JP2011527677A5 - - Google Patents

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Publication number
JP2011527677A5
JP2011527677A5 JP2011517461A JP2011517461A JP2011527677A5 JP 2011527677 A5 JP2011527677 A5 JP 2011527677A5 JP 2011517461 A JP2011517461 A JP 2011517461A JP 2011517461 A JP2011517461 A JP 2011517461A JP 2011527677 A5 JP2011527677 A5 JP 2011527677A5
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JP
Japan
Prior art keywords
alkyl
hydrogen
halogen
ring
cycloalkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2011517461A
Other languages
English (en)
Japanese (ja)
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JP2011527677A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2009/048394 external-priority patent/WO2010005783A1/en
Publication of JP2011527677A publication Critical patent/JP2011527677A/ja
Publication of JP2011527677A5 publication Critical patent/JP2011527677A5/ja
Pending legal-status Critical Current

Links

JP2011517461A 2008-07-08 2009-06-24 Ｎｈｅ−１阻害剤として有用なピロリジニル及びピペリジニル化合物 Pending JP2011527677A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7886708P 2008-07-08 2008-07-08
US61/078,867 2008-07-08
PCT/US2009/048394 WO2010005783A1 (en) 2008-07-08 2009-06-24 Pyrrolidinyl and piperidinyl compounds useful as nhe-1 inhibitors

Publications (2)

Publication Number Publication Date
JP2011527677A JP2011527677A (ja) 2011-11-04
JP2011527677A5 true JP2011527677A5 (https=) 2012-08-09

Family

ID=41090284

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011517461A Pending JP2011527677A (ja) 2008-07-08 2009-06-24 Ｎｈｅ−１阻害剤として有用なピロリジニル及びピペリジニル化合物

Country Status (5)

Country Link
US (1) US20110118262A1 (https=)
EP (1) EP2321274A1 (https=)
JP (1) JP2011527677A (https=)
CA (1) CA2730116A1 (https=)
WO (1) WO2010005783A1 (https=)

Families Citing this family (17)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP5693452B2 (ja) 2008-08-04 2015-04-01 シーエイチディーアイ ファウンデーション，インコーポレーテッド 特定のキヌレニン−３−モノオキシゲナーゼインヒビター、医薬組成物およびそれらの使用方法
CA2787365A1 (en) 2010-01-25 2011-07-28 Chdi Foundation, Inc. Certain kynurenine-3-monooxygenase inhibitors, pharmaceutical compositions, and methods of use thereof
WO2011103126A1 (en) * 2010-02-17 2011-08-25 Ampla Pharmaceuticals Inc. Treatment of metabolic syndrome with piperidine amides
SI2750677T1 (sl) 2011-08-30 2017-10-30 Chdi Foundation, Inc. Inhibitorji kinurenin-3-monooksigenaze, farmacevtski sestavki in postopki njihove uporabe
KR20140072037A (ko) 2011-08-30 2014-06-12 씨에이치디아이 파운데이션, 인코포레이티드 키뉴레닌-3-모노옥시게나제 억제제, 약학적 조성물 및 이의 사용 방법
JP6182593B2 (ja) 2012-04-20 2017-08-16 アドヴィーナス セラピューティクス リミテッド 置換ヘテロ二環化合物、組成物及び医薬並びにそれらの用途
FR3000065A1 (fr) * 2012-12-21 2014-06-27 Univ Lille Ii Droit & Sante Composes bicycliques ayant une activite potentialisatrice de l'activite d'un antibiotique actif contre les mycobacteries-composition et produit pharmaceutiques comprenant de tels composes
CN104098483A (zh) * 2013-04-12 2014-10-15 江苏英力科技发展有限公司 一种4-甲氧基-n,n-二甲基-1-萘甲酰胺制备方法
JP6820097B2 (ja) 2013-12-20 2021-01-27 サギメット バイオサイエンシーズ インコーポレイテッド 脂質合成の複素環式モジュレータ及びその組み合わせ
AU2015289492B2 (en) 2014-07-17 2020-02-20 Chdi Foundation, Inc. Methods and compositions for treating HIV-related disorders
JP6633618B2 (ja) 2014-08-21 2020-01-22 ブリストル−マイヤーズ スクイブ カンパニーＢｒｉｓｔｏｌ−Ｍｙｅｒｓ Ｓｑｕｉｂｂ Ｃｏｍｐａｎｙ 強力なｒｏｃｋ阻害剤としてのタイドバックのベンズアミド誘導体
JP6710273B2 (ja) * 2016-05-09 2020-06-17 日本曹達株式会社 環状アミン化合物および有害生物防除剤
CN106905191B (zh) * 2017-03-05 2019-03-29 北京化工大学 一种含有羟肟酸基团的氮芥类化合物及其制备方法和用途
EP3762379A1 (en) 2018-03-07 2021-01-13 Bayer Aktiengesellschaft Identification and use of erk5 inhibitors
AU2020242053C1 (en) 2019-03-20 2025-11-13 Emory University Prostaglandin receptor EP2 antagonists, derivatives, and uses related thereto
CN113968804B (zh) * 2020-07-22 2022-12-02 中国农业大学 莫奈太尔砜的半抗原、人工抗原及其制备方法与应用
EP4577202A1 (en) 2022-08-26 2025-07-02 Mitodicure GmbH Use of a therapeutic agent with sodium-hydrogen antiporter 1 inhibitory activity for the treatment and prevention of diseases associated with chronic fatigue, exhaustion and/or exertional intolerance

