JP2011505149A5 - - Google Patents
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- JP2011505149A5 JP2011505149A5 JP2010536193A JP2010536193A JP2011505149A5 JP 2011505149 A5 JP2011505149 A5 JP 2011505149A5 JP 2010536193 A JP2010536193 A JP 2010536193A JP 2010536193 A JP2010536193 A JP 2010536193A JP 2011505149 A5 JP2011505149 A5 JP 2011505149A5
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- Prior art keywords
- organism
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- halide
- gene
- organism according
- Prior art date
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- 238000000034 method Methods 0.000 claims description 55
- 229960001570 ademetionine Drugs 0.000 claims description 49
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 claims description 43
- 108090000623 proteins and genes Proteins 0.000 claims description 29
- 230000001965 increasing effect Effects 0.000 claims description 24
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims description 22
- -1 Methyl halide Chemical class 0.000 claims description 20
- 150000004820 halides Chemical class 0.000 claims description 19
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 15
- 241000894006 Bacteria Species 0.000 claims description 12
- 241000588724 Escherichia coli Species 0.000 claims description 12
- 108060004795 Methyltransferase Proteins 0.000 claims description 12
- 230000014509 gene expression Effects 0.000 claims description 12
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 11
- 229930182817 methionine Natural products 0.000 claims description 11
- 102000016397 Methyltransferase Human genes 0.000 claims description 10
- 241000235343 Saccharomycetales Species 0.000 claims description 10
- 230000003834 intracellular effect Effects 0.000 claims description 10
- 108010078791 Carrier Proteins Proteins 0.000 claims description 9
- 240000004062 Batis maritima Species 0.000 claims description 8
- 235000006469 Batis maritima Nutrition 0.000 claims description 8
- 239000001963 growth medium Substances 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 210000005253 yeast cell Anatomy 0.000 claims description 8
- 241000195493 Cryptophyta Species 0.000 claims description 7
- 101100023016 Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) mat gene Proteins 0.000 claims description 7
- 101150095438 metK gene Proteins 0.000 claims description 7
- 102000003960 Ligases Human genes 0.000 claims description 6
- 108090000364 Ligases Proteins 0.000 claims description 6
- 230000004048 modification Effects 0.000 claims description 6
- 238000012986 modification Methods 0.000 claims description 6
- 230000002018 overexpression Effects 0.000 claims description 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims description 6
- 241000233866 Fungi Species 0.000 claims description 5
- 108010043428 Glycine hydroxymethyltransferase Proteins 0.000 claims description 5
- 240000007594 Oryza sativa Species 0.000 claims description 5
- 235000007164 Oryza sativa Nutrition 0.000 claims description 5
- 102100021225 Serine hydroxymethyltransferase, cytosolic Human genes 0.000 claims description 5
- 230000001419 dependent effect Effects 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 241000219198 Brassica Species 0.000 claims description 4
- 235000011331 Brassica Nutrition 0.000 claims description 4
- 240000008100 Brassica rapa Species 0.000 claims description 4
- 235000011292 Brassica rapa Nutrition 0.000 claims description 4
- 201000007336 Cryptococcosis Diseases 0.000 claims description 4
- 241000221204 Cryptococcus neoformans Species 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 239000003054 catalyst Substances 0.000 claims description 4
- 238000009833 condensation Methods 0.000 claims description 4
