JP2011177438A - Medical double-chamber container, and medical double-chamber container including drug - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a medical double-chamber container, and a medical double-chamber container including a drug which prevent incorrect administration of the drug prior to mixing and facilitate surer mixing and discharge of a plurality of drugs. <P>SOLUTION: The medical double-chamber container comprises a couple of flexible films 11 and 12 facing each other, and includes a container body 10 separated into a plurality of drug-housing chambers 14 and 15 by a removable weak seal part 13, a hollow discharge member 20 which opens at its both ends and allows communication between the drug-housing chamber 15 and an outside of the container body 10, a removal member 30 which is adhered to an opening end face 22 on a side of the drug-housing chamber 15 of the discharge member 20 so that it can be removed and which closes the opening on the side of the drug-housing chamber 15. In the removable member 30, the opening end face 22 has a sloping surface, and the opening end face 22 and the flexible film 11 are attached to the container body 10 in such a way that they faces each other. The removal member 30 has a projection part 31 which projects from an end 22a of the discharge member 20 and is adhered to the flexible film 11 at an end 31a of the projection part 31. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to a medical multi-chamber container provided with a plurality of medicine storage chambers partitioned by weak seal portions, and a medical-containing multi-chamber container containing a medicine stored in the medicine storage chamber of the medical multi-chamber container.

It has been practiced to administer a drug solution in which a plurality of drugs are mixed to a patient, such as mixing a vitamin preparation or the like in physiological saline and injecting or instilling it into the patient.
When mixing a plurality of medicines, depending on the kind of medicines to be combined, they may be deteriorated if they are mixed in advance. Conventionally, when combining drugs that may be altered, another drug is injected into the glass container immediately before use with a syringe or the like and mixed. However, in such a mixing operation, there has been a risk of causing a human error that the mixing ratio is wrong or the mixing is forgotten.
In order to avoid such a human error, a system for preparing a chemical solution by mixing two or more types of drugs based on an inputted prescription has been shown (for example, Patent Document 1). However, this system takes time to prepare a drug and is not suitable for cases where urgent matters are required. Therefore, there has been a demand for a technique for accurately mixing drugs by a simple method.

In response to such a demand, there is provided a medical multi-chamber container in which the inside of the container body is partitioned by a weak seal portion and a plurality of medicine storage chambers are provided, and a plurality of medicines are stored in the plurality of medicine storage chambers without mixing each other. It has been proposed (for example, Patent Document 2). In the container body of such a medical multi-chamber container, usually, a mouth member serving as a discharge port for the chemical liquid is attached in fluid tight communication with one of the plurality of medicine storage chambers. The chemicals can be discharged from.
In the medical multi-chamber container, by applying pressure to the drug storage chamber from the outside when in use, the weak seal portion that partitions each drug storage chamber is peeled off. As a result, the drug stored in each drug storage chamber Are mixed. Therefore, by using the medical multi-chamber container, a plurality of medicines can be mixed at an accurate mixing rate, and the mixing operation can be simplified. However, when the medical multi-chamber container is used, there is a risk that injection or infusion may be performed without forgetting to peel off the weak seal portion. Further, even when pressure is applied to peel off the weak seal portion, it is difficult to visually confirm whether or not the peel is peeled off, and thus there is a possibility that injection or infusion may be performed in a state where the weak seal portion is not peeled off.
Various studies have been made on such problems. For example, in Patent Document 3, a medicine bag formed of a plastic film and having an internal cavity partitioned into a plurality of compartments by weak seal portions, and the outer periphery flows into the medicine bag while facing one of the plurality of compartments. A discharge port that is tightly mounted and a release film that is attached so as to close the discharge port in a normal state, and the release film is attached to the opposite surface of the drug bag to the release port. A drug storage sealing body that is more firmly attached is disclosed.

JP-T-2007-515213 JP 2003-111818 A JP 2006-020964 A

In the drug storage sealing body described in Patent Document 3, the discharge port is normally closed by a release film, and the discharge of the drug from the drug bag to the discharge port is prevented, while the release film constitutes the plastic bag. Since the weak seal part peels off and the drug bag expands and deforms because it is firmly adhered to the opposite surface of the film, the release film is displaced integrally with the drug bag and peels from the discharge port, so that the drug is discharged. It is supposed to be possible. However, in this medicine container sealing body, in the release film, the corresponding back surface of the surface adhered to the plastic film is in close contact with the discharge port in a peelable manner. Therefore, there is no chance that the peeling film is peeled off, and the peeling film may not peel from the discharge port. Also, it seems difficult to manufacture. In this case, although it is said that the release film can be easily peeled by a finger operation from the outside of the medicine bag, it cannot be denied that it takes time to discharge the medicine.
The present invention has been made in view of the circumstances described above, and is a medical multi-chamber that can prevent erroneous administration of drugs before mixing, and can more reliably and easily mix and discharge a plurality of drugs. An object is to provide a container and a medical multi-chamber container containing a medicine.

