JP2011521654A5 - - Google Patents
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- Publication number
- JP2011521654A5 JP2011521654A5 JP2011512010A JP2011512010A JP2011521654A5 JP 2011521654 A5 JP2011521654 A5 JP 2011521654A5 JP 2011512010 A JP2011512010 A JP 2011512010A JP 2011512010 A JP2011512010 A JP 2011512010A JP 2011521654 A5 JP2011521654 A5 JP 2011521654A5
- Authority
- JP
- Japan
- Prior art keywords
- gene
- replicon
- replicon according
- delivery vehicle
- pestivirus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 12
- 239000011859 microparticle Substances 0.000 claims description 5
- 241000710778 Pestivirus Species 0.000 claims description 4
- 229960005486 vaccine Drugs 0.000 claims description 2
- 208000015181 infectious disease Diseases 0.000 claims 4
- 230000002458 infectious effect Effects 0.000 claims 4
- 238000000034 method Methods 0.000 claims 4
- 108020004705 Codon Proteins 0.000 claims 3
- 101710172711 Structural protein Proteins 0.000 claims 3
- 241000700605 Viruses Species 0.000 claims 3
- 201000010099 disease Diseases 0.000 claims 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 3
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 210000005260 human cell Anatomy 0.000 claims 2
- 239000008194 pharmaceutical composition Substances 0.000 claims 2
- 239000000126 substance Substances 0.000 claims 2
- 206010008631 Cholera Diseases 0.000 claims 1
- 101800000511 Non-structural protein 2 Proteins 0.000 claims 1
- 230000002950 deficient Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 239000002245 particle Substances 0.000 description 6
- 239000003981 vehicle Substances 0.000 description 4
- 239000002502 liposome Substances 0.000 description 2
- 239000002088 nanocapsule Substances 0.000 description 2
- 239000002105 nanoparticle Substances 0.000 description 2
- 239000002202 Polyethylene glycol Substances 0.000 description 1
- 102000006382 Ribonucleases Human genes 0.000 description 1
- 108010083644 Ribonucleases Proteins 0.000 description 1
- 230000015556 catabolic process Effects 0.000 description 1
- 230000000295 complement effect Effects 0.000 description 1
- 238000006731 degradation reaction Methods 0.000 description 1
- 239000003937 drug carrier Substances 0.000 description 1
- 230000003993 interaction Effects 0.000 description 1
- 239000000825 pharmaceutical preparation Substances 0.000 description 1
- 229920001223 polyethylene glycol Polymers 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| EP08010222A EP2130912A1 (en) | 2008-06-04 | 2008-06-04 | Pestivirus replicons providing an RNA-based viral vector system |
| EP08010222.1 | 2008-06-04 | ||
| PCT/EP2009/003892 WO2009146867A1 (en) | 2008-06-04 | 2009-05-30 | Pestivirus replicons providing an rna-based viral vector system |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011521654A JP2011521654A (ja) | 2011-07-28 |
| JP2011521654A5 true JP2011521654A5 (enExample) | 2015-08-27 |
Family
ID=39967852
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011512010A Pending JP2011521654A (ja) | 2008-06-04 | 2009-05-30 | Ｒｎａに基づくウイルスベクター系を提供するペスチウイルスレプリコン |
Country Status (5)
| Country | Link |
|---|---|
| US (2) | US9249395B2 (enExample) |
| EP (2) | EP2130912A1 (enExample) |
| JP (1) | JP2011521654A (enExample) |
| CA (1) | CA2723999C (enExample) |
| WO (1) | WO2009146867A1 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2130912A1 (en) * | 2008-06-04 | 2009-12-09 | Institut für Viruskrankeiten und Immunprophylaxe | Pestivirus replicons providing an RNA-based viral vector system |
| FI4005592T3 (fi) | 2010-07-06 | 2023-01-13 | Virionin kaltaisia kuljetuspartikkeleita itsereplikoituville rna-molekyyleille | |
| CN103153284B (zh) | 2010-07-06 | 2015-11-25 | 诺华股份有限公司 | 含有其pKa值有利于RNA递送的脂质的脂质体 |
| US9770463B2 (en) | 2010-07-06 | 2017-09-26 | Glaxosmithkline Biologicals Sa | Delivery of RNA to different cell types |
| PT3243526T (pt) | 2010-07-06 | 2020-03-04 | Glaxosmithkline Biologicals Sa | Distribuição de arn para despoletar múltiplas vias imunitárias |
