JP2011500592A5 - - Google Patents
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- Publication number
- JP2011500592A5 JP2011500592A5 JP2010529076A JP2010529076A JP2011500592A5 JP 2011500592 A5 JP2011500592 A5 JP 2011500592A5 JP 2010529076 A JP2010529076 A JP 2010529076A JP 2010529076 A JP2010529076 A JP 2010529076A JP 2011500592 A5 JP2011500592 A5 JP 2011500592A5
- Authority
- JP
- Japan
- Prior art keywords
- cmv
- vaccine
- cell type
- cell
- population
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 241000701022 Cytomegalovirus Species 0.000 claims 34
- 229960005486 vaccine Drugs 0.000 claims 18
- 210000004027 cell Anatomy 0.000 claims 16
- 238000000034 method Methods 0.000 claims 10
- 210000002919 epithelial cell Anatomy 0.000 claims 6
- 238000004113 cell culture Methods 0.000 claims 5
- 210000002950 fibroblast Anatomy 0.000 claims 5
- 230000001143 conditioned effect Effects 0.000 claims 4
- 210000002845 virion Anatomy 0.000 claims 4
- 230000002238 attenuated effect Effects 0.000 claims 2
- 230000036755 cellular response Effects 0.000 claims 2
- 210000004748 cultured cell Anatomy 0.000 claims 2
- 230000006698 induction Effects 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108090000623 proteins and genes Proteins 0.000 claims 2
- 241000700605 Viruses Species 0.000 claims 1
- 230000007910 cell fusion Effects 0.000 claims 1
- 210000000170 cell membrane Anatomy 0.000 claims 1
- 210000004443 dendritic cell Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 230000004927 fusion Effects 0.000 claims 1
- 230000003053 immunization Effects 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 210000002540 macrophage Anatomy 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 210000002569 neuron Anatomy 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 210000000329 smooth muscle myocyte Anatomy 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US99842607P | 2007-10-10 | 2007-10-10 | |
| US60/998,426 | 2007-10-10 | ||
| PCT/US2008/079494 WO2009049138A1 (en) | 2007-10-10 | 2008-10-10 | Cytomegalovirus vaccines and methods of production |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500592A JP2011500592A (ja) | 2011-01-06 |
| JP2011500592A5 true JP2011500592A5 (cg-RX-API-DMAC7.html) | 2011-10-20 |
| JP5409638B2 JP5409638B2 (ja) | 2014-02-05 |
Family
ID=40549581
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010529076A Expired - Fee Related JP5409638B2 (ja) | 2007-10-10 | 2008-10-10 | サイトメガロウイルスワクチンおよび製造方法 |
Country Status (15)
| Country | Link |
|---|---|
| US (2) | US9439960B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2200645B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5409638B2 (cg-RX-API-DMAC7.html) |
| KR (1) | KR20100084627A (cg-RX-API-DMAC7.html) |
| CN (1) | CN101820906B (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008310713B2 (cg-RX-API-DMAC7.html) |
| BR (1) | BRPI0818656A2 (cg-RX-API-DMAC7.html) |
| CA (1) | CA2701727C (cg-RX-API-DMAC7.html) |
| IL (1) | IL204850A0 (cg-RX-API-DMAC7.html) |
| MX (1) | MX2010003713A (cg-RX-API-DMAC7.html) |
| NZ (1) | NZ584459A (cg-RX-API-DMAC7.html) |
| RU (1) | RU2491340C2 (cg-RX-API-DMAC7.html) |
| SG (1) | SG185291A1 (cg-RX-API-DMAC7.html) |
| WO (1) | WO2009049138A1 (cg-RX-API-DMAC7.html) |
| ZA (1) | ZA201002216B (cg-RX-API-DMAC7.html) |
Families Citing this family (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9439960B2 (en) | 2007-10-10 | 2016-09-13 | The Trustees Of Princeton University | Cytomegalovirus vaccines and methods of production |
| US8580276B2 (en) | 2009-06-05 | 2013-11-12 | City Of Hope | Genetically stable recombinant modified vaccinia ankara (rMVA) vaccines and methods of preparation thereof |
| TWI570240B (zh) * | 2011-09-09 | 2017-02-11 | 默沙東公司 | 作為細胞巨大病毒疫苗之條件式複製ｃｍｖ |
