JP2011520808A5 - - Google Patents
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- Publication number
- JP2011520808A5 JP2011520808A5 JP2011508574A JP2011508574A JP2011520808A5 JP 2011520808 A5 JP2011520808 A5 JP 2011520808A5 JP 2011508574 A JP2011508574 A JP 2011508574A JP 2011508574 A JP2011508574 A JP 2011508574A JP 2011520808 A5 JP2011520808 A5 JP 2011520808A5
- Authority
- JP
- Japan
- Prior art keywords
- sulindac
- usage according
- derivatives
- epimer
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- MLKXDPUZXIRXEP-MFOYZWKCSA-N sulindac Chemical class CC1=C(CC(O)=O)C2=CC(F)=CC=C2\C1=C/C1=CC=C(S(C)=O)C=C1 MLKXDPUZXIRXEP-MFOYZWKCSA-N 0.000 claims 12
- 229960000894 sulindac Drugs 0.000 claims 7
- 210000004027 cell Anatomy 0.000 claims 4
- QEFRNWWLZKMPFJ-ZXPFJRLXSA-N L-methionine (R)-S-oxide Chemical compound C[S@@](=O)CC[C@H]([NH3+])C([O-])=O QEFRNWWLZKMPFJ-ZXPFJRLXSA-N 0.000 claims 2
- QEFRNWWLZKMPFJ-UHFFFAOYSA-N L-methionine sulphoxide Natural products CS(=O)CCC(N)C(O)=O QEFRNWWLZKMPFJ-UHFFFAOYSA-N 0.000 claims 2
- 206010063837 Reperfusion injury Diseases 0.000 claims 1
- 210000004413 cardiac myocyte Anatomy 0.000 claims 1
- 230000006378 damage Effects 0.000 claims 1
- 208000028867 ischemia Diseases 0.000 claims 1
- 230000003647 oxidation Effects 0.000 claims 1
- 238000007254 oxidation reaction Methods 0.000 claims 1
- 230000004792 oxidative damage Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/115,331 | 2008-05-05 | ||
| US12/115,331 US8487128B2 (en) | 2002-11-26 | 2008-05-05 | Protection of normal cells |
| PCT/US2009/042703 WO2009137400A2 (en) | 2008-05-05 | 2009-05-04 | Protection of normal cells |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011520808A JP2011520808A (ja) | 2011-07-21 |
| JP2011520808A5 true JP2011520808A5 (enExample) | 2012-06-21 |
Family
ID=41265328
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011508574A Pending JP2011520808A (ja) | 2008-05-05 | 2009-05-04 | 正常細胞の保護 |
Country Status (7)
| Country | Link |
|---|---|
| US (2) | US8487128B2 (enExample) |
| EP (1) | EP2282733A4 (enExample) |
| JP (1) | JP2011520808A (enExample) |
| CN (1) | CN102112124A (enExample) |
| AU (1) | AU2009244500A1 (enExample) |
| CA (1) | CA2755499A1 (enExample) |
| WO (1) | WO2009137400A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8487128B2 (en) * | 2002-11-26 | 2013-07-16 | Chs Pharma, Inc. | Protection of normal cells |
| CA2696627C (en) | 2007-08-17 | 2016-09-27 | Purdue Research Foundation | Psma binding ligand-linker conjugates and methods for using |
| US9951324B2 (en) | 2010-02-25 | 2018-04-24 | Purdue Research Foundation | PSMA binding ligand-linker conjugates and methods for using |
| EP2882426A1 (en) * | 2012-08-13 | 2015-06-17 | Institut National de la Santé et de la Recherche Médicale (INSERM) | Methods and pharmaceutical compositions for treatment of cystic fibrosis |
| KR102354613B1 (ko) | 2012-11-15 | 2022-01-21 | 엔도사이트, 인코포레이티드 | Psma 발현 세포에 의해 야기되는 질병을 치료하기 위한 컨쥬게이트 |
| JP6295278B2 (ja) * | 2013-02-28 | 2018-03-14 | アニダ ファーマ インコーポレイテッド | 聴器毒性を治療する方法 |
