JP2011528230A5 - - Google Patents
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- Publication number
- JP2011528230A5 JP2011528230A5 JP2011518880A JP2011518880A JP2011528230A5 JP 2011528230 A5 JP2011528230 A5 JP 2011528230A5 JP 2011518880 A JP2011518880 A JP 2011518880A JP 2011518880 A JP2011518880 A JP 2011518880A JP 2011528230 A5 JP2011528230 A5 JP 2011528230A5
- Authority
- JP
- Japan
- Prior art keywords
- conjugate
- hormone
- linker
- gmbs
- spdp
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- PVGATNRYUYNBHO-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 4-(2,5-dioxopyrrol-1-yl)butanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCN1C(=O)C=CC1=O PVGATNRYUYNBHO-UHFFFAOYSA-N 0.000 claims 2
- 150000001875 compounds Chemical class 0.000 claims 2
- 235000018102 proteins Nutrition 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 102000004169 proteins and genes Human genes 0.000 claims 2
- 239000003488 releasing hormone Substances 0.000 claims 2
- JWDFQMWEFLOOED-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 3-(pyridin-2-yldisulfanyl)propanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCSSC1=CC=CC=N1 JWDFQMWEFLOOED-UHFFFAOYSA-N 0.000 claims 1
- VLARLSIGSPVYHX-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 6-(2,5-dioxopyrrol-1-yl)hexanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCN1C(=O)C=CC1=O VLARLSIGSPVYHX-UHFFFAOYSA-N 0.000 claims 1
- WCMOHMXWOOBVMZ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 6-[3-(2,5-dioxopyrrol-1-yl)propanoylamino]hexanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCNC(=O)CCN1C(=O)C=CC1=O WCMOHMXWOOBVMZ-UHFFFAOYSA-N 0.000 claims 1
- QYEAAMBIUQLHFQ-UHFFFAOYSA-N (2,5-dioxopyrrolidin-1-yl) 6-[3-(pyridin-2-yldisulfanyl)propanoylamino]hexanoate Chemical compound O=C1CCC(=O)N1OC(=O)CCCCCNC(=O)CCSSC1=CC=CC=N1 QYEAAMBIUQLHFQ-UHFFFAOYSA-N 0.000 claims 1
- 239000000579 Gonadotropin-Releasing Hormone Substances 0.000 claims 1
- 101000857870 Squalus acanthias Gonadoliberin Proteins 0.000 claims 1
- 238000010276 construction Methods 0.000 claims 1
- XUJNEKJLAYXESH-UHFFFAOYSA-N cysteine Natural products SCC(N)C(O)=O XUJNEKJLAYXESH-UHFFFAOYSA-N 0.000 claims 1
- 235000018417 cysteine Nutrition 0.000 claims 1
- XLXSAKCOAKORKW-AQJXLSMYSA-N gonadorelin Chemical compound C([C@@H](C(=O)NCC(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCNC(N)=N)C(=O)N1[C@@H](CCC1)C(=O)NCC(N)=O)NC(=O)[C@H](CO)NC(=O)[C@H](CC=1C2=CC=CC=C2NC=1)NC(=O)[C@H](CC=1N=CNC=1)NC(=O)[C@H]1NC(=O)CC1)C1=CC=C(O)C=C1 XLXSAKCOAKORKW-AQJXLSMYSA-N 0.000 claims 1
- 229940035638 gonadotropin-releasing hormone Drugs 0.000 claims 1
- 239000005556 hormone Substances 0.000 claims 1
- 229940088597 hormone Drugs 0.000 claims 1
- 239000000126 substance Substances 0.000 claims 1
- 230000008685 targeting Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8077308P | 2008-07-15 | 2008-07-15 | |
| US61/080,773 | 2008-07-15 | ||
| PCT/US2009/050685 WO2010009227A2 (en) | 2008-07-15 | 2009-07-15 | Recombinant pokeweed antiviral proteins, compositions and methods related thereto |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011528230A JP2011528230A (ja) | 2011-11-17 |
| JP2011528230A5 true JP2011528230A5 (enExample) | 2012-08-30 |
Family
ID=41319605
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011518880A Pending JP2011528230A (ja) | 2008-07-15 | 2009-07-15 | 組換えヨウシュヤマゴボウ（ｐｏｋｅｗｅｅｄ）抗ウイルスタンパク質、それに関連する組成物および方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8575109B2 (enExample) |
| EP (1) | EP2318431B1 (enExample) |
| JP (1) | JP2011528230A (enExample) |
| AU (1) | AU2009270920A1 (enExample) |
| CA (1) | CA2730933A1 (enExample) |
| WO (1) | WO2010009227A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8575109B2 (en) | 2008-07-15 | 2013-11-05 | Cedus, Inc. | Recombinant pokeweed antiviral proteins, compositions and methods related thereto |
| CN102286097B (zh) * | 2011-06-20 | 2013-04-24 | 中国农业科学院植物保护研究所 | 人工合成的美洲商陆抗病毒蛋白（pap）抗原、抗体及其制备方法、应用 |
| US20190106466A1 (en) * | 2016-04-04 | 2019-04-11 | Ophiuchus Medicine Inc. | Medicinal plants |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU5186090A (en) | 1989-02-23 | 1990-09-26 | Colorado State University Research Foundation | Gnrh analogs for destroying gonadotrophs |
| US20050277582A1 (en) | 1993-07-20 | 2005-12-15 | Nett Torrance M | Method for inactivating gonadotrophs |
| US20090028886A1 (en) * | 2004-08-04 | 2009-01-29 | Cytos Biotechnology Ag | Carrier conjugates of gnrh-peptides |
| US20070141548A1 (en) * | 2005-03-11 | 2007-06-21 | Jorg Kohl | Organ transplant solutions and method for transplanting organs |
| US8575109B2 (en) | 2008-07-15 | 2013-11-05 | Cedus, Inc. | Recombinant pokeweed antiviral proteins, compositions and methods related thereto |
-
2009
- 2009-07-15 US US13/054,187 patent/US8575109B2/en not_active Expired - Fee Related
- 2009-07-15 AU AU2009270920A patent/AU2009270920A1/en not_active Abandoned
- 2009-07-15 CA CA 2730933 patent/CA2730933A1/en not_active Abandoned
- 2009-07-15 EP EP20090790464 patent/EP2318431B1/en not_active Not-in-force
- 2009-07-15 WO PCT/US2009/050685 patent/WO2010009227A2/en not_active Ceased
- 2009-07-15 JP JP2011518880A patent/JP2011528230A/ja active Pending
-
2013
- 2013-10-03 US US14/045,437 patent/US9023596B2/en not_active Expired - Fee Related
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