JP2011511622A5 - - Google Patents
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- Publication number
- JP2011511622A5 JP2011511622A5 JP2010541803A JP2010541803A JP2011511622A5 JP 2011511622 A5 JP2011511622 A5 JP 2011511622A5 JP 2010541803 A JP2010541803 A JP 2010541803A JP 2010541803 A JP2010541803 A JP 2010541803A JP 2011511622 A5 JP2011511622 A5 JP 2011511622A5
- Authority
- JP
- Japan
- Prior art keywords
- qpct
- human animal
- mouse
- model
- gene
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 230000000694 effects Effects 0.000 claims 12
- 101150035356 Qpct gene Proteins 0.000 claims 10
- 238000000034 method Methods 0.000 claims 10
- 150000001875 compounds Chemical class 0.000 claims 9
- 241000699666 Mus <mouse, genus> Species 0.000 claims 8
- 238000010171 animal model Methods 0.000 claims 8
- 239000003795 chemical substances by application Substances 0.000 claims 7
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 7
- 238000012216 screening Methods 0.000 claims 7
- 241001465754 Metazoa Species 0.000 claims 6
- 201000010099 disease Diseases 0.000 claims 6
- 238000004519 manufacturing process Methods 0.000 claims 3
- 208000037803 restenosis Diseases 0.000 claims 3
- ODHCTXKNWHHXJC-VKHMYHEASA-N 5-oxo-L-proline Chemical compound OC(=O)[C@@H]1CCC(=O)N1 ODHCTXKNWHHXJC-VKHMYHEASA-N 0.000 claims 2
- 208000023697 ABri amyloidosis Diseases 0.000 claims 2
- 208000017227 ADan amyloidosis Diseases 0.000 claims 2
- 108700028369 Alleles Proteins 0.000 claims 2
- 208000024827 Alzheimer disease Diseases 0.000 claims 2
- 201000001320 Atherosclerosis Diseases 0.000 claims 2
- 201000010374 Down Syndrome Diseases 0.000 claims 2
- 201000000162 ITM2B-related cerebral amyloid angiopathy 1 Diseases 0.000 claims 2
- 201000000194 ITM2B-related cerebral amyloid angiopathy 2 Diseases 0.000 claims 2
- 206010033645 Pancreatitis Diseases 0.000 claims 2
- 241001323319 Psen Species 0.000 claims 2
- 241000700159 Rattus Species 0.000 claims 2
- 230000015572 biosynthetic process Effects 0.000 claims 2
- 208000010877 cognitive disease Diseases 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000001727 in vivo Methods 0.000 claims 2
- 208000027061 mild cognitive impairment Diseases 0.000 claims 2
- 230000035772 mutation Effects 0.000 claims 2
- 230000004770 neurodegeneration Effects 0.000 claims 2
- 108090000765 processed proteins & peptides Proteins 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- CWERGRDVMFNCDR-UHFFFAOYSA-N thioglycolic acid Chemical compound OC(=O)CS CWERGRDVMFNCDR-UHFFFAOYSA-N 0.000 claims 2
- 238000013279 ApoE knockout mouse model Methods 0.000 claims 1
- 108020004414 DNA Proteins 0.000 claims 1
- 108700024394 Exon Proteins 0.000 claims 1
- 208000009386 Experimental Arthritis Diseases 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 241000699670 Mus sp. Species 0.000 claims 1
- 239000013543 active substance Substances 0.000 claims 1
- 238000006555 catalytic reaction Methods 0.000 claims 1
- 208000035475 disorder Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 230000030505 negative regulation of chemotaxis Effects 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
