JP2011509956A - イミダゾリキノリン誘導体を用いた大腸疾病の治療又は結腸直腸癌腫の予防 - Google Patents

イミダゾリキノリン誘導体を用いた大腸疾病の治療又は結腸直腸癌腫の予防 Download PDF

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JP2011509956A
JP2011509956A JP2010542534A JP2010542534A JP2011509956A JP 2011509956 A JP2011509956 A JP 2011509956A JP 2010542534 A JP2010542534 A JP 2010542534A JP 2010542534 A JP2010542534 A JP 2010542534A JP 2011509956 A JP2011509956 A JP 2011509956A
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imidazoliquinoline
colorectal
treatment
imiquimod
derivative
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Japanese (ja)
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JP2011509956A5 (https=
Inventor
マウス ヨアヒム
スツェレニィ イストヴァン
ペツォルト ウルズラ
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Meda AB
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Meda AB
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4375—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a six-membered ring having nitrogen as a ring heteroatom, e.g. quinolizines, naphthyridines, berberine, vincamine
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4738—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems
    • A61K31/4745—Quinolines; Isoquinolines ortho- or peri-condensed with heterocyclic ring systems condensed with ring systems having nitrogen as a ring hetero atom, e.g. phenantrolines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents

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  • Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Organic Chemistry (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Medicinal Preparation (AREA)
JP2010542534A 2008-01-15 2008-12-23 イミダゾリキノリン誘導体を用いた大腸疾病の治療又は結腸直腸癌腫の予防 Pending JP2011509956A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US645908P 2008-01-15 2008-01-15
PCT/EP2008/011088 WO2009089900A1 (en) 2008-01-15 2008-12-23 Treatment of colon diseases or prevention of colorectal carcinoma with imidazoquinoline derivatives

Publications (2)

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JP2011509956A true JP2011509956A (ja) 2011-03-31
JP2011509956A5 JP2011509956A5 (https=) 2013-12-12

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JP2010542534A Pending JP2011509956A (ja) 2008-01-15 2008-12-23 イミダゾリキノリン誘導体を用いた大腸疾病の治療又は結腸直腸癌腫の予防

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Country Link
US (1) US8008319B2 (https=)
EP (1) EP2237780A1 (https=)
JP (1) JP2011509956A (https=)
CN (1) CN101909624A (https=)
AU (1) AU2008347400B2 (https=)
BR (1) BRPI0822002A2 (https=)
CA (1) CA2708559C (https=)
EA (1) EA018579B1 (https=)
GE (1) GEP20125605B (https=)
IL (1) IL205819A (https=)
MX (1) MX2010007699A (https=)
NZ (1) NZ586161A (https=)
UA (1) UA101339C2 (https=)
WO (1) WO2009089900A1 (https=)
ZA (1) ZA201003906B (https=)

Families Citing this family (10)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US8962652B2 (en) 2009-10-22 2015-02-24 Gilead Sciences, Inc. Derivatives of purine or deazapurine useful for the treatment of (inter alia) viral infections
CN112587671A (zh) 2012-07-18 2021-04-02 博笛生物科技有限公司 癌症的靶向免疫治疗
CN105899539B (zh) 2014-01-10 2021-11-09 博笛生物科技有限公司 用于免疫疗法的化合物和组合物
EP3166976B2 (en) 2014-07-09 2026-04-08 Birdie Biopharmaceuticals Inc. Anti-pd-l1 combinations for treating tumors
CN112587672A (zh) 2014-09-01 2021-04-02 博笛生物科技有限公司 用于治疗肿瘤的抗-pd-l1结合物
CN115252792A (zh) 2016-01-07 2022-11-01 博笛生物科技有限公司 用于治疗肿瘤的抗-egfr组合
CN115350279A (zh) 2016-01-07 2022-11-18 博笛生物科技有限公司 用于治疗肿瘤的抗-her2组合
CN106943596A (zh) 2016-01-07 2017-07-14 博笛生物科技（北京）有限公司 用于治疗肿瘤的抗-cd20组合
CN118515666A (zh) 2017-04-27 2024-08-20 博笛生物科技有限公司 2-氨基-喹啉衍生物
IL312120B2 (en) * 2017-06-23 2025-06-01 Birdie Biopharmaceuticals Inc Pharmaceutical compositions

Family Cites Families (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
RU2078547C1 (ru) * 1995-11-28 1997-05-10 Центральный научно-исследовательский рентгено-радиологический институт МЗМП РФ Способ лечения полипоза желудка и двенадцатиперстной кишки
UA75622C2 (en) * 2000-12-08 2006-05-15 3M Innovative Properties Co Aryl ether substituted imidazoquinolines, pharmaceutical composition based thereon
EP1351678A2 (en) * 2001-01-02 2003-10-15 Elizabeth Shanahan-Prendergast Treatment for inhibiting neoplastic lesions using incensole and/or furanogermacrens
US20060193789A1 (en) * 2002-10-25 2006-08-31 Foamix Ltd. Film forming foamable composition
DE602004014969D1 (de) * 2003-11-21 2008-08-21 Novartis Ag 1h-imidazochinolinderivate als proteinkinaseinhibitoren

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6013027165; ＣＡＮＣＥＲ　ＲＥＳＥＡＲＣＨ Ｖｏｌ．５２, 1992, ｐ．３５２８-３５３３ *
JPN6013027166; ＤＩＳＥＡＳＥＳ　ＯＦ　ＴＨＥ　ＣＯＬＯＮ＆ＲＥＣＴＵＭ Ｖｏｌ．５１，Ｎｏ．１, 200711, ｐ．２-９ *
JPN6013027167; Ｎ　Ｅｎｇｌ　Ｊ　Ｍｅｄ Ｖｏｌ．３４７，Ｎｏ．５, 2002, ｐ．３７４ *
JPN6013027168; Ｐｒｏｃｅｅｄ．Ｉｎｔ'ｌ．Ｓｙｍｐ．Ｃｏｎｔｒｏｌ．Ｒｅｌ．Ｂｉｏａｃｔ．Ｍａｔｅｒ．１９９７年，Ｎ２４，ｐ．３３７-３３８ *

Also Published As

Publication number Publication date
EP2237780A1 (en) 2010-10-13
AU2008347400A1 (en) 2009-07-23
MX2010007699A (es) 2010-08-04
ZA201003906B (en) 2011-03-30
CA2708559C (en) 2015-10-06
EA018579B1 (ru) 2013-09-30
BRPI0822002A2 (pt) 2015-10-13
UA101339C2 (ru) 2013-03-25
US20090182005A1 (en) 2009-07-16
IL205819A (en) 2013-02-28
AU2008347400B2 (en) 2014-12-11
WO2009089900A1 (en) 2009-07-23
EA201001164A1 (ru) 2010-12-30
US8008319B2 (en) 2011-08-30
CA2708559A1 (en) 2009-07-23
CN101909624A (zh) 2010-12-08
NZ586161A (en) 2012-05-25
GEP20125605B (en) 2012-08-10
IL205819A0 (en) 2010-11-30

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