JP2011507856A5 - - Google Patents
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- Publication number
- JP2011507856A5 JP2011507856A5 JP2010539512A JP2010539512A JP2011507856A5 JP 2011507856 A5 JP2011507856 A5 JP 2011507856A5 JP 2010539512 A JP2010539512 A JP 2010539512A JP 2010539512 A JP2010539512 A JP 2010539512A JP 2011507856 A5 JP2011507856 A5 JP 2011507856A5
- Authority
- JP
- Japan
- Prior art keywords
- connexin
- medicament
- composition
- medicament according
- agent
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Withdrawn
Links
- 239000003814 drug Substances 0.000 claims description 79
- 238000000034 method Methods 0.000 claims description 75
- 239000000203 mixture Substances 0.000 claims description 66
- 239000003795 chemical substances by application Substances 0.000 claims description 64
- 108091033319 polynucleotide Proteins 0.000 claims description 32
- 102000040430 polynucleotide Human genes 0.000 claims description 32
- 239000002157 polynucleotide Substances 0.000 claims description 32
- 239000012634 fragment Substances 0.000 claims description 21
- 102000001045 Connexin 43 Human genes 0.000 claims description 18
- 108010069241 Connexin 43 Proteins 0.000 claims description 18
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 16
- 108091034117 Oligonucleotide Proteins 0.000 claims description 14
- 230000000399 orthopedic effect Effects 0.000 claims description 14
- 238000001356 surgical procedure Methods 0.000 claims description 9
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims description 8
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims description 8
- 108091030071 RNAI Proteins 0.000 claims description 8
- 108020004459 Small interfering RNA Proteins 0.000 claims description 8
- 229940044684 anti-microtubule agent Drugs 0.000 claims description 8
- 230000008568 cell cell communication Effects 0.000 claims description 8
- 150000001875 compounds Chemical class 0.000 claims description 8
- 230000009368 gene silencing by RNA Effects 0.000 claims description 8
- 239000000816 peptidomimetic Substances 0.000 claims description 8
- 229940124597 therapeutic agent Drugs 0.000 claims description 8
- 230000029663 wound healing Effects 0.000 claims description 8
- 230000002159 abnormal effect Effects 0.000 claims description 6
- 239000000074 antisense oligonucleotide Substances 0.000 claims description 6
- 238000012230 antisense oligonucleotides Methods 0.000 claims description 6
- 230000009772 tissue formation Effects 0.000 claims description 6
- 239000000427 antigen Substances 0.000 claims description 4
- 102000036639 antigens Human genes 0.000 claims description 4
- 108091007433 antigens Proteins 0.000 claims description 4
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims description 4
- 206010023201 Joint contracture Diseases 0.000 claims description 2
- 208000027418 Wounds and injury Diseases 0.000 claims description 2
- 230000000692 anti-sense effect Effects 0.000 claims description 2
- 230000006378 damage Effects 0.000 claims description 2
- 201000010099 disease Diseases 0.000 claims description 2
- 208000035475 disorder Diseases 0.000 claims description 2
- 208000014674 injury Diseases 0.000 claims description 2
- 238000011084 recovery Methods 0.000 claims description 2
- 239000000825 pharmaceutical preparation Substances 0.000 claims 3
- 229940079593 drug Drugs 0.000 claims 1
- 230000004899 motility Effects 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US866007P | 2007-12-21 | 2007-12-21 | |
| PCT/US2008/014020 WO2009085269A2 (en) | 2007-12-21 | 2008-12-22 | Use of anti-connexin polynucleotides, peptides or antibodies for the treatment of orthopedic conditions |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014124291A Division JP2014169330A (ja) | 2007-12-21 | 2014-06-17 | 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011507856A JP2011507856A (ja) | 2011-03-10 |
| JP2011507856A5 true JP2011507856A5 (enExample) | 2013-04-25 |
Family
ID=40824954
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010539512A Withdrawn JP2011507856A (ja) | 2007-12-21 | 2008-12-22 | 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用 |
| JP2014124291A Withdrawn JP2014169330A (ja) | 2007-12-21 | 2014-06-17 | 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用 |
| JP2016169310A Pending JP2017025076A (ja) | 2007-12-21 | 2016-08-31 | 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014124291A Withdrawn JP2014169330A (ja) | 2007-12-21 | 2014-06-17 | 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用 |