- 230000005494 condensation Effects 0.000 claims description 4
- 235000003869 genetically modified organism Nutrition 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 claims description 4
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims description 3
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
- 102000005758 Adenosylmethionine decarboxylase Human genes 0.000 claims description 3
- 108010070753 Adenosylmethionine decarboxylase Proteins 0.000 claims description 3
- 101100290837 Bacillus subtilis (strain 168) metAA gene Proteins 0.000 claims description 3
- 101100076641 Bacillus subtilis (strain 168) metE gene Proteins 0.000 claims description 3
- 101100130094 Bacillus subtilis (strain 168) metK gene Proteins 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- 101710134307 Coproporphyrinogen III oxidase Proteins 0.000 claims description 3
- YPWSLBHSMIKTPR-UHFFFAOYSA-N Cystathionine Natural products OC(=O)C(N)CCSSCC(N)C(O)=O YPWSLBHSMIKTPR-UHFFFAOYSA-N 0.000 claims description 3
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims description 3
- ILRYLPWNYFXEMH-UHFFFAOYSA-N D-cystathionine Natural products OC(=O)C(N)CCSCC(N)C(O)=O ILRYLPWNYFXEMH-UHFFFAOYSA-N 0.000 claims description 3
- 101100322888 Escherichia coli (strain K12) metL gene Proteins 0.000 claims description 3
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims description 3
- 241000191005 Halorhodospira halophila Species 0.000 claims description 3
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims description 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 3
- ILRYLPWNYFXEMH-WHFBIAKZSA-N L-cystathionine Chemical compound [O-]C(=O)[C@@H]([NH3+])CCSC[C@H]([NH3+])C([O-])=O ILRYLPWNYFXEMH-WHFBIAKZSA-N 0.000 claims description 3
- 108020005196 Mitochondrial DNA Proteins 0.000 claims description 3
- 102100039270 Ribulose-phosphate 3-epimerase Human genes 0.000 claims description 3
- 108060007030 Ribulose-phosphate 3-epimerase Proteins 0.000 claims description 3
- 241000606701 Rickettsia Species 0.000 claims description 3
- 102000003929 Transaminases Human genes 0.000 claims description 3
- 108090000340 Transaminases Proteins 0.000 claims description 3
- 240000006365 Vitis vinifera Species 0.000 claims description 3
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 3
- 101150057540 aar gene Proteins 0.000 claims description 3
- 229960003767 alanine Drugs 0.000 claims description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 230000003197 catalytic effect Effects 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 239000001177 diphosphate Substances 0.000 claims description 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 3
- 235000011180 diphosphates Nutrition 0.000 claims description 3
- 239000011630 iodine Substances 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- 101150060102 metA gene Proteins 0.000 claims description 3
- 101150086633 metAA gene Proteins 0.000 claims description 3
- 101150091110 metAS gene Proteins 0.000 claims description 3
- 101150003180 metB gene Proteins 0.000 claims description 3
- 101150117293 metC gene Proteins 0.000 claims description 3
- 101150108178 metE gene Proteins 0.000 claims description 3
- 101150040895 metJ gene Proteins 0.000 claims description 3
- 101150043924 metXA gene Proteins 0.000 claims description 3
- 108010028584 nucleotidase Proteins 0.000 claims description 3
- 230000037361 pathway Effects 0.000 claims description 3
- 230000008685 targeting Effects 0.000 claims description 3
- 241000230562 Flavobacteriia Species 0.000 claims description 2
- 241000589925 Leptospirillum Species 0.000 claims description 2
- 241001261604 Maricaulis maris Species 0.000 claims description 2
- 241001221668 Ostreococcus tauri Species 0.000 claims description 2
- 241001343907 Paraburkholderia phymatum Species 0.000 claims description 2
