JP2011500084A5 - - Google Patents
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- Publication number
- JP2011500084A5 JP2011500084A5 JP2010531068A JP2010531068A JP2011500084A5 JP 2011500084 A5 JP2011500084 A5 JP 2011500084A5 JP 2010531068 A JP2010531068 A JP 2010531068A JP 2010531068 A JP2010531068 A JP 2010531068A JP 2011500084 A5 JP2011500084 A5 JP 2011500084A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutical composition
- composition according
- nucleotide
- immune response
- polynucleotide
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000008194 pharmaceutical composition Substances 0.000 claims 32
- 230000004048 modification Effects 0.000 claims 15
- 238000012986 modification Methods 0.000 claims 15
- 230000028993 immune response Effects 0.000 claims 14
- 239000002773 nucleotide Substances 0.000 claims 14
- 125000003729 nucleotide group Chemical group 0.000 claims 14
- 108091033319 polynucleotide Proteins 0.000 claims 12
- 102000040430 polynucleotide Human genes 0.000 claims 12
- 239000002157 polynucleotide Substances 0.000 claims 12
- 108091081406 G-quadruplex Proteins 0.000 claims 11
- 230000015572 biosynthetic process Effects 0.000 claims 11
- UGQMRVRMYYASKQ-KQYNXXCUSA-N Inosine Chemical compound O[C@@H]1[C@H](O)[C@@H](CO)O[C@H]1N1C2=NC=NC(O)=C2N=C1 UGQMRVRMYYASKQ-KQYNXXCUSA-N 0.000 claims 9
- 229930010555 Inosine Natural products 0.000 claims 9
- 229960003786 inosine Drugs 0.000 claims 9
- VGONTNSXDCQUGY-RRKCRQDMSA-N 2'-deoxyinosine Chemical group C1[C@H](O)[C@@H](CO)O[C@H]1N1C(N=CNC2=O)=C2N=C1 VGONTNSXDCQUGY-RRKCRQDMSA-N 0.000 claims 4
- 208000023275 Autoimmune disease Diseases 0.000 claims 4
- 230000001419 dependent effect Effects 0.000 claims 4
- VGONTNSXDCQUGY-UHFFFAOYSA-N desoxyinosine Natural products C1C(O)C(CO)OC1N1C(NC=NC2=O)=C2N=C1 VGONTNSXDCQUGY-UHFFFAOYSA-N 0.000 claims 4
- 230000002401 inhibitory effect Effects 0.000 claims 3
- RYYWUUFWQRZTIU-UHFFFAOYSA-K thiophosphate Chemical compound [O-]P([O-])([O-])=S RYYWUUFWQRZTIU-UHFFFAOYSA-K 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 150000003013 phosphoric acid derivatives Chemical class 0.000 claims 2
- 201000000596 systemic lupus erythematosus Diseases 0.000 claims 2
- NXCOIQLTGGBRJE-XLPZGREQSA-N 7-[(2r,4s,5r)-4-hydroxy-5-(hydroxymethyl)oxolan-2-yl]-1h-pyrrolo[2,3-d]pyrimidine-2,4-dione Chemical compound C1[C@H](O)[C@@H](CO)O[C@H]1N1C(NC(=O)NC2=O)=C2C=C1 NXCOIQLTGGBRJE-XLPZGREQSA-N 0.000 claims 1
- HCAJQHYUCKICQH-VPENINKCSA-N 8-Oxo-7,8-dihydro-2'-deoxyguanosine Chemical compound C1=2NC(N)=NC(=O)C=2NC(=O)N1[C@H]1C[C@H](O)[C@@H](CO)O1 HCAJQHYUCKICQH-VPENINKCSA-N 0.000 claims 1
- 206010061218 Inflammation Diseases 0.000 claims 1
- 206010033645 Pancreatitis Diseases 0.000 claims 1
- 208000037896 autoimmune cutaneous disease Diseases 0.000 claims 1
- 230000036755 cellular response Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 239000003246 corticosteroid Substances 0.000 claims 1
- 230000001934 delay Effects 0.000 claims 1
