JP2011527575A - Notchシグナル伝達のインヒビターでの処置に感受性であるがんの同定 - Google Patents

Notchシグナル伝達のインヒビターでの処置に感受性であるがんの同定 Download PDF

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JP2011527575A
JP2011527575A JP2011517443A JP2011517443A JP2011527575A JP 2011527575 A JP2011527575 A JP 2011527575A JP 2011517443 A JP2011517443 A JP 2011517443A JP 2011517443 A JP2011517443 A JP 2011517443A JP 2011527575 A JP2011527575 A JP 2011527575A
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heyl
gene expression
notch
level
treatment
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JP2011527575A5 (enExample
Inventor
ロナン オへーガン,
エイチ. ハイジ オカムラ,
アリサ シー. ベル,
ジーニン ロルッソ,
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アベオ ファーマシューティカルズ, インコーポレイテッド
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Publication of JP2011527575A publication Critical patent/JP2011527575A/ja
Publication of JP2011527575A5 publication Critical patent/JP2011527575A5/ja
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    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/68Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
    • C12Q1/6876Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
    • C12Q1/6883Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
    • C12Q1/6886Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/106Pharmacogenomics, i.e. genetic variability in individual responses to drugs and drug metabolism
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12QMEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q2600/00Oligonucleotides characterized by their use
    • C12Q2600/158Expression markers

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  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Engineering & Computer Science (AREA)
  • Immunology (AREA)
  • Pathology (AREA)
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  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
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  • Biochemistry (AREA)
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  • Molecular Biology (AREA)
  • Biophysics (AREA)
  • Physics & Mathematics (AREA)
  • Oncology (AREA)
  • Biotechnology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Engineering & Computer Science (AREA)
  • General Health & Medical Sciences (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Peptides Or Proteins (AREA)
JP2011517443A 2008-07-11 2009-05-28 Notchシグナル伝達のインヒビターでの処置に感受性であるがんの同定 Pending JP2011527575A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US8012208P 2008-07-11 2008-07-11
US61/080,122 2008-07-11
US12/360,790 US7544476B1 (en) 2008-07-11 2009-01-27 Identifying cancers sensitive to treatment with inhibitors of notch signaling
US12/360,790 2009-01-27
PCT/US2009/045479 WO2010005644A1 (en) 2008-07-11 2009-05-28 Identifying cancers sensitive to treatment with inhibitors of notch signaling

Publications (2)

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JP2011527575A true JP2011527575A (ja) 2011-11-04
JP2011527575A5 JP2011527575A5 (enExample) 2012-07-12

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ID=40688675

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JP2011517443A Pending JP2011527575A (ja) 2008-07-11 2009-05-28 Notchシグナル伝達のインヒビターでの処置に感受性であるがんの同定

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Country Link
US (1) US7544476B1 (enExample)
EP (1) EP2313526A4 (enExample)
JP (1) JP2011527575A (enExample)
AU (1) AU2009269081A1 (enExample)
CA (1) CA2730215A1 (enExample)
WO (1) WO2010005644A1 (enExample)

Families Citing this family (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2007136856A2 (en) * 2006-05-19 2007-11-29 The Johns Hopkins University Heyl as a therapeutic target and a diagnostic marker for neoplasia and uses therefor
WO2008076960A2 (en) 2006-12-18 2008-06-26 Genentech, Inc. Antagonist anti-notch3 antibodies and their use in the prevention and treatment of notch3-related diseases
US20120082659A1 (en) * 2007-10-02 2012-04-05 Hartmut Land Methods And Compositions Related To Synergistic Responses To Oncogenic Mutations
DK2935330T3 (da) 2012-12-19 2019-07-22 Aveo Pharmaceuticals Inc Anti-notch3-antistoffer
EP3448420B1 (en) 2016-04-29 2022-09-14 Aveo Pharmaceuticals, Inc. Anti-notch3 antibody
EP3462349A1 (en) * 2017-10-02 2019-04-03 Koninklijke Philips N.V. Assessment of notch cellular signaling pathway activity using mathematical modelling of target gene expression
EP3502279A1 (en) 2017-12-20 2019-06-26 Koninklijke Philips N.V. Assessment of mapk-ap 1 cellular signaling pathway activity using mathematical modelling of target gene expression

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006092062A1 (en) * 2005-03-04 2006-09-08 The Hospital For Sick Children Methods for cancer prognosis
WO2007070671A2 (en) * 2005-12-16 2007-06-21 Regeneron Pharmaceuticals, Inc. Therapeutic methods for inhibiting tumor growth with dll4 antagonists
WO2007136856A2 (en) * 2006-05-19 2007-11-29 The Johns Hopkins University Heyl as a therapeutic target and a diagnostic marker for neoplasia and uses therefor

Family Cites Families (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006047878A1 (en) 2004-11-03 2006-05-11 British Columbia Cancer Agency Branch Cancer therapeutics and methods for their use

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2006092062A1 (en) * 2005-03-04 2006-09-08 The Hospital For Sick Children Methods for cancer prognosis
WO2007070671A2 (en) * 2005-12-16 2007-06-21 Regeneron Pharmaceuticals, Inc. Therapeutic methods for inhibiting tumor growth with dll4 antagonists
WO2007136856A2 (en) * 2006-05-19 2007-11-29 The Johns Hopkins University Heyl as a therapeutic target and a diagnostic marker for neoplasia and uses therefor

Non-Patent Citations (1)

* Cited by examiner, † Cited by third party
Title
JPN6013064284; Current cancer drug targets. 2006, Vol.6, No.4, p.313-323 *

Also Published As

Publication number Publication date
CA2730215A1 (en) 2010-01-14
AU2009269081A1 (en) 2010-01-14
EP2313526A4 (en) 2011-08-31
EP2313526A1 (en) 2011-04-27
WO2010005644A1 (en) 2010-01-14
US7544476B1 (en) 2009-06-09

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