JP2011516027A5 - - Google Patents
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- Publication number
- JP2011516027A5 JP2011516027A5 JP2009546425A JP2009546425A JP2011516027A5 JP 2011516027 A5 JP2011516027 A5 JP 2011516027A5 JP 2009546425 A JP2009546425 A JP 2009546425A JP 2009546425 A JP2009546425 A JP 2009546425A JP 2011516027 A5 JP2011516027 A5 JP 2011516027A5
- Authority
- JP
- Japan
- Prior art keywords
- virus
- seq
- replikin
- protein
- peak gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 108090000623 proteins and genes Proteins 0.000 claims description 297
- 150000001413 amino acids Chemical class 0.000 claims description 21
- 241000712461 unidentified influenza virus Species 0.000 claims description 13
- 241000712431 Influenza A virus Species 0.000 claims description 12
- 208000015181 infectious disease Diseases 0.000 claims description 7
- 208000037797 influenza A Diseases 0.000 claims description 6
- 150000007523 nucleic acids Chemical group 0.000 claims description 2
- 241000700605 Viruses Species 0.000 claims 115
- 235000018102 proteins Nutrition 0.000 claims 113
- 102000004169 proteins and genes Human genes 0.000 claims 113
- 201000011510 cancer Diseases 0.000 claims 84
- 238000000034 method Methods 0.000 claims 78
- 210000004027 cell Anatomy 0.000 claims 48
- 239000012634 fragment Substances 0.000 claims 46
- 206010028980 Neoplasm Diseases 0.000 claims 29
- 230000036210 malignancy Effects 0.000 claims 29
- 208000020816 lung neoplasm Diseases 0.000 claims 28
- 229960005486 vaccine Drugs 0.000 claims 27
- 108090000765 processed proteins & peptides Proteins 0.000 claims 26
- 230000003211 malignant effect Effects 0.000 claims 24
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 22
- 201000005202 lung cancer Diseases 0.000 claims 22
- 241000723873 Tobacco mosaic virus Species 0.000 claims 20
- 210000004072 lung Anatomy 0.000 claims 19
- 230000002163 immunogen Effects 0.000 claims 13
- 241000710198 Foot-and-mouth disease virus Species 0.000 claims 11
- 241000710886 West Nile virus Species 0.000 claims 11
- 241000696962 White spot syndrome virus Species 0.000 claims 11
- 210000004392 genitalia Anatomy 0.000 claims 11
- 230000002265 prevention Effects 0.000 claims 11
- 230000000241 respiratory effect Effects 0.000 claims 11
- 241000894007 species Species 0.000 claims 11
- 208000011580 syndromic disease Diseases 0.000 claims 11
- 238000011282 treatment Methods 0.000 claims 11
- 241000202347 Porcine circovirus Species 0.000 claims 10
- 231100000225 lethality Toxicity 0.000 claims 10
- 102000004196 processed proteins & peptides Human genes 0.000 claims 10
- 230000003612 virological effect Effects 0.000 claims 10
- 241000223960 Plasmodium falciparum Species 0.000 claims 9
- 235000001014 amino acid Nutrition 0.000 claims 9
- 210000002845 virion Anatomy 0.000 claims 8
- 241000711573 Coronaviridae Species 0.000 claims 7
- 241001115402 Ebolavirus Species 0.000 claims 7
- 241000557009 Mycobacterium mucogenicum Species 0.000 claims 7
- 241000187479 Mycobacterium tuberculosis Species 0.000 claims 7
- 206010040047 Sepsis Diseases 0.000 claims 7
- 241000191967 Staphylococcus aureus Species 0.000 claims 7
- 241001265687 Taura syndrome virus Species 0.000 claims 7
- 235000019506 cigar Nutrition 0.000 claims 7
- 231100000518 lethal Toxicity 0.000 claims 7
- 230000001665 lethal effect Effects 0.000 claims 7
- 238000003745 diagnosis Methods 0.000 claims 6
