JP2011505336A5 - - Google Patents
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- Publication number
- JP2011505336A5 JP2011505336A5 JP2010532071A JP2010532071A JP2011505336A5 JP 2011505336 A5 JP2011505336 A5 JP 2011505336A5 JP 2010532071 A JP2010532071 A JP 2010532071A JP 2010532071 A JP2010532071 A JP 2010532071A JP 2011505336 A5 JP2011505336 A5 JP 2011505336A5
- Authority
- JP
- Japan
- Prior art keywords
- azacytidine
- pharmaceutical composition
- composition according
- aza
- deoxy
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Applications Claiming Priority (6)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98463807P | 2007-11-01 | 2007-11-01 | |
| US99278107P | 2007-12-06 | 2007-12-06 | |
| US3409308P | 2008-03-05 | 2008-03-05 | |
| US8606908P | 2008-08-04 | 2008-08-04 | |
| US9085208P | 2008-08-21 | 2008-08-21 | |
| PCT/US2008/012430 WO2009058394A1 (en) | 2007-11-01 | 2008-11-03 | Cytidine analogs for treatment of myelodysplastic syndromes |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011505336A JP2011505336A (ja) | 2011-02-24 |
| JP2011505336A5 true JP2011505336A5 (cg-RX-API-DMAC10.html) | 2011-12-22 |
Family
ID=40367738
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010532071A Pending JP2011505336A (ja) | 2007-11-01 | 2008-11-03 | 骨髄異形成症候群治療のためのシチジンアナログ |
Country Status (5)
| Country | Link |
|---|---|
| US (1) | US20100311683A1 (cg-RX-API-DMAC10.html) |
| EP (1) | EP2211870A1 (cg-RX-API-DMAC10.html) |
| JP (1) | JP2011505336A (cg-RX-API-DMAC10.html) |
| CA (1) | CA2742252A1 (cg-RX-API-DMAC10.html) |
| WO (1) | WO2009058394A1 (cg-RX-API-DMAC10.html) |
Families Citing this family (20)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8404716B2 (en) | 2002-10-15 | 2013-03-26 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US11116782B2 (en) | 2002-10-15 | 2021-09-14 | Celgene Corporation | Methods of treating myelodysplastic syndromes with a combination therapy using lenalidomide and azacitidine |
| US6887855B2 (en) | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
| US6943249B2 (en) * | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
| AU2004289539C1 (en) | 2003-11-14 | 2012-06-07 | Lorus Therapeutics Inc. | Aryl imidazoles and their use as anti-cancer agents |
| DK3782612T3 (da) | 2008-05-15 | 2024-01-15 | Celgene Corp | Orale formuleringer af cytidinanaloger og fremgangsmåder til anvendelse deraf |
| EP2396007A1 (en) | 2009-02-10 | 2011-12-21 | Celgene International Sarl | Methods for treating non-small cell lung cancer using 5-azacytidine |
| WO2012135405A1 (en) | 2011-03-31 | 2012-10-04 | Pharmion Llc | Systhesis of 5-azacytidine |
| WO2013022872A1 (en) * | 2011-08-10 | 2013-02-14 | Celgene Corporation | Gene methylation biomarkers and methods of use thereof |
| JP6162709B2 (ja) | 2011-11-01 | 2017-07-12 | セルジーン コーポレイション | シチジンアナログの経口製剤を使用して癌を治療する方法 |
| PL2773360T3 (pl) | 2011-11-03 | 2018-09-28 | Millennium Pharmaceuticals, Inc. | Podawanie inhibitora enzymu aktywującego NEDD8 i środka hipometylującego |
| US9493500B2 (en) * | 2012-07-19 | 2016-11-15 | Richard Daifuku | Fluorinated pyrimidine analogs and methods of use thereof |
| EP2970359B1 (en) * | 2013-03-15 | 2021-04-07 | Epigenetics Pharma LLC | Fluorinated pyrimidine analogs and methods of use thereof |
| EP3052102B1 (en) * | 2013-10-04 | 2019-12-04 | Aptose Biosciences Inc. | Compositions for treating cancers |
| AU2015305449B2 (en) | 2014-08-22 | 2021-05-06 | Celgene Corporation | Methods of treating multiple myeloma with immunomodulatory compounds in combination with antibodies |
| EP3419631A4 (en) * | 2016-02-26 | 2019-12-04 | Epigenetics Pharma, LLC | METHOD OF TREATING WILD TYPE TP53 TUMORS USING 2 ', 2'-DIFLUORO-5-AZA-2'-DEOXYCYTIDINE OR PRODRUGS THEREOF |
| WO2017189647A1 (en) * | 2016-04-26 | 2017-11-02 | Memorial Sloan Kettering Cancer Center | Methods and compositions for the treatment of myelodysplastic syndrome |
| JP2021501203A (ja) | 2017-10-30 | 2021-01-14 | アプトース バイオサイエンシズ インコーポレイテッド | がん治療用のアリールイミダゾール |
| GB201917899D0 (en) * | 2019-12-06 | 2020-01-22 | Nanexa Ab | New composition |
| CA3199623A1 (en) * | 2020-10-27 | 2022-05-05 | Vor Biopharma Inc. | Compositions and methods for treating hematopoietic malignancy |
