JP2011506276A5 - - Google Patents

Info

Publication number

JP2011506276A5

JP2011506276A5 JP2010535434A JP2010535434A JP2011506276A5 JP 2011506276 A5 JP2011506276 A5 JP 2011506276A5 JP 2010535434 A JP2010535434 A JP 2010535434A JP 2010535434 A JP2010535434 A JP 2010535434A JP 2011506276 A5 JP2011506276 A5 JP 2011506276A5

Authority

JP

Japan

Prior art keywords

active agent

derivative

derivative according

nanoparticles

solubility

Prior art date

2008-11-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

• Espacenet
• Global Dossier
• Discuss

• 239000013543 active substance Substances 0.000 claims 12
• 239000002105 nanoparticle Substances 0.000 claims 9
• XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 5
• 150000001875 compounds Chemical class 0.000 claims 4
• 239000004215 Carbon black (E152) Substances 0.000 claims 3
• 229930195733 hydrocarbon Natural products 0.000 claims 3
• AOJJSUZBOXZQNB-TZSSRYMLSA-N Doxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-TZSSRYMLSA-N 0.000 claims 2
• 239000003242 anti bacterial agent Substances 0.000 claims 2
• 239000002246 antineoplastic agent Substances 0.000 claims 2
• 239000008346 aqueous phase Substances 0.000 claims 2
• 238000002512 chemotherapy Methods 0.000 claims 2
• 150000002430 hydrocarbons Chemical class 0.000 claims 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 claims 2
• 108090000765 processed proteins & peptides Proteins 0.000 claims 2
• 239000000126 substance Substances 0.000 claims 2
• AOJJSUZBOXZQNB-VTZDEGQISA-N 4'-epidoxorubicin Chemical compound O([C@H]1C[C@@](O)(CC=2C(O)=C3C(=O)C=4C=CC=C(C=4C(=O)C3=C(O)C=21)OC)C(=O)CO)[C@H]1C[C@H](N)[C@@H](O)[C@H](C)O1 AOJJSUZBOXZQNB-VTZDEGQISA-N 0.000 claims 1
• 108090000312 Calcium Channels Proteins 0.000 claims 1
• 102000003922 Calcium Channels Human genes 0.000 claims 1
• HTIJFSOGRVMCQR-UHFFFAOYSA-N Epirubicin Natural products COc1cccc2C(=O)c3c(O)c4CC(O)(CC(OC5CC(N)C(=O)C(C)O5)c4c(O)c3C(=O)c12)C(=O)CO HTIJFSOGRVMCQR-UHFFFAOYSA-N 0.000 claims 1
• 102000004877 Insulin Human genes 0.000 claims 1
• 108090001061 Insulin Proteins 0.000 claims 1
• 229930012538 Paclitaxel Natural products 0.000 claims 1
• 239000004721 Polyphenylene oxide Substances 0.000 claims 1
• 229940123237 Taxane Drugs 0.000 claims 1
• 125000003275 alpha amino acid group Chemical group 0.000 claims 1
• 239000004037 angiogenesis inhibitor Substances 0.000 claims 1
• 229940121369 angiogenesis inhibitor Drugs 0.000 claims 1
• 229940088710 antibiotic agent Drugs 0.000 claims 1
• 239000003096 antiparasitic agent Substances 0.000 claims 1
• 229940125687 antiparasitic agent Drugs 0.000 claims 1
• 239000003443 antiviral agent Substances 0.000 claims 1
• 230000015572 biosynthetic process Effects 0.000 claims 1
• 150000001720 carbohydrates Chemical class 0.000 claims 1
• 239000003795 chemical substances by application Substances 0.000 claims 1
• 239000006185 dispersion Substances 0.000 claims 1
• 229960004679 doxorubicin Drugs 0.000 claims 1
• 229960001904 epirubicin Drugs 0.000 claims 1
• 229960003444 immunosuppressant agent Drugs 0.000 claims 1
• 239000003018 immunosuppressive agent Substances 0.000 claims 1
• 229940125396 insulin Drugs 0.000 claims 1
• 230000037356 lipid metabolism Effects 0.000 claims 1
• 238000004519 manufacturing process Methods 0.000 claims 1
• 238000000034 method Methods 0.000 claims 1
• 239000000203 mixture Substances 0.000 claims 1
• 239000000041 non-steroidal anti-inflammatory agent Substances 0.000 claims 1
• 229940021182 non-steroidal anti-inflammatory drug Drugs 0.000 claims 1
• 239000003960 organic solvent Substances 0.000 claims 1
• 229960001592 paclitaxel Drugs 0.000 claims 1
• 239000008194 pharmaceutical composition Substances 0.000 claims 1
• 229920000570 polyether Polymers 0.000 claims 1
• 229920001223 polyethylene glycol Polymers 0.000 claims 1
• 229920005862 polyol Polymers 0.000 claims 1
• 150000003077 polyols Chemical class 0.000 claims 1
• 102000004196 processed proteins & peptides Human genes 0.000 claims 1
• YYGNTYWPHWGJRM-AAJYLUCBSA-N squalene group Chemical group CC(C)=CCC\C(\C)=C\CC\C(\C)=C\CC\C=C(/C)\CC\C=C(/C)\CCC=C(C)C YYGNTYWPHWGJRM-AAJYLUCBSA-N 0.000 claims 1
• 238000003756 stirring Methods 0.000 claims 1
• 235000000346 sugar Nutrition 0.000 claims 1
• 150000008163 sugars Chemical class 0.000 claims 1
• RCINICONZNJXQF-MZXODVADSA-N taxol Chemical compound O([C@@H]1[C@@]2(C[C@@H](C(C)=C(C2(C)C)[C@H](C([C@]2(C)[C@@H](O)C[C@H]3OC[C@]3([C@H]21)OC(C)=O)=O)OC(=O)C)OC(=O)[C@H](O)[C@@H](NC(=O)C=1C=CC=CC=1)C=1C=CC=CC=1)O)C(=O)C1=CC=CC=C1 RCINICONZNJXQF-MZXODVADSA-N 0.000 claims 1
• 230000001225 therapeutic effect Effects 0.000 claims 1
• PMRIGTXNHCHDGS-VWQVGJBMSA-N CC(C(C(C1)NC(CCC(C)(C)CCC/C(/C)=C/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)=O)O)OC1O[C@H](C[C@@](Cc1c(c(C(c2cccc(OC)c22)=O)c3C2=O)O)(C(CO)=O)O)c1c3O Chemical compound CC(C(C(C1)NC(CCC(C)(C)CCC/C(/C)=C/CC/C=C(\C)/CC/C=C(\C)/CCC=C(C)C)=O)O)OC1O[C@H](C[C@@](Cc1c(c(C(c2cccc(OC)c22)=O)c3C2=O)O)(C(CO)=O)O)c1c3O PMRIGTXNHCHDGS-VWQVGJBMSA-N 0.000 description 1