JP2011519414A5 - - Google Patents
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- JP2011519414A5 JP2011519414A5 JP2011501777A JP2011501777A JP2011519414A5 JP 2011519414 A5 JP2011519414 A5 JP 2011519414A5 JP 2011501777 A JP2011501777 A JP 2011501777A JP 2011501777 A JP2011501777 A JP 2011501777A JP 2011519414 A5 JP2011519414 A5 JP 2011519414A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- virus
- dlvr
- clec
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Ceased
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- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 241000700605 Viruses Species 0.000 claims 6
- 102000004127 Cytokines Human genes 0.000 claims 4
- 108090000695 Cytokines Proteins 0.000 claims 4
- 241001465754 Metazoa Species 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 229940079593 drug Drugs 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 230000028327 secretion Effects 0.000 claims 2
- MZOFCQQQCNRIBI-VMXHOPILSA-N (3s)-4-[[(2s)-1-[[(2s)-1-[[(1s)-1-carboxy-2-hydroxyethyl]amino]-4-methyl-1-oxopentan-2-yl]amino]-5-(diaminomethylideneamino)-1-oxopentan-2-yl]amino]-3-[[2-[[(2s)-2,6-diaminohexanoyl]amino]acetyl]amino]-4-oxobutanoic acid Chemical compound OC[C@@H](C(O)=O)NC(=O)[C@H](CC(C)C)NC(=O)[C@H](CCCN=C(N)N)NC(=O)[C@H](CC(O)=O)NC(=O)CNC(=O)[C@@H](N)CCCCN MZOFCQQQCNRIBI-VMXHOPILSA-N 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 241000710831 Flavivirus Species 0.000 claims 1
- 102000006992 Interferon-alpha Human genes 0.000 claims 1
- 108010047761 Interferon-alpha Proteins 0.000 claims 1
- 241000710842 Japanese encephalitis virus Species 0.000 claims 1
- 238000012228 RNA interference-mediated gene silencing Methods 0.000 claims 1
- 108020004459 Small interfering RNA Proteins 0.000 claims 1
- 241000710771 Tick-borne encephalitis virus Species 0.000 claims 1
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims 1
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 241000710772 Yellow fever virus Species 0.000 claims 1
- 210000004102 animal cell Anatomy 0.000 claims 1
- 239000003795 chemical substances by application Substances 0.000 claims 1
- 230000008030 elimination Effects 0.000 claims 1
- 238000003379 elimination reaction Methods 0.000 claims 1
- 230000009368 gene silencing by RNA Effects 0.000 claims 1
- 208000006454 hepatitis Diseases 0.000 claims 1
- 231100000283 hepatitis Toxicity 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000002757 inflammatory effect Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000004048 modification Effects 0.000 claims 1
- 238000012986 modification Methods 0.000 claims 1
- 230000000770 proinflammatory effect Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 229940051021 yellow-fever virus Drugs 0.000 claims 1
Claims (10)
- ウイルスからの感染を処置するための医薬組成物であって、動物のウイルス感染の作用を修飾するため、動物のＤＬＶＲ １ ／ＣＬＥＣ ５ Ａに対する有効量の薬剤を含む医薬組成物。
- 前記ウイルスが肝炎ウイルスであることを特徴とする、請求項１に記載の医薬組成物。
- 前記ウイルスがフラビウイルスであることを特徴とする、請求項１に記載の医薬組成物。
- 前記フラビウイルスがウエストナイルウイルス、日本脳炎ウイルス、黄熱ウイルス、ダニ媒介脳炎ウイルスまたはデングウイルスであることを特徴とする、請求項３に記載の医薬組成物。
- 前記修飾が、少なくとも動物細胞の前炎症性サイトカイン分泌の阻害を含み、ウイルスの排除に作用するサイトカインの分泌に影響を与えることがない、請求項１〜４のいずれかに記載の医薬組成物。
- 前記炎症性サイトカインがＴＮＦ−αを含み、ウイルスの排除に作用する前記サイトカインが少なくともインターフェロンαを含むことを特徴とする、請求項５に記載の医薬組成物。
- 前記薬剤がＤＬＶＲ １ ／ＣＬＥＣ ５ Ａに対する抗体またはＲＮＡ干渉のメディエーターである、請求項１〜６のいずれかに記載の医薬組成物。
- 前記抗体が配列番号６６、６７および６８からなる群から選択されるアミノ酸配列を有する可変軽鎖を含む、請求項７に記載の医薬組成物。
- 前記抗体が配列番号６９、７０および７１からなる群から選択されるアミノ酸配列を有する可変重鎖を含む、請求項７または８に記載の医薬組成物。
- 前記薬剤がＤＶＬＲ１由来の配列を含むｓｉＲＮＡである、請求項７に記載の医薬組成物。
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/079,576 | 2008-03-27 | ||
| US12/079,576 US7943134B2 (en) | 2005-08-31 | 2008-03-27 | Compositions and methods for identifying response targets and treating flavivirus infection responses |
| PCT/US2008/065166 WO2009120225A1 (en) | 2008-03-27 | 2008-05-29 | Compositions and methods for identifying response targets and treating flavivirus infection responses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011519414A JP2011519414A (ja) | 2011-07-07 |