- 241001348363 Robiginitalea Species 0.000 claims description 2
- 241001453296 Synechococcus elongatus Species 0.000 claims description 2
- 150000001299 aldehydes Chemical class 0.000 claims description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 2
- 150000001336 alkenes Chemical class 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 235000002532 grape seed extract Nutrition 0.000 claims description 2
- 230000002779 inactivation Effects 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 235000009518 sodium iodide Nutrition 0.000 claims description 2
- 210000003934 vacuole Anatomy 0.000 claims description 2
- 241001422920 Dechloromonas aromatica Species 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 108030006597 Methyl halide transferases Proteins 0.000 description 19
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 12
- 241000235648 Pichia Species 0.000 description 4
- 241000235058 Komagataella pastoris Species 0.000 description 3
- 241000235013 Yarrowia Species 0.000 description 3
- 238000012239 gene modification Methods 0.000 description 3
- 230000005017 genetic modification Effects 0.000 description 3
- 235000013617 genetically modified food Nutrition 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 241000219195 Arabidopsis thaliana Species 0.000 description 2
- 241000203069 Archaea Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- 235000011303 Brassica alboglabra Nutrition 0.000 description 2
- 240000007124 Brassica oleracea Species 0.000 description 2
- 235000011302 Brassica oleracea Nutrition 0.000 description 2
- 241001453380 Burkholderia Species 0.000 description 2
- 241000195585 Chlamydomonas Species 0.000 description 2
- 241000193403 Clostridium Species 0.000 description 2
- 241000588698 Erwinia Species 0.000 description 2
- 241000589565 Flavobacterium Species 0.000 description 2
- 241000235649 Kluyveromyces Species 0.000 description 2
- 241001138401 Kluyveromyces lactis Species 0.000 description 2
- 241000320412 Ogataea angusta Species 0.000 description 2
- 241001221669 Ostreococcus Species 0.000 description 2
- 241000191025 Rhodobacter Species 0.000 description 2
- 241000235070 Saccharomyces Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 241000223259 Trichoderma Species 0.000 description 2
- 241000499912 Trichoderma reesei Species 0.000 description 2
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical group BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical group ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 2
- 208000006278 hypochromic anemia Diseases 0.000 description 2
- 101150042623 metH gene Proteins 0.000 description 2
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 2
- 241000157921 Actinotalea fermentans Species 0.000 description 1
- 241000219194 Arabidopsis Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 102000005572 Cathepsin A Human genes 0.000 description 1
- 108010059081 Cathepsin A Proteins 0.000 description 1
- 241001245615 Dechloromonas Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000589330 Methylococcaceae Species 0.000 description 1
- 241001430266 Methylocystaceae Species 0.000 description 1
- 241001135648 Petrotoga Species 0.000 description 1
- 241000874809 Petrotoga halophila Species 0.000 description 1
- 241000983938 Petrotoga mobilis Species 0.000 description 1
- 241000579687 Pseudothermotoga hypogea Species 0.000 description 1
- 241000235346 Schizosaccharomyces Species 0.000 description 1
- 241000235347 Schizosaccharomyces pombe Species 0.000 description 1
- 241000204652 Thermotoga Species 0.000 description 1
