JP2011527565A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011527565A5 JP2011527565A5 JP2011517318A JP2011517318A JP2011527565A5 JP 2011527565 A5 JP2011527565 A5 JP 2011527565A5 JP 2011517318 A JP2011517318 A JP 2011517318A JP 2011517318 A JP2011517318 A JP 2011517318A JP 2011527565 A5 JP2011527565 A5 JP 2011527565A5
- Authority
- JP
- Japan
- Prior art keywords
- nucleic acid
- breast cancer
- marker
- allele
- linkage disequilibrium
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 239000003550 marker Substances 0.000 claims 18
- 150000007523 nucleic acids Chemical group 0.000 claims 17
- 206010006187 Breast cancer Diseases 0.000 claims 16
- 208000026310 Breast neoplasm Diseases 0.000 claims 16
- 238000000034 method Methods 0.000 claims 16
- 108700028369 Alleles Proteins 0.000 claims 15
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 10
- 239000000523 sample Substances 0.000 claims 8
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 230000002068 genetic effect Effects 0.000 claims 5
- 102000054766 genetic haplotypes Human genes 0.000 claims 5
- 241000282412 Homo Species 0.000 claims 2
- 230000000149 penetrating effect Effects 0.000 claims 2
- 108700020463 BRCA1 Proteins 0.000 claims 1
- 102000036365 BRCA1 Human genes 0.000 claims 1
- 101150072950 BRCA1 gene Proteins 0.000 claims 1
- 108700020462 BRCA2 Proteins 0.000 claims 1
- 102000052609 BRCA2 Human genes 0.000 claims 1
- 101150008921 Brca2 gene Proteins 0.000 claims 1
- 108010011536 PTEN Phosphohydrolase Proteins 0.000 claims 1
- 102000014160 PTEN Phosphohydrolase Human genes 0.000 claims 1
- 108010078814 Tumor Suppressor Protein p53 Proteins 0.000 claims 1
- 102000015098 Tumor Suppressor Protein p53 Human genes 0.000 claims 1
- 239000012472 biological sample Substances 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- 230000035772 mutation Effects 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IS8746 | 2008-07-07 | ||
| IS8746 | 2008-07-07 | ||
| PCT/IS2009/000008 WO2010004591A2 (en) | 2008-07-07 | 2009-07-03 | Genetic variants for breast cancer risk assessment |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011527565A JP2011527565A (ja) | 2011-11-04 |
| JP2011527565A5 true JP2011527565A5 (https=) | 2012-08-16 |
Family
ID=41110719
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011517318A Pending JP2011527565A (ja) | 2008-07-07 | 2009-07-03 | 乳癌のリスクアセスメントのための遺伝的変異 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8951735B2 (https=) |
| EP (1) | EP2313525A2 (https=) |
| JP (1) | JP2011527565A (https=) |
| KR (1) | KR20110036608A (https=) |
| CN (1) | CN102144036B (https=) |
| AU (1) | AU2009269542A1 (https=) |
| CA (1) | CA2729934A1 (https=) |
| IL (1) | IL210504A0 (https=) |
| NZ (1) | NZ590833A (https=) |
| WO (1) | WO2010004591A2 (https=) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2011095999A1 (en) * | 2010-02-05 | 2011-08-11 | Decode Genetics Ehf | Genetic variants for predicting risk of breast cancer |
| HK1197085A1 (en) * | 2011-06-16 | 2015-01-02 | Decode Genetics Ehf | Genetic variants for predicting risk of breast cancer |