| US10487332B2 (en) | 2010-07-06 | 2019-11-26 | Glaxosmithkline Biologicals Sa | Immunisation of large mammals with low doses of RNA |
| JP5911870B2 (ja) * | 2010-08-31 | 2016-04-27 | ノバルティス アーゲー | 免疫原をコードするｒｎａの送達のためのｐｅｇ化リポソーム |
| EP3542789A3 (en) * | 2010-08-31 | 2020-01-01 | GlaxoSmithKline Biologicals SA | Lipids suitable for liposomal delivery of protein-coding rna |
| KR102266691B1 (ko) | 2010-10-11 | 2021-06-23 | 노파르티스 아게 | 항원 전달 플랫폼 |
| RU2014104090A (ru) * | 2011-07-06 | 2015-08-20 | Новартис Аг | Липосомы с эффективным соотношением n:p для доставки молекул phk |
| JP2014522842A (ja) | 2011-07-06 | 2014-09-08 | ノバルティス アーゲー | 免疫原性組み合わせ組成物およびその使用 |
| CN108368028B (zh) | 2015-10-28 | 2021-09-03 | 爱康泰生治疗公司 | 用于递送核酸的新型脂质和脂质纳米颗粒制剂 |
| US12678515B2 (en) | 2015-12-30 | 2026-07-14 | Acuitas Therapeutics, Inc. | Lipids and lipid nanoparticle formulations for delivery of nucleic acids |
| US10022436B2 (en) | 2016-01-11 | 2018-07-17 | Verndari, Inc. | Microneedle compositions and methods of using same |
| EP4166161B1 (en) | 2016-04-14 | 2026-03-04 | Fred Hutchinson Cancer Center | Compositions and methods to program therapeutic cells using targeted nucleic acid nanocarriers |
| KR102681292B1 (ko) | 2016-06-24 | 2024-07-03 | 론자 리미티드 | 가변 직경 생물 반응기 |
| US12491261B2 (en) | 2016-10-26 | 2025-12-09 | Acuitas Therapeutics, Inc. | Lipid nanoparticle formulations |
| WO2018129270A1 (en) | 2017-01-05 | 2018-07-12 | Fred Hutchinson Cancer Research Center | Systems and methods to improve vaccine efficacy |
| WO2019143948A1 (en) | 2018-01-18 | 2019-07-25 | Fred Hutchinson Cancer Research Center | Altering inflammatory states of immune cells in vivo by modulating cellular activation states |
| KR102764120B1 (ko) | 2019-12-31 | 2025-02-06 | 엘릭서젠 쎄라퓨틱스, 인크. | 핵산 및 단백질의 세포 및 조직으로의 온도-기반 일시적 전달 |
| KR20230051172A (ko) | 2020-07-16 | 2023-04-17 | 아퀴타스 테라퓨틱스 인크. | 지질 나노 입자에 사용하기 위한 양이온성 지질 |
| WO2023114943A2 (en) | 2021-12-16 | 2023-06-22 | Acuitas Therapeutics, Inc. | Lipids for use in lipid nanoparticle formulations |
| EP4474015A1 (en) | 2023-06-05 | 2024-12-11 | Veterna Srl | Noda-like rna-vaccine pharmacon and production and uses thereof |
| CN118955658A (zh) * | 2024-07-26 | 2024-11-15 | 华南农业大学 | 一种重组猪瘟病毒Npro蛋白、抗猪瘟病毒Npro蛋白的多克隆抗体及其制备方法与应用 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6168942B1 (en) * | 1998-11-10 | 2001-01-02 | Pfizer Inc. | Attenuated forms of bovine viral diarrhea virus |
| EP1035205A1 (en) * | 1999-03-08 | 2000-09-13 | Stichting Dienst Landbouwkundig Onderzoek | Non-spreading pestivirus |
| US20030077251A1 (en) * | 2001-05-23 | 2003-04-24 | Nicolas Escriou | Replicons derived from positive strand RNA virus genomes useful for the production of heterologous proteins |
| BR0313113A (pt) * | 2002-08-13 | 2005-06-28 | Akzo Nobel Nv | Replicon de um pestivìrus partìcula viral infecciosa de pestivìrus, método para a produção da mesma, e, vacina |
| WO2004092386A2 (en) * | 2003-04-11 | 2004-10-28 | The Government Of The United States Of America As Represented By The Secretary Of Health And Human Services | Inducing a t cell response with recombinant pestivirus replicons or recombinant pestivirus replicon-transfected dendritic cells |
| EP1874825B1 (en) * | 2005-04-26 | 2010-03-24 | Sandoz AG | Affinity ligands |
| US20080305130A1 (en) * | 2005-12-07 | 2008-12-11 | Chichi Huang | Marked Bovine Viral Diarrhea Virus Vaccines |
| EP2130912A1 (en) * | 2008-06-04 | 2009-12-09 | Institut für Viruskrankeiten und Immunprophylaxe | Pestivirus replicons providing an RNA-based viral vector system |
-
2008
- 2008-06-04 EP EP08010222A patent/EP2130912A1/en not_active Withdrawn
-
2009
- 2009-05-30 JP JP2011512010A patent/JP2011521654A/ja active Pending
- 2009-05-30 CA CA2723999A patent/CA2723999C/en active Active
- 2009-05-30 EP EP09757250A patent/EP2297309A1/en active Pending
- 2009-05-30 WO PCT/EP2009/003892 patent/WO2009146867A1/en not_active Ceased
- 2009-05-30 US US12/995,874 patent/US9249395B2/en active Active
-
2015
- 2015-12-22 US US14/978,647 patent/US9670466B2/en active Active
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