JP2011514813A5 - - Google Patents
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- JP2011514813A5 JP2011514813A5 JP2010545946A JP2010545946A JP2011514813A5 JP 2011514813 A5 JP2011514813 A5 JP 2011514813A5 JP 2010545946 A JP2010545946 A JP 2010545946A JP 2010545946 A JP2010545946 A JP 2010545946A JP 2011514813 A5 JP2011514813 A5 JP 2011514813A5
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- JP
- Japan
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- biophys
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- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 description 6
- 230000005684 electric field Effects 0.000 description 5
- 210000000988 bone and bone Anatomy 0.000 description 4
- 206010017076 Fracture Diseases 0.000 description 3
- 210000002449 bone cell Anatomy 0.000 description 3
- 230000014509 gene expression Effects 0.000 description 3
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 2
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 2
- 102000003974 Fibroblast growth factor 2 Human genes 0.000 description 2
- 108090000379 Fibroblast growth factor 2 Proteins 0.000 description 2
- 102000003973 Fibroblast growth factor 21 Human genes 0.000 description 2
- 108090000376 Fibroblast growth factor 21 Proteins 0.000 description 2
- 229940112869 bone morphogenetic protein Drugs 0.000 description 2
- 230000007547 defect Effects 0.000 description 2
- 108020004999 messenger RNA Proteins 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000010392 Bone Fractures Diseases 0.000 description 1
- 208000029725 Metabolic bone disease Diseases 0.000 description 1
- 206010031264 Osteonecrosis Diseases 0.000 description 1
- 206010049088 Osteopenia Diseases 0.000 description 1
- 208000001132 Osteoporosis Diseases 0.000 description 1
- 102100037596 Platelet-derived growth factor subunit A Human genes 0.000 description 1
- 238000009098 adjuvant therapy Methods 0.000 description 1
- 210000001188 articular cartilage Anatomy 0.000 description 1
- 210000001612 chondrocyte Anatomy 0.000 description 1
- 230000001276 controlling effect Effects 0.000 description 1
- 230000004927 fusion Effects 0.000 description 1
- 230000035876 healing Effects 0.000 description 1
- 239000011159 matrix material Substances 0.000 description 1
- 108010017843 platelet-derived growth factor A Proteins 0.000 description 1
- 230000002035 prolonged effect Effects 0.000 description 1
- 102000004169 proteins and genes Human genes 0.000 description 1
- 230000001105 regulatory effect Effects 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US12/028,530 US7981611B2 (en) | 2000-02-23 | 2008-02-08 | Regulation of fibroblastic growth factor-2 (FGF-2) gene expression in living cells with the application of specific and selective electric and electromagnetic fields |
| US12/028,530 | 2008-02-08 | ||
| PCT/US2009/032925 WO2009100048A1 (en) | 2008-02-08 | 2009-02-03 | Regulation of fibroblastic growth factor-2 (fgf-2) gene expression in living cells with the application of specific and selective electric an electromagnetic fields |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011514813A JP2011514813A (ja) | 2011-05-12 |
| JP2011514813A5 true JP2011514813A5 (enExample) | 2012-03-22 |
| JP5596563B2 JP5596563B2 (ja) | 2014-09-24 |
Family
ID=40952436
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010545946A Active JP5596563B2 (ja) | 2008-02-08 | 2009-02-03 | 特異的且つ選択的な電場および電磁場の印加を使用した生体細胞における線維芽成長因子−2(fgf−2)遺伝子発現の制御 |
Country Status (11)
| Country | Link |
|---|---|
| US (1) | US7981611B2 (enExample) |
| EP (1) | EP2250250A4 (enExample) |
| JP (1) | JP5596563B2 (enExample) |
| CN (1) | CN101939409A (enExample) |
| AU (1) | AU2009212561B2 (enExample) |
| CA (1) | CA2712991A1 (enExample) |
| IL (1) | IL207430A0 (enExample) |
| MX (1) | MX2010008765A (enExample) |
| RU (1) | RU2010137343A (enExample) |
| WO (1) | WO2009100048A1 (enExample) |
| ZA (1) | ZA201006311B (enExample) |
Families Citing this family (5)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8313908B2 (en) * | 2000-02-23 | 2012-11-20 | The Trustees Of The University Of Pennsylvania | Regulation of stem cell gene production with specific and selective electric and electromagnetic fields |
| US10188858B2 (en) | 2013-09-18 | 2019-01-29 | University Of Cincinnati | Method and device for treating a tissue with a high frequency electromagnetic field |
| WO2017118390A1 (zh) * | 2016-01-05 | 2017-07-13 | 吴翔 | 利用变化电场磁场电磁场有选择地操控分子 |