- 230000035790 physiological processes and functions Effects 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 238000011552 rat model Methods 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US2078408P | 2008-01-14 | 2008-01-14 | |
| PCT/EP2009/050387 WO2009090190A1 (en) | 2008-01-14 | 2009-01-14 | Mouse models carrying a knock-out mutation of the glutaminyl cyclase gene |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011511622A JP2011511622A (ja) | 2011-04-14 |
| JP2011511622A5 true JP2011511622A5 (cg-RX-API-DMAC10.html) | 2012-03-01 |
Family
ID=40427980
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010541803A Pending JP2011511622A (ja) | 2008-01-14 | 2009-01-14 | グルタミニルシクラーゼ遺伝子のノックアウト変異を有するマウスモデル |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US9462793B2 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2238252B1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2011511622A (cg-RX-API-DMAC10.html) |
| AU (1) | AU2009204864A1 (cg-RX-API-DMAC10.html) |
| CA (1) | CA2710494A1 (cg-RX-API-DMAC10.html) |
| IL (1) | IL206484A0 (cg-RX-API-DMAC10.html) |
| NZ (1) | NZ586665A (cg-RX-API-DMAC10.html) |
| WO (1) | WO2009090190A1 (cg-RX-API-DMAC10.html) |
| ZA (1) | ZA201004367B (cg-RX-API-DMAC10.html) |
Families Citing this family (1)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2015296135A1 (en) | 2014-08-01 | 2017-02-16 | The Johns Hopkins University | MrgprX2/MrgprB2 expressing cell based assay to detect pseudo-allergic drug reactions and to identify blockers to prevent the adverse reactions |
Family Cites Families (35)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4873191A (en) | 1981-06-12 | 1989-10-10 | Ohio University | Genetic transformation of zygotes |
| DE3751873T2 (de) | 1986-04-09 | 1997-02-13 | Genzyme Corp | Genetisch transformierte Tiere, die ein gewünschtes Protein in Milch absondern |
| US4873316A (en) * | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US5175384A (en) * | 1988-12-05 | 1992-12-29 | Genpharm International | Transgenic mice depleted in mature t-cells and methods for making transgenic mice |
| GB8901778D0 (en) | 1989-01-27 | 1989-03-15 | Univ Court Of The University O | Manipulatory technique |
| US5602299A (en) * | 1992-09-23 | 1997-02-11 | Mount Sinai School Of Medicine Of The City University Of New York | Transgenic animal models for neurodegenerative disease |
| JPH07132033A (ja) * | 1993-11-12 | 1995-05-23 | Hoechst Japan Ltd | アルツハイマー病モデルトランスジェニック動物 |
| US6066778A (en) * | 1996-11-06 | 2000-05-23 | The Regents Of The University Of Michigan | Transgenic mice expressing APC resistant factor V |
| US5981830A (en) * | 1997-05-30 | 1999-11-09 | Schering Aktiengesellschaft | Knockout mice and their progeny with a disrupted hepsin gene |
| US20030013177A1 (en) * | 2001-05-23 | 2003-01-16 | Ebens Allen J. | Polynucleotides encoding insect glutaminyl cyclase and uses thereof |
| US6948038B2 (en) * | 2001-07-24 | 2005-09-20 | Microsoft Corporation | System and method for backing up and restoring data |
| PL1620082T3 (pl) | 2003-05-05 | 2010-10-29 | Probiodrug Ag | Medyczne zastosowanie inhibitorów cyklazy glutaminylowej i glutaminianowej do leczenia choroby Alzheimera i zespołu Downa |
| EP1620091B1 (en) * | 2003-05-05 | 2010-03-31 | Probiodrug AG | Inhibitors of glutaminyl cyclase |
