JP2011519568A5 - - Google Patents
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- JP2011519568A5 JP2011519568A5 JP2011507710A JP2011507710A JP2011519568A5 JP 2011519568 A5 JP2011519568 A5 JP 2011519568A5 JP 2011507710 A JP2011507710 A JP 2011507710A JP 2011507710 A JP2011507710 A JP 2011507710A JP 2011519568 A5 JP2011519568 A5 JP 2011519568A5
- Authority
- JP
- Japan
- Prior art keywords
- cells
- culturing
- pluripotent
- item
- differentiation
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000004027 cell Anatomy 0.000 claims description 73
- 238000000034 method Methods 0.000 claims description 58
- 238000012258 culturing Methods 0.000 claims description 31
- 239000002609 medium Substances 0.000 claims description 24
- 102000004889 Interleukin-6 Human genes 0.000 claims description 18
- 108090001005 Interleukin-6 Proteins 0.000 claims description 18
- 210000003630 histaminocyte Anatomy 0.000 claims description 18
- 229940100601 interleukin-6 Drugs 0.000 claims description 18
- 102100039064 Interleukin-3 Human genes 0.000 claims description 16
- 230000004069 differentiation Effects 0.000 claims description 15
- 102000036693 Thrombopoietin Human genes 0.000 claims description 14
- 108010041111 Thrombopoietin Proteins 0.000 claims description 14
- 210000000130 stem cell Anatomy 0.000 claims description 14
- 108010002386 Interleukin-3 Proteins 0.000 claims description 12
- 210000003958 hematopoietic stem cell Anatomy 0.000 claims description 12
- 229940076264 interleukin-3 Drugs 0.000 claims description 12
- 230000002349 favourable effect Effects 0.000 claims description 8
- 210000003593 megakaryocyte Anatomy 0.000 claims description 8
- 108700014844 flt3 ligand Proteins 0.000 claims description 5
- 102100024505 Bone morphogenetic protein 4 Human genes 0.000 claims description 4
- 108090000790 Enzymes Proteins 0.000 claims description 4
- 102000004190 Enzymes Human genes 0.000 claims description 4
- 102100020715 Fms-related tyrosine kinase 3 ligand protein Human genes 0.000 claims description 4
- 101710162577 Fms-related tyrosine kinase 3 ligand protein Proteins 0.000 claims description 4
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 claims description 4
- 101000762379 Homo sapiens Bone morphogenetic protein 4 Proteins 0.000 claims description 4
- 101000746373 Homo sapiens Granulocyte-macrophage colony-stimulating factor Proteins 0.000 claims description 4
- 101001033279 Homo sapiens Interleukin-3 Proteins 0.000 claims description 4
- 102000005789 Vascular Endothelial Growth Factors Human genes 0.000 claims description 4
- 108010019530 Vascular Endothelial Growth Factors Proteins 0.000 claims description 4
- 210000002242 embryoid body Anatomy 0.000 claims description 4
- 239000003112 inhibitor Substances 0.000 claims description 4
- 239000011435 rock Substances 0.000 claims description 4
- -1 stem cell factor Proteins 0.000 claims description 3
- 102100031573 Hematopoietic progenitor cell antigen CD34 Human genes 0.000 claims description 2
- 101000777663 Homo sapiens Hematopoietic progenitor cell antigen CD34 Proteins 0.000 claims description 2
- 101000738771 Homo sapiens Receptor-type tyrosine-protein phosphatase C Proteins 0.000 claims description 2
- 102100037422 Receptor-type tyrosine-protein phosphatase C Human genes 0.000 claims description 2
- 102000004142 Trypsin Human genes 0.000 claims description 2
- 108090000631 Trypsin Proteins 0.000 claims description 2
- 229940122618 Trypsin inhibitor Drugs 0.000 claims description 2
- 101710162629 Trypsin inhibitor Proteins 0.000 claims description 2
- 102000001400 Tryptase Human genes 0.000 claims description 2
- 108060005989 Tryptase Proteins 0.000 claims description 2
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical compound [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 2
- 238000003501 co-culture Methods 0.000 claims description 2
- 210000001671 embryonic stem cell Anatomy 0.000 claims description 2
- 230000001605 fetal effect Effects 0.000 claims description 2
- 238000001943 fluorescence-activated cell sorting Methods 0.000 claims description 2
- 239000003102 growth factor Substances 0.000 claims description 2
- 230000003394 haemopoietic effect Effects 0.000 claims description 2
- 238000000338 in vitro Methods 0.000 claims description 2
- 210000004185 liver Anatomy 0.000 claims description 2
- 238000002826 magnetic-activated cell sorting Methods 0.000 claims description 2
- 229910052760 oxygen Inorganic materials 0.000 claims description 2
- 239000001301 oxygen Substances 0.000 claims description 2
- 239000012679 serum free medium Substances 0.000 claims description 2
- 210000002536 stromal cell Anatomy 0.000 claims description 2
- 239000012588 trypsin Substances 0.000 claims description 2
- 239000002753 trypsin inhibitor Substances 0.000 claims description 2
