JP2011509261A5 - - Google Patents
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- Publication number
- JP2011509261A5 JP2011509261A5 JP2010541599A JP2010541599A JP2011509261A5 JP 2011509261 A5 JP2011509261 A5 JP 2011509261A5 JP 2010541599 A JP2010541599 A JP 2010541599A JP 2010541599 A JP2010541599 A JP 2010541599A JP 2011509261 A5 JP2011509261 A5 JP 2011509261A5
- Authority
- JP
- Japan
- Prior art keywords
- optionally substituted
- independently
- alkyl
- cycloalkenyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 13
- 125000001072 heteroaryl group Chemical group 0.000 claims 13
- 125000000623 heterocyclic group Chemical group 0.000 claims 12
- 125000000547 substituted alkyl group Chemical group 0.000 claims 12
- 125000005346 substituted cycloalkyl group Chemical group 0.000 claims 12
- 125000005017 substituted alkenyl group Chemical group 0.000 claims 11
- 150000001875 compounds Chemical class 0.000 claims 10
- 125000003107 substituted aryl group Chemical group 0.000 claims 10
- 125000003710 aryl alkyl group Chemical group 0.000 claims 8
- 125000004475 heteroaralkyl group Chemical group 0.000 claims 8
- 125000004426 substituted alkynyl group Chemical group 0.000 claims 8
- 125000001475 halogen functional group Chemical group 0.000 claims 5
- 125000001188 haloalkyl group Chemical group 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 125000004093 cyano group Chemical group *C#N 0.000 claims 3
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims 3
- YTPLMLYBLZKORZ-UHFFFAOYSA-N Thiophene Chemical compound C=1C=CSC=1 YTPLMLYBLZKORZ-UHFFFAOYSA-N 0.000 claims 2
- 125000003342 alkenyl group Chemical group 0.000 claims 2
- ZUOUZKKEUPVFJK-UHFFFAOYSA-N diphenyl Chemical group C1=CC=CC=C1C1=CC=CC=C1 ZUOUZKKEUPVFJK-UHFFFAOYSA-N 0.000 claims 2
- 125000004438 haloalkoxy group Chemical group 0.000 claims 2
- RAXXELZNTBOGNW-UHFFFAOYSA-N imidazole Natural products C1=CNC=N1 RAXXELZNTBOGNW-UHFFFAOYSA-N 0.000 claims 2
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 claims 2
- 229910052757 nitrogen Inorganic materials 0.000 claims 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims 2
- -1 —OR 4 Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 125000000229 (C1-C4)alkoxy group Chemical group 0.000 claims 1
- 125000005913 (C3-C6) cycloalkyl group Chemical group 0.000 claims 1
- NOIXNOMHHWGUTG-UHFFFAOYSA-N 2-[[4-[4-pyridin-4-yl-1-(2,2,2-trifluoroethyl)pyrazol-3-yl]phenoxy]methyl]quinoline Chemical compound C=1C=C(OCC=2N=C3C=CC=CC3=CC=2)C=CC=1C1=NN(CC(F)(F)F)C=C1C1=CC=NC=C1 NOIXNOMHHWGUTG-UHFFFAOYSA-N 0.000 claims 1
- CKBWHNUQLWBTRZ-UHFFFAOYSA-N 4h-benzo[1,2]cyclohepta[3,4-b][1,3]thiazole-2-carboxamide Chemical compound C1C=CC2=CC=CC=C2C2=C1SC(C(=O)N)=N2 CKBWHNUQLWBTRZ-UHFFFAOYSA-N 0.000 claims 1
- WTKZEGDFNFYCGP-UHFFFAOYSA-N Pyrazole Chemical compound C=1C=NNC=1 WTKZEGDFNFYCGP-UHFFFAOYSA-N 0.000 claims 1
- 125000000217 alkyl group Chemical group 0.000 claims 1
- 125000003118 aryl group Chemical group 0.000 claims 1
- 125000003236 benzoyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C(*)=O 0.000 claims 1
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims 1
- 235000010290 biphenyl Nutrition 0.000 claims 1
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 1
- 125000002541 furyl group Chemical group 0.000 claims 1
- 150000002460 imidazoles Chemical class 0.000 claims 1
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 1
- 150000002916 oxazoles Chemical class 0.000 claims 1
- 125000002971 oxazolyl group Chemical group 0.000 claims 1
- 125000002924 primary amino group Chemical group [H]N([H])* 0.000 claims 1
- 125000003226 pyrazolyl group Chemical group 0.000 claims 1
- PBMFSQRYOILNGV-UHFFFAOYSA-N pyridazine Chemical group C1=CC=NN=C1 PBMFSQRYOILNGV-UHFFFAOYSA-N 0.000 claims 1
- 125000002098 pyridazinyl group Chemical group 0.000 claims 1
- JUJWROOIHBZHMG-UHFFFAOYSA-N pyridine Substances C1=CC=NC=C1 JUJWROOIHBZHMG-UHFFFAOYSA-N 0.000 claims 1
- UMJSCPRVCHMLSP-UHFFFAOYSA-N pyridine Natural products COC1=CC=CN=C1 UMJSCPRVCHMLSP-UHFFFAOYSA-N 0.000 claims 1