| US8338120B2 (en) * | 2003-05-05 | 2012-12-25 | Probiodrug Ag | Method of treating inflammation with glutaminyl cyclase inhibitors |
| US7732162B2 (en) * | 2003-05-05 | 2010-06-08 | Probiodrug Ag | Inhibitors of glutaminyl cyclase for treating neurodegenerative diseases |
| KR20060009902A (ko) * | 2003-05-05 | 2006-02-01 | 프로비오드룩 아게 | 글루타미닐 및 글루타메이트 사이클라제의 이펙터의 용도 |
| AU2004283461B2 (en) | 2003-10-15 | 2010-02-11 | Probiodrug Ag | Use of effectors of glutaminyl and glutamate cyclases |
| AU2004290499C1 (en) * | 2003-11-03 | 2011-02-24 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| US20050171112A1 (en) * | 2003-11-03 | 2005-08-04 | Probiodrug Ag | Combinations useful for the treatment of neuronal disorders |
| US7667044B2 (en) * | 2003-11-03 | 2010-02-23 | Probiodrug Ag | Compounds for the treatment of neurological disorders |
| WO2005075436A2 (en) * | 2004-02-05 | 2005-08-18 | Probiodrug Ag | Novel inhibitors of glutaminyl cyclase |
| WO2008034891A2 (en) * | 2006-09-21 | 2008-03-27 | Probiodrug Ag | Novel genes related to glutaminyl cyclase |
| US8420684B2 (en) * | 2006-11-09 | 2013-04-16 | Probiodrug Ag | Inhibitors of glutaminyl cyclase |
| JP5599614B2 (ja) * | 2006-11-09 | 2014-10-01 | プロビオドルグ エージー | グルタミニルシクラーゼの新規阻害剤 |
| ATE554085T1 (de) * | 2006-11-30 | 2012-05-15 | Probiodrug Ag | Neue inhibitoren von glutaminylcyclase |
| EP2395095A1 (en) * | 2007-01-19 | 2011-12-14 | Probiodrug AG | In vivo screening models for treatment of Alzheimer's disease and other QPCT-related disorders |
| WO2008110523A1 (en) * | 2007-03-09 | 2008-09-18 | Probiodrug Ag | Imidazo [1,5-a] pyridine derivatives as inhibitors of glutaminyl cyclase |
| JP5675341B2 (ja) * | 2007-04-18 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのチオキソキナゾリノン誘導体 |
| EP2142515B1 (en) * | 2007-04-18 | 2014-03-26 | Probiodrug AG | Nitrovinyl-diamine derivatives as glutaminyl cyclase inhibitors |
| EP2160380B1 (en) * | 2007-04-18 | 2014-04-02 | Probiodrug AG | Cyano-guanidine derivatives as glutaminyl cyclase inhibitors |
| WO2008128985A1 (en) * | 2007-04-18 | 2008-10-30 | Probiodrug Ag | Thiourea derivatives as glutaminyl cyclase inhibitors |
| ES2468551T3 (es) * | 2007-04-18 | 2014-06-16 | Probiodrug Ag | Derivados de nitrovinil-diamina como inhibidores de la glutaminil ciclasa |
| JP5675343B2 (ja) * | 2007-04-18 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としての尿素誘導体 |
| JP5676249B2 (ja) * | 2007-04-20 | 2015-02-25 | プロビオドルグ エージー | グルタミニルシクラーゼ阻害剤としてのアミノピリジン誘導体 |
| AU2008297070A1 (en) * | 2007-09-12 | 2009-03-19 | Probiodrug Ag | Transgenic mice |
-
2009
- 2009-01-14 WO PCT/EP2009/050387 patent/WO2009090190A1/en not_active Ceased
- 2009-01-14 US US12/353,463 patent/US9462793B2/en not_active Expired - Fee Related
- 2009-01-14 NZ NZ586665A patent/NZ586665A/en not_active IP Right Cessation
- 2009-01-14 JP JP2010541803A patent/JP2011511622A/ja active Pending
- 2009-01-14 EP EP09702062.2A patent/EP2238252B1/en not_active Not-in-force
- 2009-01-14 CA CA2710494A patent/CA2710494A1/en not_active Abandoned
- 2009-01-14 AU AU2009204864A patent/AU2009204864A1/en not_active Abandoned
-
2010
- 2010-06-20 IL IL206484A patent/IL206484A0/en unknown
- 2010-06-21 ZA ZA2010/04367A patent/ZA201004367B/en unknown
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