Family Cites Families (18)

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Publication number Priority date Publication date Assignee Title
EP0589336B1 (de) * 1992-09-22 1997-01-08 Hoechst Aktiengesellschaft Benzoylguanidine, Verfahren zu ihrer Herstellung, sowie ihre Verwendung als Antiarrhythmika
US5665739A (en) * 1992-12-15 1997-09-09 Hoechst Aktiengesellschaft Substituted benzoylguanidines, process and their preparation, their use as pharmaceutical or diagnostic, and pharmaceutical containing them
DE4430861A1 (de) * 1994-08-31 1996-03-07 Merck Patent Gmbh Heterocyclyl-benzoylguanidine
DE19601303A1 (de) * 1996-01-16 1997-07-17 Boehringer Ingelheim Kg Neuartige Benzoylguanidin-Derivate, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln
DE19621482A1 (de) * 1996-05-29 1997-12-04 Hoechst Ag Substituierte 1-Naphthoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
DE19843489B4 (de) * 1998-09-22 2006-12-21 Boehringer Ingelheim Pharma Gmbh & Co. Kg Benzoylguanidin-Abkömmlinge mit vorteilhaften Eigenschaften, Verfahren zu ihrer Herstellung und ihre Verwendung bei der Herstellung von Arzneimitteln, sowie diese enthaltende pharmazeutische Zubereitung
US6323207B1 (en) * 1998-09-22 2001-11-27 Boehringer Ingelheim Pharma Kg Benzoylguanidine derivatives
EP1263726B1 (en) * 1999-11-10 2007-09-26 Sanofi-Aventis Deutschland GmbH N-acylpyrrolidin-2-ylalkylbenzamidine derivatives as inhibitors of factor xa
US20020045613A1 (en) * 2000-04-27 2002-04-18 Heinz Pauls 1-aroyl-piperidinyl benzamidines
US6730678B2 (en) * 2001-02-15 2004-05-04 Boehringer Ingelheim Pharma Kg Benzoylguanidine salt and hydrates thereof
DE10106970A1 (de) * 2001-02-15 2002-08-29 Boehringer Ingelheim Pharma Neues Benzoylguanidinsalz
US20040097583A1 (en) * 2002-02-14 2004-05-20 Hans-Jochen Lang Use of inhibitors of the sodium/hydrogen exchanger for the treatment of thrombotic and inflammatory disorders
US20030220383A1 (en) * 2002-02-14 2003-11-27 Aventis Pharma Deutschland Gmbh Use of inhibitors of the sodium-dependent chloride/bicarbonate exchanger for the treatment of thrombotic and inflammatory disorders
DE10353204A1 (de) * 2003-11-13 2005-06-16 Aventis Pharma Deutschland Gmbh Verfahren zur Herstellung von 4-Pentafluorsulfanyl-benzoylguanidinen
JP2007526324A (ja) * 2004-03-02 2007-09-13 スミスクライン・ビーチャム・コーポレイション Ａｋｔ活性のある阻害剤
DE102004054847A1 (de) * 2004-11-13 2006-05-24 Sanofi-Aventis Deutschland Gmbh Substituierte Benzoylguanidine, Verfahren zu ihrer Herstellung, ihre Verwendung als Medikament oder Diagnostikum sowie sie enthaltendes Medikament
JP2008530218A (ja) * 2005-02-16 2008-08-07 シェーリング コーポレイション Ｃｘｃｒ３アンタゴニスト活性を有する、ピリジルおよびフェニルで置換されたピペラジン−ピペリジン
CA2625762A1 (en) * 2005-10-11 2007-04-26 Schering Corporation Substituted heterocyclic compounds with cxcr3 antagonist activity

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