JP2011504099A - シアリルルイスｃ、シアリルＴｎ、及びＮ−グリコリルノイラミン酸のエピトープに関連づけられるヒトモノクローナル抗体、ならびに前記エピトープを含む幹細胞の分析方法 - Google Patents

シアリルルイスｃ、シアリルＴｎ、及びＮ−グリコリルノイラミン酸のエピトープに関連づけられるヒトモノクローナル抗体、ならびに前記エピトープを含む幹細胞の分析方法 Download PDF

Info

Publication number
JP2011504099A
JP2011504099A JP2010532633A JP2010532633A JP2011504099A JP 2011504099 A JP2011504099 A JP 2011504099A JP 2010532633 A JP2010532633 A JP 2010532633A JP 2010532633 A JP2010532633 A JP 2010532633A JP 2011504099 A JP2011504099 A JP 2011504099A
Authority
JP
Japan
Prior art keywords
antibody
sequence
antibodies
human
monoclonal antibody
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Pending
Application number
JP2010532633A
Other languages
English (en)
Japanese (ja)
Other versions
JP2011504099A5 (enExample
Inventor
ラウッカネン，マルヤ−レーナ
タッキネン，クリスティーナ
ナトゥーネン，ヤリ
サトマー，テロ
パーキネン，ヤッコ
ヴァルム，レーナ
ティーティネン，サリ
ナトゥーネン，スヴィ
Original Assignee
スオメン プナイネン リスティ，ヴェリパルベル
グリコス フィンランド オイ
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by スオメン プナイネン リスティ，ヴェリパルベル, グリコス フィンランド オイ filed Critical スオメン プナイネン リスティ，ヴェリパルベル
Publication of JP2011504099A publication Critical patent/JP2011504099A/ja
Publication of JP2011504099A5 publication Critical patent/JP2011504099A5/ja
Pending legal-status Critical Current

Links

Images

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/30—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells
    • C07K16/3076—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants from tumour cells against structure-related tumour-associated moieties
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53—Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/569—Immunoassay; Biospecific binding assay; Materials therefor for microorganisms, e.g. protozoa, bacteria, viruses
    • G01N33/56966—Animal cells
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2400/00—Assays, e.g. immunoassays or enzyme assays, involving carbohydrates
    • G01N2400/10—Polysaccharides, i.e. having more than five saccharide radicals attached to each other by glycosidic linkages; Derivatives thereof, e.g. ethers, esters

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Immunology (AREA)
  • Chemical & Material Sciences (AREA)
  • Molecular Biology (AREA)
  • Cell Biology (AREA)
  • Engineering & Computer Science (AREA)
  • Urology & Nephrology (AREA)
  • Biomedical Technology (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Biochemistry (AREA)
  • Organic Chemistry (AREA)
  • Hematology (AREA)
  • Biotechnology (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Genetics & Genomics (AREA)
  • Zoology (AREA)
  • Microbiology (AREA)
  • Virology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • General Physics & Mathematics (AREA)
  • Pathology (AREA)
  • Peptides Or Proteins (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
JP2010532633A 2007-11-09 2008-11-10 シアリルルイスｃ、シアリルＴｎ、及びＮ−グリコリルノイラミン酸のエピトープに関連づけられるヒトモノクローナル抗体、ならびに前記エピトープを含む幹細胞の分析方法 Pending JP2011504099A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
FI20070853A FI20070853A0 (fi) 2007-11-09 2007-11-09 Glykaania sitovat monoklonaaliset vasta-aineet
PCT/FI2008/050643 WO2009060129A1 (en) 2007-11-09 2008-11-10 Human monoclonal antibodies directed to sialyl lewis c, sialyl tn and n-glycolylneuraminic acid epitopes and a method of analysis of stem cells comprising said epitopes

Publications (2)

Publication Number Publication Date
JP2011504099A true JP2011504099A (ja) 2011-02-03
JP2011504099A5 JP2011504099A5 (enExample) 2011-12-22

Family

ID=38786638

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010532633A Pending JP2011504099A (ja) 2007-11-09 2008-11-10 シアリルルイスｃ、シアリルＴｎ、及びＮ−グリコリルノイラミン酸のエピトープに関連づけられるヒトモノクローナル抗体、ならびに前記エピトープを含む幹細胞の分析方法

Country Status (7)

Country Link
US (1) US20100292095A1 (enExample)
EP (1) EP2209809A4 (enExample)
JP (1) JP2011504099A (enExample)
AU (1) AU2008324073A1 (enExample)
CA (1) CA2743032A1 (enExample)
FI (1) FI20070853A0 (enExample)
WO (1) WO2009060129A1 (enExample)