- 230000002008 hemorrhagic effect Effects 0.000 claims 6
- 231100000419 toxicity Toxicity 0.000 claims 6
- 230000001988 toxicity Effects 0.000 claims 6
- 208000003174 Brain Neoplasms Diseases 0.000 claims 5
- 241001465754 Metazoa Species 0.000 claims 5
- 150000001875 compounds Chemical class 0.000 claims 5
- 208000037841 lung tumor Diseases 0.000 claims 5
- 208000002154 non-small cell lung carcinoma Diseases 0.000 claims 5
- 208000029729 tumor suppressor gene on chromosome 11 Diseases 0.000 claims 5
- RJQXTJLFIWVMTO-TYNCELHUSA-N Methicillin Chemical compound COC1=CC=CC(OC)=C1C(=O)N[C@@H]1C(=O)N2[C@@H](C(O)=O)C(C)(C)S[C@@H]21 RJQXTJLFIWVMTO-TYNCELHUSA-N 0.000 claims 4
- 208000003837 Second Primary Neoplasms Diseases 0.000 claims 4
- 208000005017 glioblastoma Diseases 0.000 claims 4
- HNDVDQJCIGZPNO-UHFFFAOYSA-N histidine Natural products OC(=O)C(N)CC1=CN=CN1 HNDVDQJCIGZPNO-UHFFFAOYSA-N 0.000 claims 4
- 235000018977 lysine Nutrition 0.000 claims 4
- 150000002669 lysines Chemical class 0.000 claims 4
- 229960003085 meticillin Drugs 0.000 claims 4
- 230000010076 replication Effects 0.000 claims 4
- 208000026310 Breast neoplasm Diseases 0.000 claims 3
- 208000032843 Hemorrhage Diseases 0.000 claims 3
- 230000000740 bleeding effect Effects 0.000 claims 3
- 239000003937 drug carrier Substances 0.000 claims 3
- 108090001074 Nucleocapsid Proteins Proteins 0.000 claims 2
- 206010033128 Ovarian cancer Diseases 0.000 claims 2
- 210000000481 breast Anatomy 0.000 claims 2
- 231100000171 higher toxicity Toxicity 0.000 claims 2
- 210000000987 immune system Anatomy 0.000 claims 2
- 210000002751 lymph Anatomy 0.000 claims 2
- 108010026228 mRNA guanylyltransferase Proteins 0.000 claims 2
- 208000013223 septicemia Diseases 0.000 claims 2
- 230000004936 stimulating effect Effects 0.000 claims 2
- 230000002194 synthesizing effect Effects 0.000 claims 2
- 229940021747 therapeutic vaccine Drugs 0.000 claims 2
- 230000009385 viral infection Effects 0.000 claims 2
- 108091006112 ATPases Proteins 0.000 claims 1
- 241000251468 Actinopterygii Species 0.000 claims 1
- 102000057290 Adenosine Triphosphatases Human genes 0.000 claims 1
- 101710132601 Capsid protein Proteins 0.000 claims 1
- 101710197658 Capsid protein VP1 Proteins 0.000 claims 1
- 101710091045 Envelope protein Proteins 0.000 claims 1
- 201000010915 Glioblastoma multiforme Diseases 0.000 claims 1
- 108090000288 Glycoproteins Proteins 0.000 claims 1
- 102000003886 Glycoproteins Human genes 0.000 claims 1
- 241000726306 Irus Species 0.000 claims 1
- 235000007688 Lycopersicon esculentum Nutrition 0.000 claims 1
- 241000186359 Mycobacterium Species 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 241001135989 Porcine reproductive and respiratory syndrome virus Species 0.000 claims 1
- 101710188315 Protein X Proteins 0.000 claims 1
- 101710118046 RNA-directed RNA polymerase Proteins 0.000 claims 1
- 102000000505 Ribonucleotide Reductases Human genes 0.000 claims 1
- 108010041388 Ribonucleotide Reductases Proteins 0.000 claims 1
- 240000003768 Solanum lycopersicum Species 0.000 claims 1
- 102100021696 Syncytin-1 Human genes 0.000 claims 1
- 101150024766 VP1 gene Proteins 0.000 claims 1
- 108010003533 Viral Envelope Proteins Proteins 0.000 claims 1
- 241000711825 Viral hemorrhagic septicemia virus Species 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 101710108545 Viral protein 1 Proteins 0.000 claims 1
- 230000015572 biosynthetic process Effects 0.000 claims 1
