JP2011520465A - 新規ｇｐｒ１０１トランスジェニックマウスおよびそれを使用する方法 - Google Patents
新規ｇｐｒ１０１トランスジェニックマウスおよびそれを使用する方法 Download PDFInfo
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- JP2011520465A JP2011520465A JP2011510505A JP2011510505A JP2011520465A JP 2011520465 A JP2011520465 A JP 2011520465A JP 2011510505 A JP2011510505 A JP 2011510505A JP 2011510505 A JP2011510505 A JP 2011510505A JP 2011520465 A JP2011520465 A JP 2011520465A
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- gpr101
- human mammal
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- disruption
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Classifications
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- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K67/00—Rearing or breeding animals, not otherwise provided for; New or modified breeds of animals
- A01K67/027—New or modified breeds of vertebrates
- A01K67/0275—Genetically modified vertebrates, e.g. transgenic
- A01K67/0276—Knock-out vertebrates
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
- C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
- C07K14/705—Receptors; Cell surface antigens; Cell surface determinants
- C07K14/72—Receptors; Cell surface antigens; Cell surface determinants for hormones
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
- C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
- C12N15/09—Recombinant DNA-technology
- C12N15/63—Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
- C12N15/79—Vectors or expression systems specially adapted for eukaryotic hosts
- C12N15/85—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells
- C12N15/8509—Vectors or expression systems specially adapted for eukaryotic hosts for animal cells for producing genetically modified animals, e.g. transgenic
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/072—Animals genetically altered by homologous recombination maintaining or altering function, i.e. knock in
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2217/00—Genetically modified animals
- A01K2217/07—Animals genetically altered by homologous recombination
- A01K2217/075—Animals genetically altered by homologous recombination inducing loss of function, i.e. knock out
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2227/00—Animals characterised by species
- A01K2227/10—Mammal
- A01K2227/105—Murine
-
- A—HUMAN NECESSITIES
- A01—AGRICULTURE; FORESTRY; ANIMAL HUSBANDRY; HUNTING; TRAPPING; FISHING
- A01K—ANIMAL HUSBANDRY; AVICULTURE; APICULTURE; PISCICULTURE; FISHING; REARING OR BREEDING ANIMALS, NOT OTHERWISE PROVIDED FOR; NEW BREEDS OF ANIMALS
- A01K2267/00—Animals characterised by purpose
- A01K2267/03—Animal model, e.g. for test or diseases
- A01K2267/035—Animal model for multifactorial diseases
- A01K2267/0362—Animal model for lipid/glucose metabolism, e.g. obesity, type-2 diabetes
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
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- Engineering & Computer Science (AREA)
- General Health & Medical Sciences (AREA)
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- Molecular Biology (AREA)
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- Biotechnology (AREA)
- Immunology (AREA)
- Medicinal Chemistry (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Biomedical Technology (AREA)
- Cell Biology (AREA)
- Toxicology (AREA)
- Veterinary Medicine (AREA)
- Wood Science & Technology (AREA)
- Bioinformatics & Cheminformatics (AREA)
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- Environmental Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Biodiversity & Conservation Biology (AREA)
- Physics & Mathematics (AREA)
- Endocrinology (AREA)
- Plant Pathology (AREA)
- Animal Husbandry (AREA)
- Microbiology (AREA)
- Animal Behavior & Ethology (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Investigating Or Analysing Biological Materials (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12811008P | 2008-05-19 | 2008-05-19 | |
| US61/128,110 | 2008-05-19 | ||
| PCT/US2009/003094 WO2009142724A2 (en) | 2008-05-19 | 2009-05-18 | Novel gpr101 transgenic mice and methods of use thereof |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011520465A true JP2011520465A (ja) | 2011-07-21 |
| JP2011520465A5 JP2011520465A5 (enExample) | 2012-06-28 |
Family
ID=41010556
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011510505A Withdrawn JP2011520465A (ja) | 2008-05-19 | 2009-05-18 | 新規ｇｐｒ１０１トランスジェニックマウスおよびそれを使用する方法 |
Country Status (3)
| Country | Link |
|---|---|
| EP (1) | EP2303002A2 (enExample) |
| JP (1) | JP2011520465A (enExample) |
| WO (1) | WO2009142724A2 (enExample) |
Families Citing this family (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| WO2007142979A2 (en) | 2006-05-31 | 2007-12-13 | Arena Pharmaceuticals, Inc. | Use of gpr101 receptor in methods to identify modulators of hypothalamic proopiomelanocortin (pomc)-derived biologically active peptide secretion useful in the treatment of pomc-derived biologically active peptide-related disorders |
| US20110173706A1 (en) * | 2008-05-19 | 2011-07-14 | Beth Israel Deaconess Medical Center, Inc. | Novel gpr101 transgenic mice and methods of use thereof |
| EP2918166A1 (en) | 2014-03-10 | 2015-09-16 | Westfälische Wilhelms-Universität Münster | TTP/MRP14 double knock out mouse model of psoriasis |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| JP2003508026A (ja) * | 1999-07-15 | 2003-03-04 | ソルベイ・フアーマシユーチカルズ・ベー・ブイ | ヒトｇ−タンパク質共役型受容体 |
| WO2001024627A1 (en) * | 1999-10-05 | 2001-04-12 | Japan Science And Technology Corporation | Animal with the mass expression of human gene and test method by using the animal |
| DE10004930A1 (de) * | 2000-02-04 | 2001-08-09 | Michael Brues | Seralpha: Gen, cDNA, Expression, Aminosäuresequenz |
| GB2367295A (en) * | 2000-06-16 | 2002-04-03 | Smithkline Beecham Corp | AXOR69 polypeptides and polynucleotides |
| US20060123502A1 (en) * | 2004-12-03 | 2006-06-08 | Murphy Andrew J | Assay methods for identifying RE2-like antagonists, methods of use, and non-human transgenic animals |
| WO2007142979A2 (en) * | 2006-05-31 | 2007-12-13 | Arena Pharmaceuticals, Inc. | Use of gpr101 receptor in methods to identify modulators of hypothalamic proopiomelanocortin (pomc)-derived biologically active peptide secretion useful in the treatment of pomc-derived biologically active peptide-related disorders |
-
2009
- 2009-05-18 EP EP09750955A patent/EP2303002A2/en not_active Withdrawn
- 2009-05-18 WO PCT/US2009/003094 patent/WO2009142724A2/en not_active Ceased
- 2009-05-18 JP JP2011510505A patent/JP2011520465A/ja not_active Withdrawn
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009142724A2 (en) | 2009-11-26 |
| WO2009142724A3 (en) | 2010-01-21 |
| EP2303002A2 (en) | 2011-04-06 |
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