JP2011517405A5 - - Google Patents
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- Publication number
- JP2011517405A5 JP2011517405A5 JP2011500873A JP2011500873A JP2011517405A5 JP 2011517405 A5 JP2011517405 A5 JP 2011517405A5 JP 2011500873 A JP2011500873 A JP 2011500873A JP 2011500873 A JP2011500873 A JP 2011500873A JP 2011517405 A5 JP2011517405 A5 JP 2011517405A5
- Authority
- JP
- Japan
- Prior art keywords
- assay
- pro
- glucose polymer
- kda
- inflammatory response
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 130
- 239000008103 glucose Substances 0.000 claims description 130
- 229920000642 polymer Polymers 0.000 claims description 125
- 230000007112 pro inflammatory response Effects 0.000 claims description 107
- 238000003556 assay Methods 0.000 claims description 94
- 239000000385 dialysis solution Substances 0.000 claims description 87
- 230000004044 response Effects 0.000 claims description 83
- 239000000706 filtrate Substances 0.000 claims description 71
- 102000004889 Interleukin-6 Human genes 0.000 claims description 69
- 108090001005 Interleukin-6 Proteins 0.000 claims description 69
- 229940100601 interleukin-6 Drugs 0.000 claims description 69
- 238000000034 method Methods 0.000 claims description 69
- 238000012360 testing method Methods 0.000 claims description 48
- 238000001914 filtration Methods 0.000 claims description 30
- 229920002177 Icodextrin Polymers 0.000 claims description 27
- 229940016836 icodextrin Drugs 0.000 claims description 27
- 239000003153 chemical reaction reagent Substances 0.000 claims description 24
- 102000009571 Macrophage Inflammatory Proteins Human genes 0.000 claims description 14
- 108010009474 Macrophage Inflammatory Proteins Proteins 0.000 claims description 14
- 210000003819 peripheral blood mononuclear cell Anatomy 0.000 claims description 12
- 210000004027 cell Anatomy 0.000 claims description 11
- 108060008682 Tumor Necrosis Factor Proteins 0.000 claims description 9
- 102000004269 Granulocyte Colony-Stimulating Factor Human genes 0.000 claims description 8
- 108010017080 Granulocyte Colony-Stimulating Factor Proteins 0.000 claims description 8
- 102000003814 Interleukin-10 Human genes 0.000 claims description 8
- 108090000174 Interleukin-10 Proteins 0.000 claims description 8
- 102000000852 Tumor Necrosis Factor-alpha Human genes 0.000 claims description 8
- 229940076144 interleukin-10 Drugs 0.000 claims description 7
- 210000005087 mononuclear cell Anatomy 0.000 claims description 6
- 102000007651 Macrophage Colony-Stimulating Factor Human genes 0.000 claims description 4
- 108010046938 Macrophage Colony-Stimulating Factor Proteins 0.000 claims description 4
- 239000008187 granular material Substances 0.000 claims description 4
- 238000000338 in vitro Methods 0.000 claims 3
- 239000000523 sample Substances 0.000 description 49
- 238000000502 dialysis Methods 0.000 description 33
- 239000000243 solution Substances 0.000 description 25
- 239000000356 contaminant Substances 0.000 description 21
- 206010071648 Noninfectious peritonitis Diseases 0.000 description 20
- 230000000052 comparative effect Effects 0.000 description 20
- 239000000126 substance Substances 0.000 description 16
- 102000004127 Cytokines Human genes 0.000 description 15
- 108090000695 Cytokines Proteins 0.000 description 15
- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 description 9
- 239000002357 osmotic agent Substances 0.000 description 8
- 230000001580 bacterial effect Effects 0.000 description 7
