JP2011501672A - 腸疾患における新規な治療上の標的 - Google Patents

腸疾患における新規な治療上の標的 Download PDF

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JP2011501672A
JP2011501672A JP2010530102A JP2010530102A JP2011501672A JP 2011501672 A JP2011501672 A JP 2011501672A JP 2010530102 A JP2010530102 A JP 2010530102A JP 2010530102 A JP2010530102 A JP 2010530102A JP 2011501672 A JP2011501672 A JP 2011501672A
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Prior art keywords
pxr
gene
protein
rifax
fragment
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JP2010530102A
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Japanese (ja)
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JP2011501672A5 (enExample
Inventor
フランク ジェイ. ゴンザレス,
ローリン ジョンソン,
シャオチャオ マ,
Original Assignee
サリックス ファーマシューティカルズ, インコーポレイテッド
ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ
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Application filed by サリックス ファーマシューティカルズ, インコーポレイテッド, ザ ガバメント オブ ザ ユナイテッド ステイツ オブ アメリカ, アズ リプレゼンテッド バイ ザ セクレタリー, デパートメント オブ ヘルス アンド ヒューマン サービシーズ filed Critical サリックス ファーマシューティカルズ, インコーポレイテッド
Publication of JP2011501672A publication Critical patent/JP2011501672A/ja
Publication of JP2011501672A5 publication Critical patent/JP2011501672A5/ja
Pending legal-status Critical Current

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    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/53Immunoassay; Biospecific binding assay; Materials therefor
    • G01N33/566Immunoassay; Biospecific binding assay; Materials therefor using specific carrier or receptor proteins as ligand binding reagents where possible specific carrier or receptor proteins are classified with their target compounds
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00Medicinal preparations containing organic active ingredients
    • A61K31/33Heterocyclic compounds
    • A61K31/395Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/12Antidiarrhoeals
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61PSPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/705Assays involving receptors, cell surface antigens or cell surface determinants
    • G01N2333/70567Nuclear receptors, e.g. retinoic acid receptor [RAR], RXR, nuclear orphan receptors
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2500/00Screening for compounds of potential therapeutic value
    • G01N2500/04Screening involving studying the effect of compounds C directly on molecule A (e.g. C are potential ligands for a receptor A, or potential substrates for an enzyme A)
    • GPHYSICS
    • G01MEASURING; TESTING
    • G01NINVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00Detection or diagnosis of diseases
    • G01N2800/06Gastro-intestinal diseases
    • G01N2800/065Bowel diseases, e.g. Crohn, ulcerative colitis, IBS

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Immunology (AREA)
  • Epidemiology (AREA)
  • Molecular Biology (AREA)
  • Biomedical Technology (AREA)
  • Urology & Nephrology (AREA)
  • Hematology (AREA)
  • Organic Chemistry (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Biotechnology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Biochemistry (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
JP2010530102A 2007-10-17 2008-10-16 腸疾患における新規な治療上の標的 Pending JP2011501672A (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US99923407P 2007-10-17 2007-10-17
PCT/US2008/080115 WO2009052255A2 (en) 2007-10-17 2008-10-16 Novel therapeutic targets in bowel disease

Publications (2)

Publication Number Publication Date
JP2011501672A true JP2011501672A (ja) 2011-01-13
JP2011501672A5 JP2011501672A5 (enExample) 2011-12-01

Family

ID=40568065

Family Applications (1)

Application Number Title Priority Date Filing Date
JP2010530102A Pending JP2011501672A (ja) 2007-10-17 2008-10-16 腸疾患における新規な治療上の標的

Country Status (7)

Country Link
US (1) US20110055943A1 (enExample)
EP (1) EP2201372A4 (enExample)
JP (1) JP2011501672A (enExample)
CN (1) CN101896815A (enExample)
AU (1) AU2008312464A1 (enExample)
MX (1) MX2010004333A (enExample)
WO (1) WO2009052255A2 (enExample)

Families Citing this family (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
ITBO20050123A1 (it) 2005-03-07 2005-06-06 Alfa Wassermann Spa Formulazioni farmaceutiche gastroresistenti contenenti rifaximina
AU2009244190B2 (en) * 2008-05-07 2016-02-25 Salix Pharmaceuticals, Ltd. Methods of treating bowel disease by administering a bowel cleanser and an antibiotic
CN108267522A (zh) * 2017-12-28 2018-07-10 北京和合医学诊断技术股份有限公司 检测血液中奥氮平药物含量的液相色谱分析方法
CN110470771B (zh) * 2019-09-05 2021-06-01 清华大学 一种评价转基因植物食用安全性的方法
CN117031004B (zh) * 2023-08-09 2024-10-01 四川省医学科学院·四川省人民医院 一种检测网膜素-1的试剂在制备预测或评估ibs患者生活质量的产品中的应用

Non-Patent Citations (4)

* Cited by examiner, † Cited by third party
Title
JPN6013044892; Ma X et al: The Journal of Pharmacology and Experimental Therapeutics Vol. 322, No. 1, 20070701, p. 391-398 *
JPN6013044893; 生化学辞典(第3版) , 20020701, p. 232, 1427 *
JPN6013044894; Fang et al: The Journal of Pharmacology and Experimental Therapeutics Vol. 323, No. 2, 20071101, p. 586-598 *
JPN6013044895; Staudinger et al: PNAS vol. 98, no. 6, 20010313, p. 3369-3374 *

Also Published As

Publication number Publication date
WO2009052255A3 (en) 2009-06-11
CN101896815A (zh) 2010-11-24
MX2010004333A (es) 2010-11-30
EP2201372A2 (en) 2010-06-30
WO2009052255A2 (en) 2009-04-23
EP2201372A4 (en) 2010-11-10
AU2008312464A1 (en) 2009-04-23
US20110055943A1 (en) 2011-03-03

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