Family Cites Families (23)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US5641758A (en) * | 1993-11-10 | 1997-06-24 | Kluge; Michael | Cytarabine derivatives, the preparation and use thereof |
| US6096757A (en) * | 1998-12-21 | 2000-08-01 | Schering Corporation | Method for treating proliferative diseases |
| WO2000055134A1 (en) * | 1999-03-18 | 2000-09-21 | Celgene Corporation | Substituted 1-oxo- and 1,3-dioxoisoindolines and their use in pharmaceutical compositions for reducing inflammatory cytokine levels |
| NZ522767A (en) * | 2000-05-15 | 2004-07-30 | Celgene Corp | Thalidomide and a topoisomerase inhibitor for the treatment of cancer |
| US6905669B2 (en) * | 2001-04-24 | 2005-06-14 | Supergen, Inc. | Compositions and methods for reestablishing gene transcription through inhibition of DNA methylation and histone deacetylase |
| US7393862B2 (en) * | 2002-05-17 | 2008-07-01 | Celgene Corporation | Method using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for treatment of certain leukemias |
| US7968569B2 (en) * | 2002-05-17 | 2011-06-28 | Celgene Corporation | Methods for treatment of multiple myeloma using 3-(4-amino-1-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione |
| MXPA04011851A (es) * | 2002-05-30 | 2005-03-31 | Celgene Corp | Metodos para utilizar inhibidores de jnk o mkk para modular diferenciacion de celula y para tratar desordenes mieloproliferativos y sindromes mielodispl??sticos. |
| MXPA05003889A (es) * | 2002-10-15 | 2005-06-22 | Celgene Corp | Farmacos inhibidores de citosina selectiva para tratar sindrome mielodisplastico. |
| US7189740B2 (en) * | 2002-10-15 | 2007-03-13 | Celgene Corporation | Methods of using 3-(4-amino-oxo-1,3-dihydro-isoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myelodysplastic syndromes |
| AU2003286836A1 (en) * | 2002-10-31 | 2004-06-07 | Supergen, Inc. | Pharmaceutical formulations targeting specific regions of the gastrointestinal tract |
| US8034831B2 (en) * | 2002-11-06 | 2011-10-11 | Celgene Corporation | Methods for the treatment and management of myeloproliferative diseases using 4-(amino)-2-(2,6-Dioxo(3-piperidyl)-isoindoline-1,3-dione in combination with other therapies |
| US7563810B2 (en) * | 2002-11-06 | 2009-07-21 | Celgene Corporation | Methods of using 3-(4-amino-1-oxo-1,3-dihydroisoindol-2-yl)-piperidine-2,6-dione for the treatment and management of myeloproliferative diseases |
| US20040152632A1 (en) * | 2002-11-06 | 2004-08-05 | Wyeth | Combination therapy for the treatment of acute leukemia and myelodysplastic syndrome |
| US6943249B2 (en) * | 2003-03-17 | 2005-09-13 | Ash Stevens, Inc. | Methods for isolating crystalline Form I of 5-azacytidine |
| US6887855B2 (en) * | 2003-03-17 | 2005-05-03 | Pharmion Corporation | Forms of 5-azacytidine |
| US20080213213A1 (en) * | 2004-04-14 | 2008-09-04 | Zeldis Jerome B | Method For the Treatment of Myelodysplastic Syndromes Using (+)-2-[1-(3-Ethoxy-4-Methoxyphenyl)-2-Methylsulfonylethyl]-4-Acetylaminoisoindoline-1,3-Dione |
| JP2007532641A (ja) * | 2004-04-14 | 2007-11-15 | セルジーン・コーポレーション | 脊髄形成異常症候群の治療及び管理のための免疫調節化合物の使用法、及びそれを含む組成物 |
| US20060128654A1 (en) * | 2004-12-10 | 2006-06-15 | Chunlin Tang | Pharmaceutical formulation of cytidine analogs and derivatives |
| EP2043633B1 (en) * | 2006-07-18 | 2016-07-06 | University of Rochester | Thiadiazolidinone derivatives for treating cancer |
| US8664272B2 (en) * | 2006-08-30 | 2014-03-04 | Temple University—Of the Commonwealth System of Higher Education | Composition and methods for the treatment of myelodysplastic syndrome and acute myeloid leukemia |
| WO2008028193A2 (en) * | 2006-09-01 | 2008-03-06 | Pharmion Corporation | Colon-targeted oral formulations of cytidine analogs |
| DK3782612T3 (da) * | 2008-05-15 | 2024-01-15 | Celgene Corp | Orale formuleringer af cytidinanaloger og fremgangsmåder til anvendelse deraf |
-
2008
- 2008-11-03 US US12/740,636 patent/US20100311683A1/en not_active Abandoned
- 2008-11-03 CA CA2742252A patent/CA2742252A1/en not_active Abandoned
- 2008-11-03 JP JP2010532071A patent/JP2011505336A/ja active Pending
- 2008-11-03 EP EP08845256A patent/EP2211870A1/en not_active Withdrawn
- 2008-11-03 WO PCT/US2008/012430 patent/WO2009058394A1/en not_active Ceased