JP2011515384A5 - - Google Patents
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- Publication number
- JP2011515384A5 JP2011515384A5 JP2011500282A JP2011500282A JP2011515384A5 JP 2011515384 A5 JP2011515384 A5 JP 2011515384A5 JP 2011500282 A JP2011500282 A JP 2011500282A JP 2011500282 A JP2011500282 A JP 2011500282A JP 2011515384 A5 JP2011515384 A5 JP 2011515384A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- cyclopenta
- phenylene
- alkyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GB0805035A GB0805035D0 (en) | 2008-03-18 | 2008-03-18 | Us eof cyclopenta[G]quinazoline derivatives |
| GB0805036.1 | 2008-03-18 | ||
| GB0805035.3 | 2008-03-18 | ||
| GB0805036A GB0805036D0 (en) | 2008-03-18 | 2008-03-18 | New use of cyclopenta[g]quinazoline derivatives |
| PCT/GB2009/000687 WO2009115776A1 (en) | 2008-03-18 | 2009-03-13 | Cyclopenta[g]quinazoline derivatives for the treatment of rheumatoid arthritis or acute myeloid leukaemia |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011515384A JP2011515384A (ja) | 2011-05-19 |
| JP2011515384A5 true JP2011515384A5 (OSRAM) | 2012-05-10 |
| JP5599773B2 JP5599773B2 (ja) | 2014-10-01 |
Family
ID=40599662
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011500282A Active JP5599773B2 (ja) | 2008-03-18 | 2009-03-13 | リウマチ様関節炎又は急性骨髄性白血病の治療のためのシクロペンタ［ｇ］キナゾリン誘導体 |
Country Status (10)
| Country | Link |
|---|---|
| US (1) | US8466111B2 (OSRAM) |
| EP (1) | EP2293807B1 (OSRAM) |
| JP (1) | JP5599773B2 (OSRAM) |
| KR (1) | KR101616022B1 (OSRAM) |
| CN (1) | CN101977620B (OSRAM) |
| AT (1) | ATE556715T1 (OSRAM) |
| CA (1) | CA2717954C (OSRAM) |
| DK (1) | DK2293807T3 (OSRAM) |
| ES (1) | ES2387334T3 (OSRAM) |
| WO (1) | WO2009115776A1 (OSRAM) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| HUE028918T2 (en) * | 2010-12-22 | 2017-01-30 | Btg Int Ltd | Effective peptide couplings and their use in the synthesis and isolation of cyclopenta (G) quinazoline trinodium salt |
| EA201990473A1 (ru) | 2016-08-12 | 2019-07-31 | Эл.И.Эй.Эф. ХОЛДИНГС ГРУП ЭлЭлСи | Полиглутамированные антифолаты и их применение |
| WO2018031967A1 (en) | 2016-08-12 | 2018-02-15 | L.E.A.F. Holdings Group Llc | Polyglutamated antifolates and uses thereof |
| GB201707864D0 (en) | 2017-05-16 | 2017-06-28 | Inst Of Cancer Research: Royal Cancer Hospital | Platinum-reistant cancer treatment |
| EP3749311A4 (en) | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | PEMETREXED POLYGLUTAMATE GAMMA COMPOSITIONS AND THEIR USES |
| CA3090506A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated tetrahydrofolates and uses thereof |
| US12076402B2 (en) | 2018-02-07 | 2024-09-03 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated antifolates and uses thereof |
| EP3749316A4 (en) | 2018-02-07 | 2021-10-27 | L.E.A.F Holdings Group LLC | ALPHA-POLYGLUTAMATED PRALATREXATE AND USES THEREOF |
| CA3090389A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated raltitrexed and uses thereof |
| US12220431B2 (en) | 2018-02-07 | 2025-02-11 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated antifolates and uses thereof |
| US11779584B2 (en) | 2018-02-07 | 2023-10-10 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated pemetrexed and uses thereof |
| EP3749312A4 (en) | 2018-02-07 | 2022-02-23 | L.E.A.F Holdings Group LLC | ALPHA-POLYGLUTAMATED LOMETREXOLE AND USES THEREOF |
| CN111954529A (zh) | 2018-02-07 | 2020-11-17 | L.E.A.F.控股集团公司 | α聚谷氨酸化氨甲蝶呤及其用途 |
| WO2019157123A1 (en) | 2018-02-07 | 2019-08-15 | L.E.A.F. Holdings Group Llc | Alpha polyglutamated aminopterin and uses thereof |
| EP3749318A4 (en) | 2018-02-07 | 2022-07-06 | L.E.A.F Holdings Group LLC | GAMMA-POLYGLUTAMATED RALTITREXED AND ITS USES |
| CA3090943A1 (en) | 2018-02-14 | 2019-08-22 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated aminopterin and uses thereof |
| US11771700B2 (en) | 2018-02-14 | 2023-10-03 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated lometrexol and uses thereof |
| EP3752156A4 (en) * | 2018-02-14 | 2021-10-27 | L.E.A.F Holdings Group LLC | GAMMA-POLYGLUTAMIZED PRALATREXATE AND USES THEREOF |
| CN111936145A (zh) | 2018-02-14 | 2020-11-13 | L.E.A.F.控股集团公司 | γ聚谷氨酸化氨甲蝶呤及其用途 |
| US12048766B2 (en) | 2018-02-14 | 2024-07-30 | L.E.A.F. Holdings Group Llc | Gamma polyglutamated tetrahydrofolates and uses thereof |
| WO2019169029A1 (en) * | 2018-02-28 | 2019-09-06 | Bioxiness Pharmaceuticals, Inc. | Target specific chemotherapeutic agents |
Family Cites Families (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB9223352D0 (en) | 1992-11-06 | 1992-12-23 | Ici Plc | Tricyclic compounds |
| GB9408936D0 (en) * | 1994-05-05 | 1994-06-22 | Cancer Res Inst | Anti-cancer compounds |
| US7297701B2 (en) * | 2001-08-31 | 2007-11-20 | Btg International Limited | Anti-cancer cyclopenta [G]quinazoline compounds |
| WO2003020300A1 (en) * | 2001-08-31 | 2003-03-13 | Btg International Limited | Use of cyclopenta[g]quinazoline derivatives for treating cancer |
| CA2503094A1 (en) * | 2002-02-27 | 2003-09-04 | The Ohio State University Research Foundation | Therapeutic methods for acute myeloid leukemia |
-
2009
- 2009-03-13 DK DK09721455.5T patent/DK2293807T3/da active
- 2009-03-13 WO PCT/GB2009/000687 patent/WO2009115776A1/en not_active Ceased
- 2009-03-13 US US12/735,743 patent/US8466111B2/en active Active
- 2009-03-13 CN CN200980110610.4A patent/CN101977620B/zh active Active
- 2009-03-13 CA CA2717954A patent/CA2717954C/en active Active
- 2009-03-13 AT AT09721455T patent/ATE556715T1/de active
- 2009-03-13 ES ES09721455T patent/ES2387334T3/es active Active
- 2009-03-13 JP JP2011500282A patent/JP5599773B2/ja active Active
- 2009-03-13 EP EP09721455A patent/EP2293807B1/en active Active
- 2009-03-13 KR KR1020107023279A patent/KR101616022B1/ko active Active
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