| US10806942B2 (en) | 2016-11-10 | 2020-10-20 | Qoravita LLC | System and method for applying a low frequency magnetic field to biological tissues |
| US20240033509A1 (en) * | 2022-08-01 | 2024-02-01 | BonGenix, LLC | Method and device for stimulating bone growth |
Family Cites Families (48)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4430999A (en) * | 1981-11-10 | 1984-02-14 | Trustees Of The University Of Pennsylvania | Osteogenesis stimulating cathode assembly for use with an internal fixation device |
| US4506674A (en) * | 1981-11-10 | 1985-03-26 | Trustees Of The University Of Pennsylvania | Method of stimulating osteogenesis with distributed port cathode |
| US4442846A (en) * | 1981-11-10 | 1984-04-17 | University Of Pennsylvania | Distributed port bone-piercing cathode for electrically stimulated osteogenesis |
| US4509520A (en) * | 1982-02-22 | 1985-04-09 | Biolectron, Inc. | Electrical stimulating apparatus |
| US4549547A (en) * | 1982-07-27 | 1985-10-29 | Trustees Of The University Of Pennsylvania | Implantable bone growth stimulator |
| US4467809A (en) * | 1982-09-17 | 1984-08-28 | Biolectron, Inc. | Method for non-invasive electrical stimulation of epiphyseal plate growth |
| US4467808A (en) * | 1982-09-17 | 1984-08-28 | Biolectron, Inc. | Method for preventing and treating osteoporosis in a living body by using electrical stimulation non-invasively |
| US4487834A (en) * | 1982-09-17 | 1984-12-11 | Biolectron, Inc. | Electrical stimulation of articular chondrocytes |
| US5269746A (en) * | 1982-12-20 | 1993-12-14 | Jacobson Jerry I | Therapeutic treatment of mammals for epilepsy and Parkinson's disease |
| US4535775A (en) * | 1983-02-10 | 1985-08-20 | Biolectron, Inc. | Method for treatment of non-union bone fractures by non-invasive electrical stimulation |
| IT1159024B (it) * | 1983-06-02 | 1987-02-25 | Ruggero Cadossi | Metodo e dispositivo per il trattamento di tessuti e cellule viventi mediante campi elettromagnetici pulsanti |
| US4600010A (en) * | 1984-10-04 | 1986-07-15 | Biolectron, Inc. | Electric stimulator and test instrument therefor |
| US4998532A (en) * | 1986-05-23 | 1991-03-12 | Lti Biomedical, Inc. | Portable electro-therapy system |
| US5014699A (en) * | 1986-05-23 | 1991-05-14 | Trustees Of The University Of Pennsylvania | Electromagnetic method and apparatus for healing living tissue |
| US6120502A (en) * | 1988-06-13 | 2000-09-19 | Michelson; Gary Karlin | Apparatus and method for the delivery of electrical current for interbody spinal arthrodesis |
| US5038797A (en) * | 1990-02-20 | 1991-08-13 | Romaine, Incorporated | Electrical stimulation treatment device and method of use |
| US5273033A (en) | 1991-09-19 | 1993-12-28 | Murray Electronics Associates Limited Partnership | Electrical stimulation for treatment of osteoarthritis |
| US5338286A (en) * | 1992-12-08 | 1994-08-16 | Electro-Biology, Inc. | Electromagnetic bioresponse by selective spectral suppression in pulsed field stimulation |
| US5374283A (en) * | 1993-12-01 | 1994-12-20 | Flick; A. Bart | Electrical therapeutic apparatus |
| US5743844A (en) * | 1996-11-01 | 1998-04-28 | Amei Technologies, Inc. | High efficiency pulsed electromagnetic field (PEMF) stimulation therapy method and system |
| US6132362A (en) * | 1996-11-01 | 2000-10-17 | Amei Technologies, Inc. | Pulsed electromagnetic field (PEMF) stimulation therapy system with bi-phasic coil |
| US6261221B1 (en) * | 1996-11-01 | 2001-07-17 | Amei Technologies Inc. | Flexible coil pulsed electromagnetic field (PEMF) stimulation therapy system |
| US5968527A (en) * | 1997-02-27 | 1999-10-19 | Catholic University Of America, The | Protection of living systems from the adverse effects of stress |
| US6083149A (en) | 1997-10-22 | 2000-07-04 | Emf Therapeutics, Inc. | Magnetic field device and method for inhibiting angiogenesis and retarding growth rates of tumors in mammals |
| US6186940B1 (en) * | 1998-05-18 | 2001-02-13 | Robert N. Kirschbaum | Energized trace elements |
| RU2147895C1 (ru) | 1999-01-05 | 2000-04-27 | Корж Геннадий Михайлович | Способ лечения неосложненных переломов нижней челюсти |
| US6292699B1 (en) * | 1999-01-29 | 2001-09-18 | Electro-Biology, Inc. | Direct current stimulation of spinal interbody fixation device |
| US6747004B1 (en) * | 1999-04-29 | 2004-06-08 | North Shore - Long Island Jewish Research Institute | Method for inducing growth and enhancing survival of nervous tissue |
