursa-pastoris), Kenzin (Polygonum bistorta) selected from the group consisting of two or more plant bodies and / or extracts thereof as an active ingredient It is an accelerator .
本発明の脂肪分解促進剤及びそれを含有する飲食品は、脂肪組織において明らかな脂肪分解促進作用を有し、肥満の予防または改善、肥満体質の改善に優れた効果を有する。 The lipolysis promoter of the present invention and food and drink containing the same have an obvious lipolysis promoting action in adipose tissue, and have an excellent effect in preventing or improving obesity and improving obesity.
以下、本発明を詳細に説明する。本発明の脂肪分解促進剤、それを含有する飲食品、及びそれらの製造方法、並びにその効能等について述べるが、本発明はこれらに限定されるものではない。 Hereinafter, the present invention will be described in detail. The lipolysis promoter of the present invention, foods and drinks containing the same, methods for producing them, efficacy thereof, and the like are described below, but the present invention is not limited thereto.
本発明の脂肪分解促進剤としては、各植物をそのまま有効成分として含有しても良いが、乾燥させたもの、更に乾燥物を粉末化したものを有効成分として含有しても良い。また、各植物より抽出された抽出物を有効成分として含有しても良い。この植物抽出物とは、水、各種有機溶媒又は水を含む各種有機溶媒で抽出された液状エキスであって良いが、更にこの液状エキスを通常の乾燥方法(例えば、減圧乾燥、凍結乾燥等)や濃縮方法等により乾固又は濃縮したものであっても良い。有機溶媒の種類は特に限定されないが、エタノール、メタノール、アセトン、酢酸エチル、ヘキサン等が挙げられる。また更に、この植物抽出物に対し、必要に応じてその効果に影響が無い範囲で脱臭、脱色等の精製処理を施しても良い。 The lipolysis promoter of the present invention may contain each plant as an active ingredient as it is, but may contain a dried product or a powdered dried product as an active ingredient. Moreover, you may contain the extract extracted from each plant as an active ingredient. The plant extract may be a liquid extract extracted with water, various organic solvents, or various organic solvents including water, and the liquid extract is further dried by a normal drying method (for example, vacuum drying, freeze drying, etc.). Or it may be dried or concentrated by a concentration method or the like. Although the kind of organic solvent is not specifically limited, Ethanol, methanol, acetone, ethyl acetate, hexane, etc. are mentioned. Furthermore, you may perform refinement | purification processes, such as deodorizing and decoloring, to this plant extract in the range which does not affect the effect as needed.
本発明の脂肪分解促進剤は、経口剤、外用剤等の任意の形態で用いることができる。従って、適宜賦形剤等を用いてこの植物抽出物を顆粒状にする等、服用剤として使用しやすい状態に製剤化しても良い。更に当該脂肪分解促進剤は顔や腹部に直接塗布することで、これらの部位の脂肪を局所的に減少させることも可能であるので、化粧水、ジェル、スキンローション、軟膏剤、ペースト剤、パップ剤、プラスター剤、スティック剤、シート剤、入浴剤、身体洗浄用錠剤等として用いることができる。 The lipolysis promoter of the present invention can be used in any form such as an oral preparation and an external preparation. Therefore, the plant extract may be formulated into a state that can be easily used as an ingestion agent, for example, by using an excipient or the like as appropriate. Furthermore, since the lipolysis promoter can be applied directly to the face and abdomen to locally reduce the fat in these areas, lotion, gel, skin lotion, ointment, paste, paste It can be used as an agent, plaster agent, stick agent, sheet agent, bath agent, body washing tablet and the like.
本発明の脂肪分解促進剤の配合量は、添加形態及び投与形態によっても異なるが、広い範囲から選択できる。例えば、外用剤の場合には、溶媒抽出乾燥物換算で、組成物中に0.005重量%(以下、単に%で示す)以上、特に0.01〜30%配合するのが好ましい。また、経口剤の場合には、溶媒抽出乾燥物換算で、成人1日あたり0.01〜10g、特に0.05〜3gになるようにするのが好ましい。 The blending amount of the lipolysis promoter of the present invention varies depending on the addition form and administration form, but can be selected from a wide range. For example, in the case of an external preparation, it is preferably blended in the composition in an amount of 0.005% by weight (hereinafter simply referred to as%) or more, particularly 0.01 to 30% in terms of a solvent-extracted dried product. In the case of an oral preparation, it is preferably 0.01 to 10 g, particularly 0.05 to 3 g per day for an adult in terms of a solvent-extracted dried product.
