JP2011505149A5 - - Google Patents
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- JP2011505149A5 JP2011505149A5 JP2010536193A JP2010536193A JP2011505149A5 JP 2011505149 A5 JP2011505149 A5 JP 2011505149A5 JP 2010536193 A JP2010536193 A JP 2010536193A JP 2010536193 A JP2010536193 A JP 2010536193A JP 2011505149 A5 JP2011505149 A5 JP 2011505149A5
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- Prior art keywords
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- sam
- halide
- gene
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- 238000000034 method Methods 0.000 claims description 55
- 229960001570 ademetionine Drugs 0.000 claims description 49
- MEFKEPWMEQBLKI-AIRLBKTGSA-N S-adenosyl-L-methioninate Chemical compound O[C@@H]1[C@H](O)[C@@H](C[S+](CC[C@H](N)C([O-])=O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 MEFKEPWMEQBLKI-AIRLBKTGSA-N 0.000 claims description 43
- 108090000623 proteins and genes Proteins 0.000 claims description 29
- 230000001965 increasing effect Effects 0.000 claims description 24
- 230000006696 biosynthetic metabolic pathway Effects 0.000 claims description 22
- -1 Methyl halide Chemical class 0.000 claims description 20
- 150000004820 halides Chemical class 0.000 claims description 19
- 240000004808 Saccharomyces cerevisiae Species 0.000 claims description 15
- 241000894006 Bacteria Species 0.000 claims description 12
- 241000588724 Escherichia coli Species 0.000 claims description 12
- 108060004795 Methyltransferase Proteins 0.000 claims description 12
- 230000014509 gene expression Effects 0.000 claims description 12
- FFEARJCKVFRZRR-BYPYZUCNSA-N L-methionine Chemical compound CSCC[C@H](N)C(O)=O FFEARJCKVFRZRR-BYPYZUCNSA-N 0.000 claims description 11
- 229930182817 methionine Natural products 0.000 claims description 11
- 102000016397 Methyltransferase Human genes 0.000 claims description 10
- 241000235343 Saccharomycetales Species 0.000 claims description 10
- 230000003834 intracellular effect Effects 0.000 claims description 10
- 108010078791 Carrier Proteins Proteins 0.000 claims description 9
- 240000004062 Batis maritima Species 0.000 claims description 8
- 235000006469 Batis maritima Nutrition 0.000 claims description 8
- 239000001963 growth medium Substances 0.000 claims description 8
- 238000004519 manufacturing process Methods 0.000 claims description 8
- 239000000203 mixture Substances 0.000 claims description 8
- 210000005253 yeast cell Anatomy 0.000 claims description 8
- 241000195493 Cryptophyta Species 0.000 claims description 7
- 101100023016 Methanothermobacter marburgensis (strain ATCC BAA-927 / DSM 2133 / JCM 14651 / NBRC 100331 / OCM 82 / Marburg) mat gene Proteins 0.000 claims description 7
- 101150095438 metK gene Proteins 0.000 claims description 7
- 102000003960 Ligases Human genes 0.000 claims description 6
- 108090000364 Ligases Proteins 0.000 claims description 6
- 230000004048 modification Effects 0.000 claims description 6
- 238000012986 modification Methods 0.000 claims description 6
- 230000002018 overexpression Effects 0.000 claims description 6
- FVAUCKIRQBBSSJ-UHFFFAOYSA-M sodium iodide Chemical compound [Na+].[I-] FVAUCKIRQBBSSJ-UHFFFAOYSA-M 0.000 claims description 6
- 241000233866 Fungi Species 0.000 claims description 5