| WO2014160702A1 (en) | 2013-03-25 | 2014-10-02 | Chs Pharma, Inc. | Retinopathy treatment |
| HUE066137T2 (hu) | 2013-10-18 | 2024-07-28 | Novartis Ag | A prosztata-specifikus membrán antigén (PSMA) jelzett inhibitorai, alkalmazásuk képalkotásban és gyógyszerkészítmények prosztatarák kezelésére |
| JP6464166B2 (ja) | 2013-11-14 | 2019-02-06 | エンドサイト・インコーポレイテッドＥｎｄｏｃｙｔｅ， Ｉｎｃ． | 陽電子放出断層撮影用の化合物 |
| US10188759B2 (en) | 2015-01-07 | 2019-01-29 | Endocyte, Inc. | Conjugates for imaging |
| JP6735225B2 (ja) * | 2015-12-25 | 2020-08-05 | 共栄化学工業株式会社 | 皮膚外用組成物及び経口組成物 |
| US11186534B2 (en) * | 2017-03-17 | 2021-11-30 | University Of South Alabama | Derivatives of sulindac can protect normal cells against oxidative damage |
| PL237474B1 (pl) * | 2017-05-04 | 2021-04-19 | Wyzsza Szkola Medyczna W Bialymstoku | Nowe zastosowanie kwasu 2-[(3Z)-6-fluoro-2-metylo-3-[(4-metylosulfinylofenylo) metylideno]inden-1-ylo] octowego |
| CA3097381A1 (en) | 2018-04-17 | 2019-10-24 | Endocyte, Inc. | Methods of treating cancer |
| CN120097930A (zh) | 2019-05-20 | 2025-06-06 | 因多塞特股份有限公司 | 制备psma缀合物的方法 |
Family Cites Families (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5053429A (en) | 1988-04-08 | 1991-10-01 | The Lithox Corporation, Inc. | Treating inflammatory pain with methionine |
| US5401774A (en) * | 1991-03-08 | 1995-03-28 | University Of Arizona | Method for treating patients with precancerous lesions by administering substituted sulfonyl idenyl acetic and propionic acids and esters to patients with lesions sensitive to such compounds |
| US5608067A (en) | 1993-12-09 | 1997-03-04 | Afonso; Adriano | 4-substituted pyrazoloquinoline derivatives |
| US6201028B1 (en) * | 1998-12-08 | 2001-03-13 | The Rockefeller University | Methods and compositions for prevention and treatment of atherosclerosis and hyperlipidemia with non-steroidal anti-inflammatory drugs |
| EP1469884A1 (en) * | 2002-01-30 | 2004-10-27 | Pharmacia Corporation | Aldosterone antagonist and non-steroidal anti-inflammatory agent combination therapy to prevent or treat cardiovascular disorders |
| US8487128B2 (en) * | 2002-11-26 | 2013-07-16 | Chs Pharma, Inc. | Protection of normal cells |
| AU2003298020A1 (en) * | 2002-11-26 | 2004-06-18 | Florida Atlantic University | Catalytic antioxidants and methods of use |
| WO2007130575A2 (en) | 2006-05-03 | 2007-11-15 | Florida Atlantic University | Protection against oxidative damage in cells |
-
2008
- 2008-05-05 US US12/115,331 patent/US8487128B2/en not_active Expired - Fee Related
-
2009
- 2009-05-04 WO PCT/US2009/042703 patent/WO2009137400A2/en not_active Ceased
- 2009-05-04 EP EP09743387A patent/EP2282733A4/en not_active Withdrawn
- 2009-05-04 CA CA2755499A patent/CA2755499A1/en not_active Abandoned
- 2009-05-04 CN CN2009801268109A patent/CN102112124A/zh active Pending
- 2009-05-04 AU AU2009244500A patent/AU2009244500A1/en not_active Abandoned
- 2009-05-04 JP JP2011508574A patent/JP2011520808A/ja active Pending
-
2013
- 2013-07-16 US US13/943,218 patent/US8871971B2/en not_active Expired - Fee Related
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