本発明の飲食品には前記の脂肪分解促進剤が配合されており、配合可能な飲食品は特に限定されず、ガム、キャンディ、チョコレートといった種々の形態の菓子や、健康食品、飲料、ドリンク剤、調味料、パン、麺類に配合されることができる。本発明における飲食品としては、肥満予防効果及び肥満改善効果を持たせた健康食品、機能性食品、或いは特定保健用食品の形態を取っていても構わない。また一般の食事に利用することもできる。そしてこのように配合された飲食品を摂取することで、肥満の改善や、肥満から派生する生活習慣病を改善することが可能である。この場合、脂肪分解促進剤の配合量は溶媒抽出乾燥物換算で、飲食品中に0.0001以上、好ましくは0.01〜99重量%配合するのが好ましい。 The above-described lipolysis promoter is blended in the food and drink of the present invention, and the food and drink that can be blended is not particularly limited, and various forms of confectionery such as gum, candy, and chocolate, health foods, beverages, and drinks , Seasonings, breads, noodles. The food and drink in the present invention may take the form of a health food, a functional food, or a food for specified health use that has an obesity prevention effect and an obesity improvement effect. It can also be used for general meals. And it is possible to improve obesity and lifestyle-related diseases derived from obesity by ingesting food and drink blended in this way. In this case, the blending amount of the lipolysis accelerator is preferably 0.0001 or more, and preferably 0.01 to 99% by weight in the food or drink in terms of the solvent-extracted dried product.
以下、試験例を挙げて本発明品を更に詳細に説明するが、それらによって本発明品の範囲を制限するものではない。 Hereinafter, although a test example is given and this invention product is demonstrated still in detail, the range of this invention product is not restrict | limited by them.
本試験は、植物体より植物抽出物を得るために実施した。 This test was conducted to obtain a plant extract from the plant body.
1)供試試料
表1に示す18種の植物を用いた。
1) Test sample Eighteen kinds of plants shown in Table 1 were used.
2)試験法
植物を乾燥させ、その乾燥体10gに50%エタノール又は水を100mlを加え、撹拌しながら70℃で2時間抽出処理を行い、得られた抽出液をろ過後減圧濃縮し、次いで凍結乾燥し、植物抽出物を得た。
2) Test method After drying the plant, adding 100 ml of 50% ethanol or water to 10 g of the dried product, performing an extraction treatment at 70 ° C. for 2 hours with stirring, filtering the obtained extract and concentrating under reduced pressure, Lyophilized to obtain a plant extract.
3)試験結果
各抽出物の収率を[表1]に示す。
3) Test results The yield of each extract is shown in [Table 1].
本試験は、試験例1で得られた植物抽出物の脂肪分解促進作用を調べるために行なった。 This test was conducted in order to examine the lipolysis promoting action of the plant extract obtained in Test Example 1.
1)供試試料
試験例1で調製した50%エタノール抽出物18種、水抽出物7種の凍結乾燥植物抽出物を単独又は2種類以上組み合わせて用いた。
1) Test sample The lyophilized plant extracts of 18 kinds of 50% ethanol extract and 7 kinds of water extract prepared in Test Example 1 were used alone or in combination of two or more kinds.
2)試験法
(I)脂肪細胞の培養
マウス由来の前駆脂肪細胞であるMC3T3−G2/PA6細胞を24wellプレートに5×104個/wellになるように播き、10%牛胎児血清(FBS)添加α‐MEM培地にて5%CO2存在下、37℃で培養した。コンフルエントになる直前、デキサメタゾン、3−イソブチル−1−メチルキサンチン及びグルコースを添加した10%FBSα−MEM培地に交換し、脂肪細胞への分化を誘導した。誘導後8〜9日間培養を行い、脂肪細胞を成熟させた後に試験を行った。
2) Test method (I) Adipocyte culture MC3T3-G2 / PA6 cells, which are mouse-derived preadipocytes, are seeded on a 24-well plate at 5 × 10 4 cells / well, and 10% fetal bovine serum (FBS) The cells were cultured at 37 ° C. in the presence of 5% CO 2 in an added α-MEM medium. Immediately before becoming confluent, the medium was replaced with a 10% FBSα-MEM medium supplemented with dexamethasone, 3-isobutyl-1-methylxanthine and glucose to induce differentiation into adipocytes. Cultivation was carried out for 8-9 days after induction, and the test was performed after adipocytes were matured.