- 239000013642 negative control Substances 0.000 description 7
- BVKZGUZCCUSVTD-UHFFFAOYSA-M Bicarbonate Chemical compound OC([O-])=O BVKZGUZCCUSVTD-UHFFFAOYSA-M 0.000 description 6
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 description 6
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 description 6
- 230000008901 benefit Effects 0.000 description 6
- JVTAAEKCZFNVCJ-UHFFFAOYSA-N lactic acid Chemical compound CC(O)C(O)=O JVTAAEKCZFNVCJ-UHFFFAOYSA-N 0.000 description 6
- 238000002560 therapeutic procedure Methods 0.000 description 6
- MSFSPUZXLOGKHJ-UHFFFAOYSA-N Muraminsaeure Natural products OC(=O)C(C)OC1C(N)C(O)OC(CO)C1O MSFSPUZXLOGKHJ-UHFFFAOYSA-N 0.000 description 5
- 108010013639 Peptidoglycan Proteins 0.000 description 5
- 239000002253 acid Substances 0.000 description 5
- 238000004891 communication Methods 0.000 description 5
- 239000012530 fluid Substances 0.000 description 5
- 206010034674 peritonitis Diseases 0.000 description 5
- 108010017213 Granulocyte-Macrophage Colony-Stimulating Factor Proteins 0.000 description 4
- 102100039620 Granulocyte-macrophage colony-stimulating factor Human genes 0.000 description 4
- LCTONWCANYUPML-UHFFFAOYSA-M Pyruvate Chemical compound CC(=O)C([O-])=O LCTONWCANYUPML-UHFFFAOYSA-M 0.000 description 4
- 150000001413 amino acids Chemical class 0.000 description 4
- 238000001514 detection method Methods 0.000 description 4
- 239000003792 electrolyte Substances 0.000 description 4
- 239000000203 mixture Substances 0.000 description 4
- 239000000047 product Substances 0.000 description 4
- 229940076788 pyruvate Drugs 0.000 description 4
- PEDCQBHIVMGVHV-UHFFFAOYSA-N Glycerine Chemical compound OCC(O)CO PEDCQBHIVMGVHV-UHFFFAOYSA-N 0.000 description 3
- JVTAAEKCZFNVCJ-UHFFFAOYSA-M Lactate Chemical compound CC(O)C([O-])=O JVTAAEKCZFNVCJ-UHFFFAOYSA-M 0.000 description 3
- 210000004369 blood Anatomy 0.000 description 3
- 239000008280 blood Substances 0.000 description 3
- 239000000872 buffer Substances 0.000 description 3
- 150000001875 compounds Chemical class 0.000 description 3
- 239000002158 endotoxin Substances 0.000 description 3
- 238000002474 experimental method Methods 0.000 description 3
- 238000009472 formulation Methods 0.000 description 3
- 238000001631 haemodialysis Methods 0.000 description 3
- 230000000322 hemodialysis Effects 0.000 description 3
- 239000004310 lactic acid Substances 0.000 description 3
- 235000014655 lactic acid Nutrition 0.000 description 3
- 229920006008 lipopolysaccharide Polymers 0.000 description 3
- 238000004519 manufacturing process Methods 0.000 description 3
- 238000002156 mixing Methods 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 230000003204 osmotic effect Effects 0.000 description 3
- 239000013641 positive control Substances 0.000 description 3
- 230000000770 proinflammatory effect Effects 0.000 description 3
- 230000000717 retained effect Effects 0.000 description 3
- 239000011734 sodium Substances 0.000 description 3
- 238000010998 test method Methods 0.000 description 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-K Citrate Chemical compound [O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O KRKNYBCHXYNGOX-UHFFFAOYSA-K 0.000 description 2
- 238000002965 ELISA Methods 0.000 description 2
- CPELXLSAUQHCOX-UHFFFAOYSA-N Hydrogen bromide Chemical compound Br CPELXLSAUQHCOX-UHFFFAOYSA-N 0.000 description 2
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 2
