JP2011506274A - ファスチンを阻害するための方法 - Google Patents

ファスチンを阻害するための方法 Download PDF

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JP2011506274A
JP2011506274A JP2010534970A JP2010534970A JP2011506274A JP 2011506274 A JP2011506274 A JP 2011506274A JP 2010534970 A JP2010534970 A JP 2010534970A JP 2010534970 A JP2010534970 A JP 2010534970A JP 2011506274 A JP2011506274 A JP 2011506274A
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fastin
cancer
actin
inhibitor
thr318
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JP2011506274A5 (https=
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シン−ユン ファン，
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Cornell University
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Cornell University
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    • A61K31/35—Heterocyclic compounds having oxygen as the only ring hetero atom, e.g. fungichromin having six-membered rings with one oxygen as the only ring hetero atom
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    • A61P35/02—Antineoplastic agents specific for leukemia
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
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    • A61P9/00—Drugs for disorders of the cardiovascular system
    • A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
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    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/11—DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • C12N15/113—Non-coding nucleic acids modulating the expression of genes, e.g. antisense oligonucleotides; Antisense DNA or RNA; Triplex- forming oligonucleotides; Catalytic nucleic acids, e.g. ribozymes; Nucleic acids used in co-suppression or gene silencing
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    • C12N2310/00—Structure or type of the nucleic acid
    • C12N2310/10—Type of nucleic acid
    • C12N2310/14—Type of nucleic acid interfering nucleic acids [NA]

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  • Biotechnology (AREA)
  • Immunology (AREA)
  • Microbiology (AREA)
  • Neurology (AREA)
  • Neurosurgery (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biochemistry (AREA)
  • Physics & Mathematics (AREA)
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  • Plant Pathology (AREA)
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JP2010534970A 2007-11-21 2008-11-21 ファスチンを阻害するための方法 Withdrawn JP2011506274A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US98960907P 2007-11-21 2007-11-21
PCT/US2008/012988 WO2009070244A2 (en) 2007-11-21 2008-11-21 Methods for inhibiting fascin

Publications (2)

Publication Number Publication Date
JP2011506274A true JP2011506274A (ja) 2011-03-03
JP2011506274A5 JP2011506274A5 (https=) 2012-11-29

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ID=40679192

Family Applications (1)

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JP2010534970A Withdrawn JP2011506274A (ja) 2007-11-21 2008-11-21 ファスチンを阻害するための方法

Country Status (6)

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US (2) US20100297109A1 (https=)
EP (1) EP2222343A4 (https=)
JP (1) JP2011506274A (https=)
CN (1) CN101918036A (https=)
CA (1) CA2707009A1 (https=)
WO (1) WO2009070244A2 (https=)

Families Citing this family (15)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP4928937B2 (ja) 2003-03-28 2012-05-09 スローン−ケッタリング・インスティテュート・フォー・キャンサー・リサーチ ミグラスタチンアナログおよびその使用
WO2006001967A2 (en) 2004-05-25 2006-01-05 Sloan-Kettering Institute For Cancer Research Migrastatin analogs in the treatment of cancer
US8188141B2 (en) 2004-09-23 2012-05-29 Sloan-Kettering Institute For Cancer Research Isomigrastatin analogs in the treatment of cancer
JP5744560B2 (ja) * 2011-02-21 2015-07-08 シーシーアイ株式会社 ファスシン（Ｆａｓｃｉｎ）遺伝子の働きを抑える短鎖ＲＮＡを含有する癌の予防、治療剤
AU2012239977B9 (en) 2011-04-07 2016-11-17 Sloan-Kettering Institute For Cancer Research Migrastatins and uses thereof
JP5806168B2 (ja) * 2012-06-19 2015-11-10 国立大学法人 岡山大学 抗浸潤薬の新規スクリーニング法
CA3139033A1 (en) 2012-08-22 2014-02-27 Cornell University Methods for inhibiting fascin
CN111349087B (zh) 2014-02-20 2023-07-14 康奈尔大学 用于抑制肌成束蛋白的化合物和方法
JP7231551B2 (ja) * 2017-02-24 2023-03-01 フラグシップ パイオニアリング イノベーションズ ブイ，インコーポレーテッド 内部共生体を調節するための組成物及び関連方法
CN107446949A (zh) * 2017-07-25 2017-12-08 国家纳米科学中心 Pls3重组蛋白真核表达质粒及其构建方法和应用
EP3713570A4 (en) * 2017-11-22 2021-08-04 Cornell University CO THERAPIES WITH A METASTASIS INHIBITOR
CN112080499A (zh) * 2020-08-12 2020-12-15 南京医科大学 一种降低fascin-1基因表达的siRNA及其应用
GB202012761D0 (en) * 2020-08-14 2020-09-30 Univ Oxford Brookes Metastatis treatment or prevention
CN111944812A (zh) * 2020-08-17 2020-11-17 南通大学 靶向Fascin基因的siRNA分子及其应用
CN112243955B (zh) * 2020-10-23 2022-09-30 中国医学科学院北京协和医院 新型pls3基因敲除大鼠动物模型的构建方法和应用

Family Cites Families (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US20030194702A1 (en) * 2000-12-22 2003-10-16 Engelhard Eric K. Novel compositions and methods for cancer
WO2006001967A2 (en) * 2004-05-25 2006-01-05 Sloan-Kettering Institute For Cancer Research Migrastatin analogs in the treatment of cancer
WO2006074367A2 (en) * 2005-01-05 2006-07-13 Sloan-Kettering Institute For Cancer Research Method of predicting and reducing risk of metastasis of breast cancer to lung
US7829066B2 (en) * 2006-12-27 2010-11-09 Memorial Sloan-Kettering Cancer Center Assay for anti-metastatic agents

Also Published As

Publication number Publication date
EP2222343A2 (en) 2010-09-01
CA2707009A1 (en) 2009-06-04
WO2009070244A2 (en) 2009-06-04
WO2009070244A3 (en) 2009-11-05
US20100297109A1 (en) 2010-11-25
EP2222343A4 (en) 2012-03-14
US20130259857A1 (en) 2013-10-03
CN101918036A (zh) 2010-12-15

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