In order to solve the above problems, the present invention employs the following configuration.
[1] A container body composed of a pair of opposing flexible films and partitioned into a plurality of drug storage chambers by a peelable weak seal portion, and both ends open, and one of the plurality of drug storage chambers A hollow discharge port member capable of communicating with the outside of the container main body, and an opening on the drug storage chamber side, which is detachably bonded to the opening end surface of the discharge port member on the drug storage chamber side. A peeling member,
The discharge port member is attached to the container body such that the opening end surface on the drug storage chamber side has an inclined surface, and the opening end surface and one of the pair of flexible films face each other.
The peeling member has a protruding portion that protrudes from the tip of the discharge port member on the drug storage chamber side, and is bonded to a flexible film that faces the opening end surface at the protruding portion. A medical multi-chamber container.
[2] The medical multi-chamber container according to [1], wherein an end surface of the discharge port member is formed on a plane different from a plane including the inclined surface at the distal end on the medicine storage chamber side.
[3] The medical multi-chamber container according to [1] or [2], wherein the discharge port member is formed with a ridge surrounding the opening on an opening end surface on the medicine storage chamber side.
[4] The medical multi-chamber container according to [3], wherein the ridge has a stress concentration portion at least on a distal end side of the opening end face.
[5] The discharge port member is bonded to the flexible film to which the release member is not bonded in the medicine storage chamber that can communicate with the outside of the container main body by the discharge port member [1]. The medical multi-chamber container according to any one of to [4].
[6] The medical multi-chamber container according to any one of [1] to [5], wherein the discharge port member and the medicine storage chamber are closed in a non-liquid-tight manner.
[7] A medical-equipped medical multi-chamber container in which a medicine is contained in the medical multi-chamber container according to any one of [1] to [6].

  According to the present invention, there are provided a medical multi-chamber container and a medical multi-chamber container containing a drug that can prevent erroneous administration of a drug before mixing and can more reliably and easily mix and discharge a plurality of drugs. Can be provided.

It is a front view of the medical multi-chamber container of one embodiment (first embodiment) of the present invention. It is a fragmentary sectional view of the medical multiple-chamber container shown in FIG. 1 is a longitudinal cross-sectional view (FIG. 3A) showing a state in which a medicine is stored in the medical multi-chamber container shown in FIG. 1 and is hung so that the side to which the discharge port member is attached is downward, and the medical multi-chamber FIG. 3B is a longitudinal sectional view showing a state after the pressure is applied to the container from the outside, the weak seal portion is peeled off, and the first drug storage chamber 14 and the second drug storage chamber 15 are opened. )). It is a perspective view of the front-end | tip part by the side of the chemical | medical agent storage of the discharge port member with which the medical multiple-chamber container of one Embodiment (2nd embodiment) of this invention is provided. FIG. 5 is a top view (FIG. 5A) and a side view (FIG. 5B) of the distal end portion shown in FIG. 4 as viewed from the opening end face side. It is a perspective view of the front-end | tip part by the side of the chemical | medical agent storage of the discharge port member with which the medical multiple-chamber container of one Embodiment (3rd embodiment) of this invention is provided. It is a fragmentary sectional view of the medical multiple-chamber container of one embodiment (fourth embodiment) of the present invention.

  Hereinafter, the embodiment of the medical multi-chamber container of the present invention will be described. However, the present invention is not limited to the following embodiments.

[First embodiment]
The medical multiple chamber container 1 of this embodiment is shown in FIGS. FIG. 1 is a front view of the medical multi-chamber container 1, and FIG. 2 is a partial cross-sectional view of the medical multi-chamber container 1 at a position AA ′ in FIG.
The medical multi-chamber container 1 includes a container body 10 composed of a pair of opposing substantially rectangular flexible films 11 and 12 whose peripheral portions are fused so as not to be peeled off, and both ends open. A hollow discharge port member 20 that enables communication between the inside and the outside of the container, and a substantially rectangular release film (release member) 30 that closes the opening of the discharge port member 20 inside the container body 10 are provided.

The container body 10 is provided with a weak seal portion 13 in which the flexible film 11 and the flexible film 12 are detachably sealed so as to be linear in the short direction of the container body 10. The inside of the container body 10 is partitioned into a first drug storage chamber 14 and a second drug storage chamber 15 by the portion 13. The first medicine storage chamber 14 and the second medicine storage chamber 15 are arranged side by side in the longitudinal direction of the container body 10.
The weak seal portion 13 applies a force from the outside to at least one of the drug storage chambers 14 and 15 in a state where the drug is stored in each of the first drug storage chamber 14 and the second drug storage chamber 15. As a result, the flexible film 11 and the flexible film 12 are peeled off.
The container body 10 has an end on the second drug storage chamber 15 side as a lower end and an end on the first drug storage chamber 14 side as an upper end, and the discharge port member 20 is a flexible film at the peripheral edge on the lower end side. 11 and the flexible film 12, and are integrated by heat welding. A circular suspension hole 16 is provided at the peripheral edge on the upper end side.

