JP2011518816A5 - - Google Patents

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Publication number

JP2011518816A5

JP2011518816A5 JP2011505583A JP2011505583A JP2011518816A5 JP 2011518816 A5 JP2011518816 A5 JP 2011518816A5 JP 2011505583 A JP2011505583 A JP 2011505583A JP 2011505583 A JP2011505583 A JP 2011505583A JP 2011518816 A5 JP2011518816 A5 JP 2011518816A5

Authority

JP

Japan

Prior art keywords

alkyl

hydrogen

optionally substituted

group

compound according

Prior art date

2009-04-23

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Withdrawn

Links

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• 229910052739 hydrogen Inorganic materials 0.000 claims 25
• 239000001257 hydrogen Substances 0.000 claims 25
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 23
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 20
• 150000001875 compounds Chemical class 0.000 claims 16
• 125000000882 C2-C6 alkenyl group Chemical group 0.000 claims 11
• 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims 9
• 125000000623 heterocyclic group Chemical group 0.000 claims 9
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 8
• 125000006413 ring segment Chemical group 0.000 claims 8
• 125000003601 C2-C6 alkynyl group Chemical group 0.000 claims 7
• 125000002950 monocyclic group Chemical group 0.000 claims 5
• 125000006552 (C3-C8) cycloalkyl group Chemical group 0.000 claims 4
• RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims 4
• 125000000217 alkyl group Chemical group 0.000 claims 4
• 229910052799 carbon Inorganic materials 0.000 claims 4
• 125000000753 cycloalkyl group Chemical group 0.000 claims 4
• 125000001072 heteroaryl group Chemical group 0.000 claims 4
• -1 methylpiperidin-4-yl Chemical group 0.000 claims 4
• 150000001721 carbon Chemical group 0.000 claims 3
• 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 3
• 229910052736 halogen Inorganic materials 0.000 claims 3
• 150000002367 halogens Chemical class 0.000 claims 3
• 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 3
• 125000003161 (C1-C6) alkylene group Chemical group 0.000 claims 2
• 125000006590 (C2-C6) alkenylene group Chemical group 0.000 claims 2
• 125000006591 (C2-C6) alkynylene group Chemical group 0.000 claims 2
• 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 2
• 125000006554 (C4-C8) cycloalkenyl group Chemical group 0.000 claims 2
• 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 2
• 125000002527 bicyclic carbocyclic group Chemical group 0.000 claims 2
• 125000002843 carboxylic acid group Chemical group 0.000 claims 2
• 125000004093 cyano group Chemical group *C#N 0.000 claims 2
• 125000004122 cyclic group Chemical group 0.000 claims 2
• 125000001316 cycloalkyl alkyl group Chemical group 0.000 claims 2
• 125000001511 cyclopentyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C1([H])[H] 0.000 claims 2
• 150000002431 hydrogen Chemical class 0.000 claims 2
• 125000004356 hydroxy functional group Chemical group O* 0.000 claims 2
• 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
• 125000004108 n-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
• 125000004123 n-propyl group Chemical group [H]C([H])([H])C([H])([H])C([H])([H])* 0.000 claims 2
• 125000005010 perfluoroalkyl group Chemical group 0.000 claims 2
• 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 2
• 125000004076 pyridyl group Chemical group 0.000 claims 2
• 125000002914 sec-butyl group Chemical group [H]C([H])([H])C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
• 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 2
• 150000003568 thioethers Chemical class 0.000 claims 2
• 125000003903 2-propenyl group Chemical group [H]C([*])([H])C([H])=C([H])[H] 0.000 claims 1
• OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical group [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims 1
• 102000013392 Carboxylesterase Human genes 0.000 claims 1
• 108010051152 Carboxylesterase Proteins 0.000 claims 1
• PXGOKWXKJXAPGV-UHFFFAOYSA-N Fluorine Chemical compound FF PXGOKWXKJXAPGV-UHFFFAOYSA-N 0.000 claims 1
• 206010028980 Neoplasm Diseases 0.000 claims 1
• 102100031463 Serine/threonine-protein kinase PLK1 Human genes 0.000 claims 1
• DGYIJVNZSDYBOE-UHFFFAOYSA-N [CH2]C1=CC=NC=C1 Chemical group [CH2]C1=CC=NC=C1 DGYIJVNZSDYBOE-UHFFFAOYSA-N 0.000 claims 1
• 125000005073 adamantyl group Chemical group C12(CC3CC(CC(C1)C3)C2)* 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 125000003118 aryl group Chemical group 0.000 claims 1
• 125000002619 bicyclic group Chemical group 0.000 claims 1
• 125000002618 bicyclic heterocycle group Chemical group 0.000 claims 1
• 201000011510 cancer Diseases 0.000 claims 1
• 125000003178 carboxy group Chemical group [H]OC(*)=O 0.000 claims 1
• 125000000113 cyclohexyl group Chemical group [H]C1([H])C([H])([H])C([H])([H])C([H])(*)C([H])([H])C1([H])[H] 0.000 claims 1
• 201000010099 disease Diseases 0.000 claims 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 1
• 239000003937 drug carrier Substances 0.000 claims 1
• 230000000694 effects Effects 0.000 claims 1
• 125000004185 ester group Chemical group 0.000 claims 1
• 229910052731 fluorine Inorganic materials 0.000 claims 1
• 239000011737 fluorine Substances 0.000 claims 1
• 125000003709 fluoroalkyl group Chemical group 0.000 claims 1
• 125000000524 functional group Chemical group 0.000 claims 1
• 125000004446 heteroarylalkyl group Chemical group 0.000 claims 1
• 238000000338 in vitro Methods 0.000 claims 1
• 238000001727 in vivo Methods 0.000 claims 1
• 125000003392 indanyl group Chemical group C1(CCC2=CC=CC=C12)* 0.000 claims 1
• 230000002401 inhibitory effect Effects 0.000 claims 1
• 230000003834 intracellular effect Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 125000001620 monocyclic carbocycle group Chemical group 0.000 claims 1
• 125000002911 monocyclic heterocycle group Chemical group 0.000 claims 1
• 125000006203 morpholinoethyl group Chemical group [H]C([H])(*)C([H])([H])N1C([H])([H])C([H])([H])OC([H])([H])C1([H])[H] 0.000 claims 1
• 229910052757 nitrogen Inorganic materials 0.000 claims 1
• IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 1
• QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 1
• 125000002868 norbornyl group Chemical group C12(CCC(CC1)C2)* 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 125000003884 phenylalkyl group Chemical group 0.000 claims 1
• 108010056274 polo-like kinase 1 Proteins 0.000 claims 1
• 230000002062 proliferating effect Effects 0.000 claims 1
• 150000003839 salts Chemical class 0.000 claims 1
• SNOOUWRIMMFWNE-UHFFFAOYSA-M sodium;6-[(3,4,5-trimethoxybenzoyl)amino]hexanoate Chemical compound [Na+].COC1=CC(C(=O)NCCCCCC([O-])=O)=CC(OC)=C1OC SNOOUWRIMMFWNE-UHFFFAOYSA-M 0.000 claims 1
• 125000001424 substituent group Chemical group 0.000 claims 1
• 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 1