- 108010043428 Glycine hydroxymethyltransferase Proteins 0.000 claims description 5
- 240000007594 Oryza sativa Species 0.000 claims description 5
- 235000007164 Oryza sativa Nutrition 0.000 claims description 5
- 102100021225 Serine hydroxymethyltransferase, cytosolic Human genes 0.000 claims description 5
- 230000001419 dependent effect Effects 0.000 claims description 5
- 230000000694 effects Effects 0.000 claims description 5
- 241000219198 Brassica Species 0.000 claims description 4
- 235000011331 Brassica Nutrition 0.000 claims description 4
- 240000008100 Brassica rapa Species 0.000 claims description 4
- 235000011292 Brassica rapa Nutrition 0.000 claims description 4
- 201000007336 Cryptococcosis Diseases 0.000 claims description 4
- 241000221204 Cryptococcus neoformans Species 0.000 claims description 4
- RTZKZFJDLAIYFH-UHFFFAOYSA-N Diethyl ether Chemical compound CCOCC RTZKZFJDLAIYFH-UHFFFAOYSA-N 0.000 claims description 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims description 4
- 230000015572 biosynthetic process Effects 0.000 claims description 4
- 239000003054 catalyst Substances 0.000 claims description 4
- 238000009833 condensation Methods 0.000 claims description 4
- 230000005494 condensation Effects 0.000 claims description 4
- 235000003869 genetically modified organism Nutrition 0.000 claims description 4
- 108090000765 processed proteins & peptides Proteins 0.000 claims description 4
- 102000004169 proteins and genes Human genes 0.000 claims description 4
- JHJLBTNAGRQEKS-UHFFFAOYSA-M sodium bromide Chemical compound [Na+].[Br-] JHJLBTNAGRQEKS-UHFFFAOYSA-M 0.000 claims description 4
- 102100031126 6-phosphogluconolactonase Human genes 0.000 claims description 3
- 108010029731 6-phosphogluconolactonase Proteins 0.000 claims description 3
- ZCYVEMRRCGMTRW-UHFFFAOYSA-N 7553-56-2 Chemical compound [I] ZCYVEMRRCGMTRW-UHFFFAOYSA-N 0.000 claims description 3
- 102000005758 Adenosylmethionine decarboxylase Human genes 0.000 claims description 3
- 108010070753 Adenosylmethionine decarboxylase Proteins 0.000 claims description 3
- 101100290837 Bacillus subtilis (strain 168) metAA gene Proteins 0.000 claims description 3
- 101100076641 Bacillus subtilis (strain 168) metE gene Proteins 0.000 claims description 3
- 101100130094 Bacillus subtilis (strain 168) metK gene Proteins 0.000 claims description 3
- WKBOTKDWSSQWDR-UHFFFAOYSA-N Bromine atom Chemical compound [Br] WKBOTKDWSSQWDR-UHFFFAOYSA-N 0.000 claims description 3
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 3
- ZAMOUSCENKQFHK-UHFFFAOYSA-N Chlorine atom Chemical compound [Cl] ZAMOUSCENKQFHK-UHFFFAOYSA-N 0.000 claims description 3
- 101710134307 Coproporphyrinogen III oxidase Proteins 0.000 claims description 3
- YPWSLBHSMIKTPR-UHFFFAOYSA-N Cystathionine Natural products OC(=O)C(N)CCSSCC(N)C(O)=O YPWSLBHSMIKTPR-UHFFFAOYSA-N 0.000 claims description 3
- QNAYBMKLOCPYGJ-UHFFFAOYSA-N D-alpha-Ala Natural products CC([NH3+])C([O-])=O QNAYBMKLOCPYGJ-UHFFFAOYSA-N 0.000 claims description 3
- ILRYLPWNYFXEMH-UHFFFAOYSA-N D-cystathionine Natural products OC(=O)C(N)CCSCC(N)C(O)=O ILRYLPWNYFXEMH-UHFFFAOYSA-N 0.000 claims description 3
- 101100322888 Escherichia coli (strain K12) metL gene Proteins 0.000 claims description 3
- 108010018962 Glucosephosphate Dehydrogenase Proteins 0.000 claims description 3