In the discharge port member 20, the opening end surface 22 of the container main body 10 on the second medicine storage chamber 15 side is an inclined surface inclined at a constant inclination angle θ ₁ with respect to the length direction of the discharge port member 20. Yes. The inclination angle θ ₁ is preferably about 30 to 45 degrees because the release film 30 is easily peeled off.
The opening on the outside of the container body 10 of the discharge port member 20 is closed with a rubber stopper (not shown), and prevents the medicine from flowing out of the container body 10 before use (during transportation and storage). The medicine in the container body 10 can be discharged by connecting discharge means such as a puncture needle and a dedicated adapter. In addition, a protective film (not shown) that covers a surface into which the piercing needle can be inserted is provided on the opening end surface 21 of the discharge port member 20 outside the container body 10 so as to be peelable.

The discharge port member 20 is attached to the container main body 10 so that the opening end surface 22 on the second medicine storage chamber 15 side and the inner surface of the flexible film 11 face each other. The release film 30 is detachably bonded to the opening end surface 22 of the discharge port member 20, thereby closing the opening on the second drug storage chamber 15 side of the discharge port member 20.
When the release film 30 is bonded to the opening end surface 22, a part of the release film 30 is formed with a protruding portion 31 that protrudes in the longitudinal direction of the container body 10 from the tip of the discharge port member 20 on the drug storage chamber side. The surface opposite to the surface bonded to the discharge port member 20 at the end 31a of the protrusion 31 is flexible in the second medicine storage chamber 15. The adhesive film 11 is adhered to the inner surface.
The adhesive strength of the adhesion between the end 31a of the protruding portion 31 of the release film 30 and the inner surface of the flexible film 11 should not be such that the opening end surface 22 of the discharge port member 20 and the release film 30 are peeled off. That's fine.

As described above, one end of the release film 30 is detachably bonded to the inclined opening end surface 22 of the discharge port member 20, and the protruding portion 31 provided at the other end protruding is bonded to the flexible film 11. As a result, the release film 30 is removed from the opening end face 22 simultaneously with the mixing of the drug stored in the first drug storage chamber 14 of the medical multi-chamber container 1 and the drug stored in the second drug storage chamber 15. It can be reliably and easily peeled off.
An example of mixing and discharging procedures with the medicine using the medical multi-chamber container 1 will be described with reference to FIG. FIG. 3A shows the first drug storage chamber 14 and the second drug storage chamber 15 in which the first chemical liquid L ₁ and the second chemical liquid L ₂ are stored, respectively, before the weak seal portion 13 is peeled off. FIG. 3B is a longitudinal sectional view showing a state in which the medical multi-chamber container 1 is suspended on a hook F such as an infusion stand so that the side on which the discharge port member 20 is attached is downward, and FIG. It is a longitudinal cross-sectional view which shows the state after peeling the weak seal | sticker part 13 and opening the 1st chemical | medical agent storage chamber 14 and the 2nd chemical | medical agent storage chamber 15. FIG.
As shown in FIG. 3 (a), before the weak seal portion 13 is peeled off, the opening on the second medicine storage chamber 15 side of the discharge port member 20 is closed by the release film 30, and the second medicine storage chamber 15. The outflow of the chemical liquid L ₂ inside is prevented.
When pressure is applied from the outside to either one or both of the first drug storage chamber 14 and the second drug storage chamber 15 of the medical multi-chamber container 1, the inner surface of the flexible film 11 is allowed to be pressed. The weak seal part 13 with the inner surface of the flexible film 12 peels off. When the weak seal portion 13 is peeled off, the first agent housing chamber 14 opened and the second agent housing chamber 15, the chemical liquid L ₁ in the first agent housing chamber 14 is moved downward, and the chemical solution L ₂ are mixed, mixed liquid medicine L _M is prepared.
At this time, the release film 30 peels from the opening end face 22 simultaneously with the mixing of the chemical liquid L ₁ and the chemical liquid L ₂ . That is, the weak seal portion 13 is peeled off, the liquid medicine L ₁ is moved downward, as shown in FIG. 3 (b), in the vicinity of the tip 22a of the outlet member 20, by use basic pair 10 is inflated, the flexible The distance between the conductive film 11 and the flexible film 12 becomes long. Along with the deformation of the flexible film 11, the release film 30 is pulled toward the flexible film 11 because the end 31 a is bonded to the inner surface of the flexible film 11, and the release film 30 The distance between the end 31a and the tip 22a of the discharge port member 20 is increased, and a force for peeling the release film 30 is applied to the tip 22a of the opening end surface 22. This triggers the peeling film 30 to start peeling from the tip 22a of the opening end face 22. Further, since the opening end surface 22 has an inclined surface, the release film 30 is sequentially peeled from the tip 22 a of the opening end surface 22. Furthermore, the opening end face 22 has an inclined surface, even small bulging of the container body 10, release film 30 is easily peeled off from the opening end face 22, sufficient openings to mix the chemical solution L _M is discharged Can be obtained. In some cases, the release film 30 may be completely separated from the opening end face 22.

