CA2730116A1 - Pyrrolidinyl and piperidinyl compounds useful as nhe-1 inhibitors - Google Patents

Pyrrolidinyl and piperidinyl compounds useful as nhe-1 inhibitors Download PDF

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Publication number
CA2730116A1
CA2730116A1 CA2730116A CA2730116A CA2730116A1 CA 2730116 A1 CA2730116 A1 CA 2730116A1 CA 2730116 A CA2730116 A CA 2730116A CA 2730116 A CA2730116 A CA 2730116A CA 2730116 A1 CA2730116 A1 CA 2730116A1
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Canada
Prior art keywords
benzoyl
trifluoromethyl
guanidine
piperidin
alkyl
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Abandoned
Application number
CA2730116A
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English (en)
French (fr)
Inventor
Joerg Martin Bentzien
Stephen James Boyer
Jennifer Burke
Anne Bettina Eldrup
Xin Guo
John David Huber
Thomas Martin Kirrane
Fariba Soleymanzadeh
Alan David Swinamer
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Boehringer Ingelheim International GmbH
Original Assignee
Boehringer Ingelheim International GmbH
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Filing date
Publication date
Application filed by Boehringer Ingelheim International GmbH filed Critical Boehringer Ingelheim International GmbH
Publication of CA2730116A1 publication Critical patent/CA2730116A1/en
Abandoned legal-status Critical Current

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    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/06—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
    • C07D211/08—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms
    • C07D211/18—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms
    • C07D211/34—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members with hydrocarbon or substituted hydrocarbon radicals directly attached to ring carbon atoms with substituted hydrocarbon radicals attached to ring carbon atoms with hydrocarbon radicals, substituted by carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals
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    • C07D207/04—Heterocyclic compounds containing five-membered rings not condensed with other rings, with one nitrogen atom as the only ring hetero atom with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having no double bonds between ring members or between ring members and non-ring members
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D211/00—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings
    • C07D211/04—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom
    • C07D211/80—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members
    • C07D211/82—Heterocyclic compounds containing hydrogenated pyridine rings, not condensed with other rings with only hydrogen or carbon atoms directly attached to the ring nitrogen atom having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
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    • C07D471/04—Ortho-condensed systems

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CA2730116A 2008-07-08 2009-06-24 Pyrrolidinyl and piperidinyl compounds useful as nhe-1 inhibitors Abandoned CA2730116A1 (en)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US7886708P 2008-07-08 2008-07-08
US61/078,867 2008-07-08
PCT/US2009/048394 WO2010005783A1 (en) 2008-07-08 2009-06-24 Pyrrolidinyl and piperidinyl compounds useful as nhe-1 inhibitors

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CA2730116A1 true CA2730116A1 (en) 2010-01-14

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CA2730116A Abandoned CA2730116A1 (en) 2008-07-08 2009-06-24 Pyrrolidinyl and piperidinyl compounds useful as nhe-1 inhibitors

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US (1) US20110118262A1 (https=)
EP (1) EP2321274A1 (https=)
JP (1) JP2011527677A (https=)
CA (1) CA2730116A1 (https=)
WO (1) WO2010005783A1 (https=)

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