- 238000012790 confirmation Methods 0.000 claims 1
- 230000007773 growth pattern Effects 0.000 claims 1
- 231100000086 high toxicity Toxicity 0.000 claims 1
- 108010064513 influenza virus polymerase basic protein 1 Proteins 0.000 claims 1
- 238000002955 isolation Methods 0.000 claims 1
- 230000002611 ovarian Effects 0.000 claims 1
- 230000000069 prophylactic effect Effects 0.000 claims 1
- 229940021993 prophylactic vaccine Drugs 0.000 claims 1
- 238000011321 prophylaxis Methods 0.000 claims 1
- 238000003786 synthesis reaction Methods 0.000 claims 1
- 231100000331 toxic Toxicity 0.000 claims 1
- 230000002588 toxic effect Effects 0.000 claims 1
- 206010022000 influenza Diseases 0.000 description 5
- 208000037798 influenza B Diseases 0.000 description 2
- 241000287828 Gallus gallus Species 0.000 description 1
- 238000000126 in silico method Methods 0.000 description 1
Images
Applications Claiming Priority (23)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US88096607P | 2007-01-18 | 2007-01-18 | |
| US60/880,966 | 2007-01-18 | ||
| US89809707P | 2007-01-30 | 2007-01-30 | |
| US60/898,097 | 2007-01-30 | ||
| US11/755,597 | 2007-05-30 | ||
| US11/755,597 US20080260764A1 (en) | 2006-05-30 | 2007-05-30 | Replikin peptides and uses thereof |
| US95474307P | 2007-08-08 | 2007-08-08 | |
| US60/954,743 | 2007-08-08 | ||
| US93549907P | 2007-08-16 | 2007-08-16 | |
| US60/935,499 | 2007-08-16 | ||
| US93581607P | 2007-08-31 | 2007-08-31 | |
| US60/935,816 | 2007-08-31 | ||
| US98233307P | 2007-10-24 | 2007-10-24 | |
| US98233607P | 2007-10-24 | 2007-10-24 | |
| US98233807P | 2007-10-24 | 2007-10-24 | |
| US60/982,338 | 2007-10-24 | ||
| US11/923,559 | 2007-10-24 | ||
| US11/923,559 US8050871B2 (en) | 2006-10-24 | 2007-10-24 | Method of predicting influenza outbreaks by correlating an increase in replikin count in shrimp white spot syndrome virus and/or taura syndrome virus |
| US60/982,333 | 2007-10-24 | ||
| US60/982,336 | 2007-10-24 | ||
| US99167607P | 2007-11-30 | 2007-11-30 | |
| US60/991,676 | 2007-11-30 | ||
| PCT/US2008/000645 WO2008143717A2 (en) | 2007-01-18 | 2008-01-18 | Methods of determining lethality of pathogens and malignancies involving replikin peak genes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011516027A JP2011516027A (ja) | 2011-05-26 |
| JP2011516027A5 true JP2011516027A5 (https=) | 2011-07-07 |
Family
ID=40032325
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009546425A Pending JP2011516027A (ja) | 2007-01-18 | 2008-01-18 | レプリキンピーク遺伝子が関与する病原体および悪性腫瘍の致死性を判定する方法 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20090017052A1 (https=) |
| EP (1) | EP2126140A4 (https=) |
| JP (1) | JP2011516027A (https=) |
| AU (2) | AU2008253721A1 (https=) |
| CA (1) | CA2676028A1 (https=) |
| WO (1) | WO2008143717A2 (https=) |
Families Citing this family (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7566458B2 (en) | 2003-06-16 | 2009-07-28 | Medimmune, Llc | Influenza hemagglutinin and neuraminidase variants |
| EP2471552B1 (en) | 2005-03-08 | 2015-05-06 | MedImmune, LLC | Reassortant influenza viruses |
| US8050871B2 (en) * | 2006-10-24 | 2011-11-01 | Samuel Bogoch | Method of predicting influenza outbreaks by correlating an increase in replikin count in shrimp white spot syndrome virus and/or taura syndrome virus |
| JP5675348B2 (ja) | 2007-05-30 | 2015-02-25 | ボゴーク,サミュエル | 水産養殖における無脊椎動物の病原性感染に対する合成レプリキンペプチド |