| US6923784B2 (en) | 1999-04-30 | 2005-08-02 | Medtronic, Inc. | Therapeutic treatment of disorders based on timing information |
| DE19933719A1 (de) | 1999-07-19 | 2001-01-25 | Medigene Ag | Strukturprotein in Adeno-assoziiertem Virus mit veränderten chromatographischen Eigenschaften, seine Herstellung und Verwendung |
| US7022506B2 (en) * | 2000-02-23 | 2006-04-04 | The Trustees Of The University Of Pennsylvania | Method and device for treating osteoarthritis, cartilage disease, defects and injuries in the human knee |
| US7465546B2 (en) | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of transforming growth factor-beta (TGF-β) gene expression in living cells via the application of specific and selective electric and electromagnetic fields |
| US7465566B2 (en) * | 2000-02-23 | 2008-12-16 | The Trustees Of The University Of Pennsylvania | Regulation of genes via application of specific and selective electrical and electromagnetic signals |
| US6919205B2 (en) * | 2000-02-23 | 2005-07-19 | The Trustees Of The University Of Pennsylvania | Regulation of type II collagen gene expression using specific and selective electrical and electromagnetic signals |
| US7374916B2 (en) * | 2000-02-23 | 2008-05-20 | The Trustees Of The University Of Pennsylvania | Regulation of aggrecan gene expression using specific and selective electrical and electromagnetic signals |
| US7130692B2 (en) * | 2000-02-23 | 2006-10-31 | The Trustees Of The University Of Pennsylvania | Portable electrotherapy device for treating osteoarthritis and other diseases, defects and injuries of the knee joint |
| US7429471B2 (en) * | 2000-02-23 | 2008-09-30 | The Trustees Of The University Of Pennsylvania | Regulation of matrix metalloproteinase gene expression using specific and selective electrical and electromagnetic signals |
| US6485963B1 (en) * | 2000-06-02 | 2002-11-26 | The United States Of America As Represented By The Administrator Of The National Aeronautics And Space Administration | Growth stimulation of biological cells and tissue by electromagnetic fields and uses thereof |
| AU2002227147A1 (en) * | 2000-11-02 | 2002-05-15 | Keith L March | Method and system for modulation of oscillating signals to enhance biologic effects |
| US6485113B2 (en) * | 2001-03-08 | 2002-11-26 | Delphi Technologies, Inc. | Haptic braking method and system |
| US7167753B2 (en) * | 2001-07-03 | 2007-01-23 | The Trustees Of The University Of Pennsylvania | Device and method for electrically inducing osteogenesis in the spine |
| EP1465703A4 (en) * | 2001-12-21 | 2007-05-23 | Univ Pennsylvania | "APPARATUS FOR TREATING OSTEOPOROSIS, HIP AND SPINAL FRACTURES AND FUSIONS WITH ELECTRIC FIELDS" |
| US6955642B1 (en) * | 2002-11-26 | 2005-10-18 | Ebi, Lp | Pulsed electromagnetic field stimulation method and apparatus with improved dosing |
| US20050049640A1 (en) * | 2003-05-12 | 2005-03-03 | Gurtner Geoffrey C. | Electromagnetic fields increase in vitro and in vivo angiogenesis through endothelial release of FGF-2 |
| US20050084962A1 (en) * | 2003-08-20 | 2005-04-21 | Bruce Simon | Methods of treatment using electromagnetic field stimulated stem cells |
| CA2545860A1 (en) * | 2003-11-14 | 2005-06-02 | The Trustees Of The University Of Pennsylvania | Device for treating osteoarthritis and cartilage disease, defects, and injuries in the human hip |
| KR101324824B1 (ko) * | 2004-01-12 | 2013-11-01 | 더 트러스티스 오브 더 유니버시티 오브 펜실바니아 | 특이적이고 선택적인 전기 신호 및 전자기 신호에 의해생성된 장의 적용을 통해 골 세포에서의 골 형태형성단백질 (bmp) 유전자 발현을 상향-조절하는 시스템 및방법 |
| US8034014B2 (en) * | 2007-03-06 | 2011-10-11 | Biomet Biologics, Llc | Angiogenesis initation and growth |
-
2008
- 2008-02-08 US US12/028,530 patent/US7981611B2/en not_active Expired - Lifetime
-
2009
- 2009-02-03 CA CA2712991A patent/CA2712991A1/en not_active Abandoned
- 2009-02-03 WO PCT/US2009/032925 patent/WO2009100048A1/en not_active Ceased
- 2009-02-03 JP JP2010545946A patent/JP5596563B2/ja active Active
- 2009-02-03 MX MX2010008765A patent/MX2010008765A/es active IP Right Grant
- 2009-02-03 EP EP09707589A patent/EP2250250A4/en not_active Withdrawn
- 2009-02-03 RU RU2010137343/10A patent/RU2010137343A/ru not_active Application Discontinuation
- 2009-02-03 CN CN2009801045897A patent/CN101939409A/zh active Pending
- 2009-02-03 AU AU2009212561A patent/AU2009212561B2/en active Active
-
2010
- 2010-08-05 IL IL207430A patent/IL207430A0/en unknown
- 2010-09-02 ZA ZA2010/06311A patent/ZA201006311B/en unknown
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