- 241000191005 Halorhodospira halophila Species 0.000 claims description 3
- QNAYBMKLOCPYGJ-UWTATZPHSA-N L-Alanine Natural products C[C@@H](N)C(O)=O QNAYBMKLOCPYGJ-UWTATZPHSA-N 0.000 claims description 3
- QNAYBMKLOCPYGJ-REOHCLBHSA-N L-alanine Chemical compound C[C@H](N)C(O)=O QNAYBMKLOCPYGJ-REOHCLBHSA-N 0.000 claims description 3
- ILRYLPWNYFXEMH-WHFBIAKZSA-N L-cystathionine Chemical compound [O-]C(=O)[C@@H]([NH3+])CCSC[C@H]([NH3+])C([O-])=O ILRYLPWNYFXEMH-WHFBIAKZSA-N 0.000 claims description 3
- 108020005196 Mitochondrial DNA Proteins 0.000 claims description 3
- 102100039270 Ribulose-phosphate 3-epimerase Human genes 0.000 claims description 3
- 108060007030 Ribulose-phosphate 3-epimerase Proteins 0.000 claims description 3
- 241000606701 Rickettsia Species 0.000 claims description 3
- 102000003929 Transaminases Human genes 0.000 claims description 3
- 108090000340 Transaminases Proteins 0.000 claims description 3
- 240000006365 Vitis vinifera Species 0.000 claims description 3
- 235000014787 Vitis vinifera Nutrition 0.000 claims description 3
- 101150057540 aar gene Proteins 0.000 claims description 3
- 229960003767 alanine Drugs 0.000 claims description 3
- GDTBXPJZTBHREO-UHFFFAOYSA-N bromine Substances BrBr GDTBXPJZTBHREO-UHFFFAOYSA-N 0.000 claims description 3
- 229910052794 bromium Inorganic materials 0.000 claims description 3
- 229910052799 carbon Inorganic materials 0.000 claims description 3
- 230000003197 catalytic effect Effects 0.000 claims description 3
- 229910052801 chlorine Inorganic materials 0.000 claims description 3
- 239000000460 chlorine Substances 0.000 claims description 3
- 239000001177 diphosphate Substances 0.000 claims description 3
- XPPKVPWEQAFLFU-UHFFFAOYSA-J diphosphate(4-) Chemical compound [O-]P([O-])(=O)OP([O-])([O-])=O XPPKVPWEQAFLFU-UHFFFAOYSA-J 0.000 claims description 3
- 235000011180 diphosphates Nutrition 0.000 claims description 3
- 239000011630 iodine Substances 0.000 claims description 3
- 229910052740 iodine Inorganic materials 0.000 claims description 3
- 101150060102 metA gene Proteins 0.000 claims description 3
- 101150086633 metAA gene Proteins 0.000 claims description 3
- 101150091110 metAS gene Proteins 0.000 claims description 3
- 101150003180 metB gene Proteins 0.000 claims description 3
- 101150117293 metC gene Proteins 0.000 claims description 3
- 101150108178 metE gene Proteins 0.000 claims description 3
- 101150040895 metJ gene Proteins 0.000 claims description 3
- 101150043924 metXA gene Proteins 0.000 claims description 3
- 108010028584 nucleotidase Proteins 0.000 claims description 3
- 230000037361 pathway Effects 0.000 claims description 3
- 230000008685 targeting Effects 0.000 claims description 3
- 241000230562 Flavobacteriia Species 0.000 claims description 2
- 241000589925 Leptospirillum Species 0.000 claims description 2
- 241001261604 Maricaulis maris Species 0.000 claims description 2
- 241001221668 Ostreococcus tauri Species 0.000 claims description 2
- 241001343907 Paraburkholderia phymatum Species 0.000 claims description 2
- 241001348363 Robiginitalea Species 0.000 claims description 2
- 241001453296 Synechococcus elongatus Species 0.000 claims description 2
- 150000001299 aldehydes Chemical class 0.000 claims description 2
- 150000001335 aliphatic alkanes Chemical class 0.000 claims description 2