- DGAQECJNVWCQMB-PUAWFVPOSA-M Ilexoside XXIX Chemical compound C[C@@H]1CC[C@@]2(CC[C@@]3(C(=CC[C@H]4[C@]3(CC[C@@H]5[C@@]4(CC[C@@H](C5(C)C)OS(=O)(=O)[O-])C)C)[C@@H]2[C@]1(C)O)C)C(=O)O[C@H]6[C@@H]([C@H]([C@@H]([C@H](O6)CO)O)O)O.[Na+] DGAQECJNVWCQMB-PUAWFVPOSA-M 0.000 description 2
- 206010061218 Inflammation Diseases 0.000 description 2
- 229920002774 Maltodextrin Polymers 0.000 description 2
- 239000005913 Maltodextrin Substances 0.000 description 2
- OVRNDRQMDRJTHS-UHFFFAOYSA-N N-acelyl-D-glucosamine Natural products CC(=O)NC1C(O)OC(CO)C(O)C1O OVRNDRQMDRJTHS-UHFFFAOYSA-N 0.000 description 2
- OVRNDRQMDRJTHS-FMDGEEDCSA-N N-acetyl-beta-D-glucosamine Chemical compound CC(=O)N[C@H]1[C@H](O)O[C@H](CO)[C@@H](O)[C@@H]1O OVRNDRQMDRJTHS-FMDGEEDCSA-N 0.000 description 2
- MBLBDJOUHNCFQT-LXGUWJNJSA-N N-acetylglucosamine Natural products CC(=O)N[C@@H](C=O)[C@@H](O)[C@H](O)[C@H](O)CO MBLBDJOUHNCFQT-LXGUWJNJSA-N 0.000 description 2
- ZLMJMSJWJFRBEC-UHFFFAOYSA-N Potassium Chemical compound [K] ZLMJMSJWJFRBEC-UHFFFAOYSA-N 0.000 description 2
- LCTONWCANYUPML-UHFFFAOYSA-N Pyruvic acid Chemical compound CC(=O)C(O)=O LCTONWCANYUPML-UHFFFAOYSA-N 0.000 description 2
- 239000006146 Roswell Park Memorial Institute medium Substances 0.000 description 2
- QAOWNCQODCNURD-UHFFFAOYSA-N Sulfuric acid Chemical compound OS(O)(=O)=O QAOWNCQODCNURD-UHFFFAOYSA-N 0.000 description 2
- 230000002378 acidificating effect Effects 0.000 description 2
- WQZGKKKJIJFFOK-VFUOTHLCSA-N beta-D-glucose Chemical compound OC[C@H]1O[C@@H](O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-VFUOTHLCSA-N 0.000 description 2
- 239000006172 buffering agent Substances 0.000 description 2
- 239000003795 chemical substances by application Substances 0.000 description 2
- 208000020832 chronic kidney disease Diseases 0.000 description 2
- 238000011161 development Methods 0.000 description 2
- 229940050526 hydroxyethylstarch Drugs 0.000 description 2
- 230000004054 inflammatory process Effects 0.000 description 2
- 239000004615 ingredient Substances 0.000 description 2
- 239000007788 liquid Substances 0.000 description 2
- 229940035034 maltodextrin Drugs 0.000 description 2
- 239000000463 material Substances 0.000 description 2
- 210000004379 membrane Anatomy 0.000 description 2
- 239000012528 membrane Substances 0.000 description 2
- 150000007522 mineralic acids Chemical class 0.000 description 2
- 239000011259 mixed solution Substances 0.000 description 2
- 229950006780 n-acetylglucosamine Drugs 0.000 description 2
- 150000007524 organic acids Chemical class 0.000 description 2
- 239000011591 potassium Substances 0.000 description 2
- 229910052700 potassium Inorganic materials 0.000 description 2
- 102000004196 processed proteins & peptides Human genes 0.000 description 2
- 108090000765 processed proteins & peptides Proteins 0.000 description 2
- 102000004169 proteins and genes Human genes 0.000 description 2
- 108090000623 proteins and genes Proteins 0.000 description 2
- 239000002994 raw material Substances 0.000 description 2
- 229910052708 sodium Inorganic materials 0.000 description 2
- 241000894007 species Species 0.000 description 2
- 230000001954 sterilising effect Effects 0.000 description 2
- 238000004659 sterilization and disinfection Methods 0.000 description 2
- 239000006228 supernatant Substances 0.000 description 2
- 238000012956 testing procedure Methods 0.000 description 2
- 238000011282 treatment Methods 0.000 description 2
