JP2011523415A5 - - Google Patents
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- Publication number
- JP2011523415A5 JP2011523415A5 JP2011509923A JP2011509923A JP2011523415A5 JP 2011523415 A5 JP2011523415 A5 JP 2011523415A5 JP 2011509923 A JP2011509923 A JP 2011509923A JP 2011509923 A JP2011509923 A JP 2011509923A JP 2011523415 A5 JP2011523415 A5 JP 2011523415A5
- Authority
- JP
- Japan
- Prior art keywords
- formula
- absent
- cyclic peptide
- compound
- same
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 102000001189 Cyclic Peptides Human genes 0.000 claims 12
- 108010069514 Cyclic Peptides Proteins 0.000 claims 12
- 150000001875 compounds Chemical class 0.000 claims 8
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102000006495 integrins Human genes 0.000 claims 2
- 108010044426 integrins Proteins 0.000 claims 2
- 230000002194 synthesizing effect Effects 0.000 claims 2
- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 claims 1
- 241000124008 Mammalia Species 0.000 claims 1
- 206010028980 Neoplasm Diseases 0.000 claims 1
- 102000015636 Oligopeptides Human genes 0.000 claims 1
- 108010038807 Oligopeptides Proteins 0.000 claims 1
- 206010060862 Prostate cancer Diseases 0.000 claims 1
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 1
- 239000004480 active ingredient Substances 0.000 claims 1
- 239000000654 additive Substances 0.000 claims 1
- 230000000996 additive effect Effects 0.000 claims 1
- 150000001413 amino acids Chemical class 0.000 claims 1
- 150000001540 azides Chemical class 0.000 claims 1
- VSJKWCGYPAHWDS-FQEVSTJZSA-N camptothecin Chemical group C1=CC=C2C=C(CN3C4=CC5=C(C3=O)COC(=O)[C@]5(O)CC)C4=NC2=C1 VSJKWCGYPAHWDS-FQEVSTJZSA-N 0.000 claims 1
- 201000011510 cancer Diseases 0.000 claims 1
- 125000002915 carbonyl group Chemical group [*:2]C([*:1])=O 0.000 claims 1
- 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
- 230000010261 cell growth Effects 0.000 claims 1
- 230000004709 cell invasion Effects 0.000 claims 1
- 231100000433 cytotoxic Toxicity 0.000 claims 1
- 230000001472 cytotoxic effect Effects 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 235000013601 eggs Nutrition 0.000 claims 1
- 150000002411 histidines Chemical class 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 230000001394 metastastic effect Effects 0.000 claims 1
- 206010061289 metastatic neoplasm Diseases 0.000 claims 1
- 239000000203 mixture Substances 0.000 claims 1
- -1 p-aminobenzyloxycarbonyl Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 102000005962 receptors Human genes 0.000 claims 1
- 108020003175 receptors Proteins 0.000 claims 1
- 150000003839 salts Chemical class 0.000 claims 1
- 125000001425 triazolyl group Chemical group 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08156575 | 2008-05-20 | ||
| EP08156575.6 | 2008-05-20 | ||
| PCT/EP2009/055653 WO2009141240A1 (en) | 2008-05-20 | 2009-05-11 | Novel dual targeting antitumoural conjugates |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011523415A JP2011523415A (ja) | 2011-08-11 |
| JP2011523415A5 true JP2011523415A5 (https=) | 2012-06-28 |
Family
ID=39765065
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011509923A Pending JP2011523415A (ja) | 2008-05-20 | 2009-05-11 | 新規な二重標的化抗腫瘍複合体 |
Country Status (16)
| Country | Link |
|---|---|
| US (1) | US20110160147A1 (https=) |
| EP (1) | EP2285396A1 (https=) |
| JP (1) | JP2011523415A (https=) |
| KR (1) | KR20110022594A (https=) |
| CN (1) | CN102036676A (https=) |
| AR (1) | AR071840A1 (https=) |
| AU (1) | AU2009249795A1 (https=) |
| BR (1) | BRPI0911978A2 (https=) |
| CA (1) | CA2724562A1 (https=) |
| EA (1) | EA201071326A1 (https=) |
| IL (1) | IL208920A0 (https=) |
| MX (1) | MX2010012320A (https=) |
| NZ (1) | NZ588948A (https=) |
| TW (1) | TW201004647A (https=) |