- NAGJZTKCGNOGPW-UHFFFAOYSA-K dioxido-sulfanylidene-sulfido-$l^{5}-phosphane Chemical compound [O-]P([O-])([S-])=S NAGJZTKCGNOGPW-UHFFFAOYSA-K 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- IIRDTKBZINWQAW-UHFFFAOYSA-N hexaethylene glycol Chemical compound OCCOCCOCCOCCOCCOCCO IIRDTKBZINWQAW-UHFFFAOYSA-N 0.000 claims 1
- 230000004054 inflammatory process Effects 0.000 claims 1
- 230000005764 inhibitory process Effects 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- YACKEPLHDIMKIO-UHFFFAOYSA-L methylphosphonate(2-) Chemical compound CP([O-])([O-])=O YACKEPLHDIMKIO-UHFFFAOYSA-L 0.000 claims 1
- 244000052769 pathogen Species 0.000 claims 1
- 230000001717 pathogenic effect Effects 0.000 claims 1
- PTMHPRAIXMAOOB-UHFFFAOYSA-L phosphoramidate Chemical compound NP([O-])([O-])=O PTMHPRAIXMAOOB-UHFFFAOYSA-L 0.000 claims 1
- 150000003016 phosphoric acids Chemical class 0.000 claims 1
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 1
- 230000000638 stimulation Effects 0.000 claims 1
- 208000024891 symptom Diseases 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US98307307P | 2007-10-26 | 2007-10-26 | |
| US60/983,073 | 2007-10-26 | ||
| PCT/US2008/012220 WO2009055076A2 (en) | 2007-10-26 | 2008-10-27 | Methods and compositions for inhibition of immune responses and autoimmunity |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011500084A JP2011500084A (ja) | 2011-01-06 |
| JP2011500084A5 true JP2011500084A5 (enExample) | 2011-12-15 |
| JP5749492B2 JP5749492B2 (ja) | 2015-07-15 |
Family
ID=40513681
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010531068A Expired - Fee Related JP5749492B2 (ja) | 2007-10-26 | 2008-10-27 | 免疫応答と自己免疫を阻害する方法及び組成物 |
Country Status (6)
| Country | Link |
|---|---|
| US (2) | US8962579B2 (enExample) |
| EP (2) | EP2209896B1 (enExample) |
| JP (1) | JP5749492B2 (enExample) |
| AU (1) | AU2008317261B2 (enExample) |
| CA (1) | CA2703931C (enExample) |
| WO (1) | WO2009055076A2 (enExample) |
Families Citing this family (21)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| SI1794174T1 (sl) | 2004-09-01 | 2012-09-28 | Dynavax Tech Corp | Postopki in sestavki za inhibiranje prirojenih imunskih odzivov in avtoimunosti |
| WO2006066003A2 (en) * | 2004-12-17 | 2006-06-22 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
| ES2542989T3 (es) | 2005-10-12 | 2015-08-13 | Idera Pharmaceuticals, Inc. | Compuestos oligonucleótidos inmuno reguladores (IRO) para modular la respuesta inmune basada en receptor semejante a Toll |
| CA2703931C (en) | 2007-10-26 | 2016-08-16 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
| KR20110071108A (ko) * | 2008-10-06 | 2011-06-28 | 이데라 파마슈티칼즈, 인코포레이티드 | 고콜레스테롤혈증 및 고지혈증 및 이에 관련된 질병의 예방 및 치료에서 톨-유사 수용체의 저해제의 용도 |
| BR112012032240A2 (pt) | 2010-06-16 | 2019-09-24 | Dynavax Technologies Corporation | método de tratamento utilizando inibidores tlr7 e/ou tlr9 |
| WO2011159328A1 (en) * | 2010-06-16 | 2011-12-22 | Dynavax Technologies Corporation | Methods of treatment using tlr7 and/or tlr9 inhibitors |