- 241000334121 Thermotoga naphthophila Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 241000235015 Yarrowia lipolytica Species 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical group O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical group IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 229940102396 methyl bromide Drugs 0.000 description 1
- 229940050176 methyl chloride Drugs 0.000 description 1
- PUGUQINMNYINPK-UHFFFAOYSA-N tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate Chemical group CC(C)(C)OC(=O)N1CCN(C(=O)CCl)CC1 PUGUQINMNYINPK-UHFFFAOYSA-N 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99167807P | 2007-11-30 | 2007-11-30 | |
| US3836808P | 2008-03-20 | 2008-03-20 | |
| US4146708P | 2008-04-01 | 2008-04-01 | |
| US9822108P | 2008-09-18 | 2008-09-18 | |
| PCT/US2008/085019 WO2009073560A1 (en) | 2007-11-30 | 2008-11-26 | Industrial production of organic compounds using recombinant organisms expressing methyl halide transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011505149A JP2011505149A (ja) | 2011-02-24 |
| JP2011505149A5 true JP2011505149A5 (enExample) | 2013-01-24 |
Family
ID=40718114
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536193A Pending JP2011505149A (ja) | 2007-11-30 | 2008-11-26 | ハロゲン化メチルトランスフェラーゼを発現する組換え型生物を用いた、有機化合物の工業的生産方法 |
| JP2010536192A Pending JP2011505148A (ja) | 2007-11-30 | 2008-11-26 | 商業的に価値のある化合物を産生するための生物学的システム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536192A Pending JP2011505148A (ja) | 2007-11-30 | 2008-11-26 | 商業的に価値のある化合物を産生するための生物学的システム |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US9657279B2 (enExample) |
| EP (2) | EP2222833A4 (enExample) |
| JP (2) | JP2011505149A (enExample) |
| CN (2) | CN101932699A (enExample) |
| AU (2) | AU2008334087A1 (enExample) |
| BR (2) | BRPI0819649A2 (enExample) |
| CA (2) | CA2706894A1 (enExample) |
| WO (2) | WO2009073557A2 (enExample) |
Families Citing this family (14)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2222833A4 (en) | 2007-11-30 | 2011-05-18 | Univ California | Industrial production of organic compounds using recombinant organisms expressing methyl halide transferase |
| EP2456852A4 (en) * | 2009-07-22 | 2013-03-27 | Univ California | CELL-BASED SYSTEMS FOR THE PRODUCTION OF METHYLFORMAT |
| US20110177564A1 (en) * | 2010-01-15 | 2011-07-21 | Massachusetts Institute Of Technology | Bioprocess and microbe engineering for total carbon utilization in biofuel production |
| WO2011105241A1 (ja) * | 2010-02-25 | 2011-09-01 | 富山県 | 出芽酵母を用いたグルクロン酸抱合体の製造方法 |
| CN102766586B (zh) * | 2011-05-12 | 2013-05-15 | 江南大学 | 中国酱香型白酒生产中高产乙醇低产杂醇油的酵母cgmcc 4747的筛选与应用 |
| AT511856A1 (de) * | 2011-09-01 | 2013-03-15 | Univ Graz Tech | Mittel und verfahren zur alkylierung |
| EP2871234A1 (en) * | 2013-11-06 | 2015-05-13 | Leibniz-Institut für Pflanzenbiochemie (IPB) | S-Adenosylmethionine (SAM) synthase variants for the synthesis of artificial cofactors |
| WO2016181216A1 (en) | 2015-05-08 | 2016-11-17 | Universidad Adolfo Ibanez | Pgpr compositions and methods for improved cultivation of tomato and potato species |
| US20160347682A1 (en) * | 2015-05-26 | 2016-12-01 | Sabic Global Technologies, B.V. | Zeolite Catalyst for Alkyl Halide to Olefin Conversion |
| CN106994134B (zh) * | 2016-01-25 | 2020-08-25 | 深圳华大生命科学研究院 | 肠道益生菌在预防和/或治疗糖尿病及其相关疾病中的应用 |
| IL265109B2 (en) | 2016-09-13 | 2024-05-01 | Allergan Inc | Stabilized non-protein clostridial toxin compositions |
| CN109306333B (zh) * | 2018-10-25 | 2020-06-12 | 北京润世能源技术有限公司 | 一株微生物采油菌w-y8及其应用 |
| CN109536426B (zh) * | 2019-01-25 | 2021-11-16 | 黑龙江大学 | 一株嗜冷菌及其应用 |
| CA3218163A1 (en) | 2021-05-17 | 2022-11-24 | Anne PALERMO | Food product comprising a co-culture of bacteria and fungi |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5940518B2 (ja) | 1981-10-14 | 1984-10-01 | 工業技術院長 | セルロ−ス含有廃棄物の嫌気性消化方法 |
| US4794080A (en) * | 1984-04-16 | 1988-12-27 | Igene Biotechnology, Inc. | Microbial co-culture production of propionic acid |
