JP2011520921A - 抗腫瘍アルカロイドとの併用療法 - Google Patents

抗腫瘍アルカロイドとの併用療法 Download PDF

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Publication number
JP2011520921A
JP2011520921A JP2011509790A JP2011509790A JP2011520921A JP 2011520921 A JP2011520921 A JP 2011520921A JP 2011509790 A JP2011509790 A JP 2011509790A JP 2011509790 A JP2011509790 A JP 2011509790A JP 2011520921 A JP2011520921 A JP 2011520921A
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combination
tumor
cancer
day
treatment
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JP2011520921A5 (enExample
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ドリーン・ルパージュ
パブロ・マニュエル・アヴィレス・マリン
マリア・ホセ・ギリェン・ナヴァーロ
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ファルマ・マール・ソシエダード・アノニマ
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/28—Compounds containing heavy metals
    • A61K31/282—Platinum compounds
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/335—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin
    • A61K31/337—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having four-membered rings, e.g. taxol
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/436—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having oxygen as a ring hetero atom, e.g. rapamycin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4995—Pyrazines or piperazines forming part of bridged ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
    • A61K31/517—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim ortho- or peri-condensed with carbocyclic ring systems, e.g. quinazoline, perimidine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7028—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages
    • A61K31/7034—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin
    • A61K31/704—Compounds having saccharide radicals attached to non-saccharide compounds by glycosidic linkages attached to a carbocyclic compound, e.g. phloridzin attached to a condensed carbocyclic ring system, e.g. sennosides, thiocolchicosides, escin, daunorubicin
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Epidemiology (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Molecular Biology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
JP2011509790A 2008-05-16 2009-05-18 抗腫瘍アルカロイドとの併用療法 Pending JP2011520921A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US5372608P 2008-05-16 2008-05-16
US61/053,726 2008-05-16
PCT/US2009/044334 WO2009140675A2 (en) 2008-05-16 2009-05-18 Combination therapy with an antitumor alkaloid

Publications (2)

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JP2011520921A true JP2011520921A (ja) 2011-07-21
JP2011520921A5 JP2011520921A5 (enExample) 2012-07-05

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JP2011509790A Pending JP2011520921A (ja) 2008-05-16 2009-05-18 抗腫瘍アルカロイドとの併用療法

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US (1) US20110070232A1 (enExample)
EP (1) EP2307003A2 (enExample)
JP (1) JP2011520921A (enExample)
KR (1) KR20110025178A (enExample)
CN (1) CN102099025A (enExample)
AU (1) AU2009246130A1 (enExample)
CA (1) CA2724325A1 (enExample)
IL (1) IL209361A0 (enExample)
MX (1) MX2010012501A (enExample)
NZ (1) NZ589269A (enExample)
RU (1) RU2010151602A (enExample)
WO (1) WO2009140675A2 (enExample)

Cited By (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016518371A (ja) * 2013-04-17 2016-06-23 メイン ファーマ インターナショナル プロプライエタリー リミテッドＭａｙｎｅ Ｐｈａｒｍａ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｐｔｙ．Ｌｔｄ． Ｈｅｄｇｅｈｏｇ経路阻害剤を用いた増殖障害の処置および予後モニタリングの方法
JP2023011569A (ja) * 2016-03-15 2023-01-24 オリソン ヘノミクス エセ． アー． 固形腫瘍の治療における使用のための、ｌｓｄ１阻害剤の組合せ

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US7919493B2 (en) 2000-04-12 2011-04-05 Pharma Mar, S.A. Anititumoral ecteinascidin derivatives
MXPA02011319A (es) 2000-05-15 2003-06-06 Pharma Mar Sa Analogos antitumorales de ecteinascidina 743.
GB0117402D0 (en) 2001-07-17 2001-09-05 Pharma Mar Sa New antitumoral derivatives of et-743
GB0202544D0 (en) 2002-02-04 2002-03-20 Pharma Mar Sa The synthesis of naturally occuring ecteinascidins and related compounds
WO2011048210A1 (en) 2009-10-22 2011-04-28 Pharma Mar, S.A. PDGFR-α AS RESPONSE MARKER FOR PM00104 TREATMENT
HUE042801T2 (hu) 2010-11-12 2019-07-29 Pharma Mar Sa Kombinációs terápia mitózisgátlóval
JOP20190254A1 (ar) 2017-04-27 2019-10-27 Pharma Mar Sa مركبات مضادة للأورام
KR102260846B1 (ko) * 2018-07-09 2021-06-07 국립암센터 고시폴, 펜포르민 및 항암제를 포함하는 암 예방 또는 치료용 약학적 조성물
PH12022551216A1 (en) 2019-11-21 2023-07-17 Pharma Mar Sa Methods of treating small cell lung cancer with lurbinectedin formulations
US12441707B2 (en) 2019-12-30 2025-10-14 Tyra Biosciences, Inc. Indazole compounds