| US8486908B2 (en) | 2010-11-19 | 2013-07-16 | Idera Pharmaceuticals, Inc. | Immune regulatory oligonucleotide (IRO) compounds to modulate toll-like receptor based immune response |
| US9452212B2 (en) * | 2011-04-14 | 2016-09-27 | Dynavax Technologies Corporation | Methods and compositions for eliciting an immune response against hepatitis B virus |
| US9228184B2 (en) | 2012-09-29 | 2016-01-05 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| US9868955B2 (en) | 2012-09-29 | 2018-01-16 | Dynavax Technologies Corporation | Human toll-like receptor inhibitors and methods of use thereof |
| CN105597079A (zh) * | 2016-01-11 | 2016-05-25 | 中国人民解放军第三军医大学第一附属医院 | 用于治疗银屑病的药物 |
| CN105541947A (zh) * | 2016-01-11 | 2016-05-04 | 中国人民解放军第三军医大学第一附属医院 | 拮抗tlr7/8及tlr9活化的药物分子及用途 |
| EP3436066A1 (en) | 2016-04-01 | 2019-02-06 | Checkmate Pharmaceuticals, Inc. | Fc receptor-mediated drug delivery |
| EP3468605A4 (en) | 2016-06-08 | 2020-01-08 | President and Fellows of Harvard College | MANIPULATED VIRAL VECTOR TO REDUCE INDUCTION OF IGNITION AND IMMUNE REACTIONS |
| JP2021502381A (ja) | 2017-11-08 | 2021-01-28 | プレジデント アンド フェローズ オブ ハーバード カレッジ | ウイルスベクター誘発性炎症反応を阻害するための組成物および方法 |
| EP3752194A4 (en) | 2018-02-13 | 2022-03-16 | Checkmate Pharmaceuticals, Inc. | COMPOSITIONS AND METHODS FOR TUMOR IMMUNOTHERAPY |
| EP3775218A1 (en) | 2018-04-09 | 2021-02-17 | Checkmate Pharmaceuticals | Packaging oligonucleotides into virus-like particles |
| US11504425B2 (en) * | 2019-02-26 | 2022-11-22 | Wayne State University | Amphiphilic oligodeoxynucleotide conjugates as adjuvant enhancers |
| US20220296628A1 (en) | 2019-08-14 | 2022-09-22 | Curevac Ag | Rna combinations and compositions with decreased immunostimulatory properties |
| KR20230165907A (ko) * | 2021-04-08 | 2023-12-05 | 허드슨 인스티튜트 오브 메디컬 리서치 | 올리고뉴클레오티드 |
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| US983073A (en) | 1908-05-28 | 1911-01-31 | Arcade Mallet | Kinematographic apparatus. |
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| US4948882A (en) | 1983-02-22 | 1990-08-14 | Syngene, Inc. | Single-stranded labelled oligonucleotides, reactive monomers and methods of synthesis |
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| US5015733A (en) | 1983-12-20 | 1991-05-14 | California Institute Of Technology | Nucleosides possessing blocked aliphatic amino groups |
| US5118800A (en) | 1983-12-20 | 1992-06-02 | California Institute Of Technology | Oligonucleotides possessing a primary amino group in the terminal nucleotide |
| US5118802A (en) | 1983-12-20 | 1992-06-02 | California Institute Of Technology | DNA-reporter conjugates linked via the 2' or 5'-primary amino group of the 5'-terminal nucleoside |
| US4849513A (en) | 1983-12-20 | 1989-07-18 | California Institute Of Technology | Deoxyribonucleoside phosphoramidites in which an aliphatic amino group is attached to the sugar ring and their use for the preparation of oligonucleotides containing aliphatic amino groups |
| US4587329A (en) | 1984-08-17 | 1986-05-06 | The Dow Chemical Company | Dense star polymers having two dimensional molecular diameter |