| US5643758A (en) * | 1987-03-10 | 1997-07-01 | New England Biolabs, Inc. | Production and purification of a protein fused to a binding protein |
| GB8923998D0 (en) * | 1989-10-25 | 1989-12-13 | Nestle Sa | Food additives |
| US7109005B2 (en) * | 1990-01-15 | 2006-09-19 | Danisco Sweeteners Oy | Process for the simultaneous production of xylitol and ethanol |
| DE69422160T2 (de) * | 1994-05-27 | 2000-04-06 | Agrano Ag, Allschwil | Verfahren zur Herstellung von Kulturmedien, welche für die individuelle Kultur von Hefen und Milchsäurebakterien oder die Kokultur von Hefen und Milchsäurebakterien verwendbar sind. |
| DK0684308T4 (da) * | 1994-05-27 | 2004-05-10 | Agrano Ag | Fremgangsmåde til fremstilling af en biomasse, anvendelse af den ved fremgangsmåden opnåede biomasse samt brödbagningsgærstof |
| JP4402290B2 (ja) * | 1997-10-17 | 2010-01-20 | ソシエテ・デ・プロデュイ・ネスレ・エス・アー | 新規な乳酸菌種 |
| CN1300318A (zh) * | 1998-05-06 | 2001-06-20 | 中村启次郎 | 含有性质不同且彼此共生的微生物和其代谢物的微生物培养物,含有该培养物活性组分的载体和吸附剂及其用途 |
| US6610504B1 (en) | 2000-04-10 | 2003-08-26 | General Atomics | Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase |
| WO2002014540A1 (en) | 2000-08-11 | 2002-02-21 | Cornell Research Foundation, Inc. | Production and use of inducible enzymes from trichoderma and bacteria for control of plant pests and for industrial processes |
| CN1649808A (zh) * | 2001-05-23 | 2005-08-03 | 陶氏环球技术公司 | 从单碳原料的卤乙烯生产 |
| US20030152586A1 (en) * | 2002-01-25 | 2003-08-14 | Biomedis | Dietary supplements comprising growth media |
| US7977049B2 (en) | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| JP2004261150A (ja) | 2003-03-04 | 2004-09-24 | Ajinomoto Co Inc | 目的物質の製造法 |
| DE10309856A1 (de) | 2003-03-06 | 2004-09-23 | Consortium für elektrochemische Industrie GmbH | Verfahren zur fermentativen Herstellung von S-Adenosylmethionin |
| WO2006092449A2 (en) * | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| CA2604574C (en) | 2005-04-15 | 2013-11-19 | University Of Southern California | Selective oxidative conversion of methane to methanol, dimethyl ether and derived products |
| CA2611513A1 (en) | 2005-06-17 | 2006-12-28 | Microbia, Inc. | Improved amino acid and metabolite biosynthesis |
| EP1984514A4 (en) * | 2006-01-27 | 2010-09-01 | Univ Massachusetts | SYSTEMS AND METHOD FOR PRODUCING BIOFUELS AND CORRESPONDING MATERIALS |
| EP2222833A4 (en) | 2007-11-30 | 2011-05-18 | Univ California | Industrial production of organic compounds using recombinant organisms expressing methyl halide transferase |
-
2008
- 2008-11-26 EP EP08857534A patent/EP2222833A4/en not_active Withdrawn
- 2008-11-26 US US12/745,539 patent/US9657279B2/en active Active
- 2008-11-26 EP EP08858165A patent/EP2238239A4/en not_active Withdrawn
- 2008-11-26 BR BRPI0819649A patent/BRPI0819649A2/pt not_active IP Right Cessation
- 2008-11-26 CA CA2706894A patent/CA2706894A1/en not_active Abandoned
- 2008-11-26 BR BRPI0819648A patent/BRPI0819648A2/pt not_active IP Right Cessation
- 2008-11-26 CN CN2008801259730A patent/CN101932699A/zh active Pending
- 2008-11-26 JP JP2010536193A patent/JP2011505149A/ja active Pending
- 2008-11-26 WO PCT/US2008/085013 patent/WO2009073557A2/en not_active Ceased
- 2008-11-26 CN CN2008801259726A patent/CN101932694A/zh active Pending
- 2008-11-26 AU AU2008334087A patent/AU2008334087A1/en not_active Abandoned
- 2008-11-26 US US12/745,538 patent/US20110151534A1/en not_active Abandoned
- 2008-11-26 WO PCT/US2008/085019 patent/WO2009073560A1/en not_active Ceased
- 2008-11-26 CA CA2707446A patent/CA2707446A1/en not_active Abandoned
- 2008-11-26 AU AU2008334090A patent/AU2008334090A1/en not_active Abandoned
- 2008-11-26 JP JP2010536192A patent/JP2011505148A/ja active Pending
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