JP2011516453A - 治療用化合物としての置換ピペリジン - Google Patents

治療用化合物としての置換ピペリジン Download PDF

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Publication number
JP2011516453A
JP2011516453A JP2011502382A JP2011502382A JP2011516453A JP 2011516453 A JP2011516453 A JP 2011516453A JP 2011502382 A JP2011502382 A JP 2011502382A JP 2011502382 A JP2011502382 A JP 2011502382A JP 2011516453 A JP2011516453 A JP 2011516453A
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JP
Japan
Prior art keywords
methoxy
linear
acid
methyl
mmol
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
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JP2011502382A
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English (en)
Japanese (ja)
Inventor
ペーター・ヘロルト
ロバート・マー
シュテファン・シュトゥッツ
ヴィンセンツォ・チュインケ
アレクザンダル・シュトヤノフィク
ディルク・ベーンケ
ストイェパン・イェラコヴィッチ
Original Assignee
ノバルティス アーゲー
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Application filed by ノバルティス アーゲー filed Critical ノバルティス アーゲー
Publication of JP2011516453A publication Critical patent/JP2011516453A/ja
Pending legal-status Critical Current

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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
    • C07D413/02—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings
    • C07D413/12—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing two hetero rings linked by a chain containing hetero atoms as chain links
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P25/00—Drugs for disorders of the nervous system
    • A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/06—Antimalarials
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00

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  • Health & Medical Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Medicinal Chemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biomedical Technology (AREA)
  • Neurosurgery (AREA)
  • Virology (AREA)
  • Neurology (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
  • Hospice & Palliative Care (AREA)
  • Communicable Diseases (AREA)
  • AIDS & HIV (AREA)
  • Psychiatry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Hydrogenated Pyridines (AREA)
  • Plural Heterocyclic Compounds (AREA)
JP2011502382A 2008-04-02 2009-04-01 治療用化合物としての置換ピペリジン Pending JP2011516453A (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
EP08153929 2008-04-02
EP08153929.8 2008-04-02
PCT/EP2009/053898 WO2009121914A1 (en) 2008-04-02 2009-04-01 Substituted piperidines as therapeutic compounds

Publications (1)

Publication Number Publication Date
JP2011516453A true JP2011516453A (ja) 2011-05-26

Family

ID=40627638

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2011502382A Pending JP2011516453A (ja) 2008-04-02 2009-04-01 治療用化合物としての置換ピペリジン

Country Status (10)

Country Link
EP (1) EP2271644A1 (pt)
JP (1) JP2011516453A (pt)
KR (1) KR20110002459A (pt)
CN (1) CN101970431A (pt)
AU (1) AU2009232012A1 (pt)
BR (1) BRPI0910991A2 (pt)
CA (1) CA2719070A1 (pt)
EA (1) EA201001517A1 (pt)
MX (1) MX2010010876A (pt)
WO (1) WO2009121914A1 (pt)

Families Citing this family (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2011057160A2 (en) * 2009-11-06 2011-05-12 The Regents Of The Uiversity Of California Method to improve the immunogenicity of vaccine antigens by modification of cleavage sites in hiv-1 gp 120
CN102638981B (zh) 2009-10-14 2015-07-22 默沙东公司 提高p53活性的取代的哌啶和其用途
GB201008209D0 (en) * 2010-05-17 2010-06-30 Senexis Ltd Compounds
US8987274B2 (en) 2011-10-28 2015-03-24 Merck Sharp & Dohme Corp Macrocycles that increase p53 activity and the uses thereof
TW201429969A (zh) 2012-12-20 2014-08-01 Merck Sharp & Dohme 作爲ｈｄｍ２抑制劑之經取代咪唑吡啶
CN105001300A (zh) * 2014-04-17 2015-10-28 复旦大学 组织蛋白酶d抑制剂及其制备方法、药物组合物和应用

Family Cites Families (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
EP1816122A3 (en) * 2006-01-19 2007-09-19 Speedel Experimenta AG 3,4,5-substituted piperidines as therapeutic compounds
EP1911758A1 (en) * 2006-10-04 2008-04-16 Speedel Experimenta AG Phenyl piperidine derivatives for use as renin inhibitors
EP1908761A1 (en) * 2006-10-04 2008-04-09 Speedel Experimenta AG Organic compounds

Also Published As

Publication number Publication date
EA201001517A1 (ru) 2011-04-29
AU2009232012A1 (en) 2009-10-08
CN101970431A (zh) 2011-02-09
KR20110002459A (ko) 2011-01-07
BRPI0910991A2 (pt) 2016-01-19
EP2271644A1 (en) 2011-01-12
CA2719070A1 (en) 2009-10-08
MX2010010876A (es) 2010-10-26
WO2009121914A1 (en) 2009-10-08

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