- 150000001336 alkenes Chemical class 0.000 claims description 2
- 238000006243 chemical reaction Methods 0.000 claims description 2
- 108020001507 fusion proteins Proteins 0.000 claims description 2
- 102000037865 fusion proteins Human genes 0.000 claims description 2
- 235000002532 grape seed extract Nutrition 0.000 claims description 2
- 230000002779 inactivation Effects 0.000 claims description 2
- 230000001939 inductive effect Effects 0.000 claims description 2
- JRZJOMJEPLMPRA-UHFFFAOYSA-N olefin Natural products CCCCCCCC=C JRZJOMJEPLMPRA-UHFFFAOYSA-N 0.000 claims description 2
- 230000008569 process Effects 0.000 claims description 2
- 239000011780 sodium chloride Substances 0.000 claims description 2
- 235000009518 sodium iodide Nutrition 0.000 claims description 2
- 210000003934 vacuole Anatomy 0.000 claims description 2
- 241001422920 Dechloromonas aromatica Species 0.000 claims 1
- 230000000415 inactivating effect Effects 0.000 claims 1
- 239000007788 liquid Substances 0.000 claims 1
- MYWUZJCMWCOHBA-VIFPVBQESA-N methamphetamine Chemical compound CN[C@@H](C)CC1=CC=CC=C1 MYWUZJCMWCOHBA-VIFPVBQESA-N 0.000 claims 1
- 241000894007 species Species 0.000 claims 1
- 108030006597 Methyl halide transferases Proteins 0.000 description 19
- 235000014680 Saccharomyces cerevisiae Nutrition 0.000 description 12
- 241000235648 Pichia Species 0.000 description 4
- 241000235058 Komagataella pastoris Species 0.000 description 3
- 241000235013 Yarrowia Species 0.000 description 3
- 238000012239 gene modification Methods 0.000 description 3
- 230000005017 genetic modification Effects 0.000 description 3
- 235000013617 genetically modified food Nutrition 0.000 description 3
- 235000009566 rice Nutrition 0.000 description 3
- 241000219195 Arabidopsis thaliana Species 0.000 description 2
- 241000203069 Archaea Species 0.000 description 2
- 235000014469 Bacillus subtilis Nutrition 0.000 description 2
- 235000011303 Brassica alboglabra Nutrition 0.000 description 2
- 240000007124 Brassica oleracea Species 0.000 description 2
- 235000011302 Brassica oleracea Nutrition 0.000 description 2
- 241001453380 Burkholderia Species 0.000 description 2
- 241000195585 Chlamydomonas Species 0.000 description 2
- 241000193403 Clostridium Species 0.000 description 2
- 241000588698 Erwinia Species 0.000 description 2
- 241000589565 Flavobacterium Species 0.000 description 2
- 241000235649 Kluyveromyces Species 0.000 description 2
- 241001138401 Kluyveromyces lactis Species 0.000 description 2
- 241000320412 Ogataea angusta Species 0.000 description 2
- 241001221669 Ostreococcus Species 0.000 description 2
- 241000191025 Rhodobacter Species 0.000 description 2
- 241000235070 Saccharomyces Species 0.000 description 2
- 241000607142 Salmonella Species 0.000 description 2
- 241000223259 Trichoderma Species 0.000 description 2
- 241000499912 Trichoderma reesei Species 0.000 description 2
- GZUXJHMPEANEGY-UHFFFAOYSA-N bromomethane Chemical group BrC GZUXJHMPEANEGY-UHFFFAOYSA-N 0.000 description 2
- NEHMKBQYUWJMIP-UHFFFAOYSA-N chloromethane Chemical group ClC NEHMKBQYUWJMIP-UHFFFAOYSA-N 0.000 description 2
- 208000006278 hypochromic anemia Diseases 0.000 description 2
- 101150042623 metH gene Proteins 0.000 description 2