| WO (1) | WO2009141240A1 (https=) |
| ZA (1) | ZA201009036B (https=) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7985401B2 (en) | 2003-10-31 | 2011-07-26 | The Regents Of The University Of California | Peptides whose uptake by cells is controllable |
| CA2770980A1 (en) | 2009-07-15 | 2011-01-20 | Roger Y. Tsien | Peptides whose uptake in cells is controllable |
| CA2816041C (en) * | 2010-12-29 | 2019-01-08 | Arrowhead Research Corporation | In vivo polynucleotide delivery conjugates having enzyme sensitive linkages |
| CA2841249C (en) | 2011-07-29 | 2023-09-26 | Avelas Biosciences, Inc. | Selective delivery molecules and methods of use |
| US10029017B2 (en) | 2013-01-29 | 2018-07-24 | The Regents Of The University Of California | Pretargeted activatable cell penetrating peptide with intracellularly releasable prodrug |
| EA031930B1 (ru) | 2013-01-30 | 2019-03-29 | Авелас Байосайенсиз, Инк. | Молекула селективной доставки для визуализации злокачественной ткани |
| CN103333227B (zh) * | 2013-06-07 | 2015-10-07 | 东南大学 | 转移肿瘤缺失蛋白小分子环肽抑制剂及其制备方法与应用 |
| WO2015095227A2 (en) | 2013-12-16 | 2015-06-25 | Genentech, Inc. | Peptidomimetic compounds and antibody-drug conjugates thereof |
| WO2016008112A1 (en) * | 2014-07-16 | 2016-01-21 | Medshine Discovery Inc. | Linkers and application towards adc thereof |
| US10385380B2 (en) | 2014-10-02 | 2019-08-20 | The Regents Of The University Of California | Personalized protease assay to measure protease activity in neoplasms |
| US10125124B2 (en) | 2015-03-20 | 2018-11-13 | Massachusetts Institute Of Technology | Formation of macromolecules using iterative growth and related compounds |
| US10596259B2 (en) | 2015-05-20 | 2020-03-24 | The Regents Of The University Of California | Tumor radiosensitization with monomethyl auristatin E (MMAE) and derivatives thereof |
| CN108064246A (zh) | 2015-06-15 | 2018-05-22 | 基因泰克公司 | 抗体和免疫结合物 |
| EA202191244A1 (ru) * | 2018-11-05 | 2021-10-11 | Байер Фарма Акциенгезельшафт | Новые цитостатические конъюгаты с лигандами интегрина |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2370245A1 (en) * | 1999-05-14 | 2000-11-23 | Boehringer Ingelheim Pharmaceuticals, Inc. | Enzyme-activated anti-tumor prodrug compounds |
| ITRM20040240A1 (it) * | 2004-05-13 | 2004-08-13 | Ist Naz Stud Cura Dei Tumori | Camptotecine coniugate in posizione 7 con antagonisti delle integrine. |
| US8404650B2 (en) * | 2005-10-28 | 2013-03-26 | The Regents Of The University Of Colorado, A Body Corporate | Methods of treating cancer with doxazolidine and prodrugs thereof |
-
2009
- 2009-05-04 TW TW098114716A patent/TW201004647A/zh unknown
- 2009-05-11 EA EA201071326A patent/EA201071326A1/ru unknown
- 2009-05-11 BR BRPI0911978A patent/BRPI0911978A2/pt not_active IP Right Cessation
- 2009-05-11 AU AU2009249795A patent/AU2009249795A1/en not_active Abandoned
- 2009-05-11 KR KR1020107027835A patent/KR20110022594A/ko not_active Withdrawn
- 2009-05-11 CA CA2724562A patent/CA2724562A1/en not_active Abandoned
- 2009-05-11 NZ NZ588948A patent/NZ588948A/en not_active IP Right Cessation
- 2009-05-11 EP EP09749730A patent/EP2285396A1/en not_active Withdrawn
- 2009-05-11 JP JP2011509923A patent/JP2011523415A/ja active Pending
- 2009-05-11 CN CN200980118231XA patent/CN102036676A/zh active Pending
- 2009-05-11 MX MX2010012320A patent/MX2010012320A/es not_active Application Discontinuation
- 2009-05-11 WO PCT/EP2009/055653 patent/WO2009141240A1/en not_active Ceased
- 2009-05-19 AR ARP090101790A patent/AR071840A1/es unknown
- 2009-09-02 US US12/993,738 patent/US20110160147A1/en not_active Abandoned
-
2010
- 2010-10-25 IL IL208920A patent/IL208920A0/en unknown
- 2010-12-15 ZA ZA2010/09036A patent/ZA201009036B/en unknown
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