| CN102643905B (zh) * | 2012-04-01 | 2014-06-11 | 周宏灏 | 焦磷酸测序法检测他莫昔芬个体化用药基因多态性的试剂盒及方法 |
| WO2014119914A1 (ko) * | 2013-02-01 | 2014-08-07 | 에스케이텔레콤 주식회사 | 유전자 서열 기반 개인 마커에 관한 정보를 제공하는 방법 및 이를 이용한 장치 |
| KR101770962B1 (ko) * | 2013-02-01 | 2017-08-24 | 에스케이텔레콤 주식회사 | 유전자 서열 기반 개인 마커에 관한 정보를 제공하는 방법 및 이를 이용한 장치 |
| WO2014145705A2 (en) | 2013-03-15 | 2014-09-18 | Battelle Memorial Institute | Progression analytics system |
| CN103981273B (zh) * | 2014-05-30 | 2017-01-18 | 复旦大学附属肿瘤医院 | 一组评估乳腺癌风险的突变基因群及其检测试剂盒 |
| US10395759B2 (en) | 2015-05-18 | 2019-08-27 | Regeneron Pharmaceuticals, Inc. | Methods and systems for copy number variant detection |
| CN105069322B (zh) * | 2015-07-24 | 2018-01-12 | 上海尔云信息科技有限公司 | 疾病易感风险预测装置 |
| CA3014292A1 (en) | 2016-02-12 | 2017-08-17 | Regeneron Pharmaceuticals, Inc. | Methods and systems for detection of abnormal karyotypes |
| CN105586427B (zh) * | 2016-03-10 | 2020-06-19 | 厦门艾德生物医药科技股份有限公司 | 检测人类brca1和brca2基因突变的引物、试剂盒及方法 |
| US11332530B2 (en) | 2016-09-23 | 2022-05-17 | Memorial Sloan Kettering Cancer Center | Determinants of cancer response to immunotherapy |
| CN106676169B (zh) * | 2016-11-15 | 2021-01-12 | 上海派森诺医学检验所有限公司 | 一种用于乳腺癌易感基因brca1和brca2突变检测的杂交捕获试剂盒及其方法 |
| JP2020508643A (ja) * | 2017-01-24 | 2020-03-26 | ジェネティック テクノロジーズ リミテッド | 乳癌発症リスクの改良された評価法 |
| CN107341347A (zh) * | 2017-06-27 | 2017-11-10 | 天方创新（北京）信息技术有限公司 | 基于评分模型对乳腺癌进行风险评分的方法及装置 |
| CN112534070B (zh) * | 2018-06-29 | 2024-07-30 | 杰克逊实验室 | 乳腺癌剪接变体 |
| CN108676890B (zh) * | 2018-07-12 | 2022-01-28 | 吉林大学 | 一种女性乳腺恶性肿瘤易感性预测试剂盒及系统 |
| US20230170045A1 (en) * | 2020-04-20 | 2023-06-01 | Myriad Genetics, Inc. | Comprehensive polygenic risk prediction for breast cancer |
| WO2024085660A1 (ko) * | 2022-10-18 | 2024-04-25 | 제노플랜 인크 | 질병 발생 위험도 예측 장치 및 방법 |
| EP4646208A1 (en) | 2023-01-06 | 2025-11-12 | Ideaya Biosciences, Inc. | Treatment of er+ breast cancer comprising homologous recombination deficiency using parg inhibitor |
| CN119446277B (zh) * | 2024-10-31 | 2026-03-27 | 中国人民解放军总医院 | 分子检测方法、装置、计算机设备、存储介质和程序产品 |
Family Cites Families (29)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4376110A (en) | 1980-08-04 | 1983-03-08 | Hybritech, Incorporated | Immunometric assays using monoclonal antibodies |
| GB8810400D0 (en) | 1988-05-03 | 1988-06-08 | Southern E | Analysing polynucleotide sequences |
| US5700637A (en) | 1988-05-03 | 1997-12-23 | Isis Innovation Limited | Apparatus and method for analyzing polynucleotide sequences and method of generating oligonucleotide arrays |
| US6054270A (en) | 1988-05-03 | 2000-04-25 | Oxford Gene Technology Limited | Analying polynucleotide sequences |
| EP0436597B1 (en) | 1988-09-02 | 1997-04-02 | Protein Engineering Corporation | Generation and selection of recombinant varied binding proteins |
| US5223409A (en) | 1988-09-02 | 1993-06-29 | Protein Engineering Corp. | Directed evolution of novel binding proteins |
| US5143854A (en) | 1989-06-07 | 1992-09-01 | Affymax Technologies N.V. | Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof |
| US5744101A (en) | 1989-06-07 | 1998-04-28 | Affymax Technologies N.V. | Photolabile nucleoside protecting groups |