| JP2016169310A Pending JP2017025076A (ja) | 2007-12-21 | 2016-08-31 | 整形外科状態の治療のための抗コネキシンポリヌクレオチド、ペプチド、または抗体の使用 |
Country Status (6)
| Country | Link |
|---|---|
| US (1) | US20110217313A1 (enExample) |
| EP (1) | EP2238250B1 (enExample) |
| JP (3) | JP2011507856A (enExample) |
| AU (1) | AU2008343840A1 (enExample) |
| CA (1) | CA2710375A1 (enExample) |
| WO (1) | WO2009085269A2 (enExample) |
Families Citing this family (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AU2006257283A1 (en) | 2005-02-03 | 2006-12-21 | Coda Therapeutics Limited | Anti-connexin compounds and uses thereof |
| JP2011507857A (ja) | 2007-12-21 | 2011-03-10 | コーダ セラピューティクス， インコーポレイテッド | 線維症性の状態の処置のためのコネキシン４３の阻害剤の使用 |
| JP6185937B2 (ja) | 2012-03-01 | 2017-08-23 | ファーストストリング・リサーチ・インコーポレイテッドＦｉｒｓｔｓｔｒｉｎｇ Ｒｅｓｅａｒｃｈ，Ｉｎｃ． | アルファコネキシンｃ末端（ａｃｔ）ペプチド含有局所用ゲル剤 |
| JP2015513905A (ja) | 2012-03-27 | 2015-05-18 | コーダ セラピューティクス， インコーポレイテッド | カドヘリン調節に基づく組成物および処置 |
| US10465188B2 (en) | 2014-08-22 | 2019-11-05 | Auckland Uniservices Limited | Channel modulators |
| CN109414475A (zh) * | 2016-05-03 | 2019-03-01 | 奥克兰大学 | 新型肽和肽模拟物 |
| WO2018199777A1 (en) | 2017-04-28 | 2018-11-01 | Auckland Uniservices Limited | Methods of treatment and novel constructs |
| CN116710474A (zh) | 2020-10-22 | 2023-09-05 | 撒凯尔生物公司 | 肽制剂及其眼科用途 |
| WO2022103636A1 (en) * | 2020-11-16 | 2022-05-19 | Orcosa Inc. | Improved use of cannabinoids in the treatment of alzheimer's disease |
| US11672761B2 (en) | 2020-11-16 | 2023-06-13 | Orcosa Inc. | Rapidly infusing platform and compositions for therapeutic treatment in humans |
Family Cites Families (19)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4861757A (en) * | 1986-11-14 | 1989-08-29 | Institute Of Molecular Biology | Wound healing and bone regeneration using PDGF and IGF-I |
| US5004810A (en) * | 1988-09-30 | 1991-04-02 | Schering Corporation | Antiviral oligomers |
| US5166195A (en) * | 1990-05-11 | 1992-11-24 | Isis Pharmaceuticals, Inc. | Antisense inhibitors of the human immunodeficiency virus phosphorothioate oligonucleotides |
| GB9206861D0 (en) * | 1992-03-28 | 1992-05-13 | Univ Manchester | Wound healing and treatment of fibrotic disorders |
| US6566339B1 (en) * | 1995-08-04 | 2003-05-20 | Renovo Limited | Pharmaceutical composition |
| GB2304047A (en) * | 1995-08-09 | 1997-03-12 | Univ Manchester | Pharmaceutical compositions containing cytokines |
| EP1486565B1 (en) * | 1995-10-11 | 2007-11-21 | Novartis Vaccines and Diagnostics, Inc. | Combination of PDGF, KGF, IGF, and IGFBP for wound healing |
| EP1506775A1 (en) * | 1996-07-22 | 2005-02-16 | Renovo Limited | Use of sex steroid function modulators to treat wounds and fibrotic disorders |
| GB9702943D0 (en) * | 1997-02-13 | 1997-04-02 | Univ Manchester | Wound healing |
| US6855505B2 (en) * | 1998-06-26 | 2005-02-15 | Renovo Limited | Method for quantifying TGF-β |
| ATE533515T1 (de) * | 1999-01-27 | 2011-12-15 | Coda Therapeutics Inc | Formulierungen enthaltend antisense nukleotide spezifisch für connexine |
| GB9903598D0 (en) * | 1999-02-18 | 1999-04-07 | Univ Manchester | Connective tissue healing |
| US7250397B2 (en) * | 2000-02-23 | 2007-07-31 | Zealand Pharma A/S | Antiarrhythmic peptides |
| JP2005516054A (ja) * | 2002-01-29 | 2005-06-02 | ワイス | コネキシンヘミチャンネルを調節する組成物及びその方法 |
| AU2005210668A1 (en) * | 2004-01-30 | 2005-08-18 | Angiotech International Ag | Compositions and methods for treating contracture |
| AU2006257283A1 (en) * | 2005-02-03 | 2006-12-21 | Coda Therapeutics Limited | Anti-connexin compounds and uses thereof |
| EP1890727B1 (en) * | 2005-05-25 | 2012-10-03 | CaloSyn Pharma, Inc | Method and composition for treating osteoarthritis |
| US7767710B2 (en) * | 2005-05-25 | 2010-08-03 | Calosyn Pharma, Inc. | Method for treating osteoarthritis |
| WO2009085271A2 (en) * | 2007-12-21 | 2009-07-09 | Coda Therapeutics, Inc. | Use of anti-connexin peptides, alone or in combination with anti-connexin polynucleotides, for the treatment of orthopedic conditions |
-
2008
- 2008-12-22 AU AU2008343840A patent/AU2008343840A1/en not_active Abandoned
- 2008-12-22 JP JP2010539512A patent/JP2011507856A/ja not_active Withdrawn
- 2008-12-22 CA CA2710375A patent/CA2710375A1/en not_active Abandoned
- 2008-12-22 WO PCT/US2008/014020 patent/WO2009085269A2/en not_active Ceased
- 2008-12-22 US US12/809,902 patent/US20110217313A1/en not_active Abandoned
- 2008-12-22 EP EP08866608.6A patent/EP2238250B1/en not_active Not-in-force
-
2014
- 2014-06-17 JP JP2014124291A patent/JP2014169330A/ja not_active Withdrawn
-
2016
- 2016-08-31 JP JP2016169310A patent/JP2017025076A/ja active Pending
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