- HDTRYLNUVZCQOY-UHFFFAOYSA-N α-D-glucopyranosyl-α-D-glucopyranoside Natural products OC1C(O)C(O)C(CO)OC1OC1C(O)C(O)C(O)C(CO)O1 HDTRYLNUVZCQOY-UHFFFAOYSA-N 0.000 description 1
- QTBSBXVTEAMEQO-UHFFFAOYSA-M Acetate Chemical compound CC([O-])=O QTBSBXVTEAMEQO-UHFFFAOYSA-M 0.000 description 1
- 208000035143 Bacterial infection Diseases 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N Calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- VEXZGXHMUGYJMC-UHFFFAOYSA-M Chloride anion Chemical compound [Cl-] VEXZGXHMUGYJMC-UHFFFAOYSA-M 0.000 description 1
- 229920002261 Corn starch Polymers 0.000 description 1
- 229920000858 Cyclodextrin Polymers 0.000 description 1
- 238000008157 ELISA kit Methods 0.000 description 1
- 229930091371 Fructose Natural products 0.000 description 1
- RFSUNEUAIZKAJO-ARQDHWQXSA-N Fructose Chemical compound OC[C@H]1O[C@](O)(CO)[C@@H](O)[C@@H]1O RFSUNEUAIZKAJO-ARQDHWQXSA-N 0.000 description 1
- 239000005715 Fructose Substances 0.000 description 1
- FYYHWMGAXLPEAU-UHFFFAOYSA-N Magnesium Chemical compound [Mg] FYYHWMGAXLPEAU-UHFFFAOYSA-N 0.000 description 1
- 229920000881 Modified starch Polymers 0.000 description 1
- 239000004368 Modified starch Substances 0.000 description 1
- GRYLNZFGIOXLOG-UHFFFAOYSA-N Nitric acid Chemical compound O[N+]([O-])=O GRYLNZFGIOXLOG-UHFFFAOYSA-N 0.000 description 1
- 208000001647 Renal Insufficiency Diseases 0.000 description 1
- HDTRYLNUVZCQOY-WSWWMNSNSA-N Trehalose Natural products O[C@@H]1[C@@H](O)[C@@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-WSWWMNSNSA-N 0.000 description 1
- 102100040247 Tumor necrosis factor Human genes 0.000 description 1
- 150000001242 acetic acid derivatives Chemical class 0.000 description 1
- 239000003929 acidic solution Substances 0.000 description 1
- 150000007513 acids Chemical class 0.000 description 1
- 239000012670 alkaline solution Substances 0.000 description 1
- HDTRYLNUVZCQOY-LIZSDCNHSA-N alpha,alpha-trehalose Chemical compound O[C@@H]1[C@@H](O)[C@H](O)[C@@H](CO)O[C@@H]1O[C@@H]1[C@H](O)[C@@H](O)[C@H](O)[C@@H](CO)O1 HDTRYLNUVZCQOY-LIZSDCNHSA-N 0.000 description 1
- 208000022362 bacterial infectious disease Diseases 0.000 description 1
- 230000004888 barrier function Effects 0.000 description 1
- 239000012472 biological sample Substances 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000006285 cell suspension Substances 0.000 description 1
- 210000002421 cell wall Anatomy 0.000 description 1
- 230000036755 cellular response Effects 0.000 description 1
- 238000005119 centrifugation Methods 0.000 description 1
- 208000022831 chronic renal failure syndrome Diseases 0.000 description 1
- 239000012141 concentrate Substances 0.000 description 1
- 238000011109 contamination Methods 0.000 description 1
- 238000007796 conventional method Methods 0.000 description 1
- 239000008120 corn starch Substances 0.000 description 1
- 230000016396 cytokine production Effects 0.000 description 1
- 239000012470 diluted sample Substances 0.000 description 1
- 230000003467 diminishing effect Effects 0.000 description 1
- 231100000673 dose–response relationship Toxicity 0.000 description 1
- 239000003814 drug Substances 0.000 description 1
- 229940079593 drug Drugs 0.000 description 1
- 239000008151 electrolyte solution Substances 0.000 description 1
- 239000007789 gas Substances 0.000 description 1
- 229930182478 glucoside Natural products 0.000 description 1
- 210000003714 granulocyte Anatomy 0.000 description 1
- 238000002615 hemofiltration Methods 0.000 description 1
- 210000005260 human cell Anatomy 0.000 description 1
