JP2011520465A5 - - Google Patents
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- Publication number
- JP2011520465A5 JP2011520465A5 JP2011510505A JP2011510505A JP2011520465A5 JP 2011520465 A5 JP2011520465 A5 JP 2011520465A5 JP 2011510505 A JP2011510505 A JP 2011510505A JP 2011510505 A JP2011510505 A JP 2011510505A JP 2011520465 A5 JP2011520465 A5 JP 2011520465A5
- Authority
- JP
- Japan
- Prior art keywords
- human mammal
- genome
- disruption
- transgenic non
- gpr101
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 230000009261 transgenic effect Effects 0.000 claims 20
- 101150089560 GPR101 gene Proteins 0.000 claims 16
- 101100449163 Homo sapiens GPR101 gene Proteins 0.000 claims 16
- 238000000034 method Methods 0.000 claims 12
- 210000004027 cell Anatomy 0.000 claims 11
- 239000003795 chemical substances by application Substances 0.000 claims 9
- 230000006801 homologous recombination Effects 0.000 claims 7
- 238000002744 homologous recombination Methods 0.000 claims 7
- 230000008685 targeting Effects 0.000 claims 7
- 125000003275 alpha amino acid group Chemical group 0.000 claims 6
- 238000006467 substitution reaction Methods 0.000 claims 6
- 230000037396 body weight Effects 0.000 claims 5
- 230000037406 food intake Effects 0.000 claims 5
- 235000012631 food intake Nutrition 0.000 claims 5
- 101001070479 Homo sapiens Probable G-protein coupled receptor 101 Proteins 0.000 claims 3
- 241000124008 Mammalia Species 0.000 claims 3
- 102100034137 Probable G-protein coupled receptor 101 Human genes 0.000 claims 3
- 230000000694 effects Effects 0.000 claims 3
- 210000001671 embryonic stem cell Anatomy 0.000 claims 3
- 238000012216 screening Methods 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12811008P | 2008-05-19 | 2008-05-19 | |
| US61/128,110 | 2008-05-19 | ||
| PCT/US2009/003094 WO2009142724A2 (en) | 2008-05-19 | 2009-05-18 | Novel gpr101 transgenic mice and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011520465A JP2011520465A (ja) | 2011-07-21 |
| JP2011520465A5 true JP2011520465A5 (enExample) | 2012-06-28 |
Family
ID=41010556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510505A Withdrawn JP2011520465A (ja) | 2008-05-19 | 2009-05-18 | 新規gpr101トランスジェニックマウスおよびそれを使用する方法 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2303002A2 (enExample) |
| JP (1) | JP2011520465A (enExample) |
| WO (1) | WO2009142724A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP2009538623A (ja) | 2006-05-31 | 2009-11-12 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 視床下部プロオピオメラノコルチン(pomc)由来生物活性ペプチドに関連する障害の処置において有用な、視床下部プロオピオメラノコルチン(pomc)由来生物活性ペプチドの分泌の調節因子を同定するための方法における、gpr101受容体の使用 |
| US20110173706A1 (en) * | 2008-05-19 | 2011-07-14 | Beth Israel Deaconess Medical Center, Inc. | Novel gpr101 transgenic mice and methods of use thereof |
| EP2918166A1 (en) | 2014-03-10 | 2015-09-16 | Westfälische Wilhelms-Universität Münster | TTP/MRP14 double knock out mouse model of psoriasis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| JP2003508026A (ja) * | 1999-07-15 | 2003-03-04 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | ヒトg−タンパク質共役型受容体 |
| EP1224861B1 (en) * | 1999-10-05 | 2009-06-24 | Japan Science and Technology Agency | Test method relating to adipose cells and to obesity by using a human h-pgds overexpressing non-human animal |
| DE10004930A1 (de) * | 2000-02-04 | 2001-08-09 | Michael Brues | Seralpha: Gen, cDNA, Expression, Aminosäuresequenz |
| GB2367295A (en) * | 2000-06-16 | 2002-04-03 | Smithkline Beecham Corp | AXOR69 polypeptides and polynucleotides |
| US20060123502A1 (en) * | 2004-12-03 | 2006-06-08 | Murphy Andrew J | Assay methods for identifying RE2-like antagonists, methods of use, and non-human transgenic animals |
| JP2009538623A (ja) * | 2006-05-31 | 2009-11-12 | アリーナ ファーマシューティカルズ, インコーポレイテッド | 視床下部プロオピオメラノコルチン(pomc)由来生物活性ペプチドに関連する障害の処置において有用な、視床下部プロオピオメラノコルチン(pomc)由来生物活性ペプチドの分泌の調節因子を同定するための方法における、gpr101受容体の使用 |
-
2009
- 2009-05-18 JP JP2011510505A patent/JP2011520465A/ja not_active Withdrawn
- 2009-05-18 EP EP09750955A patent/EP2303002A2/en not_active Withdrawn
- 2009-05-18 WO PCT/US2009/003094 patent/WO2009142724A2/en not_active Ceased
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