| JP2011519414A5 true JP2011519414A5 (ja) | 2011-11-10 |
Family
ID=39722300
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011501777A Ceased JP2011519414A (ja) | 2008-03-27 | 2008-05-29 | 応答標的の同定及びフラビウイルス感染反応の治療に用いる組成物及び方法 |
Country Status (9)
| Country | Link |
|---|---|
| US (2) | US7943134B2 (ja) |
| EP (1) | EP2257806A4 (ja) |
| JP (1) | JP2011519414A (ja) |
| CN (1) | CN102084250B (ja) |
| AU (1) | AU2008353452A1 (ja) |
| BR (1) | BRPI0822472A2 (ja) |
| GB (1) | GB2458715A (ja) |
| TW (1) | TWI403586B (ja) |
| WO (1) | WO2009120225A1 (ja) |
Families Citing this family (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8354127B2 (en) * | 2008-02-12 | 2013-01-15 | Academia Sinica | Structure and bioactivity of the polysaccharides and oligomers in medicinal plant Dendrobium huoshanense |
| CA2887933A1 (en) | 2012-10-12 | 2014-04-17 | Arizona Board Of Agents, On Behalf Of Arizona State University | Antibody based reagents that specifically recognize toxic oligomeric forms of tau |
| WO2014183469A1 (zh) * | 2013-05-16 | 2014-11-20 | 清华大学 | 一种用于登革热预防和/或治疗的疫苗 |
| CN106211773B (zh) | 2014-02-11 | 2021-09-03 | 威特拉公司 | 用于登革病毒的抗体分子及其应用 |
| CN109311986A (zh) | 2016-03-25 | 2019-02-05 | 威特拉公司 | 登革热病毒抗体分子的制剂 |
| TWI672504B (zh) * | 2017-03-16 | 2019-09-21 | Academia Sinica | 用以診斷病毒感染的方法 |
| CN113573699A (zh) * | 2019-01-08 | 2021-10-29 | 乔治亚大学研究基金会 | 靶向纳米颗粒以及它们的与真菌感染有关的用途 |
| CN113122628B (zh) * | 2019-12-30 | 2023-08-11 | 广州医科大学附属第三医院（广州重症孕产妇救治中心、广州柔济医院） | Clec5a基因作为标志物在子宫内膜癌中诊断及治疗的应用 |
| CN111650308B (zh) * | 2020-07-13 | 2022-10-14 | 贵州中医药大学 | 一种金钗石斛花的hplc指纹图谱构建方法 |
| CN113713105A (zh) * | 2021-09-13 | 2021-11-30 | 中国人民解放军军事科学院军事医学研究院 | 用于抑制clec5a的物质在制备治疗和/或预防乙型病毒性肝炎的药物中的应用 |
| CN115804362A (zh) * | 2023-02-08 | 2023-03-17 | 中国医学科学院医学生物学研究所 | 一种IFN-α/βR-/-小鼠抗体依赖性增强感染的注射液及其制备方法 |
Family Cites Families (40)
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| US4217344A (en) * | 1976-06-23 | 1980-08-12 | L'oreal | Compositions containing aqueous dispersions of lipid spheres |
| US4235871A (en) * | 1978-02-24 | 1980-11-25 | Papahadjopoulos Demetrios P | Method of encapsulating biologically active materials in lipid vesicles |
| US4186183A (en) * | 1978-03-29 | 1980-01-29 | The United States Of America As Represented By The Secretary Of The Army | Liposome carriers in chemotherapy of leishmaniasis |
| US4261975A (en) * | 1979-09-19 | 1981-04-14 | Merck & Co., Inc. | Viral liposome particle |
| US4485054A (en) * | 1982-10-04 | 1984-11-27 | Lipoderm Pharmaceuticals Limited | Method of encapsulating biologically active materials in multilamellar lipid vesicles (MLV) |
| US4501728A (en) * | 1983-01-06 | 1985-02-26 | Technology Unlimited, Inc. | Masking of liposomes from RES recognition |
| US4946787A (en) * | 1985-01-07 | 1990-08-07 | Syntex (U.S.A.) Inc. | N-(ω,(ω-1)-dialkyloxy)- and N-(ω,(ω-1)-dialkenyloxy)-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor |
| US5506337A (en) * | 1985-03-15 | 1996-04-09 | Antivirals Inc. | Morpholino-subunit combinatorial library and method |
| US4774085A (en) * | 1985-07-09 | 1988-09-27 | 501 Board of Regents, Univ. of Texas | Pharmaceutical administration systems containing a mixture of immunomodulators |
| US4837028A (en) * | 1986-12-24 | 1989-06-06 | Liposome Technology, Inc. | Liposomes with enhanced circulation time |
| US5010175A (en) * | 1988-05-02 | 1991-04-23 | The Regents Of The University Of California | General method for producing and selecting peptides with specific properties |
| US5328470A (en) * | 1989-03-31 | 1994-07-12 | The Regents Of The University Of Michigan | Treatment of diseases by site-specific instillation of cells or site-specific transformation of cells and kits therefor |
| DK0452457T3 (da) | 1989-11-03 | 1998-03-02 | Univ Vanderbilt | Fremgangsmåde til in vivo fjernelse af funktionelle fremmede gener |