- 239000003446 ligand Substances 0.000 claims 2
- 102000049772 Interleukin-16 Human genes 0.000 claims 1
- 101800003050 Interleukin-16 Proteins 0.000 claims 1
- 210000004748 cultured cell Anatomy 0.000 claims 1
- 239000002243 precursor Substances 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 description 1
- 238000012986 modification Methods 0.000 description 1
- 230000004048 modification Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US5008608P | 2008-05-02 | 2008-05-02 | |
| US61/050,086 | 2008-05-02 | ||
| PCT/US2009/042701 WO2009135206A1 (en) | 2008-05-02 | 2009-05-04 | Method for production of mast cells from stem cells |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519568A JP2011519568A (ja) | 2011-07-14 |
| JP2011519568A5 true JP2011519568A5 (https=) | 2013-02-14 |
| JP5632831B2 JP5632831B2 (ja) | 2014-11-26 |
Family
ID=40852030
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011507710A Active JP5632831B2 (ja) | 2008-05-02 | 2009-05-04 | 幹細胞からの肥満細胞の生産のための方法 |
Country Status (4)
| Country | Link |
|---|---|
| US (1) | US8513012B2 (https=) |
| EP (1) | EP2291511B1 (https=) |
| JP (1) | JP5632831B2 (https=) |
| WO (1) | WO2009135206A1 (https=) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2398897B1 (en) | 2009-02-20 | 2017-06-28 | Cellular Dynamics International, Inc. | Methods and compositions for the differentiation of stem cells |
| KR101720961B1 (ko) | 2009-02-27 | 2017-03-29 | 셀룰러 다이내믹스 인터내셔널, 인코포레이티드 | 다능성 세포의 분화 |
| US8741644B2 (en) | 2009-09-08 | 2014-06-03 | Kyoto University | Method for producing mast cells from pluripotent stem cells |
| CN102234627B (zh) * | 2010-04-30 | 2015-06-03 | 中国科学院广州生物医药与健康研究院 | 一种培养基添加剂及其应用 |
| EP2601288B1 (en) * | 2010-08-05 | 2016-04-06 | Wisconsin Alumni Research Foundation | Simplified basic media for human pluripotent cell culture |
| US9279107B2 (en) | 2010-08-05 | 2016-03-08 | Wisconsin Alumni Research Foundation | Simplified basic media for human pluripotent cell culture |
| CN102329769B (zh) * | 2011-09-28 | 2013-07-31 | 浙江大学 | 一种获得造血干细胞的方法 |
| EP2788475A1 (en) | 2011-12-05 | 2014-10-15 | Primorigen Biosciences Inc. | Compositions and methods for differentiating pluripotent stem cells into primitive blood cells and uses thereof |
| EP2841563B1 (en) | 2012-04-24 | 2019-06-12 | Dan S. Kaufman | Method for developing natural killer cells from stem cells |
| JP6419455B2 (ja) * | 2013-05-15 | 2018-11-07 | 国立研究開発法人医薬基盤・健康・栄養研究所 | 成熟マスト細胞の作製方法及び得られた成熟マスト細胞 |
| CN108431211B (zh) * | 2015-10-20 | 2026-03-24 | 富士胶片细胞动力公司 | 通过遗传编程的多谱系造血前体细胞产生 |
| US11542473B2 (en) | 2016-10-21 | 2023-01-03 | Amniotics Ab | Methods and compositions for generating hematopoietic cells |
| WO2018195175A1 (en) | 2017-04-18 | 2018-10-25 | FUJIFILM Cellular Dynamics, Inc. | Antigen-specific immune effector cells |
| CN107338220A (zh) * | 2017-06-07 | 2017-11-10 | 北京呈诺医学科技有限公司 | 诱导性多能干细胞向造血干细胞分化的方法及其培养基 |
| US11365390B2 (en) | 2017-12-19 | 2022-06-21 | Xcell Biosciences, Inc. | Methods of modulating cell phenotype by way of regulating the gaseous environment |
| CN108642013A (zh) * | 2018-05-02 | 2018-10-12 | 中航（宁夏）生物股份有限公司 | 一种从脐带血中分离cd34造血干细胞扩大培养后大规模诱导制备树突状细胞方法 |
| WO2020256628A1 (en) | 2019-06-20 | 2020-12-24 | Amniotics Ab | An apparatus for filtering amniotic fluid |
| AU2020368845A1 (en) | 2019-10-18 | 2022-05-12 | Amniotics Ab | Processes and apparatuses for obtaining amniotic mesenchymal stem cells from amniotic fluid and cells derived thereof |
| US20220348876A1 (en) * | 2019-11-28 | 2022-11-03 | Amniotics Ab | Metabolism guides definitive lineage specification during endothelial to hematopoietic transition |
| US12435308B2 (en) | 2020-11-06 | 2025-10-07 | Amniotics Ab | Immunomodulation by amniotic fluid mesenchymal stem cells |
| CN112779218B (zh) * | 2021-01-29 | 2022-12-06 | 西南医科大学 | 用于原代培养肿瘤浸润性肥大细胞的培养基及培养方法 |
| CN114515296B (zh) * | 2022-02-25 | 2024-01-12 | 和携科技有限公司 | 一种脂肪间充质干细胞分泌因子的制备方法 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101052712A (zh) * | 2004-09-08 | 2007-10-10 | 威斯康星校友研究基金会 | 培养人胚胎干细胞 |
| US20070077654A1 (en) * | 2004-11-01 | 2007-04-05 | Thomson James A | Platelets from stem cells |
| WO2008089351A1 (en) | 2007-01-17 | 2008-07-24 | Wisconsin Alumni Research Foundation | Improved culture of stem cells |
| US7615374B2 (en) * | 2007-09-25 | 2009-11-10 | Wisconsin Alumni Research Foundation | Generation of clonal mesenchymal progenitors and mesenchymal stem cell lines under serum-free conditions |
-
2009
- 2009-05-04 US US12/435,123 patent/US8513012B2/en active Active
- 2009-05-04 WO PCT/US2009/042701 patent/WO2009135206A1/en not_active Ceased
- 2009-05-04 JP JP2011507710A patent/JP5632831B2/ja active Active
- 2009-05-04 EP EP09740008.9A patent/EP2291511B1/en active Active
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