JP2011528354A5 - - Google Patents

Info

Publication number

JP2011528354A5

JP2011528354A5 JP2011518807A JP2011518807A JP2011528354A5 JP 2011528354 A5 JP2011528354 A5 JP 2011528354A5 JP 2011518807 A JP2011518807 A JP 2011518807A JP 2011518807 A JP2011518807 A JP 2011518807A JP 2011528354 A5 JP2011528354 A5 JP 2011528354A5

Authority

JP

Japan

Prior art keywords

piperidinyl

cyclopropyl

dihydro

oxo

methoxy

Prior art date

2009-07-10

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

• Espacenet
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• BJEPYKJPYRNKOW-UHFFFAOYSA-N malic acid Chemical compound OC(=O)C(O)CC(O)=O BJEPYKJPYRNKOW-UHFFFAOYSA-N 0.000 claims 12
• 150000003839 salts Chemical class 0.000 claims 9
• BJEPYKJPYRNKOW-REOHCLBHSA-N (S)-malic acid Chemical compound OC(=O)[C@@H](O)CC(O)=O BJEPYKJPYRNKOW-REOHCLBHSA-N 0.000 claims 6
• 235000011090 malic acid Nutrition 0.000 claims 6
• 239000008194 pharmaceutical composition Substances 0.000 claims 6
• AVPQPGFLVZTJOR-NEPJUHHUSA-N 7-[(3s,5r)-3-amino-5-methylpiperidin-1-yl]-1-cyclopropyl-8-methoxy-4-oxoquinoline-3-carboxylic acid Chemical compound COC1=C(N2C[C@@H](N)C[C@@H](C)C2)C=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 AVPQPGFLVZTJOR-NEPJUHHUSA-N 0.000 claims 5
• 241000191967 Staphylococcus aureus Species 0.000 claims 5
• 229940049920 malate Drugs 0.000 claims 5
• 241000193998 Streptococcus pneumoniae Species 0.000 claims 4
• 229940099690 malic acid Drugs 0.000 claims 4
• 239000001630 malic acid Substances 0.000 claims 4
• 208000035143 Bacterial infection Diseases 0.000 claims 3
• RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 3
• 241000191963 Staphylococcus epidermidis Species 0.000 claims 3
• 208000022362 bacterial infectious disease Diseases 0.000 claims 3
• 229960003085 meticillin Drugs 0.000 claims 3
• 229940031000 streptococcus pneumoniae Drugs 0.000 claims 3
• 208000015181 infectious disease Diseases 0.000 claims 2
• AVPQPGFLVZTJOR-RYUDHWBXSA-N nemonoxacin Chemical compound COC1=C(N2C[C@@H](N)C[C@H](C)C2)C=CC(C(C(C(O)=O)=C2)=O)=C1N2C1CC1 AVPQPGFLVZTJOR-RYUDHWBXSA-N 0.000 claims 2
• LISFMEBWQUVKPJ-UHFFFAOYSA-N quinolin-2-ol Chemical compound C1=CC=C2NC(=O)C=CC2=C1 LISFMEBWQUVKPJ-UHFFFAOYSA-N 0.000 claims 2
• BJEPYKJPYRNKOW-UWTATZPHSA-N (R)-malic acid Chemical compound OC(=O)[C@H](O)CC(O)=O BJEPYKJPYRNKOW-UWTATZPHSA-N 0.000 claims 1
• 241000194032 Enterococcus faecalis Species 0.000 claims 1
• 241000588724 Escherichia coli Species 0.000 claims 1
• 241000606768 Haemophilus influenzae Species 0.000 claims 1
• 241000588652 Neisseria gonorrhoeae Species 0.000 claims 1
• 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
• 241000191940 Staphylococcus Species 0.000 claims 1
• 201000005010 Streptococcus pneumonia Diseases 0.000 claims 1
• 108010059993 Vancomycin Proteins 0.000 claims 1
• 239000002253 acid Substances 0.000 claims 1
• 239000003814 drug Substances 0.000 claims 1
• 229940032049 enterococcus faecalis Drugs 0.000 claims 1
• 229940047650 haemophilus influenzae Drugs 0.000 claims 1
• 229940116298 l- malic acid Drugs 0.000 claims 1
• 229960003165 vancomycin Drugs 0.000 claims 1
• MYPYJXKWCTUITO-UHFFFAOYSA-N vancomycin Natural products O1C(C(=C2)Cl)=CC=C2C(O)C(C(NC(C2=CC(O)=CC(O)=C2C=2C(O)=CC=C3C=2)C(O)=O)=O)NC(=O)C3NC(=O)C2NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(CC(C)C)NC)C(O)C(C=C3Cl)=CC=C3OC3=CC2=CC1=C3OC1OC(CO)C(O)C(O)C1OC1CC(C)(N)C(O)C(C)O1 MYPYJXKWCTUITO-UHFFFAOYSA-N 0.000 claims 1
• MYPYJXKWCTUITO-LYRMYLQWSA-O vancomycin(1+) Chemical compound O([C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@H]1OC1=C2C=C3C=C1OC1=CC=C(C=C1Cl)[C@@H](O)[C@H](C(N[C@@H](CC(N)=O)C(=O)N[C@H]3C(=O)N[C@H]1C(=O)N[C@H](C(N[C@@H](C3=CC(O)=CC(O)=C3C=3C(O)=CC=C1C=3)C([O-])=O)=O)[C@H](O)C1=CC=C(C(=C1)Cl)O2)=O)NC(=O)[C@@H](CC(C)C)[NH2+]C)[C@H]1C[C@](C)([NH3+])[C@H](O)[C@H](C)O1 MYPYJXKWCTUITO-LYRMYLQWSA-O 0.000 claims 1