- 150000003222 pyridines Chemical class 0.000 claims 1
- 125000004076 pyridyl group Chemical group 0.000 claims 1
- 150000003536 tetrazoles Chemical class 0.000 claims 1
- 125000001113 thiadiazolyl group Chemical group 0.000 claims 1
- 150000003557 thiazoles Chemical class 0.000 claims 1
- 125000001544 thienyl group Chemical group 0.000 claims 1
- 229930192474 thiophene Natural products 0.000 claims 1
- 0 CC1C(C)***1 Chemical compound CC1C(C)***1 0.000 description 7
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US1052308P | 2008-01-07 | 2008-01-07 | |
| US7072108P | 2008-03-25 | 2008-03-25 | |
| US7269608P | 2008-04-01 | 2008-04-01 | |
| PCT/US2009/030367 WO2009089305A1 (en) | 2008-01-07 | 2009-01-07 | Compounds for inflammation and immune-related uses |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011509261A JP2011509261A (ja) | 2011-03-24 |
| JP2011509261A5 true JP2011509261A5 (cg-RX-API-DMAC7.html) | 2013-07-04 |
Family
ID=40853449
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010541599A Pending JP2011509261A (ja) | 2008-01-07 | 2009-01-07 | 炎症および免疫関連用途向けの化合物 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110052643A1 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2240029A4 (cg-RX-API-DMAC7.html) |
| JP (1) | JP2011509261A (cg-RX-API-DMAC7.html) |
| AU (1) | AU2009204147A1 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2711644A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009089305A1 (cg-RX-API-DMAC7.html) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI444187B (zh) | 2005-01-25 | 2014-07-11 | Synta Pharmaceuticals Corp | 用於炎症及免疫相關用途之噻吩化合物 |
| CA2640091A1 (en) | 2006-01-25 | 2007-08-02 | Synta Pharmaceuticals Corp. | Vinyl-phenyl derivatives for inflammation and immune-related uses |
| US8623871B2 (en) | 2006-01-25 | 2014-01-07 | Synta Pharmaceuticals Corp. | Substituted biaryl compounds for inflammation and immune-related uses |
| AU2007208239B2 (en) | 2006-01-25 | 2013-04-18 | Synta Pharmaceuticals Corp. | Substituted aromatic compounds for inflammation and immune-related uses |
| CA2645434A1 (en) | 2006-03-20 | 2007-09-27 | Synta Pharmaceutical Corp. | Benzoimidazolyl-parazine compounds for inflammation and immune-related uses |
| US8779154B2 (en) | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
| US8993612B2 (en) | 2009-10-08 | 2015-03-31 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel and methods for treatment of non-small cell lung cancer |
| US8377970B2 (en) | 2009-10-08 | 2013-02-19 | Rhizen Pharmaceuticals Sa | Modulators of calcium release-activated calcium channel |
| EP2597089A1 (en) * | 2009-10-29 | 2013-05-29 | Bristol-Myers Squibb Company | Tricyclic heterocyclic compounds |
| EP2563759B1 (en) | 2010-04-27 | 2022-04-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US10703722B2 (en) | 2010-04-27 | 2020-07-07 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| HUE029570T2 (en) | 2010-04-27 | 2017-03-28 | Calcimedica Inc | Intracellular calcium modifying compounds |
| EP2609095A4 (en) | 2010-08-27 | 2014-06-18 | Calcimedica Inc | COMPOUNDS MODULATING INTRACELLULAR CALCIUM |
| EP2668190B1 (en) | 2011-01-26 | 2016-08-17 | Nerviano Medical Sciences S.r.l. | Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors |
| WO2012101029A1 (en) | 2011-01-26 | 2012-08-02 | Nerviano Medical Sciences S.R.L. | Tricyclic derivatives, process for their preparation and their use as kinase inhibitors |
| WO2012170931A2 (en) | 2011-06-10 | 2012-12-13 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| WO2013059677A1 (en) | 2011-10-19 | 2013-04-25 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| US9512116B2 (en) | 2012-10-12 | 2016-12-06 | Calcimedica, Inc. | Compounds that modulate intracellular calcium |
| MX2015008919A (es) | 2013-01-10 | 2015-10-22 | Gruenenthal Gmbh | Carboxamidas basadas en pirazolilo i como inhibidores del canal de calcio activado por liberacion de calcio (crac). |
| AR094411A1 (es) | 2013-01-10 | 2015-07-29 | Gruenenthal Gmbh | Carboxamidas basadas en pirazolilo ii |
