JP2011530585A5 - - Google Patents

Info

Publication number

JP2011530585A5

JP2011530585A5 JP2011522927A JP2011522927A JP2011530585A5 JP 2011530585 A5 JP2011530585 A5 JP 2011530585A5 JP 2011522927 A JP2011522927 A JP 2011522927A JP 2011522927 A JP2011522927 A JP 2011522927A JP 2011530585 A5 JP2011530585 A5 JP 2011530585A5

Authority

JP

Japan

Prior art keywords

noise

administered

agent according

exposure

receptor agonist

Prior art date

2009-08-11

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 239000003795 chemical substances by application Substances 0.000 claims 20
• 239000003379 purinergic P1 receptor agonist Substances 0.000 claims 10
• 229940122614 Adenosine receptor agonist Drugs 0.000 claims 9
• OIRDTQYFTABQOQ-KQYNXXCUSA-N adenosine Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O OIRDTQYFTABQOQ-KQYNXXCUSA-N 0.000 claims 4
• 239000003814 drug Substances 0.000 claims 4
• 229940124597 therapeutic agent Drugs 0.000 claims 4
• XSMYYYQVWPZWIZ-IDTAVKCVSA-N (2r,3r,4s,5r)-2-[2-chloro-6-(cyclopentylamino)purin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC(Cl)=NC(NC3CCCC3)=C2N=C1 XSMYYYQVWPZWIZ-IDTAVKCVSA-N 0.000 claims 3
• GYWXTRVEUURNEW-TVDBPQCTSA-N (2R,3R,4S,5R)-2-[6-[[(1S,2S)-2-hydroxycyclopentyl]amino]-9-purinyl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(N[C@@H]3[C@H](CCC3)O)=C2N=C1 GYWXTRVEUURNEW-TVDBPQCTSA-N 0.000 claims 2
• -1 3-chloro-2-thienyl Chemical group 0.000 claims 2
• 239000002126 C01EB10 - Adenosine Substances 0.000 claims 2
• 206010011903 Deafness traumatic Diseases 0.000 claims 2
• 208000002946 Noise-Induced Hearing Loss Diseases 0.000 claims 2
• 229960005305 adenosine Drugs 0.000 claims 2
• 150000003839 salts Chemical class 0.000 claims 2
• 239000012453 solvate Substances 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• JAKAFSGZUXCHLF-LSCFUAHRSA-N (2r,3r,4r,5r)-5-[6-(cyclohexylamino)purin-9-yl]-2-(hydroxymethyl)-4-methoxyoxolan-3-ol Chemical compound CO[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(NC3CCCCC3)=C2N=C1 JAKAFSGZUXCHLF-LSCFUAHRSA-N 0.000 claims 1
• VFEGXMIJIICQBD-SRNJXLPISA-N (2r,3r,4s,5r)-2-[6-[[(2r)-1-(1,3-benzothiazol-2-ylsulfanyl)propan-2-yl]amino]-2-chloropurin-9-yl]-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound N([C@@H](CSC=1SC2=CC=CC=C2N=1)C)C(C=1N=C2)=NC(Cl)=NC=1N2[C@@H]1O[C@H](CO)[C@@H](O)[C@H]1O VFEGXMIJIICQBD-SRNJXLPISA-N 0.000 claims 1
• OESBDSFYJMDRJY-BAYCTPFLSA-N (2r,3s,4r,5r)-2-(hydroxymethyl)-5-[6-[[(3r)-oxolan-3-yl]amino]purin-9-yl]oxolane-3,4-diol Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(N[C@H]3COCC3)=C2N=C1 OESBDSFYJMDRJY-BAYCTPFLSA-N 0.000 claims 1
• FPHJJCBLRAPJQJ-CRKDRTNXSA-N (2s,3r,4s,5r)-2-amino-2-(6-aminopurin-9-yl)-5-(hydroxymethyl)oxolane-3,4-diol Chemical compound C1=NC=2C(N)=NC=NC=2N1[C@]1(N)O[C@H](CO)[C@@H](O)[C@H]1O FPHJJCBLRAPJQJ-CRKDRTNXSA-N 0.000 claims 1
• 241000283690 Bos taurus Species 0.000 claims 1
• 241000124008 Mammalia Species 0.000 claims 1
• 241001465754 Metazoa Species 0.000 claims 1
• 230000001154 acute effect Effects 0.000 claims 1
• 210000003477 cochlea Anatomy 0.000 claims 1
• 239000000039 congener Substances 0.000 claims 1
• XRLDSWLMHUQECH-UHFFFAOYSA-N cyclopentanecarboxamide Chemical compound NC(=O)C1CCCC1 XRLDSWLMHUQECH-UHFFFAOYSA-N 0.000 claims 1
• 239000012528 membrane Substances 0.000 claims 1
• SQMWSBKSHWARHU-SDBHATRESA-N n6-cyclopentyladenosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(NC3CCCC3)=C2N=C1 SQMWSBKSHWARHU-SDBHATRESA-N 0.000 claims 1
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
• 230000000451 tissue damage Effects 0.000 claims 1
• 231100000827 tissue damage Toxicity 0.000 claims 1
• 208000037816 tissue injury Diseases 0.000 claims 1