JP2011509146A5 - - Google Patents

Info

Publication number

JP2011509146A5

JP2011509146A5 JP2010542246A JP2010542246A JP2011509146A5 JP 2011509146 A5 JP2011509146 A5 JP 2011509146A5 JP 2010542246 A JP2010542246 A JP 2010542246A JP 2010542246 A JP2010542246 A JP 2010542246A JP 2011509146 A5 JP2011509146 A5 JP 2011509146A5

Authority

JP

Japan

Prior art keywords

granular particles

agents

drug delivery

tack coat

therapeutic agent

Prior art date

2008-12-22

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
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• 239000002245 particle Substances 0.000 claims description 10
• 150000003839 salts Chemical class 0.000 claims description 2
• 238000000034 method Methods 0.000 claims 8
• 238000012377 drug delivery Methods 0.000 claims 6
• 229920001971 elastomer Polymers 0.000 claims 6
• 239000000806 elastomer Substances 0.000 claims 6
• 239000011148 porous material Substances 0.000 claims 6
• 239000003814 drug Substances 0.000 claims 5
• 229940124597 therapeutic agent Drugs 0.000 claims 5
• 239000003795 chemical substances by application Substances 0.000 claims 3
• 239000002260 anti-inflammatory agent Substances 0.000 claims 2
• 230000001028 anti-proliverative effect Effects 0.000 claims 2
• 239000003146 anticoagulant agent Substances 0.000 claims 2
• JYGXADMDTFJGBT-VWUMJDOOSA-N hydrocortisone Chemical compound O=C1CC[C@]2(C)[C@H]3[C@@H](O)C[C@](C)([C@@](CC4)(O)C(=O)CO)[C@@H]4[C@@H]3CCC2=C1 JYGXADMDTFJGBT-VWUMJDOOSA-N 0.000 claims 2
• YGSDEFSMJLZEOE-UHFFFAOYSA-N salicylic acid Chemical compound OC(=O)C1=CC=CC=C1O YGSDEFSMJLZEOE-UHFFFAOYSA-N 0.000 claims 2
• HKVAMNSJSFKALM-GKUWKFKPSA-N Everolimus Chemical compound C1C[C@@H](OCCO)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 HKVAMNSJSFKALM-GKUWKFKPSA-N 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 229940121363 anti-inflammatory agent Drugs 0.000 claims 1
• 229940124599 anti-inflammatory drug Drugs 0.000 claims 1
• 229940127090 anticoagulant agent Drugs 0.000 claims 1
• 239000002246 antineoplastic agent Substances 0.000 claims 1
• 229940127218 antiplatelet drug Drugs 0.000 claims 1
• 229960004676 antithrombotic agent Drugs 0.000 claims 1
• 230000003115 biocidal effect Effects 0.000 claims 1
• 239000003246 corticosteroid Substances 0.000 claims 1
• 229960001334 corticosteroids Drugs 0.000 claims 1
• 229960003957 dexamethasone Drugs 0.000 claims 1
• UREBDLICKHMUKA-CXSFZGCWSA-N dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims 1
• 238000007598 dipping method Methods 0.000 claims 1
• 229960005167 everolimus Drugs 0.000 claims 1
• 239000012530 fluid Substances 0.000 claims 1
• 229960001347 fluocinolone acetonide Drugs 0.000 claims 1
• FEBLZLNTKCEFIT-VSXGLTOVSA-N fluocinolone acetonide Chemical compound C1([C@@H](F)C2)=CC(=O)C=C[C@]1(C)[C@]1(F)[C@@H]2[C@@H]2C[C@H]3OC(C)(C)O[C@@]3(C(=O)CO)[C@@]2(C)C[C@@H]1O FEBLZLNTKCEFIT-VSXGLTOVSA-N 0.000 claims 1
• 229960000890 hydrocortisone Drugs 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• FJKROLUGYXJWQN-UHFFFAOYSA-N papa-hydroxy-benzoic acid Natural products OC(=O)C1=CC=C(O)C=C1 FJKROLUGYXJWQN-UHFFFAOYSA-N 0.000 claims 1
• KASDHRXLYQOAKZ-ZPSXYTITSA-N pimecrolimus Chemical compound C/C([C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@]2(O)O[C@@H]([C@H](C[C@H]2C)OC)[C@@H](OC)C[C@@H](C)C/C(C)=C/[C@H](C(C[C@H](O)[C@H]1C)=O)CC)=C\[C@@H]1CC[C@@H](Cl)[C@H](OC)C1 KASDHRXLYQOAKZ-ZPSXYTITSA-N 0.000 claims 1
• 229960005330 pimecrolimus Drugs 0.000 claims 1
• 239000000106 platelet aggregation inhibitor Substances 0.000 claims 1
• ZAHRKKWIAAJSAO-UHFFFAOYSA-N rapamycin Natural products COCC(O)C(=C/C(C)C(=O)CC(OC(=O)C1CCCCN1C(=O)C(=O)C2(O)OC(CC(OC)C(=CC=CC=CC(C)CC(C)C(=O)C)C)CCC2C)C(C)CC3CCC(O)C(C3)OC)C ZAHRKKWIAAJSAO-UHFFFAOYSA-N 0.000 claims 1
• 229960004889 salicylic acid Drugs 0.000 claims 1
• QFJCIRLUMZQUOT-HPLJOQBZSA-N sirolimus Chemical compound C1C[C@@H](O)[C@H](OC)C[C@@H]1C[C@@H](C)[C@H]1OC(=O)[C@@H]2CCCCN2C(=O)C(=O)[C@](O)(O2)[C@H](C)CC[C@H]2C[C@H](OC)/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C1 QFJCIRLUMZQUOT-HPLJOQBZSA-N 0.000 claims 1
• 229960002930 sirolimus Drugs 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 208000019553 vascular disease Diseases 0.000 claims 1
• CGTADGCBEXYWNE-JUKNQOCSSA-N zotarolimus Chemical compound N1([C@H]2CC[C@@H](C[C@@H](C)[C@H]3OC(=O)[C@@H]4CCCCN4C(=O)C(=O)[C@@]4(O)[C@H](C)CC[C@H](O4)C[C@@H](/C(C)=C/C=C/C=C/[C@@H](C)C[C@@H](C)C(=O)[C@H](OC)[C@H](O)/C(C)=C/[C@@H](C)C(=O)C3)OC)C[C@H]2OC)C=NN=N1 CGTADGCBEXYWNE-JUKNQOCSSA-N 0.000 claims 1
• 229950009819 zotarolimus Drugs 0.000 claims 1
• 229920000642 polymer Polymers 0.000 description 4
• BASFCYQUMIYNBI-UHFFFAOYSA-N platinum Chemical compound [Pt] BASFCYQUMIYNBI-UHFFFAOYSA-N 0.000 description 2
• 238000003618 dip coating Methods 0.000 description 1
• 238000001035 drying Methods 0.000 description 1
• 229910052697 platinum Inorganic materials 0.000 description 1