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019503985A (ja) * 2015-11-03 2019-02-14 グリコミメティクス， インコーポレイテッド モノクローナル抗体、造血幹細胞の産生のための方法および組成物、ならびにそれらを使用する方法

Families Citing this family (22)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
FI20095418A0 (fi) * 2009-04-16 2009-04-16 Suomen Punainen Risti Veripalv Kryptinen subpopulaatio
EP2345964A4 (en) * 2008-10-13 2013-11-20 Mitsubishi Electric Corp CONTRACTING APPROACH, OPERATING PROGRAM, RECORDING MEDIUM AND CONTRACTING PROCESS
WO2013151649A1 (en) 2012-04-04 2013-10-10 Sialix Inc Glycan-interacting compounds
PL2928476T3 (pl) 2012-12-07 2018-07-31 Glycomimetics, Inc. Związki, kompozycje i sposoby wykorzystujące antagonistów e-selektyny do mobilizacji komórek hematopoietycznych
US9879087B2 (en) 2014-11-12 2018-01-30 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
EP3218005B1 (en) 2014-11-12 2023-01-04 Seagen Inc. Glycan-interacting compounds and methods of use
PT3227310T (pt) 2014-12-03 2019-11-06 Glycomimetics Inc Inibidores heterobifuncionais de e-selectinas e recetores de quimiocina cxcr4
WO2017083582A1 (en) 2015-11-12 2017-05-18 Siamab Therapeutics, Inc. Glycan-interacting compounds and methods of use
US11291678B2 (en) 2016-03-02 2022-04-05 Glycomimetics, Inc Methods for the treatment and/or prevention of cardiovascular disease by inhibition of E-selectin
US11433086B2 (en) 2016-08-08 2022-09-06 Glycomimetics, Inc. Combination of T-cell checkpoint inhibitors with inhibitors of e-selectin or CXCR4, or with heterobifunctional inhibitors of both E-selectin and CXCR4
CN109890421B (zh) 2016-10-07 2023-10-20 糖模拟物有限公司 高效的多聚体e-选择蛋白拮抗剂
US11401330B2 (en) 2016-11-17 2022-08-02 Seagen Inc. Glycan-interacting compounds and methods of use
GB201703212D0 (en) * 2017-02-28 2017-04-12 Nat Univ Ireland Galway The detectionm quantification and discrimination of the sialic acid N-glycolylneuraminic (Neu5Gc) acid and N-acetylneuraminic acid (Neu5gc)
CA3054939A1 (en) 2017-03-03 2018-09-07 Seattle Genetics, Inc. Glycan-interacting compounds and methods of use
JP7272956B2 (ja) 2017-03-15 2023-05-12 グリコミメティクス， インコーポレイテッド Ｅ－セレクチンアンタゴニストとしてのガラクトピラノシル－シクロヘキシル誘導体
JP7275131B2 (ja) 2017-11-30 2023-05-17 グリコミメティクス， インコーポレイテッド 骨髄浸潤リンパ球を動員する方法、およびその使用
KR20200104889A (ko) 2017-12-29 2020-09-04 글리코미메틱스, 인크. E-셀렉틴 및 갈렉틴-3의 이종이기능성 억제제
PT110526B (pt) * 2018-01-26 2021-02-04 Univ Nova De Lisboa Anticorpo, fragmento funcional ou sonda do mesmo contra antigénios tumorais
CA3091454A1 (en) 2018-03-05 2019-09-12 Glycomimetics, Inc. Methods for treating acute myeloid leukemia and related conditions
BR112021004444A2 (pt) * 2018-09-10 2021-06-01 Cold Spring Harbor Laboratory métodos para tratar pancreatite
US11845771B2 (en) 2018-12-27 2023-12-19 Glycomimetics, Inc. Heterobifunctional inhibitors of E-selectin and galectin-3
WO2025149667A1 (en) 2024-01-12 2025-07-17 Pheon Therapeutics Ltd Antibody drug conjugates and uses thereof