- -1 hydrochloric acid Chemical class 0.000 description 1
- 229910000042 hydrogen bromide Inorganic materials 0.000 description 1
- XMBWDFGMSWQBCA-UHFFFAOYSA-N hydrogen iodide Chemical compound I XMBWDFGMSWQBCA-UHFFFAOYSA-N 0.000 description 1
- 229910000043 hydrogen iodide Inorganic materials 0.000 description 1
- 230000007062 hydrolysis Effects 0.000 description 1
- 238000006460 hydrolysis reaction Methods 0.000 description 1
- 238000011534 incubation Methods 0.000 description 1
- 238000002347 injection Methods 0.000 description 1
- 239000007924 injection Substances 0.000 description 1
- 150000007529 inorganic bases Chemical class 0.000 description 1
- 239000000543 intermediate Substances 0.000 description 1
- 238000007912 intraperitoneal administration Methods 0.000 description 1
- 239000002085 irritant Substances 0.000 description 1
- 231100000021 irritant Toxicity 0.000 description 1
- 201000006370 kidney failure Diseases 0.000 description 1
- 230000007774 longterm Effects 0.000 description 1
- 238000004020 luminiscence type Methods 0.000 description 1
- 239000011777 magnesium Substances 0.000 description 1
- 229910052749 magnesium Inorganic materials 0.000 description 1
- 230000007246 mechanism Effects 0.000 description 1
- 239000012569 microbial contaminant Substances 0.000 description 1
- 235000019426 modified starch Nutrition 0.000 description 1
- 229910017604 nitric acid Inorganic materials 0.000 description 1
- 230000000474 nursing effect Effects 0.000 description 1
- 210000004303 peritoneum Anatomy 0.000 description 1
- 229920005862 polyol Polymers 0.000 description 1
- 150000003077 polyols Chemical class 0.000 description 1
- 238000002360 preparation method Methods 0.000 description 1
- 230000008569 process Effects 0.000 description 1
- 238000012545 processing Methods 0.000 description 1
- 238000000746 purification Methods 0.000 description 1
- 229940107700 pyruvic acid Drugs 0.000 description 1
- 238000011084 recovery Methods 0.000 description 1
- 239000004627 regenerated cellulose Substances 0.000 description 1
- 238000012959 renal replacement therapy Methods 0.000 description 1
- 239000011347 resin Substances 0.000 description 1
- 229920005989 resin Polymers 0.000 description 1
- HFHDHCJBZVLPGP-UHFFFAOYSA-N schardinger α-dextrin Chemical compound O1C(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC(C(O)C2O)C(CO)OC2OC(C(C2O)O)C(CO)OC2OC2C(O)C(O)C1OC2CO HFHDHCJBZVLPGP-UHFFFAOYSA-N 0.000 description 1
- 230000028327 secretion Effects 0.000 description 1
- 238000000926 separation method Methods 0.000 description 1
- 230000036332 sexual response Effects 0.000 description 1
- 230000000638 stimulation Effects 0.000 description 1
- 238000003860 storage Methods 0.000 description 1
- 238000006467 substitution reaction Methods 0.000 description 1
- 230000004102 tricarboxylic acid cycle Effects 0.000 description 1
- 238000000108 ultra-filtration Methods 0.000 description 1
- 238000005406 washing Methods 0.000 description 1
- 239000002699 waste material Substances 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/052,446 | 2008-03-20 | ||
| US12/052,446 US20090239819A1 (en) | 2008-03-20 | 2008-03-20 | Peritoneal dialysis solution test method |
| PCT/US2009/036940 WO2009117304A1 (en) | 2008-03-20 | 2009-03-12 | Peritoneal dialysis solution test method |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014146508A Division JP2014197033A (ja) | 2008-03-20 | 2014-07-17 | 腹膜透析溶液の試験方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011517405A JP2011517405A (ja) | 2011-06-09 |