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WO1999006024A1 (en) * 1997-07-29 1999-02-11 Pharmacia & Upjohn Company Self-emulsifying formulation for lipophilic compounds
JP2000504020A (ja) * 1996-01-31 2000-04-04 ボード オブ リージェンツ，ザ ユニバーシティ オブ テキサス システム ＨＥＲ２／ｎｅｕを過剰発現するガン細胞の化学療法剤に対する感作
JP2003533532A (ja) * 2000-05-15 2003-11-11 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３の抗腫瘍性類似体
WO2007008200A1 (en) * 2004-07-09 2007-01-18 Prolx Pharmaceuticals Corp. Wortmannin analogs and methods of using same in combination with chemotherapeutic agents
WO2007056118A1 (en) * 2005-11-04 2007-05-18 Wyeth Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
WO2007056135A1 (en) * 2005-11-04 2007-05-18 Merck & Co., Inc. Method of treating cancers with saha and pemetrexed
WO2007149891A2 (en) * 2006-06-21 2007-12-27 Eli Lilly And Company Crystalline forms of gemcitabine amide prodrug, compositions and use thereof

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AU770309B2 (en) * 1998-06-05 2004-02-19 Regent Court Technologies Monoamine oxidase (MAO) inhibitors and uses thereof
US6124292A (en) * 1998-09-30 2000-09-26 President And Fellows Of Harvard College Synthetic analogs of ecteinascidin-743
AR035842A1 (es) * 1999-05-14 2004-07-21 Pharma Mar Sa Metodo de hemisintesis para la formacion de compuestos intermediarios y derivados y de estructuras relacionadas con la ecteinascidina y de tetrahidroisoquinolinfenoles y compuestos intermediarios de aplicacion en dicho metodo
EP1254140A4 (en) * 2000-01-19 2003-03-12 Univ Columbia SAFRAMYCIN-ECTEINASCIDIN SERIES COMPOUNDS, USES AND SYNTHESIS
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GB0522082D0 (en) * 2005-10-31 2005-12-07 Pharma Mar Sa Formulations
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WO1999006024A1 (en) * 1997-07-29 1999-02-11 Pharmacia & Upjohn Company Self-emulsifying formulation for lipophilic compounds
JP2003533532A (ja) * 2000-05-15 2003-11-11 ファルマ・マール・ソシエダード・アノニマ Ｅｔ−７４３の抗腫瘍性類似体
WO2007008200A1 (en) * 2004-07-09 2007-01-18 Prolx Pharmaceuticals Corp. Wortmannin analogs and methods of using same in combination with chemotherapeutic agents
WO2007056118A1 (en) * 2005-11-04 2007-05-18 Wyeth Antineoplastic combinations with mtor inhibitor, herceptin, and/or hki-272
WO2007056135A1 (en) * 2005-11-04 2007-05-18 Merck & Co., Inc. Method of treating cancers with saha and pemetrexed
WO2007149891A2 (en) * 2006-06-21 2007-12-27 Eli Lilly And Company Crystalline forms of gemcitabine amide prodrug, compositions and use thereof