- SUKJFIGYRHOWBL-UHFFFAOYSA-N sodium hypochlorite Chemical compound [Na+].Cl[O-] SUKJFIGYRHOWBL-UHFFFAOYSA-N 0.000 description 2
- 241000157921 Actinotalea fermentans Species 0.000 description 1
- 241000219194 Arabidopsis Species 0.000 description 1
- 241000193830 Bacillus <bacterium> Species 0.000 description 1
- 244000063299 Bacillus subtilis Species 0.000 description 1
- 102000005572 Cathepsin A Human genes 0.000 description 1
- 108010059081 Cathepsin A Proteins 0.000 description 1
- 241001245615 Dechloromonas Species 0.000 description 1
- 241000196324 Embryophyta Species 0.000 description 1
- 241000589330 Methylococcaceae Species 0.000 description 1
- 241001430266 Methylocystaceae Species 0.000 description 1
- 241001135648 Petrotoga Species 0.000 description 1
- 241000874809 Petrotoga halophila Species 0.000 description 1
- 241000983938 Petrotoga mobilis Species 0.000 description 1
- 241000579687 Pseudothermotoga hypogea Species 0.000 description 1
- 241000235346 Schizosaccharomyces Species 0.000 description 1
- 241000235347 Schizosaccharomyces pombe Species 0.000 description 1
- 241000204652 Thermotoga Species 0.000 description 1
- 241000334121 Thermotoga naphthophila Species 0.000 description 1
- 241000219094 Vitaceae Species 0.000 description 1
- 235000009754 Vitis X bourquina Nutrition 0.000 description 1
- 235000012333 Vitis X labruscana Nutrition 0.000 description 1
- 241000235015 Yarrowia lipolytica Species 0.000 description 1
- 229910021536 Zeolite Inorganic materials 0.000 description 1
- 229940024606 amino acid Drugs 0.000 description 1
- 150000001413 amino acids Chemical class 0.000 description 1
- 230000003247 decreasing effect Effects 0.000 description 1
- 238000012217 deletion Methods 0.000 description 1
- 230000037430 deletion Effects 0.000 description 1
- HNPSIPDUKPIQMN-UHFFFAOYSA-N dioxosilane;oxo(oxoalumanyloxy)alumane Chemical group O=[Si]=O.O=[Al]O[Al]=O HNPSIPDUKPIQMN-UHFFFAOYSA-N 0.000 description 1
- 235000021021 grapes Nutrition 0.000 description 1
- INQOMBQAUSQDDS-UHFFFAOYSA-N iodomethane Chemical group IC INQOMBQAUSQDDS-UHFFFAOYSA-N 0.000 description 1
- 229940102396 methyl bromide Drugs 0.000 description 1
- 229940050176 methyl chloride Drugs 0.000 description 1
- PUGUQINMNYINPK-UHFFFAOYSA-N tert-butyl 4-(2-chloroacetyl)piperazine-1-carboxylate Chemical group CC(C)(C)OC(=O)N1CCN(C(=O)CCl)CC1 PUGUQINMNYINPK-UHFFFAOYSA-N 0.000 description 1
- 239000010457 zeolite Substances 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99167807P | 2007-11-30 | 2007-11-30 | |
| US3836808P | 2008-03-20 | 2008-03-20 | |
| US4146708P | 2008-04-01 | 2008-04-01 | |
| US9822108P | 2008-09-18 | 2008-09-18 | |
| PCT/US2008/085019 WO2009073560A1 (en) | 2007-11-30 | 2008-11-26 | Industrial production of organic compounds using recombinant organisms expressing methyl halide transferase |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2011505149A JP2011505149A (ja) | 2011-02-24 |
| JP2011505149A5 true JP2011505149A5 (enExample) | 2013-01-24 |
Family
ID=40718114
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536193A Pending JP2011505149A (ja) | 2007-11-30 | 2008-11-26 | ハロゲン化メチルトランスフェラーゼを発現する組換え型生物を用いた、有機化合物の工業的生産方法 |
| JP2010536192A Pending JP2011505148A (ja) | 2007-11-30 | 2008-11-26 | 商業的に価値のある化合物を産生するための生物学的システム |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010536192A Pending JP2011505148A (ja) | 2007-11-30 | 2008-11-26 | 商業的に価値のある化合物を産生するための生物学的システム |