| RU2660712C2 (ru) * | 2012-03-27 | 2018-07-09 | Вэриэйшн Биотекнолоджиз, Инк. | Способы детекции антицитомегаловирусных нейтрализующих антител |
| GB2513768B (en) | 2012-07-06 | 2015-04-15 | Novartis Ag | Complexes of cytomegalovirus proteins and nucleic acids encoding such proteins |
| CN104838000B (zh) | 2012-07-27 | 2022-12-20 | 希望之城 | 一种递送ul128复合体和预防cmv感染的mva疫苗 |
| US9395369B2 (en) | 2012-10-19 | 2016-07-19 | Regents Of The University Of Minnesota | Guinea pig cytomegalovirus (CIDMTR strain) |
| CN103937871B (zh) * | 2013-01-23 | 2019-07-23 | 上海市东方医院 | Srrp35基因和表达产物在癌症诊断与治疗中的应用 |
| WO2015073788A2 (en) * | 2013-11-15 | 2015-05-21 | President And Fellows Of Harvard College | Methods and compositions for the treatment of hcmv |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| WO2018183429A1 (en) * | 2017-03-30 | 2018-10-04 | Merck Sharp & Dohme Corp. | Addition of nucleases directly to cell culture to facilitate digestion and clearance of host cell nucleic acids |
| US20230248820A1 (en) * | 2017-04-19 | 2023-08-10 | Glaxosmithkline Biologicals, S.A. | Modified cytomegalovirus proteins and stabilized complexes |
| CA3079828A1 (en) * | 2017-11-01 | 2019-05-09 | Merck Sharp & Dohme Corp. | Stable formulations of cytomegalovirus |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| TWI810589B (zh) | 2020-06-21 | 2023-08-01 | 美商輝瑞股份有限公司 | 人巨細胞病毒糖蛋白Ｂ（ｇＢ）多肽 |
Family Cites Families (7)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3959466A (en) | 1974-04-15 | 1976-05-25 | The Wistar Institute | Highly attenuated cytomegalovirus vaccine and production thereof |
| US4058598A (en) | 1974-10-18 | 1977-11-15 | Harold Stern | Cytomegalovirus attenuation method and vaccine |
| US6471965B1 (en) | 1994-07-27 | 2002-10-29 | Bio-Virus Research Incorporated | Vaccine containing whole killed herpes viruses to prevent development of atherosclerotic plaque |
| DE10144906B4 (de) * | 2001-09-12 | 2013-11-28 | Novartis Vaccines And Diagnostics Gmbh | Verfahren zur großtechnischen Herstellung von Impfstoffen |
| US7407744B2 (en) | 2003-07-25 | 2008-08-05 | The Regents Of The University Of California | Cytomegalovirus gene function and methods for developing antivirals, anti-CMV vaccines, and CMV-based vectors |
| JP5822433B2 (ja) | 2006-06-07 | 2015-11-24 | ザ・トラスティーズ・オブ・プリンストン・ユニバーシティＴｈｅ Ｔｒｕｓｔｅｅｓ Ｏｆ Ｐｒｉｎｃｅｔｏｎ Ｕｎｉｖｅｒｓｉｔｙ | ワクチン中に薬剤標的として用いるサイトメガロウイルス表面タンパク質複合体 |
| US9439960B2 (en) | 2007-10-10 | 2016-09-13 | The Trustees Of Princeton University | Cytomegalovirus vaccines and methods of production |
-
2008
- 2008-10-01 US US12/681,504 patent/US9439960B2/en active Active
- 2008-10-10 EP EP08836810.5A patent/EP2200645B1/en active Active
- 2008-10-10 CN CN200880111084.9A patent/CN101820906B/zh not_active Expired - Fee Related
- 2008-10-10 RU RU2010117741/10A patent/RU2491340C2/ru not_active IP Right Cessation
- 2008-10-10 CA CA2701727A patent/CA2701727C/en active Active
- 2008-10-10 AU AU2008310713A patent/AU2008310713B2/en not_active Ceased
- 2008-10-10 BR BRPI0818656-1A patent/BRPI0818656A2/pt not_active IP Right Cessation
- 2008-10-10 JP JP2010529076A patent/JP5409638B2/ja not_active Expired - Fee Related
- 2008-10-10 WO PCT/US2008/079494 patent/WO2009049138A1/en not_active Ceased
- 2008-10-10 SG SG2012075594A patent/SG185291A1/en unknown
- 2008-10-10 MX MX2010003713A patent/MX2010003713A/es active IP Right Grant
- 2008-10-10 NZ NZ584459A patent/NZ584459A/en not_active IP Right Cessation
- 2008-10-10 KR KR1020107008187A patent/KR20100084627A/ko not_active Withdrawn
-
2010
- 2010-03-29 ZA ZA2010/02216A patent/ZA201002216B/en unknown
- 2010-04-06 IL IL204850A patent/IL204850A0/en unknown
-
2016
- 2016-07-29 US US15/223,980 patent/US10300130B2/en active Active
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