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JPN5011002667; ＬＥＰＡＧＥ　ＤＯＲＥＥＮ: 'ＡＮＴＩＴＵＭＯＲ　ＡＣＴＩＶＩＴＹ　ＯＦ　ＺＡＬＹＰＳＩＳ（Ｒ）　ＩＮ　ＨＵＭＡＮ　ＰＡＮＣＲＥＡＳ　ＴＵＭＯＲＳ' ＰＲＯＣＥＥＤＩＮＧＳ　ＯＦ　ＴＨＥ　ＡＮＮＵＡＬ　ＭＥＥＴＩＮＧ　ＯＦ　ＴＨＥ　ＡＭＥＲＩＣＡＮ　ＡＳＳＯＣＩＡＴＩＯＮ　ＦＯＲ　ＣＡＮＣＥＲ　ＲＥＳＥＡＲＣＨ Ｖ４８, 20070401, Ｐ３６０-３６１ *
JPN5011002668; ＷＡＬＫＥＲ　ＫＡＲＥＮ: 'ＡＭＥＲＩＣＡＮ　ＳＯＣＩＥＴＹ　ＯＦ　ＣＬＩＮＩＣＡＬ　ＯＮＣＯＬＯＧＹ-４３ＲＤ　ＡＮＮＵＡＬ　ＭＥＥＴＩＮＧ．　ＲＥＳＥＡＲＣＨ　ＩＮＴＯ　ＴＨＥＲＡＰＥＵＴＩＣＳ：　ＰＡＲＴ　２' ＩＤＲＵＧＳ Ｖ１０　Ｎ８, 20070801, Ｐ５１７-５１９, ＣＵＲＲＥＮＴ　ＤＲＵＧＳ　ＬＴＤ． *
JPN6013041999; Ａｎｎａｌｓ　ｏｆ　Ｏｎｃｏｌｏｇｙ Ｖｏｌ．１８，　Ｓｕｐｐｌｅｍｅｎｔ　６, 2007, ｐ．　ｖｉ３５-ｖｉ４１ *
JPN6013042002; Ｃｌｉｎ　Ｃａｎｃｅｒ　Ｒｅｓ Ｖｏｌ．１３，　Ｎｏ．２, 2007, ｐ．７４７ｓ-７５２ｓ *

Cited By (7)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2016518371A (ja) * 2013-04-17 2016-06-23 メイン ファーマ インターナショナル プロプライエタリー リミテッドＭａｙｎｅ Ｐｈａｒｍａ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｐｔｙ．Ｌｔｄ． Ｈｅｄｇｅｈｏｇ経路阻害剤を用いた増殖障害の処置および予後モニタリングの方法
US9962381B2 (en) 2013-04-17 2018-05-08 Hedgepath Pharmaceuticals, Inc. Treatment and prognostic monitoring of cancerous proliferation disorders using Hedgehog pathway inhibitors
US9968600B2 (en) 2013-04-17 2018-05-15 Hedgepath Pharmaceuticals, Inc. Treatment and prognostic monitoring of non-cancerous proliferation disorders using hedgehog pathway inhibitors
US10328072B2 (en) 2013-04-17 2019-06-25 Hedgepath Pharmaceuticals, Inc. Treatment of lung cancer using hedgehog pathway inhibitors
US10363252B2 (en) 2013-04-17 2019-07-30 Hedgepath Pharmaceuticals, Inc. Treatment of prostate cancer using hedgehog pathway inhibitors
JP2019151652A (ja) * 2013-04-17 2019-09-12 メイン ファーマ インターナショナル プロプライエタリー リミテッドＭａｙｎｅ Ｐｈａｒｍａ Ｉｎｔｅｒｎａｔｉｏｎａｌ Ｐｔｙ．Ｌｔｄ． Ｈｅｄｇｅｈｏｇ経路阻害剤を用いた増殖障害の処置および予後モニタリングの方法
JP2023011569A (ja) * 2016-03-15 2023-01-24 オリソン ヘノミクス エセ． アー． 固形腫瘍の治療における使用のための、ｌｓｄ１阻害剤の組合せ

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WO2009140675A2 (en) 2009-11-19
CN102099025A (zh) 2011-06-15
KR20110025178A (ko) 2011-03-09
RU2010151602A (ru) 2012-06-27
WO2009140675A3 (en) 2010-04-01
US20110070232A1 (en) 2011-03-24
IL209361A0 (en) 2011-01-31
AU2009246130A1 (en) 2009-11-19
CA2724325A1 (en) 2009-11-19
NZ589269A (en) 2013-03-28
MX2010012501A (es) 2010-12-20
EP2307003A2 (en) 2011-04-13

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