JP2011512123A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011512123A5 JP2011512123A5 JP2010543441A JP2010543441A JP2011512123A5 JP 2011512123 A5 JP2011512123 A5 JP 2011512123A5 JP 2010543441 A JP2010543441 A JP 2010543441A JP 2010543441 A JP2010543441 A JP 2010543441A JP 2011512123 A5 JP2011512123 A5 JP 2011512123A5
- Authority
- JP
- Japan
- Prior art keywords
- liver
- derived peptide
- seq
- pres
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US6234708P | 2008-01-25 | 2008-01-25 | |
| US61/062,347 | 2008-01-25 | ||
| PCT/EP2009/000477 WO2009092612A1 (en) | 2008-01-25 | 2009-01-26 | Hydrophobic modified pres-derived peptides of hepatitis b virus (hbv) and their use as vehicles for the specific delivery of compounds to the liver |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011512123A JP2011512123A (ja) | 2011-04-21 |
| JP2011512123A5 true JP2011512123A5 (https=) | 2012-03-08 |
| JP5686468B2 JP5686468B2 (ja) | 2015-03-18 |
Family
ID=40521848
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010543441A Expired - Fee Related JP5686468B2 (ja) | 2008-01-25 | 2009-01-26 | Ｂ型肝炎ウイルス（ＨＢＶ）の疎水性修飾されたｐｒｅＳ由来ペプチド及び肝臓に化合物を特異的に送達するためのビヒクルとしてのそれらの使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US9868768B2 (https=) |
| EP (1) | EP2245047B1 (https=) |
| JP (1) | JP5686468B2 (https=) |
| CN (1) | CN102015753A (https=) |
| ES (1) | ES2847288T3 (https=) |
| WO (1) | WO2009092612A1 (https=) |
Families Citing this family (28)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP1281761A1 (en) | 2001-07-27 | 2003-02-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Hepatitis B virus pre-S1 derived synthetic polypeptides and their use thereof. |
| EP2596799B1 (en) | 2007-02-08 | 2016-11-23 | University of Utah Research Foundation | Methods and compositions related to inhibition of viral entry |
| US8875361B2 (en) | 2008-05-21 | 2014-11-04 | Wirtz Manufacturing Co., Inc. | Reformed battery grids |
| TWI555531B (zh) * | 2009-08-07 | 2016-11-01 | 傳斯堅公司 | 用以治療ｂ型肝炎病毒（ｈｂｖ）感染之組成物 |
| CN102241744B (zh) * | 2010-05-14 | 2015-03-04 | 上海贺普药业股份有限公司 | 一种病毒感染阻断剂、其药物组合物及其应用 |
| US9402890B2 (en) * | 2011-02-01 | 2016-08-02 | Uab Research Foundation | Methods and compositions for pseudoinfectious alphaviruses |
| ES2663368T3 (es) | 2011-02-10 | 2018-04-12 | Ruprecht-Karls-Universität Heidelberg | Péptidos modificados hidrófobos y uso de los mismos para su direccionamiento específico al hígado |
| CN103402546B (zh) * | 2011-02-10 | 2018-04-13 | 海德堡鲁普雷希特卡尔斯大学 | 用于肝特异性诊断的疏水性修饰肽 |
| JP6205345B2 (ja) | 2011-03-28 | 2017-09-27 | ユニヴァーシティー オブ ユタ リサーチ ファウンデーション | ウイルス侵入の阻害に関する方法および組成物 |
| CN104662036B (zh) * | 2012-04-25 | 2018-11-09 | 华辉安健（北京）生物科技有限公司 | 乙肝肝炎病毒功能性受体的组成以及相关应用 |
| EP2703001A1 (en) | 2012-08-26 | 2014-03-05 | XAX Kft. | Tumor vaccination |
| CN103665095A (zh) * | 2012-09-11 | 2014-03-26 | 中国人民解放军军事医学科学院卫生学环境医学研究所 | 一种疏水性多肽修饰抗体的合成方法 |
| US8961995B2 (en) * | 2012-09-20 | 2015-02-24 | Uab Research Foundation | Methods and compositions for alphavirus replicons |
| CN104781274B (zh) | 2012-11-12 | 2020-03-06 | 海德堡吕布莱希特-卡尔斯大学 | 用于治疗肝脏疾病和心血管疾病的脂肽 |
| CN107106686B (zh) * | 2014-10-07 | 2022-09-27 | Myr有限公司 | Hbv和hdv感染的联合治疗 |
| EP3138579A1 (en) * | 2015-09-05 | 2017-03-08 | Biomay Ag | Fusion protein for use in the treatment of a hepatitis b virus infection |
| EP3189850A1 (en) * | 2015-12-16 | 2017-07-12 | Ruprecht-Karls-Universität Heidelberg | Liver targeting of cyclic pres-derived peptides of hbv |