As described above, the release film 30 is peeled off from the opening end face 22, whereby the inside of the container body 10 and the inside of the discharge port member 20 are communicated. Therefore, a mixed drug solution prepared in the container body 10 by inserting a piercing needle such as a drip needle into a rubber plug or the like that closes the opening on the opening end face 21 side of the discharge port member 20 outside the container body 10. the L _M drained, can be administered to a patient such as by infusion.
On the other hand, in the medical multi-chamber container 1, since the peeling film 30 does not peel off when the weak seal portion 13 shown in FIG. 3 (a) is not peeled off, a puncture needle is inserted in that state. also, the discharge of only a chemical solution L ₂ in the second agent housing chamber 15 is not started, it can be prevented administered erroneous unmixed.

In addition, although the example which mixes in the state which suspended the medical multi-chamber container 1 was shown in FIG. 3, this invention is not limited to this. For example, even when it is not suspended, the weak seal portion 13 is peeled off by applying pressure from the outside to one or both of the first drug storage chamber 14 and the second drug storage chamber 15, In the second medicine storage chamber 15, the container body 10 swells and the release film 30 peels from the opening end surface 22 of the discharge port member 20. At this time, in some cases, the possibility that the release film 30 does not occur peeling for only a mixed chemical solution L _M slightly detached from the opening end face 22 of the outlet member 20 to obtain a sufficient aperture to be discharged. But this case, then, when the side where the discharge port member 20 is attached is suspended on the hook F so that the lower, mixed liquid medicine L _M moves downward, the container main body in the second agent housing chamber 15 10 since the swell sufficiently, even right out additional operations, release film 30 can be sufficiently separated from the opening end face 22, can mix the chemical solution L _M is obtained sufficient aperture to be discharged it can.

In the medical multi-chamber container 1, as the flexible film 11, a synthetic resin film used in the field of medical containers can be used. In general, a material having transparency enough to visually recognize a medicine stored in the container body 10 is used.
Synthetic resins used in the field of medical containers include, for example, polyolefin resin, polyamide resin, polyester resin, (meth) acrylic resin, vinyl chloride resin, vinylidene chloride resin, polyethersulfone, ethylene-vinyl alcohol copolymer Etc. Among these, polyolefin resins are preferable because they are excellent in transparency, flexibility and hygiene, and are low in cost.
Examples of the polyolefin resin include high-density polyethylene, medium-density polyethylene, high-pressure low-density polyethylene, linear low-density polyethylene, polyethylene-based resins such as ethylene-vinyl acetate copolymer, and ethylene-α olefin random copolymer. Olefin-based elastomers, polypropylene, ethylene-propylene random copolymers, polypropylene resins such as α-olefin-propylene random copolymers, cyclic polyolefin resins, and mixtures of any two or more thereof.
These synthetic resins may be partially cross-linked for the purpose of improving heat resistance.
The flexible film 11 may be a single layer film or a multilayer film.
The thickness of the flexible film 11 is preferably about 50 to 1000 μm, and more preferably about 100 to 500 μm.

As the flexible film 12, the thing similar to the flexible film 11 is mentioned, A preferable aspect is also the same.
The material constituting the flexible film 11 and the material constituting the flexible film 12 may be different or the same, but at least the inner surface of the container body 10 is the same kind from the viewpoint of easy thermal welding. A film made of the above synthetic resin is preferable.

The discharge port member 20 has at least a portion to be bonded to the container main body 10 (hereinafter sometimes referred to as a seal portion) and an opening end surface 22 inside the container main body 10 from the viewpoint of being easily bonded to the container main body 10 by heat sealing. It is preferably composed of a synthetic resin.
Examples of the synthetic resin include polyolefin resin, polyamide resin, polyester resin, (meth) acrylic resin, vinyl chloride resin, vinylidene chloride resin, polyethersulfone, ethylene-vinyl alcohol copolymer, and the like. Among these, polyolefin resins are preferable because they are excellent in transparency, flexibility and hygiene, and are low in cost.
Examples of the polyolefin resin include high-density polyethylene, medium-density polyethylene, high-pressure low-density polyethylene, linear low-density polyethylene, polyethylene-based resins such as ethylene-vinyl acetate copolymer, and ethylene-α olefin random copolymer. Olefin-based elastomers, polypropylene, ethylene-propylene random copolymers, polypropylene resins such as α-olefin-propylene random copolymers, cyclic polyolefin resins, and mixtures of any two or more thereof.
These synthetic resins may be blended for improving performance, or may be partially crosslinked for the purpose of improving heat resistance.
Each of the seal portion and the opening end face 22 may have a single layer structure made of a single material, or may have a multilayer structure made of a plurality of synthetic resin layers.
As the synthetic resin that constitutes each of the seal portion and the opening end surface 22, the same kind of synthetic resin as the synthetic resin that constitutes the inner surface of the container body 10 is preferable because adhesion by heat welding is easy and the adhesive strength is high.
As for the discharge port member 20, only the seal part and the opening end surface 22 may be made of synthetic resin, or the entire discharge port member 20 may be made of synthetic resin. Moreover, you may form each part of the discharge port member 20 with different synthetic resins or materials other than a synthetic resin, respectively.
The discharge port member 20 can be produced by a known molding method.
The discharge port member 20 may be formed by integrating a plurality of members. For example, a portion of the discharge port member 20 on the opening end surface 22 side including the seal portion and a portion on the opening end surface 21 side of the seal portion may be separately molded and fused.