Family Cites Families (11)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4342566A (en) * 1980-02-22 1982-08-03 Scripps Clinic & Research Foundation Solid phase anti-C3 assay for detection of immune complexes
US4965198A (en) * 1985-12-24 1990-10-23 Konica Corporation Monoclonal antibody and method of manufacturing hybridoma producing the same
US4949778A (en) * 1987-12-16 1990-08-21 Kawasaki Steel Corporation Immersion nozzle for continuous casting
DE4208795A1 (de) * 1992-03-19 1993-09-23 Behringwerke Ag Monoklonaler anti-gangliosid-antikoerper, seine herstellung und verwendung als tumortherapeutikum
EP2261255A1 (en) * 2003-07-15 2010-12-15 The Regents of The University of California Methods for purifying sialic acid-specific antibodies and composition comprising affinity-purified antibodies
FI20055398A0 (fi) * 2005-07-08 2005-07-08 Suomen Punainen Risti Veripalv Menetelmä solupopulaatioiden evaluoimiseksi
WO2007054622A1 (en) * 2005-11-08 2007-05-18 Suomen Punainen Risti, Veripalvelu Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof
AU2007264846A1 (en) * 2006-06-29 2008-01-03 Glykos Finland Oy Novel cellular glycan compositions
WO2008087259A1 (en) * 2007-01-18 2008-07-24 Suomen Punainen Risti, Veripalvelu Novel carbohydrate profile compositions from human cells and methods for analysis and modification thereof
US20100047827A1 (en) * 2007-01-18 2010-02-25 Suomen Punainen Risti, Veripalvelu Novel specific cell binders
CA2712556A1 (en) * 2007-01-18 2008-07-24 Glykos Finland Ltd Novel carbohydrate from human cells and methods for analysis and modification thereof

Non-Patent Citations (3)

* Cited by examiner, † Cited by third party
Title
JPN6013048914; Ｊ．　Ｂｉｏｌ．　Ｃｈｅｍ．，　（１９８８），　２６３，　［３４］，　ｐ．１８５０７-１８５１２ *
JPN6013048915; Ｓｔｅｍ　Ｃｅｌｌｓ，　（２００７．０１），　２５，　［１］，　ｐ．１９７-２０２ *
JPN6013048916; Ｇｌｙｃｏｂｉｏｌｏｇｙ，　（１９９８），　８，［７］，　ｐ．６９５-７０５ *

Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2019503985A (ja) * 2015-11-03 2019-02-14 グリコミメティクス， インコーポレイテッド モノクローナル抗体、造血幹細胞の産生のための方法および組成物、ならびにそれらを使用する方法

Also Published As

Publication number Publication date
FI20070853A0 (fi) 2007-11-09
CA2743032A1 (en) 2009-05-14
EP2209809A4 (en) 2011-03-30
EP2209809A1 (en) 2010-07-28
AU2008324073A1 (en) 2009-05-14
US20100292095A1 (en) 2010-11-18
WO2009060129A1 (en) 2009-05-14

Similar Documents

Publication Publication Date Title
JP2011504099A (ja) シアリルルイスｃ、シアリルＴｎ、及びＮ−グリコリルノイラミン酸のエピトープに関連づけられるヒトモノクローナル抗体、ならびに前記エピトープを含む幹細胞の分析方法
JP5773352B2 (ja) 抗ｍｕｃ１抗体
JP5916017B2 (ja) 新規なｍｕｃ１抗体
KR101924673B1 (ko) 미분화 세포 검출 방법 및 복합 당질 검출 방법
Ohyabu et al. An essential epitope of anti-MUC1 monoclonal antibody KL-6 revealed by focused glycopeptide library
JP2011504099A5 (enExample)
Müller-Loennies et al. A monoclonal antibody against a carbohydrate epitope in lipopolysaccharide differentiates Chlamydophila psittaci from Chlamydophila pecorum, Chlamydophila pneumoniae, and Chlamydia trachomatis
Steigmeyer et al. Decoding extracellular protein glycosylation in human health and disease
JP6754932B2 (ja) 幹細胞を検出するための方法及びキット
JP7424718B2 (ja) 抗原の処理方法。
US20210388108A1 (en) Antibodies specific for glycosylated apoj and uses thereof
JP2010156699A (ja) ヤドリギレクチンに対する個体の応答性を判定する方法
CN120035450A (zh) 造血干细胞移植物相关血栓性微血管病（hsct-tma）患者的诊断和预后生物标志物谱
US20110045497A1 (en) Novel acidic glycan markers of human cells
JP2020162572A (ja) 抗原の処理方法。
CN118140144A (zh) 用于诊断癌症的糖蛋白生物标志物
CA3231890A1 (en) Use of lectins to determine mammaglobin-a glycoforms in breast cancer

Legal Events

Date Code Title Description
A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20111107

A621 Written request for application examination

Free format text: JAPANESE INTERMEDIATE CODE: A621

Effective date: 20111107

A521 Request for written amendment filed

Free format text: JAPANESE INTERMEDIATE CODE: A523

Effective date: 20121004

A131 Notification of reasons for refusal

Free format text: JAPANESE INTERMEDIATE CODE: A131

Effective date: 20131001

A02 Decision of refusal

Free format text: JAPANESE INTERMEDIATE CODE: A02

Effective date: 20140311