JP2011519367A5 - - Google Patents
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- Publication number
- JP2011519367A5 JP2011519367A5 JP2011506768A JP2011506768A JP2011519367A5 JP 2011519367 A5 JP2011519367 A5 JP 2011519367A5 JP 2011506768 A JP2011506768 A JP 2011506768A JP 2011506768 A JP2011506768 A JP 2011506768A JP 2011519367 A5 JP2011519367 A5 JP 2011519367A5
- Authority
- JP
- Japan
- Prior art keywords
- contrast agent
- individual
- detectable label
- treatment
- agent according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000002872 contrast media Chemical group 0.000 claims 20
- 206010028980 Neoplasm Diseases 0.000 claims 9
- 238000000034 method Methods 0.000 claims 9
- 230000030833 cell death Effects 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 4
- 125000000151 cysteine group Chemical group N[C@@H](CS)C(=O)* 0.000 claims 4
- 229920001184 polypeptide Polymers 0.000 claims 4
- 102000004196 processed proteins & peptides Human genes 0.000 claims 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims 4
- 102000003137 synaptotagmin Human genes 0.000 claims 4
- 108060008004 synaptotagmin Proteins 0.000 claims 4
- 238000003384 imaging method Methods 0.000 claims 3
- 150000002500 ions Chemical class 0.000 claims 3
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 230000000694 effects Effects 0.000 claims 2
- 125000005439 maleimidyl group Chemical group C1(C=CC(N1*)=O)=O 0.000 claims 2
- 229910021645 metal ion Inorganic materials 0.000 claims 2
- 238000013421 nuclear magnetic resonance imaging Methods 0.000 claims 2
- 125000003396 thiol group Chemical group [H]S* 0.000 claims 2
- 229910052688 Gadolinium Inorganic materials 0.000 claims 1
- GYHNNYVSQQEPJS-YPZZEJLDSA-N Gallium-68 Chemical compound [68Ga] GYHNNYVSQQEPJS-YPZZEJLDSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- QPCDCPDFJACHGM-UHFFFAOYSA-N N,N-bis{2-[bis(carboxymethyl)amino]ethyl}glycine Chemical compound OC(=O)CN(CC(O)=O)CCN(CC(=O)O)CCN(CC(O)=O)CC(O)=O QPCDCPDFJACHGM-UHFFFAOYSA-N 0.000 claims 1
- GKLVYJBZJHMRIY-OUBTZVSYSA-N Technetium-99 Chemical compound [99Tc] GKLVYJBZJHMRIY-OUBTZVSYSA-N 0.000 claims 1
- WDLRUFUQRNWCPK-UHFFFAOYSA-N Tetraxetan Chemical compound OC(=O)CN1CCN(CC(O)=O)CCN(CC(O)=O)CCN(CC(O)=O)CC1 WDLRUFUQRNWCPK-UHFFFAOYSA-N 0.000 claims 1
- 230000001588 bifunctional effect Effects 0.000 claims 1
- 230000000747 cardiac effect Effects 0.000 claims 1
- 239000013522 chelant Substances 0.000 claims 1
- 230000000536 complexating effect Effects 0.000 claims 1
- RYGMFSIKBFXOCR-IGMARMGPSA-N copper-64 Chemical compound [64Cu] RYGMFSIKBFXOCR-IGMARMGPSA-N 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 238000000684 flow cytometry Methods 0.000 claims 1
- YCKRFDGAMUMZLT-BJUDXGSMSA-N fluorine-18 atom Chemical compound [18F] YCKRFDGAMUMZLT-BJUDXGSMSA-N 0.000 claims 1
- UIWYJDYFSGRHKR-UHFFFAOYSA-N gadolinium atom Chemical compound [Gd] UIWYJDYFSGRHKR-UHFFFAOYSA-N 0.000 claims 1
- 238000000338 in vitro Methods 0.000 claims 1
- APFVFJFRJDLVQX-AHCXROLUSA-N indium-111 Chemical compound [111In] APFVFJFRJDLVQX-AHCXROLUSA-N 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 208000010125 myocardial infarction Diseases 0.000 claims 1