| US20090269367A1 (en) * | 2008-04-23 | 2009-10-29 | Samuel Bogoch | Methods and compounds for mitigating pathogenic outbreaks using replikin count cycles |
| RU2523587C2 (ru) * | 2008-07-11 | 2014-07-20 | МЕДИММЬЮН, ЭлЭлСи | Варианты гемагглютинина и нейрамидазы вируса гриппа |
| SG193783A1 (en) * | 2008-08-08 | 2013-10-30 | Samuel Bogoch | Methods of predicting cancer lethality using replikin counts |
| US20100144589A1 (en) * | 2008-08-08 | 2010-06-10 | Samuel Bogoch | Methods of predicting cancer lethality using replikin counts |
| US9233148B2 (en) | 2009-01-09 | 2016-01-12 | Samuel Bogoch | Replikin-based compounds for prevention and treatment of influenza and methods of differentiating infectivity and lethality in influenza |
| CN107375919B (zh) | 2009-03-27 | 2022-07-29 | 台湾地区“中央研究院” | 抗病毒免疫的方法和组合物 |
| CN103977394B (zh) * | 2009-07-17 | 2016-03-09 | 翰林大学校产学协力团 | 包含脂质体包胶的寡核苷酸和表位的免疫刺激性组合物 |
| US9594599B1 (en) * | 2009-10-14 | 2017-03-14 | Nvidia Corporation | Method and system for distributing work batches to processing units based on a number of enabled streaming multiprocessors |
| TWI537385B (zh) | 2010-11-04 | 2016-06-11 | 中央研究院 | 產生具簡單醣基化之表面蛋白質之病毒顆粒的方法 |
| WO2013013075A2 (en) | 2011-07-20 | 2013-01-24 | Samuel Bogoch | Peptides shared among lethal cancers and therapeutic compositions comprising said peptides |
| JP2013049645A (ja) * | 2011-08-30 | 2013-03-14 | National Agriculture & Food Research Organization | 口蹄疫ウイルスと反応する抗体、当該抗体を用いて口蹄疫ウイルスを検出する方法、および当該抗体を含んでいるストリップ |
| US20130243803A1 (en) | 2012-03-09 | 2013-09-19 | Samuel Bogoch | Therapies, vaccines, and predictive methods for infectious salmon anemia virus |
| WO2014074927A1 (en) * | 2012-11-09 | 2014-05-15 | Samuel Bogoch | Methods of identifying, preventing, and treating virulent aleutian mink disease virus using replikin sequences |
| WO2014165274A2 (en) * | 2013-03-13 | 2014-10-09 | Samuel Bogoch | Methods of diagnosing, preventing, and treating drug-resistant pathogenic infections using replikin sequences |
| WO2014172664A2 (en) * | 2013-04-19 | 2014-10-23 | Samuel Bogoch | Replikin-based compounds for prevention and treatment of h7 strains of influenza |
Family Cites Families (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6002A (en) * | 1849-01-02 | Screw-wrench for grasping cylindrical forms | ||
| US3018A (en) * | 1843-03-21 | Coupling for qttilting-frames | ||
| US3019A (en) * | 1843-03-30 | Hatching chickens | ||
| EP0221748A3 (en) * | 1985-11-01 | 1988-10-12 | Samuel Dr. Bogoch | A process for the production of human antibodies |
| US4946778A (en) | 1987-09-21 | 1990-08-07 | Genex Corporation | Single polypeptide chain binding molecules |
| US5104854A (en) * | 1989-02-01 | 1992-04-14 | Washington University | Antiviral peptides |
| US5280113A (en) * | 1989-08-16 | 1994-01-18 | Monsanto Company | Method for producing synthetic N-linked glycoconjugates |
| US5231167A (en) * | 1989-09-08 | 1993-07-27 | The Regents Of The University Of California | Immunoglobulin-binding polypeptides |
| GB9202219D0 (en) * | 1992-02-03 | 1992-03-18 | Connaught Lab | A synthetic heamophilus influenzae conjugate vaccine |
| US20050271676A1 (en) * | 1993-03-05 | 2005-12-08 | Epimmune Inc. | Inducing cellular immune responses to human immunodeficiency virus-1 using peptide and nucleic acid compositions |
| US6242578B1 (en) * | 1994-02-17 | 2001-06-05 | Samuel Bogoch | Aglyco products and methods of use |