The material of the layer that forms the surface of the release film 30 that adheres to the inner surface of the flexible film 11 in the container body 10 (hereinafter, may be referred to as an adhesive surface 30A) is acceptable in the container body 10. Since heat welding with the inner surface of the flexible film 11 is possible, it is preferable that the inner surface of the flexible film 11 is made of the same type of synthetic resin as the synthetic resin.
The thickness of the layer forming the adhesive surface 30A is preferably 50 to 500 μm, and particularly preferably 100 to 350 μm. If this layer is 50 μm or more, it is the opposite surface without being thinned by the pressure when the release film 30 is bonded to the opening end surface 22 of the discharge port member 20 and the inner surface of the flexible film 11 by heat sealing. Since the layer forming the surface to be bonded to the opening end surface 22 is suppressed from being exposed to the bonding surface 30A and sufficient bonding strength can be obtained between the bonding surface 30A and the inner surface of the flexible film 11, preferable. Moreover, if this layer is 500 micrometers or less, since the heat conductivity at the time of making it adhere to the inner surface of the flexible film 11 by heat sealing does not fall, since it can be made to adhere with required adhesive strength, it is preferable.

On the other hand, the material of the layer forming the surface of the release film 30 that is bonded to the opening end surface 22 of the discharge port member 20 (hereinafter sometimes referred to as the bonding surface 30B) is bonded to the opening end surface 22 so as to be peelable. Any material can be used. As such a material, for example, a synthetic resin of the same type as the synthetic resin constituting the opening end face 22, a synthetic resin compatible with the synthetic resin constituting the opening end face 22, and an incompatible synthetic resin are used. Examples thereof include a mixed resin obtained by melt kneading. When using the same kind of synthetic resin as the synthetic resin constituting the opening end face 22, it is possible to adhere to the opening end face 22 in a peelable manner by changing the conditions such as temperature and pressure when adhering to the opening end face 22 by heat sealing. It is. The mixed resin may be, for example, a mixture of polyethylene and incompatible polypropylene when the opening end face 22 is made of polyethylene.
The thickness of the layer forming the adhesive surface 30B is preferably 20 to 60 μm, and particularly preferably 25 to 50 μm. If this layer is 20 μm or more, the adhesive surface 30 </ b> A that is the opposite surface is formed by the pressure when the release film 30 is adhered to the opening end surface 22 of the discharge port member 20 and the inner surface of the flexible film 11 by heat sealing. It is preferable because the layer is exposed to the adhesive surface 30B and the adhesive strength between the adhesive surface B and the release film 30 is strengthened and difficult to peel off, and the peelable adhesive strength necessary for the present invention can be obtained. Moreover, if this layer is 60 micrometers or less, since the heat conductivity at the time of making it adhere to the opening end surface 22 by heat sealing does not fall, since it can be made to adhere | attach so that opening is possible, it is preferable.

The release film 30 may be a film formed by coextrusion of films made of materials that form both the adhesive surface 30A and the adhesive surface 30B, or may be a laminated film. As a laminating method, a known method such as a dry laminating method, an extrusion laminating method, or a thermal laminating method is used. In addition to the layers forming both surfaces, other layers may be included as necessary. Furthermore, the release film 30 may be formed of a single layer.
The total thickness of the release film 30 is preferably 70 to 560 μm, and particularly preferably 125 to 400 μm. If this layer is 70 μm or more, each of the adhesive surface 30A and the adhesive surface 30B is formed by pressure when the release film 30 is adhered to the opening end surface 22 and the inner surface of the flexible film 11 by heat sealing. The preferred adhesive strength can be expressed without reducing the thickness of each layer. Further, if this layer is 560 μm or less, the heat conductivity when bonding to the opening end surface 22 and the inner surface of the flexible film 11 by heat sealing does not decrease, so that the bonding surface 30A and the bonding surface 30B are flexible. This is preferable because it can be adhered to the inner surface of the film 11 and the opening end surface 22 with the necessary adhesive strength.