| JP2011517405A5 true JP2011517405A5 (enExample) | 2014-03-20 |
| JP5628786B2 JP5628786B2 (ja) | 2014-11-19 |
Family
ID=40785585
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011500873A Active JP5628786B2 (ja) | 2008-03-20 | 2009-03-12 | 腹膜透析溶液の試験方法 |
| JP2014146508A Withdrawn JP2014197033A (ja) | 2008-03-20 | 2014-07-17 | 腹膜透析溶液の試験方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014146508A Withdrawn JP2014197033A (ja) | 2008-03-20 | 2014-07-17 | 腹膜透析溶液の試験方法 |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20090239819A1 (enExample) |
| EP (1) | EP2268830B2 (enExample) |
| JP (2) | JP5628786B2 (enExample) |
| MX (1) | MX2010010270A (enExample) |
| WO (1) | WO2009117304A1 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| DE102010012281A1 (de) | 2010-03-22 | 2011-09-22 | Fresenius Medical Care Deutschland Gmbh | Pharmazeutische Zusammensetzungen enthaltend substituiertes 6-Deoxy-6-sulfanylcyclodextrin |
| FR2978774B1 (fr) * | 2011-08-02 | 2015-02-20 | Roquette Freres | Methodes de detection des contaminants des circuits de production de polymeres de glucose |
| JP5989088B2 (ja) | 2011-04-08 | 2016-09-07 | ロケット フレールＲｏｑｕｅｔｔｅ Ｆｒｅｒｅｓ | グルコースポリマーに含まれる汚染物質の検出方法 |
| JP6244356B2 (ja) * | 2012-05-29 | 2017-12-06 | ロケット フレールＲｏｑｕｅｔｔｅ Ｆｒｅｒｅｓ | グルコースポリマーおよびグルコースポリマー加水分解物の製造回路の除染方法 |
| WO2014154651A1 (fr) * | 2013-03-26 | 2014-10-02 | Roquette Freres | Dosage biologique des peptidoglycanes |
| JP6284651B2 (ja) | 2014-03-21 | 2018-02-28 | ロケット フレールＲｏｑｕｅｔｔｅ Ｆｒｅｒｅｓ | グルコースポリマーおよびグルコースポリマー加水分解物の生成物を汚染除去するための最適化された方法 |
| FR3037063B1 (fr) | 2015-06-04 | 2017-05-19 | Roquette Freres | Procede optimise de decontamination de l'amidon utilise comme matiere premiere pour l'obtention de polymeres de glucose destines a la dialyse peritoneale |
| CN105131135B (zh) * | 2015-09-17 | 2018-08-14 | 四川博佳制药有限公司 | 艾考糊精的工业化生产方法 |
| US11116881B2 (en) | 2016-05-27 | 2021-09-14 | Cook Medical Technologies Llc | Filtration system and process for peritoneal dialysis |
| EP3786618A1 (en) * | 2019-08-26 | 2021-03-03 | Veterinärmedizinische Universität Wien | A method for analyzing a peritoneal dialysis sample |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| LU73094A1 (enExample) * | 1975-07-29 | 1977-03-24 | ||
| US5731164A (en) * | 1991-08-06 | 1998-03-24 | Sanorell Pharma Gmbh & Co. | method of checking the rate of removal of pyrogenic substances, in particular viruses, from organic material |
| US7118857B2 (en) * | 2004-02-27 | 2006-10-10 | Baxter International Inc. | Methods and compositions for detection of microbial contaminants in peritoneal dialysis solutions |
| EP1977252B1 (en) | 2005-12-22 | 2012-12-05 | Baxter International Inc. | Improved monocyte activation test better able to detect non-endotoxin pyrogenic contaminants in medical products |
| WO2008009292A1 (en) * | 2006-07-18 | 2008-01-24 | Kobenhavns Universitet | An in vitro method for detection of inflammatory contaminants |
-
2008
- 2008-03-20 US US12/052,446 patent/US20090239819A1/en not_active Abandoned
-
2009
- 2009-03-12 MX MX2010010270A patent/MX2010010270A/es active IP Right Grant
- 2009-03-12 WO PCT/US2009/036940 patent/WO2009117304A1/en not_active Ceased
- 2009-03-12 JP JP2011500873A patent/JP5628786B2/ja active Active
- 2009-03-12 EP EP09721862.2A patent/EP2268830B2/en active Active
-
2014
- 2014-07-17 JP JP2014146508A patent/JP2014197033A/ja not_active Withdrawn
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