| EP3181146A1 (en) | 2015-12-16 | 2017-06-21 | Ruprecht-Karls-Universität Heidelberg | Cyclic ntcp-targeting peptides and their uses as entry inhibitors |
| BR112018013872A2 (pt) | 2016-01-07 | 2018-12-18 | Navigen Inc | inibidores de peptídeo d da entrada do hiv e métodos de uso |
| WO2018054891A1 (en) | 2016-09-20 | 2018-03-29 | Ruprecht-Karls-Universität | Compounds and combinations thereof for preventing and/or treating hbv and/or hdv infections |
| EP3392267A1 (en) * | 2017-04-18 | 2018-10-24 | Myr GmbH | Therapy of atherosclerosis, primary biliary cirrhosis and nrlp3 inflammasome-associated disease by htcp inhibitors |
| CN109718364A (zh) * | 2017-10-27 | 2019-05-07 | 上海贺普药业股份有限公司 | 充分剂量条件下治疗乙肝病毒相关肝病的药物和方法 |
| CN119770638A (zh) | 2019-09-30 | 2025-04-08 | 吉利德科学公司 | Hbv疫苗和治疗hbv的方法 |
| EP3804750A1 (en) | 2019-10-10 | 2021-04-14 | Universität Heidelberg | Conjugate compounds for preventing and/or treating hbv and/or hdv infections, liver diseases and for targeting ntcp |
| US12350286B2 (en) * | 2020-02-27 | 2025-07-08 | Quadrumix Biotechnology Inc. | Polypeptides directed against viral infection and uses thereof |
| KR20240052981A (ko) | 2021-09-14 | 2024-04-23 | 어드바팜 게엠베하 | 신규 지질펩티드 제형 |
| CN116621944A (zh) * | 2022-02-10 | 2023-08-22 | 成都奥达生物科技有限公司 | 一种长效肝炎病毒进入抑制剂 |
| WO2025031397A1 (zh) * | 2023-08-08 | 2025-02-13 | 前沿生物药业(南京)股份有限公司 | 钠离子-牛磺胆酸共转运蛋白长效抑制剂及其应用 |
Family Cites Families (4)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5204096A (en) * | 1984-03-07 | 1993-04-20 | New York Blood Center, Inc. | Pre-S gene coded peptide hepatitis B immunogens, vaccines, diagnostics, and synthetic lipid vesicle carriers |
| EP1281761A1 (en) | 2001-07-27 | 2003-02-05 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Hepatitis B virus pre-S1 derived synthetic polypeptides and their use thereof. |
| CN101045156B (zh) * | 2006-03-29 | 2012-05-02 | 刘宏利 | 特异靶向性药物及其用途 |
| WO2008103380A2 (en) * | 2007-02-21 | 2008-08-28 | Fox Chase Cancer Center | Hepatitis b virus compositions and methods of use |
-
2009
- 2009-01-26 US US12/864,197 patent/US9868768B2/en not_active Expired - Fee Related
- 2009-01-26 JP JP2010543441A patent/JP5686468B2/ja not_active Expired - Fee Related
- 2009-01-26 ES ES09704030T patent/ES2847288T3/es active Active
- 2009-01-26 CN CN2009801125069A patent/CN102015753A/zh active Pending
- 2009-01-26 EP EP09704030.7A patent/EP2245047B1/en not_active Not-in-force
- 2009-01-26 WO PCT/EP2009/000477 patent/WO2009092612A1/en not_active Ceased
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2011512123A5 (https=) | ||
| JP5791900B2 (ja) | Ｂ型肝炎ウイルス（ＨＢＶ）の疎水性改変ｐｒｅＳ由来ペプチドならびにＨＢＶ侵入インヒビターおよびＨＤＶ侵入インヒビターとしてのそれらの使用 | |
| JP7362142B2 (ja) | 環状ｎｔｃｐ標的化ペプチドおよび侵入阻害剤としてのその使用 | |
| US9868768B2 (en) | Hydrophobic modified pres-derived peptides of hepatitis B virus (HBV) and their use as vehicles for the specific delivery of compounds to the liver | |
| KR102599942B1 (ko) | Hbv 및 hdv 감염의 조합 치료법 | |
| JP7672677B2 (ja) | 全用量条件下でｂ型肝炎ウイルス関連肝疾患を治療する医薬品および方法 | |
| EP3189850A1 (en) | Liver targeting of cyclic pres-derived peptides of hbv | |
| HK40083480A (en) | Combination therapy of hbv and hdv infection | |
| HK1150168B (en) | Hydrophobic modified pres-derived peptides of hepatitis b virus (hbv) and their use as hbv and hdv entry inhibitors | |
| EA047071B1 (ru) | Комбинированная терапия вызываемой вирусами hbv и hdv инфекции |