- 230000005298 paramagnetic effect Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 230000007505 plaque formation Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0807831.3 | 2008-04-29 | ||
| GBGB0807831.3A GB0807831D0 (en) | 2008-04-29 | 2008-04-29 | Agents for imaging cell death |
| PCT/GB2009/001082 WO2009133362A2 (en) | 2008-04-29 | 2009-04-29 | Agents for detecting and imaging cell death |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011519367A JP2011519367A (ja) | 2011-07-07 |
| JP2011519367A5 true JP2011519367A5 (https=) | 2012-06-07 |
| JP5539324B2 JP5539324B2 (ja) | 2014-07-02 |
Family
ID=39522785
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506768A Expired - Fee Related JP5539324B2 (ja) | 2008-04-29 | 2009-04-29 | 細胞死を検出しイメージングするための薬剤 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US8685371B2 (https=) |
| EP (1) | EP2280735B1 (https=) |
| JP (1) | JP5539324B2 (https=) |
| CA (1) | CA2722914A1 (https=) |
| GB (1) | GB0807831D0 (https=) |
| WO (1) | WO2009133362A2 (https=) |
Families Citing this family (8)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JP5858932B2 (ja) | 2010-02-04 | 2016-02-10 | モルフォテック， インコーポレイテッド | クロロトキシンポリペプチドおよびコンジュゲートならびにその使用 |
| JP2013532126A (ja) | 2010-05-11 | 2013-08-15 | フレッド ハッチンソン キャンサー リサーチ センター | クロロトキシン変異体、コンジュゲート、およびそれらを使用する方法 |
| CA2801064A1 (en) | 2010-06-01 | 2011-12-08 | Advanced Proteome Therapeutics Inc. | Crosslinking of proteins and other entities via conjugates of alpha-haloacetophenones, benzyl halides, quinones, and their derivatives |
| CN105008393A (zh) | 2012-12-10 | 2015-10-28 | 弗莱德哈钦森癌症研究中心 | 用于筛选的方法 |
| US11559580B1 (en) | 2013-09-17 | 2023-01-24 | Blaze Bioscience, Inc. | Tissue-homing peptide conjugates and methods of use thereof |
| WO2017181149A1 (en) | 2016-04-15 | 2017-10-19 | Blaze Bioscience, Inc. | Methods of treating breast cancer |
| US11690919B2 (en) | 2017-01-17 | 2023-07-04 | The Texas A&M University System | Endolysosomal targeting conjugates for improved delivery of cargo molecules to the endolysosomal compartment of target cells |
| SG11202011500UA (en) | 2018-07-12 | 2020-12-30 | Beckman Coulter Inc | Fixable viability dyes and their uses |
Family Cites Families (3)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20040022731A1 (en) | 2002-04-26 | 2004-02-05 | Alexei Bogdanov | In vivo imaging of apoptosis |
| JP2008521013A (ja) * | 2004-11-19 | 2008-06-19 | エムシーダブリユー リサーチ フオンデーシヨン インコーポレーテツド | インビボでの細胞死の画像化方法 |
| US8506928B2 (en) * | 2007-09-07 | 2013-08-13 | The Regents Of The University Of California | Methods and compounds for targeting tissues |
-
2008
- 2008-04-29 GB GBGB0807831.3A patent/GB0807831D0/en not_active Ceased
-
2009
- 2009-04-29 EP EP09738392.1A patent/EP2280735B1/en active Active
- 2009-04-29 WO PCT/GB2009/001082 patent/WO2009133362A2/en not_active Ceased
- 2009-04-29 US US12/989,310 patent/US8685371B2/en active Active
- 2009-04-29 JP JP2011506768A patent/JP5539324B2/ja not_active Expired - Fee Related
- 2009-04-29 CA CA2722914A patent/CA2722914A1/en not_active Abandoned
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