| US5288644A (en) | 1990-04-04 | 1994-02-22 | The Rockefeller University | Instrument and method for the sequencing of genome |
| US5427908A (en) | 1990-05-01 | 1995-06-27 | Affymax Technologies N.V. | Recombinant library screening methods |
| EP0585287B1 (en) | 1990-07-10 | 1999-10-13 | Cambridge Antibody Technology Limited | Methods for producing members of specific binding pairs |
| GB9015198D0 (en) | 1990-07-10 | 1990-08-29 | Brien Caroline J O | Binding substance |
| CA2405246A1 (en) | 1990-12-03 | 1992-06-11 | Genentech, Inc. | Enrichment method for variant proteins with alterred binding properties |
| EP0575485A1 (en) | 1991-03-01 | 1993-12-29 | Dyax Corp. | Process for the development of binding mini-proteins |
| DK0580737T3 (da) | 1991-04-10 | 2004-11-01 | Scripps Research Inst | Heterodimere receptorbiblioteker ved anvendelse af phagemider |
| DE4122599C2 (de) | 1991-07-08 | 1993-11-11 | Deutsches Krebsforsch | Phagemid zum Screenen von Antikörpern |
| US6287850B1 (en) | 1995-06-07 | 2001-09-11 | Affymetrix, Inc. | Bioarray chip reaction apparatus and its manufacture |
| EP0695941B1 (en) | 1994-06-08 | 2002-07-31 | Affymetrix, Inc. | Method and apparatus for packaging a chip |
| US6300063B1 (en) | 1995-11-29 | 2001-10-09 | Affymetrix, Inc. | Polymorphism detection |
| EP1736554B1 (en) | 1996-05-29 | 2013-10-09 | Cornell Research Foundation, Inc. | Detection of nucleic acid sequence differences using coupled ligase detection and polymerase chain reactions |
| US6429027B1 (en) | 1998-12-28 | 2002-08-06 | Illumina, Inc. | Composite arrays utilizing microspheres |
| US20040009481A1 (en) * | 2001-06-11 | 2004-01-15 | Millennium Pharmaceuticals, Inc. | Compositions, kits, and methods for identification, assessment, prevention, and therapy of human prostate cancer |
| DE10228081A1 (de) * | 2002-06-18 | 2004-01-08 | InViTek Gesellschaft für Biotechnik & Biodesign mbH | Verfahren zum Nachweis einer gesteigerten Tumorsuszeptibilität |
| KR100763902B1 (ko) * | 2004-02-20 | 2007-10-05 | 삼성전자주식회사 | 유방암 특이적 단백질, 그를 코딩하는 유전자, 및 상기단백질 또는 유전자를 이용한 유방암의 진단 방법 |
| WO2006063285A2 (en) * | 2004-12-10 | 2006-06-15 | Sequenom, Inc. | Methods for identifying risk of breast cancer or prostate cancer and treatments thereof |
| CN101037690B (zh) * | 2006-03-16 | 2011-07-20 | 国家人口计生委科学技术研究所 | 具有新的单核苷酸多态性的brca1基因变体和其编码的蛋白质变体 |
| JP5631000B2 (ja) * | 2006-10-27 | 2014-11-26 | デコード・ジェネティクス・イーエイチエフ | Ｃｈｒ８ｑ２４．２１上の癌感受性変異体 |
| EA019953B1 (ru) | 2007-03-26 | 2014-07-30 | Декоуд Дженетикс Ехф | Генетические варианты chr2 и chr16 в качестве маркеров для применения при оценке риска, диагностировании, прогнозировании и лечении рака молочной железы |
| CA2688312A1 (en) | 2007-05-25 | 2008-12-04 | Decode Genetics Ehf. | Genetic variants on chr 5p12 and 10q26 as markers for use in breast cancer risk assessment, diagnosis, prognosis and treatment |
-
2009
- 2009-07-03 JP JP2011517318A patent/JP2011527565A/ja active Pending
- 2009-07-03 WO PCT/IS2009/000008 patent/WO2010004591A2/en not_active Ceased
- 2009-07-03 CA CA2729934A patent/CA2729934A1/en not_active Abandoned