Country Status (8)
| Country | Link |
|---|---|
| US (2) | US20110151534A1 (enExample) |
| EP (2) | EP2238239A4 (enExample) |
| JP (2) | JP2011505149A (enExample) |
| CN (2) | CN101932694A (enExample) |
| AU (2) | AU2008334090A1 (enExample) |
| BR (2) | BRPI0819649A2 (enExample) |
| CA (2) | CA2706894A1 (enExample) |
| WO (2) | WO2009073557A2 (enExample) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN101932694A (zh) | 2007-11-30 | 2010-12-29 | 加利福尼亚大学董事会 | 使用表达卤代甲烷转移酶的重组生物进行有机化合物的工业生产 |
| CA2805041A1 (en) | 2009-07-22 | 2011-01-27 | The Regents Of The University Of California | Cell-based systems for production of methyl formate |
| US20110177564A1 (en) * | 2010-01-15 | 2011-07-21 | Massachusetts Institute Of Technology | Bioprocess and microbe engineering for total carbon utilization in biofuel production |
| US8741602B2 (en) | 2010-02-25 | 2014-06-03 | Toyama Prefecture | Method for producing glucuronic acid conjugate using Saccharomyces cerevisiae |
| CN102766586B (zh) * | 2011-05-12 | 2013-05-15 | 江南大学 | 中国酱香型白酒生产中高产乙醇低产杂醇油的酵母cgmcc 4747的筛选与应用 |
| AT511856A1 (de) * | 2011-09-01 | 2013-03-15 | Univ Graz Tech | Mittel und verfahren zur alkylierung |
| EP2871234A1 (en) * | 2013-11-06 | 2015-05-13 | Leibniz-Institut für Pflanzenbiochemie (IPB) | S-Adenosylmethionine (SAM) synthase variants for the synthesis of artificial cofactors |
| WO2016181216A1 (en) * | 2015-05-08 | 2016-11-17 | Universidad Adolfo Ibanez | Pgpr compositions and methods for improved cultivation of tomato and potato species |
| WO2016191141A1 (en) * | 2015-05-26 | 2016-12-01 | Sabic Global Technologies, B.V. | Zeolite catalyst for alkyl halide to olefin conversion |
| CN106994134B (zh) * | 2016-01-25 | 2020-08-25 | 深圳华大生命科学研究院 | 肠道益生菌在预防和/或治疗糖尿病及其相关疾病中的应用 |
| JP7217700B2 (ja) | 2016-09-13 | 2023-02-03 | アラーガン、インコーポレイテッド | 安定化非タンパク質クロストリジウム毒素組成物 |
| CN109306333B (zh) * | 2018-10-25 | 2020-06-12 | 北京润世能源技术有限公司 | 一株微生物采油菌w-y8及其应用 |
| CN109536426B (zh) * | 2019-01-25 | 2021-11-16 | 黑龙江大学 | 一株嗜冷菌及其应用 |
| CA3218163A1 (en) | 2021-05-17 | 2022-11-24 | Anne PALERMO | Food product comprising a co-culture of bacteria and fungi |
| CN121427760A (zh) * | 2025-12-09 | 2026-01-30 | 中国科学院沈阳应用生态研究所 | 一株放线纤细菌、分离纯化方法及其在秸秆降解中的应用 |
Family Cites Families (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPS5940518B2 (ja) | 1981-10-14 | 1984-10-01 | 工業技術院長 | セルロ−ス含有廃棄物の嫌気性消化方法 |
| US4794080A (en) * | 1984-04-16 | 1988-12-27 | Igene Biotechnology, Inc. | Microbial co-culture production of propionic acid |
| US5643758A (en) * | 1987-03-10 | 1997-07-01 | New England Biolabs, Inc. | Production and purification of a protein fused to a binding protein |
| GB8923998D0 (en) * | 1989-10-25 | 1989-12-13 | Nestle Sa | Food additives |
| US7109005B2 (en) * | 1990-01-15 | 2006-09-19 | Danisco Sweeteners Oy | Process for the simultaneous production of xylitol and ethanol |
| DK0684307T3 (da) * | 1994-05-27 | 2000-05-15 | Agrano Ag | Fremgangsmåde til fremstilling af næringssubstrater, der kan anvendes til individuel dyrkning af gærarter og mælkesyrebakte |
| ES2142920T5 (es) * | 1994-05-27 | 2004-09-16 | Agrano Ag | Procedimiento de obtencion de una biomasa y fermento de panificacion. |