By filling each of the first drug storage chamber 14 and the second drug storage chamber 15 of the medical multi-chamber container 1 with a drug, the medical multi-chamber container can be made.
The drug stored in the first drug storage chamber 14 (hereinafter also referred to as the first drug) may be any one having fluidity, and includes liquid and powder drugs.
The medicine stored in the second medicine storage chamber 15 (hereinafter sometimes referred to as second medicine) is the same as the first medicine. However, since the medical multi-chamber container 1 is often used for storing a drug for infusion or a drug for injection, one or both of the first drug and the second drug are liquid drugs (medical solutions). Is preferred.
The filling amount of the first drug and the second drug can be determined according to the type of each drug.
The discharge port member 20 can also be used as an injection port for filling the second drug solution storage chamber 15 with the second drug. The first chemical solution storage chamber 14 is filled with the first drug from a first chemical solution injection port (not shown).

The medical-equipped medical multi-chamber container can be manufactured, for example, by the following manufacturing method.
First, the flexible film 11 and the flexible film 12 are overlapped, and the peripheral edge on the side end portion side of the container body 10 is bonded by heat sealing so as not to be peeled off.
Next, a weak seal portion 13 that can be peeled off by heat sealing is provided at a position partitioned into the first drug storage chamber 14 and the second drug storage chamber 15.
Separately, the release film 30 is adhered to the opening end surface 22 of the discharge port member 20 so as to be peelable by heat sealing.
After the discharge port member 20 to which the release film 30 has been fused is sandwiched between the flexible film 11 and the flexible film 12 so as to be positioned at an arbitrary position on the lower end side of the container body 10, heat sealing is performed. Then, the peripheral portion on the lower end side and the discharge port member 20 are bonded so as not to be peeled off.
Then, the surface opposite to the surface bonded to the opening end surface 22 is bonded to the flexible film 11 by heat sealing at the end 31a portion of the release film 30. Thus, the medical multi-chamber container 1 in a state where the upper end side of the container body 10 is opened is obtained.
Next, the first medicine storage chamber 14 is filled with an arbitrary amount of the first medicine from the upper end portion of the container main body 10, and then the peripheral portion on the upper end side is bonded so as not to be peeled off by heat sealing. The hanging hole 16 is provided by drilling an arbitrary position on the bonded upper end side.
Next, for example, the second drug storage chamber 15 is filled with the second drug from the discharge port member 20, and then the discharge port member 20 is closed with a rubber plug or the like, and the discharge port member is further peeled off with a protective film. 20 open end faces 21 are covered. In this way, a medicine-filled medical multi-chamber container in which the first medicine storage chamber 14 of the medical multi-chamber container 1 is filled with the first medicine and the second medicine housing chamber 15 is filled with the second medicine can be obtained. it can.
However, the manufacturing method of the medical-equipped medical multi-chamber container in this invention is not limited to this, You may change the order of each process in the range which does not impair the effect of this invention.
The obtained medical multi-chamber container with medicine may be sterilized. As the sterilization treatment, heat sterilization treatment with high-pressure steam is usually performed.

Here, “adhesive releasable” indicates that the medical multi-chamber container with medicine is adhered with such a strength as to be peeled when pressed from the outside. The strength is preferably 2.0 to 5.0 N / 15 mm, and preferably 2.5 to 3.0 N / 15 mm, for example, as a heat seal strength measured by a peel test (JIS Z0238) using a strip having a width of 15 mm. More preferred. The heat seal strength between the opening end face 22 of the discharge port member 20 and the release film 30 and the heat seal strength of the weak seal portion 13 may be the same or different as long as they can be peeled. .
“Adhesive so as not to peel” indicates that the drug-containing medical multi-chamber container is bonded with a strength that does not peel when pressed from the outside. The strength is, for example, preferably 20 to 30 N / 15 mm, more preferably 23 to 25 N / 15 mm, as a heat seal strength measured by a peel test (JIS Z0238) using a strip having a width of 15 mm. The heat seal strength at the peripheral edge of the container body 10, the heat seal strength between the container body 10 and the discharge port member 20, and the heat seal strength between the release film 30 and the flexible film 11 are respectively They may be the same or different as long as they cannot be peeled.
The heat seal strength may be hereinafter referred to as peel strength or adhesive strength.
The heat seal strength can be adjusted by changing conditions such as the temperature and pressure of the heat seal. Moreover, the method of making the heat seal strength of the weak seal part 13 into a peelable strength is made of, for example, a resin mixture having different melting points and compatibility, such as a mixture of polyethylene and polypropylene, on the inner surface side of the container body 10. The method of sealing at the temperature below the melting temperature of high melting point resin using the synthetic resin film in which the layer was formed is mentioned. Also, a method of performing heat sealing at a low temperature and weakly adhering in a semi-welded state, a method of using a flexible material previously cross-linked with an electron beam or the like in the formation portion of the weak seal portion 13, a specific area ratio of the strong fusion portion And a method using a seal bar generated by the method, a method of sandwiching an easily peelable resin tape between the flexible film 11 and the flexible film 12, and the like.
Moreover, you may manufacture by the adhesion | attachment method by the seal | sticker using an impulse seal | sticker or an adhesive agent other than the adhesion | attachment method by heat sealing.