| WO2015197187A1 (en) | 2014-06-24 | 2015-12-30 | Grünenthal GmbH | Pyrazolyl-based carboxamides v |
| BR112017005104B1 (pt) * | 2014-10-10 | 2022-08-23 | Pulmocide Limited | Derivados de 5,6-di-hidro-4h-benzotieno-[2,3-d]azepina, seus usos, composição farmacêutica e processo para a preparação dos mesmos |
| BR112017018413B1 (pt) | 2015-02-27 | 2023-05-02 | CalciMedica, Inc | Uso de inibidores intracelulares de sinalização de cálcio no tratamento de pancreatite, composições e compostos relacionados |
| WO2017027400A1 (en) | 2015-08-07 | 2017-02-16 | Calcimedica, Inc. | Use of crac channel inhibitors for the treatment of stroke and traumatic brain injury |
| JP6900406B2 (ja) * | 2016-06-16 | 2021-07-07 | ハルビン チェンバオ ファーマシューティカル カンパニー リミテッド | Ａｋｔ阻害剤としてのジヒドロピラゾロアゼピン系化合物 |
| EP3507278B1 (en) | 2016-09-02 | 2021-01-27 | Bristol-Myers Squibb Company | Substituted tricyclic heterocyclic compounds |
| WO2019032631A1 (en) | 2017-08-09 | 2019-02-14 | Bristol-Myers Squibb Company | Oxime ether compounds |
| US11046646B2 (en) | 2017-08-09 | 2021-06-29 | Bristol-Myers Squibb Company | Alkylphenyl compounds |
| EA202190556A1 (ru) | 2018-09-14 | 2021-08-24 | Ризен Фармасьютикалс А Г | Композиции, содержащие ингибитор crac и кортикостероид, и способы их применения |
| EP4090426B1 (en) | 2020-01-13 | 2025-12-31 | Verge Analytics, Inc. | Substitutes for pyrazolos and pyrimidines and their uses |
| IL295955A (en) * | 2020-02-28 | 2022-10-01 | Remix Therapeutics Inc | Compounds and methods for modulating splicing |
| CN113264917B (zh) * | 2021-05-28 | 2022-07-01 | 华南理工大学 | 一种抗乙肝病毒化合物及其制备方法和应用 |
Family Cites Families (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4313950A (en) * | 1978-10-30 | 1982-02-02 | Gruppo Lepetit S.P.A. | Antireproductive tricyclic ortho-fused nitrogen containing compounds |
| FR2601011B1 (fr) * | 1986-07-03 | 1988-10-28 | Sanofi Sa | Nouveaux derives tricycliques agonistes des recepteurs cholinergiques et medicaments en contenant |
| FR2677356B1 (fr) * | 1991-06-05 | 1995-03-17 | Sanofi Sa | Derives heterocycliques d'acylamino-2 thiazoles-5 substitues, leur preparation et compositions pharmaceutiques en contenant. |
| UA64690C2 (en) * | 1993-07-21 | 2004-03-15 | Yamanouty Farmaceutical Co Ltd | A condensed benzadepine derivative, an intermediate compound for preparing thereof and a pharmaceutical composition |
| SG78360A1 (en) * | 1998-06-03 | 2001-02-20 | Givaudan Roure Int | Bicyclic aldehydes and ketones |
| US7273880B2 (en) * | 1999-06-30 | 2007-09-25 | H. Lunbeck A/S | Selective NPY (Y5) antagonists |
| CA2474460C (en) * | 2002-02-13 | 2009-12-22 | F. Hoffmann-La Roche Ag | Pyridine- and quinoline-derivatives |
| AU2003256650A1 (en) * | 2002-07-19 | 2004-02-09 | Pharmacia Corporation | Substituted thiophene carboxamide compounds for the treatment of inflammation |
| AU2005268899B2 (en) * | 2004-08-05 | 2009-09-24 | F. Hoffmann-La Roche Ag | Substituted N-acyl-2-aminothiazoles |
| CA2579279C (en) * | 2004-10-07 | 2013-10-01 | Boehringer Ingelheim International Gmbh | Tricyclic thiazole derivatives as pi3 kinases |
| TWI444187B (zh) * | 2005-01-25 | 2014-07-11 | Synta Pharmaceuticals Corp | 用於炎症及免疫相關用途之噻吩化合物 |
| JP2009524677A (ja) * | 2006-01-25 | 2009-07-02 | シンタ ファーマシューティカルズ コーポレーション | 炎症および免疫関連使用用のチアゾールおよびチアジアゾール化合物 |
| US7659281B2 (en) * | 2006-04-25 | 2010-02-09 | Bristol-Myers Squibb Company | HMG-CoA reductase inhibitors |
| US8779154B2 (en) * | 2006-09-26 | 2014-07-15 | Qinglin Che | Fused ring compounds for inflammation and immune-related uses |
-
2009
- 2009-01-07 US US12/811,402 patent/US20110052643A1/en not_active Abandoned
- 2009-01-07 CA CA2711644A patent/CA2711644A1/en not_active Abandoned
- 2009-01-07 JP JP2010541599A patent/JP2011509261A/ja active Pending
- 2009-01-07 EP EP09701319A patent/EP2240029A4/en not_active Withdrawn
- 2009-01-07 AU AU2009204147A patent/AU2009204147A1/en not_active Abandoned
- 2009-01-07 WO PCT/US2009/030367 patent/WO2009089305A1/en not_active Ceased