| US5270163A (en) * | 1990-06-11 | 1993-12-14 | University Research Corporation | Methods for identifying nucleic acid ligands |
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| US5650489A (en) | 1990-07-02 | 1997-07-22 | The Arizona Board Of Regents | Random bio-oligomer library, a method of synthesis thereof, and a method of use thereof |
| US5573905A (en) | 1992-03-30 | 1996-11-12 | The Scripps Research Institute | Encoded combinatorial chemical libraries |
| US5288514A (en) * | 1992-09-14 | 1994-02-22 | The Regents Of The University Of California | Solid phase and combinatorial synthesis of benzodiazepine compounds on a solid support |
| US5519134A (en) * | 1994-01-11 | 1996-05-21 | Isis Pharmaceuticals, Inc. | Pyrrolidine-containing monomers and oligomers |
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| US5549974A (en) * | 1994-06-23 | 1996-08-27 | Affymax Technologies Nv | Methods for the solid phase synthesis of thiazolidinones, metathiazanones, and derivatives thereof |
| US5820873A (en) | 1994-09-30 | 1998-10-13 | The University Of British Columbia | Polyethylene glycol modified ceramide lipids and liposome uses thereof |
| US5885613A (en) | 1994-09-30 | 1999-03-23 | The University Of British Columbia | Bilayer stabilizing components and their use in forming programmable fusogenic liposomes |
| US5753613A (en) | 1994-09-30 | 1998-05-19 | Inex Pharmaceuticals Corporation | Compositions for the introduction of polyanionic materials into cells |
| US5804162A (en) | 1995-06-07 | 1998-09-08 | Alliance Pharmaceutical Corp. | Gas emulsions stabilized with fluorinated ethers having low Ostwald coefficients |
| AU6113396A (en) | 1995-06-14 | 1997-01-15 | Regents Of The University Of California, The | Novel high affinity human antibodies to tumor antigens |
| US5811097A (en) * | 1995-07-25 | 1998-09-22 | The Regents Of The University Of California | Blockade of T lymphocyte down-regulation associated with CTLA-4 signaling |
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| US6416973B1 (en) * | 1997-08-01 | 2002-07-09 | Schering Corporation | Nucleic acids encoding mammalian cell membrane protein MDL-1 |
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| JP2005504741A (ja) | 2001-07-17 | 2005-02-17 | ユニバーシティー オブ ヴァージニア パテント ファウンデーション | 改良されたヘテロポリマー複合体およびそれらの使用法 |
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| ATE428437T1 (de) * | 2002-11-05 | 2009-05-15 | Pasteur Institut | Dc-sign blockern und deren verwendung zur vorbeugung oder behandlung von viraleninfektionen |
| EP1817590A2 (en) * | 2004-11-08 | 2007-08-15 | Schering Corporation | Tumor association of mdl-1 and methods |
| US20070072247A1 (en) * | 2005-08-31 | 2007-03-29 | Academia Sinica | Methods and reagents for the analysis and purification of polysaccharides |
| AR059193A1 (es) | 2006-01-31 | 2008-03-12 | Bayer Schering Pharma Ag | Modulacion de la actividad de mdl-1 para el tratamiento de enfermedades inflamatorias |
| US8153134B2 (en) * | 2007-04-23 | 2012-04-10 | Schering Corporation | Anti-MDL-1 antibodies |
-
2008
- 2008-03-27 US US12/079,576 patent/US7943134B2/en active Active
- 2008-05-29 CN CN200880129343.0A patent/CN102084250B/zh not_active Expired - Fee Related
- 2008-05-29 BR BRPI0822472-2A patent/BRPI0822472A2/pt not_active IP Right Cessation
- 2008-05-29 WO PCT/US2008/065166 patent/WO2009120225A1/en active Application Filing
- 2008-05-29 AU AU2008353452A patent/AU2008353452A1/en not_active Abandoned
- 2008-05-29 JP JP2011501777A patent/JP2011519414A/ja not_active Ceased
- 2008-05-29 EP EP08873539A patent/EP2257806A4/en not_active Withdrawn
- 2008-07-15 GB GB0812915A patent/GB2458715A/en not_active Withdrawn
-
2009
- 2009-03-27 TW TW098110058A patent/TWI403586B/zh not_active IP Right Cessation
-
2011
- 2011-05-12 US US13/106,046 patent/US8460669B2/en active Active
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