[Second Embodiment]
In the medical multi-chamber container of the present embodiment, instead of the discharge port member 20, the discharge port has an end surface formed on a plane different from the plane including the inclined surface at the tip on the second medicine storage chamber 15 side. The configuration is the same as that of the medical multi-chamber container of the first embodiment except that the member 20 ′ is provided.
In FIG. 4, the perspective view of the front-end | tip part by the side of the 2nd chemical | medical agent storage chamber 15 of discharge port member 20 'with which the medical multiple-chamber container of this embodiment is provided is shown. FIG. 5 shows a top view (FIG. 5 (a)) and a side view (FIG. 5 (b)) of the tip portion viewed from the opening end face 22 side. In the embodiments described below, the same reference numerals are given to the components corresponding to the first embodiment, and detailed description thereof will be omitted.
As shown in FIGS. 4 to 5, the discharge port member 20 ′ used in the present embodiment has an end surface 23 formed on a plane different from the plane including the inclined surface at the tip on the second medicine storage chamber 15 side. Has been.
By forming the end face 23, the peelability of the release film 30 is further improved. That is, when the end face 23 is not formed and the tip is pointed, the tip is very thin. When the release film 30 is pulled toward the flexible film 11, the tip of the open end face 22 is at the same time. There is a case where the release film 30 is hardly peeled by being pulled toward the flexible film 11. However, by forming the end face 23 and increasing the thickness of the tip portion of the discharge port member 20, the rigidity of the discharge port member 20 at the tip portion is improved, and stress is applied to the corner portion at the tip of the opening end surface 22. Since it becomes easy to start, since peeling from the front-end | tip part of the opening end surface 22 tends to arise, it is preferable.
The discharge port member 20 ′ can be produced by a known molding method. Further, for example, a discharge port member having the same shape as the discharge port member 20 may be manufactured, and the front end of the opening end surface 22 may be cut.

[Third embodiment]
The medical multi-chamber container of the present embodiment is the medical of the second embodiment, except that the opening end face 22 of the discharge port member 20 ′ is provided with a discharge port member 20 ″ formed with a ridge surrounding the opening. The configuration is the same as that of the multi-chamber container.
FIG. 6 is a perspective view of the distal end portion on the second medicine storage chamber 15 side of the discharge port member 20 ″ included in the medical multi-chamber container of the present embodiment.
As shown in FIG. 6, the discharge port member 20 ″ used in the present embodiment has a continuous substantially elliptical ridge 25 surrounding the opening 24 formed on the opening end surface 22. 25 are provided with corner portions 25a and 25b that protrude outwardly and serve as stress concentration portions, respectively, at two positions on the distal end side of the opening end face 22 and on the opposite side.
By forming the ridges 25, the peelability from the opening end face 22 of the release film 30 is further improved. That is, in this embodiment, since the peeling film 30 adheres to the upper end of the ridge 25, the adhesive area is small compared to the case where the peeling film 30 is adhered to the entire opening end face 22, and the peeling film 30 is easy to peel off. In addition, when there is a corner 25a protruding on the distal end side of the opening end surface 22 of the ridge 25, when the weak seal portion 13 is peeled and the release film 30 is pulled to the flexible film 11 side, Since the force applied to the tip of the opening end face 22 concentrates on the corner 25a and becomes the starting point of peeling of the release film 30, peeling is likely to occur.
The discharge port member 20 ″ can be manufactured by a known molding method. For example, a discharge port member having the same shape as the discharge port member 20 ′ is manufactured, and a ridge 25 is formed on the opening end surface 22 by heat welding. You may produce by doing.
In the present embodiment, the example in which the two corners 25a and 25b are provided has been described. However, the above effect can be obtained if at least the corner 25a on the distal end side of the opening end surface 22 is provided, and the corner 25b is necessarily provided. There is no. Moreover, you may provide the protruding item | line 25 and the corner | angular part 25a, 25b in the opening end surface 22 of the discharge port member 20 in 1st embodiment.

[Fourth embodiment]
The medical multi-chamber container 2 of the present embodiment has a discharge port member 20 ′ in the flexible film 12 that is the flexible film to which the release film 30 is not bonded in the second drug storage chamber 15. The structure is the same as that of the medical multi-chamber container of the second embodiment except that is adhered.
In FIG. 7, the fragmentary sectional view of the medical multi-chamber container 2 of this embodiment is shown. As shown in FIG. 7, the medical multi-chamber container 2 has the back portion 26 of the opening end surface 22 of the discharge port member 20 ′ adhered to the inner surface of the flexible film 12 in the second medicine storage chamber 15. ing.
By setting it as this structure, the peelability of the peeling film 30 further improves. That is, when the back surface portion 26 of the opening end surface 22 of the discharge port member 20 ′ is adhered to the flexible film 12, the peeling film 30 is flexible when the weak seal portion 13 peels and the container body 10 swells. Since the back surface portion 26 is pulled toward the flexible film 12 and the release film 30 and the back surface portion 26 of the opening end surface 22 are pulled in directions opposite to each other, the opening end surface 22 of the release film 30 is pulled. It is easy to peel off.
In addition, in this embodiment, although the back surface part 26 of the opening end surface 22 of discharge port member 20 'in 2nd embodiment was shown on the inner surface of the flexible film 12, the example in 1st embodiment was shown. The back surface portion 26 of the opening end face 22 of the discharge port member 20 or the discharge port member 20 ″ in the third embodiment may be bonded to the inner surface of the flexible film 12.