| US7794729B2 (en) * | 1994-11-08 | 2010-09-14 | The Trustees Of The University Of Pennsylvania | Methods and compositions for immunotherapy of cancer |
| US6023659A (en) * | 1996-10-10 | 2000-02-08 | Incyte Pharmaceuticals, Inc. | Database system employing protein function hierarchies for viewing biomolecular sequence data |
| WO1998023755A1 (en) * | 1996-11-26 | 1998-06-04 | Bio Merieux | Viral material and nucleotide fragments associated with multiple sclerosis, for diagnostic, prophylactic and therapeutic purposes |
| US6070126A (en) * | 1997-06-13 | 2000-05-30 | William J. Kokolus | Immunobiologically-active linear peptides and method of identification |
| JPH11232291A (ja) * | 1998-02-16 | 1999-08-27 | Seibutsu Bunshi Kogaku Kenkyusho:Kk | 蛋白質立体構造データベース検索方法 |
| US7176275B2 (en) | 1998-09-04 | 2007-02-13 | Samuel Bogoch | Anthrax and small pox replikins and methods of use |
| US6175830B1 (en) * | 1999-05-20 | 2001-01-16 | Evresearch, Ltd. | Information management, retrieval and display system and associated method |
| US6470277B1 (en) * | 1999-07-30 | 2002-10-22 | Agy Therapeutics, Inc. | Techniques for facilitating identification of candidate genes |
| US7774144B2 (en) * | 2001-10-26 | 2010-08-10 | Samuel Bogoch | System and method for identifying complex patterns of amino acids |
| US7189800B2 (en) * | 2001-03-27 | 2007-03-13 | Samuel Bogoch | Replikin peptides in rapid replication of glioma cells and in influenza epidemics |
| US7442761B2 (en) * | 2003-06-06 | 2008-10-28 | Samuel Bogoch | Replikin peptides and uses thereof |
| US7420028B2 (en) * | 2001-03-27 | 2008-09-02 | Samuel Bogoch | Replikins and methods of identifying replikin-containing sequences |
| US7452963B2 (en) * | 2001-03-27 | 2008-11-18 | Samuel Bogoch | Replikin peptides and antibodies therefore |
| US7894999B2 (en) * | 2001-03-27 | 2011-02-22 | Samuel Bogoch | Systems and methods for identifying Replikin Scaffolds and uses of said Replikin Scaffolds |
| WO2004085455A1 (en) * | 2003-03-24 | 2004-10-07 | The University Of Hong Kong | A diagnostic assay for the human virus causing severe acute respiratory syndrome (sars) |
| WO2005012337A2 (en) * | 2003-07-15 | 2005-02-10 | Crucell Holland B.V. | Antigenic peptides of sars coronavirus and uses thereof |
| WO2006088962A2 (en) | 2005-02-16 | 2006-08-24 | Samuel Bogoch | Replikin peptides and uses thereof |
| KR20090016671A (ko) * | 2006-05-30 | 2009-02-17 | 사무엘 보고치 | 레플리킨 펩티드 및 이의 용도 |
| WO2008073161A2 (en) * | 2006-08-14 | 2008-06-19 | Massachusetts Institute Of Technology | Hemagglutinin polypeptides, and reagents and methods relating thereto |
| US8050871B2 (en) * | 2006-10-24 | 2011-11-01 | Samuel Bogoch | Method of predicting influenza outbreaks by correlating an increase in replikin count in shrimp white spot syndrome virus and/or taura syndrome virus |
| JP5675348B2 (ja) * | 2007-05-30 | 2015-02-25 | ボゴーク,サミュエル | 水産養殖における無脊椎動物の病原性感染に対する合成レプリキンペプチド |
-
2008
- 2008-01-18 US US12/010,027 patent/US20090017052A1/en not_active Abandoned
- 2008-01-18 EP EP08794275A patent/EP2126140A4/en not_active Withdrawn
- 2008-01-18 WO PCT/US2008/000645 patent/WO2008143717A2/en not_active Ceased
- 2008-01-18 CA CA002676028A patent/CA2676028A1/en not_active Abandoned
- 2008-01-18 AU AU2008253721A patent/AU2008253721A1/en not_active Abandoned
- 2008-01-18 JP JP2009546425A patent/JP2011516027A/ja active Pending
-
2014
- 2014-06-18 AU AU2014203304A patent/AU2014203304A1/en not_active Abandoned
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