| EP1023435B1 (fr) * | 1997-10-17 | 2006-09-06 | Societe Des Produits Nestle S.A. | Nouvelle espece de bacterie lactique |
| AU771630B2 (en) * | 1998-05-06 | 2004-04-01 | Keijiro Nakamura | Microbial culture liquors containing microorganisms differing in characteristics and living in symbiosis and metabolites thereof, carriers and adsorbents containing the active components of the culture liquors and utilization of the same |
| US6610504B1 (en) * | 2000-04-10 | 2003-08-26 | General Atomics | Methods of determining SAM-dependent methyltransferase activity using a mutant SAH hydrolase |
| AU2001284793A1 (en) * | 2000-08-11 | 2002-02-25 | Cornell Research Foundation Inc. | Production and use of inducible enzymes from trichoderma and bacteria for control of plant pests and for industrial processes |
| CN1649808A (zh) * | 2001-05-23 | 2005-08-03 | 陶氏环球技术公司 | 从单碳原料的卤乙烯生产 |
| US20030152586A1 (en) * | 2002-01-25 | 2003-08-14 | Biomedis | Dietary supplements comprising growth media |
| US7977049B2 (en) * | 2002-08-09 | 2011-07-12 | President And Fellows Of Harvard College | Methods and compositions for extending the life span and increasing the stress resistance of cells and organisms |
| JP2004261150A (ja) * | 2003-03-04 | 2004-09-24 | Ajinomoto Co Inc | 目的物質の製造法 |
| DE10309856A1 (de) * | 2003-03-06 | 2004-09-23 | Consortium für elektrochemische Industrie GmbH | Verfahren zur fermentativen Herstellung von S-Adenosylmethionin |
| WO2006092449A2 (en) | 2005-03-02 | 2006-09-08 | Metanomics Gmbh | Process for the production of fine chemicals |
| AU2006236802B2 (en) * | 2005-04-15 | 2011-09-01 | University Of Southern California | Selective oxidative conversion of methane to methanol, dimethyl ether and derived products |
| JP2009501512A (ja) * | 2005-06-17 | 2009-01-22 | アイアンウッド ファーマシューティカルズ インコーポレイテッド | 改良されたアミノ酸及び代謝産物生合成 |
| US7682811B2 (en) * | 2006-01-27 | 2010-03-23 | University Of Massachusetts | Systems and methods for producing biofuels and related materials |
| CN101932694A (zh) | 2007-11-30 | 2010-12-29 | 加利福尼亚大学董事会 | 使用表达卤代甲烷转移酶的重组生物进行有机化合物的工业生产 |
-
2008
- 2008-11-26 CN CN2008801259726A patent/CN101932694A/zh active Pending
- 2008-11-26 JP JP2010536193A patent/JP2011505149A/ja active Pending
- 2008-11-26 WO PCT/US2008/085013 patent/WO2009073557A2/en not_active Ceased
- 2008-11-26 JP JP2010536192A patent/JP2011505148A/ja active Pending
- 2008-11-26 AU AU2008334090A patent/AU2008334090A1/en not_active Abandoned
- 2008-11-26 US US12/745,538 patent/US20110151534A1/en not_active Abandoned
- 2008-11-26 US US12/745,539 patent/US9657279B2/en active Active
- 2008-11-26 CA CA2706894A patent/CA2706894A1/en not_active Abandoned
- 2008-11-26 CA CA2707446A patent/CA2707446A1/en not_active Abandoned
- 2008-11-26 BR BRPI0819649A patent/BRPI0819649A2/pt not_active IP Right Cessation
- 2008-11-26 BR BRPI0819648A patent/BRPI0819648A2/pt not_active IP Right Cessation
- 2008-11-26 WO PCT/US2008/085019 patent/WO2009073560A1/en not_active Ceased
- 2008-11-26 CN CN2008801259730A patent/CN101932699A/zh active Pending
- 2008-11-26 EP EP08858165A patent/EP2238239A4/en not_active Withdrawn
- 2008-11-26 EP EP08857534A patent/EP2222833A4/en not_active Withdrawn
- 2008-11-26 AU AU2008334087A patent/AU2008334087A1/en not_active Abandoned
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