(II)脂肪分解活性測定法
培養上清を捨て、ウェルをPBS(−)で洗浄後、凍結乾燥植物抽出物と2%BSA、4.5g/Lグルコースを含むダルベッコリン酸緩衝液を加え、1時間インキュベートした。尚、凍結乾燥植物抽出物の量は単独又は2種類以上組み合わせて使用した場合の何れにおいても、この反応系における最終濃度が100μg/mlとなるように調整した。インキュベート後、上清をサンプリングし、トリグリセライドE−テストワコーを用いて脂肪の分解産物であるグリセロールの遊離量を測定した。なお、脂肪分解促進率は、以下の式で示されるコントロール(凍結乾燥植物抽出物を加えない場合)の値を100%とした場合の相対的な数値である。
(II) Lipolytic activity measurement method Discard the culture supernatant, wash the well with PBS (-), add lyophilized plant extract and Dulbecco's phosphate buffer containing 2% BSA, 4.5 g / L glucose, Incubated for 1 hour. The amount of the lyophilized plant extract was adjusted so that the final concentration in this reaction system would be 100 μg / ml when used alone or in combination of two or more. After the incubation, the supernatant was sampled, and the amount of glycerol that is a degradation product of fat was measured using Triglyceride E-Test Wako. The rate of promoting lipolysis is a relative value when the value of the control (when no lyophilized plant extract is added) represented by the following formula is 100%.
脂肪分解促進率(%)=[A/B]×100
A:抽出物添加時の遊離グリセロール量
B:抽出物無添加時の遊離グリセロール量
Lipolysis promotion rate (%) = [A / B] × 100
A: Free glycerol amount when the extract is added B: Free glycerol amount when the extract is not added
3)試験結果
脂肪分解促進作用の判定は、脂肪分解により生成する遊離グリセロール量の測定値より求めた脂肪分解促進率により行った。[表2]、[表3]及び[表4]に示すように、供試植物抽出物を単独或いは2種類以上組み合わせて添加した場合、無添加の場合と比較して、明らかに脂肪分解が促進されていた。
3) Test results The determination of the lipolysis promoting action was performed based on the rate of lipolysis promotion determined from the measured value of the amount of free glycerol produced by lipolysis. As shown in [Table 2], [Table 3] and [Table 4], when the test plant extract was added alone or in combination of two or more kinds, the lipolysis was clearly reduced as compared with the case of no addition. Has been promoted.
以下、実施例を挙げて本発明品を更に詳細に説明するが、それらによって本発明品の範囲を制限するものではない。 EXAMPLES Hereinafter, although an Example is given and this invention product is demonstrated further in detail, the range of this invention product is not restrict | limited by them.
下記処方にしたがってチューイングガムを調製した。
ガムベース 20.0部
砂糖 55.0部
ブドウ糖 23.7部
軟化剤 1.0部
オレゴンマウンテングレープ50%エタノール抽出物 0.8部
Chewing gum was prepared according to the following formulation.
Gum base 20.0 parts Sugar 55.0 parts Glucose 23.7 parts Softener 1.0 parts Oregon Mountain Grape 50% ethanol extract 0.8 parts
下記処方にしたがってチューイングガムを調製した。
ガムベース 20.0部
キシリトール 75.0部
還元麦芽糖 3.8部
軟化剤 1.0部
オレゴンマウンテングレープ水抽出物 0.2部
Chewing gum was prepared according to the following formulation.
Gum base 20.0 parts Xylitol 75.0 parts Reduced maltose 3.8 parts Softener 1.0 part Oregon mountain grape water extract 0.2 parts
下記処方にしたがって錠菓を調製した。
砂糖 75.0部
乳糖 20.0部
グリセリン脂肪酸エステル 0.2部
香料 0.4部
クレソン50%エタノール抽出物 0.1部
精製水 4.3部
Tablet confectionery was prepared according to the following formulation.
Sugar 75.0 parts Lactose 20.0 parts Glycerin fatty acid ester 0.2 parts Fragrance 0.4 parts Watercress 50% ethanol extract 0.1 parts Purified water 4.3 parts
下記処方にしたがってチョコレートを調製した。
砂糖 41.0部
カカオマス 15.0部
全脂粉乳 25.0部
ココアバター 18.0部
乳化剤 0.3部
香料 0.4部
スカンクキャベッジ50%エタノール抽出物 0.3部
Chocolate was prepared according to the following formulation.
Sugar 41.0 parts Cacao mass 15.0 parts Whole milk powder 25.0 parts Cocoa butter 18.0 parts Emulsifier 0.3 parts
Fragrance 0.4 parts Skunk Cabbage 50% Ethanol Extract 0.3 parts
下記処方にしたがって飲料を調製した。
果糖ブドウ糖飲料 5.00部
砂糖 4.50部
酸味料 1.28部
香料 0.20部
ケンジン50%エタノール抽出物 0.02部
精製水 89.0 部
A beverage was prepared according to the following formulation.
Fructose glucose beverage 5.00 parts Sugar 4.50 parts Acidulant 1.28 parts Fragrance 0.20 parts Kenzin 50% ethanol extract 0.02 parts Purified water 89.0 parts
下記処方にしたがって飲料を調製した。
オレンジ果汁 85.25部
砂糖 11.70部
クエン酸 2.00部
香料 1.00部
メース50%エタノール抽出物 0.05部
A beverage was prepared according to the following formulation.