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| JP2000512981A (ja) | 1996-06-06 | 2000-10-03 | ラ ホヤ ファーマシューティカル カンパニー | ａＰＬ免疫応答性ペプチド、その結合体およびａＰＬ抗体媒介病理のための処置方法 |
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| ES2649817T3 (es) * | 2002-04-05 | 2018-01-15 | Roche Innovation Center Copenhagen A/S | Compuestos oligom¿¿ricos para la modulaci¿®n de la expresi¿®n de HIF-1¿Á |
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| PT1569696E (pt) | 2002-11-21 | 2010-11-11 | Bayhill Therapeutics Inc | Composições para prevenção e tratamento de esclerose múltipla e diabetes de tipo 1 |
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| US20060193821A1 (en) * | 2004-03-05 | 2006-08-31 | Diener John L | Aptamers to the human IL-12 cytokine family and their use as autoimmune disease therapeutics |
| RU2006135119A (ru) * | 2004-03-05 | 2008-04-10 | Аркемикс Корп. (Us) | Аптамеры к семейству цитокинов il-12 человека и их применение в качестве лекарственных средств для аутоиммунных заболеваний |
| US20050288246A1 (en) | 2004-05-24 | 2005-12-29 | Iversen Patrick L | Peptide conjugated, inosine-substituted antisense oligomer compound and method |
| SI1794174T1 (sl) | 2004-09-01 | 2012-09-28 | Dynavax Tech Corp | Postopki in sestavki za inhibiranje prirojenih imunskih odzivov in avtoimunosti |
| WO2006066003A2 (en) | 2004-12-17 | 2006-06-22 | Dynavax Technologies Corporation | Methods and compositions for induction or promotion of immune tolerance |
| CA2632940A1 (en) * | 2005-12-20 | 2007-07-05 | Idera Pharmaceuticals, Inc. | Immunostimulatory activity of palindromic immune modulatory oligonucleotides (imo tm) contiaining different lengths of palindromic segments |
| WO2007095387A2 (en) * | 2006-02-17 | 2007-08-23 | Dharmacon, Inc. | Compositions and methods for inhibiting gene silencing by rna interference |
| KR20120115412A (ko) | 2006-04-07 | 2012-10-17 | 이데라 파마슈티칼즈, 인코포레이티드 | Ｔｌｒ７ 및 ｔｌｒ８에 대한 안정화된 면역 조절성 ｒｎａ〔ｓｉｍｒａ〕 화합물 |
| EP1881080A1 (en) | 2006-07-18 | 2008-01-23 | Institut Gustave Roussy | Toll like receptor 4 dysfunction and the biological applications thereof |
| CA2703931C (en) | 2007-10-26 | 2016-08-16 | Dynavax Technologies Corporation | Methods and compositions for inhibition of immune responses and autoimmunity |
| BR112012032240A2 (pt) | 2010-06-16 | 2019-09-24 | Dynavax Technologies Corporation | método de tratamento utilizando inibidores tlr7 e/ou tlr9 |
-
2008
- 2008-10-27 CA CA2703931A patent/CA2703931C/en active Active
- 2008-10-27 EP EP08841867.8A patent/EP2209896B1/en active Active
- 2008-10-27 JP JP2010531068A patent/JP5749492B2/ja not_active Expired - Fee Related
- 2008-10-27 WO PCT/US2008/012220 patent/WO2009055076A2/en not_active Ceased
- 2008-10-27 AU AU2008317261A patent/AU2008317261B2/en not_active Ceased
- 2008-10-27 EP EP11155868.0A patent/EP2361980B1/en active Active
-
2010
- 2010-04-26 US US12/767,692 patent/US8962579B2/en active Active
-
2015
- 2015-02-03 US US14/613,280 patent/US9476053B2/en active Active
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