- 2009-07-03 CN CN200980134453.0A patent/CN102144036B/zh not_active Expired - Fee Related
- 2009-07-03 NZ NZ590833A patent/NZ590833A/xx not_active IP Right Cessation
- 2009-07-03 US US13/002,619 patent/US8951735B2/en not_active Expired - Fee Related
- 2009-07-03 EP EP09787620A patent/EP2313525A2/en not_active Withdrawn
- 2009-07-03 AU AU2009269542A patent/AU2009269542A1/en not_active Abandoned
- 2009-07-03 KR KR1020117002889A patent/KR20110036608A/ko not_active Ceased
-
2011
- 2011-01-06 IL IL210504A patent/IL210504A0/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011527565A5 (https=) | ||
| JP7689557B2 (ja) | 相同組換え欠損を推定するための統合された機械学習フレームワーク | |
| Morales Berstein et al. | Assessing the causal role of epigenetic clocks in the development of multiple cancers: a Mendelian randomization study | |
| JP7145907B2 (ja) | 疾患細胞不均一性を示す疾患の検出および処置、ならびに通信試験結果のためのシステムおよび方法 | |
| Banovich et al. | Methylation QTLs are associated with coordinated changes in transcription factor binding, histone modifications, and gene expression levels | |
| Boyle et al. | Annotation of functional variation in personal genomes using RegulomeDB | |
| Alazami et al. | Mutation in ADAT3, encoding adenosine deaminase acting on transfer RNA, causes intellectual disability and strabismus | |
| CN107423534B (zh) | 基因组拷贝数变异的检测方法和系统 | |
| KR102384620B1 (ko) | 유전적 변이의 비침습 평가를 위한 방법 및 프로세스 | |
| JP2011530306A5 (https=) | ||
| JP2025106239A (ja) | 病原体検出のための配列決定データを使用するためのシステムおよび方法 | |
| Kommadath et al. | Gene co-expression network analysis identifies porcine genes associated with variation in Salmonella shedding | |
| Ullah et al. | Detection of novel infiltrating ductal carcinoma-associated BReast CAncer gene 2 mutations which alter the deoxyribonucleic acid-binding ability of BReast CAncer gene 2 protein | |
| Huang et al. | Genome-wide association study on chicken carcass traits using sequence data imputed from SNP array | |
| CN103045739A (zh) | 一种拟穴青蟹SNPs分子标记的筛选方法 | |
| Lai et al. | Speed-mapping quantitative trait loci using microarrays | |
| Xue et al. | Genome-wide association study reveals additive and non-additive effects on growth traits in Duroc pigs | |
| Li et al. | Incorporating local ancestry improves identification of ancestry-associated methylation signatures and meQTLs in African Americans | |
| EP2973117A2 (en) | Electronic medical records system utilizing genetic information | |
| JP2020536585A (ja) | 乳癌発症リスクの評価法 | |
| Mohindra et al. | Development of EST derived SSRs and SNPs as a genomic resource in Indian catfish, Clarias batrachus | |
| Shi et al. | Influence of validating the parental origin on the clinical interpretation of fetal copy number variations in 141 core family cases | |
| Halder et al. | SNP microarray in FISH negative clinically suspected 22q11. 2 microdeletion syndrome | |
| Rashkin et al. | Pan-cancer study detects novel genetic risk variants and shared genetic basis in two large cohorts | |
| Hishida et al. | Genome-wide association study of serum prostate-specific antigen levels based on 1000 Genomes imputed data in Japanese: the Japan Multi-Institutional Collaborative Cohort Study |