Orange fruit juice 85.25 parts Sugar 11.70 parts Citric acid 2.00 parts Fragrance 1.00 parts Mace 50% ethanol extract 0.05 parts
下記の処方に従ってアイスクリームを調製した。
果糖ブドウ糖液糖 0.5部
砂糖 8.7部
酸味料 1.2部
香料 0.3部
精製水 89.0部
安定剤 0.2部
ブラッククミン水抽出物 0.1部
Ice cream was prepared according to the following formulation.
Fructose glucose liquid sugar 0.5 parts Sugar 8.7 parts Acidulant 1.2 parts Fragrance 0.3 parts Purified water 89.0 parts Stabilizer 0.2 parts Black cumin water extract 0.1 parts
下記の処方に従ってドッグフードを調製した。
トウモロコシ 33.0部
小麦粉 35.0部
大豆粕 21.0部
米ぬか(脱脂) 5.5部
ミートミール 5.0部
ミネラルミックス 0.2部
イコジャ50%エタノール抽出物 0.3部
Dog food was prepared according to the following recipe.
Corn 33.0 parts Wheat flour 35.0 parts Soybean meal 21.0 parts Rice bran (defatted) 5.5 parts Meat meal 5.0 parts Mineral mix 0.2 parts Ikoja 50% ethanol extract 0.3 parts
下記の処方に従ってカプセル剤を調製した。
スカンクキャベッジ水抽出物 50.0部
乳糖 48.0部
ステアリン酸マグネシウム 2.0部
上記成分を均一に混合し、その混合末をハードカプセルに充填した。
Capsules were prepared according to the following formulation.
Skunk cabbage water extract 50.0 parts Lactose 48.0 parts Magnesium stearate 2.0 parts The above ingredients were mixed uniformly, and the mixed powder was filled into hard capsules.
下記の処方に従って錠剤を調製した。
ネトル50%エタノール抽出物 20.0部
直打用微粒 48.0部
(メタケイ酸アルミン酸マグネシウム20%、トウモロコシデンプン30%、乳糖50%)
結晶セルロース 30.0部
ステアリン酸マグネシウム 2.0部
上記成分を均一に混合し、その混合末を打錠して、1錠200mgの錠剤とした。
Tablets were prepared according to the following formulation.
Netol 50% ethanol extract 20.0 parts Granules for direct hitting 48.0 parts (magnesium aluminate metasilicate 20%, corn starch 30%, lactose 50%)
Crystalline cellulose 30.0 parts Magnesium stearate 2.0 parts The above ingredients were mixed uniformly, and the mixed powder was tableted into a tablet of 200 mg.
下記の処方に従ってシロップ剤を調製した。
メース水抽出物 0.1部
単シロップ 30.0部
精製水 69.9部
上記植物抽出物を、精製水で完全に溶解し、単シロップを加えて混合し、シロップ剤とした。
A syrup was prepared according to the following formulation.
Mace water extract 0.1 part simple syrup 30.0 parts purified water 69.9 parts The above plant extract was completely dissolved in purified water, and added with simple syrup and mixed to obtain a syrup agent.
下記の処方に従ってキャンディを調製した。
カリフォルニアンポピー水抽出物 0.2部
砂糖 50.0部
水飴 35.3部
香料 0.5部
精製水 14.0部
Candy was prepared according to the following formulation.
California poppy water extract 0.2 parts Sugar 50.0 parts Minamata 35.3 parts Fragrance 0.5 parts Purified water 14.0 parts
下記の処方に従ってビスケットを調製した。
メース50%エタノール抽出物 0.5部
小麦粉 50.6部
コーンスターチ 5.1部
砂糖 12.7部
マーガリン 6.5部
食塩 0.3部
炭酸ナトリウム 1.3部
炭酸アンモニウム 0.5部
大豆レシチン 0.3部
全卵 4.1部
香料 0.3部
精製水 17.8部
上記材料を混合してドウを形成し、延展後これを成型してオーブンで焙焼し、ビスケットを製造した。
Biscuits were prepared according to the following recipe.
Mace 50% ethanol extract 0.5 parts wheat flour 50.6 parts corn starch 5.1 parts sugar 12.7 parts margarine 6.5 parts salt 0.3 parts sodium carbonate 1.3 parts ammonium carbonate 0.5 parts soy lecithin 0 .3 parts whole egg 4.1 parts fragrance 0.3 parts purified water 17.8 parts The above materials were mixed to form a dough. After spreading, this was molded and baked in an oven to produce biscuits.
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