The first to fourth embodiments have been described above, but the present invention is not limited to these embodiments.
For example, the number of drug solution storage chambers formed in the medical multi-chamber container is not limited to two, and may be three or more.
Although the example which comprised the container main body 10 with two flexible films was shown, for example, one flexible film may be folded and used, and the film formed by blow molding may be used. .
The release film 30 has been described by taking a substantially rectangular shape as an example, but is not limited thereto, and may have a shape other than a substantially rectangular shape as long as the effects of the present invention are not impaired.
Although the example which used the peeling film 30 as a peeling member was shown, you may use a nonwoven fabric, paper, etc., for example.
In the discharge port member 20 ″, the protrusion 25 having the corners 25a and 25b is provided on the opening end face 22, but the corners 25a and 25b may not be provided.

In the present invention, the inside of the discharge port member 20 and the inside of the second medicine storage chamber 15 are preferably closed in a non-liquid-tight manner. Specifically, the cross-sectional area of the second medicine storage chamber 15 and the inside of the discharge port member 20 is communicated with at least one of the discharge port member 20 (or the discharge port member 20 ′ or 20 ″) and the release film 30. It is preferable that a hole or notch of 5 to 5.0 mm ² is formed.
In general, a medical multi-chamber container containing a chemical solution is subjected to a heat sterilization process using high-pressure steam in order to ensure sterility after filling the drug. However, when the heat sterilization process using high-pressure steam is performed with the openings at both ends of the discharge port member 20 closed, moisture or the like cannot be present in the discharge port member 20, which may result in insufficient sterilization. The inside of the second medicine storage chamber 15 and the discharge port member 20 are closed in a non-liquid-tight manner so as to have air permeability or liquid permeability. The inside of the discharge port member 20 can be distributed through the notch, and sterilization can be sufficiently performed.
A hole or a notch may be provided in any one of the discharge port member 20 and the peeling film 30, and may be provided in both.
In the case of the release film 30, it is preferable to provide a hole at a position overlapping the opening 24 on the second drug storage chamber 15 side of the discharge port member 20.
In the case of the discharge port member 20, it is preferable to provide a notch in the opening end surface 22. The position where the cutout is provided on the opening end surface 22 is not particularly limited, but the tip of the opening end surface 22 is preferable. Thereby, the notch functions as a stress concentration portion like the corner portion 25a, and the peelability from the opening end surface 22 of the release film 30 is further improved.
In the case of the discharge port member 20 ″, the protrusion 25 may be discontinuous by providing a notch. When the notch is provided at the tip of the opening end face 22, a corner 25a is formed. Even if not, the same peelability can be obtained.

  DESCRIPTION OF SYMBOLS 1 ... Medical multi-chamber container, 2 ... Medical multi-chamber container, 10 ... Container main body, 11 ... Flexible film, 12 ... Flexible film, 13 ... Weak seal part, 14 ... 1st chemical | medical solution storage chamber, DESCRIPTION OF SYMBOLS 15 ... 2nd chemical | medical solution storage chamber, 16 ... Hanging hole, 20 ... Discharge port member, 20 '... Discharge port member, 20 "... Discharge port member, 21 ... Open end surface, 22 ... Open end surface, 23 ... End surface, 24 ... Opening, 25 ... convex, 30 ... release film, 31 ... protrusion

Claims (7)

A container body composed of a pair of opposing flexible films and partitioned into a plurality of drug storage chambers by a weak seal portion that can be peeled off, one end of the plurality of drug storage chambers and the container being opened at both ends A hollow discharge port member that allows communication with the outside of the main body, and a peeling member that detachably adheres to the opening end surface of the discharge port member on the drug storage chamber side, and closes the opening on the drug storage chamber side With
The discharge port member is attached to the container body such that the opening end surface on the drug storage chamber side has an inclined surface, and the opening end surface and one of the pair of flexible films face each other.
The peeling member has a protruding portion that protrudes from the tip of the discharge port member on the drug storage chamber side, and is bonded to a flexible film that faces the opening end surface at the protruding portion. A medical multi-chamber container.   2. The medical multi-chamber container according to claim 1, wherein an end surface of the discharge port member is formed on a plane different from a plane including the inclined surface at a distal end of the medicine storage chamber.   3. The medical multi-chamber container according to claim 1, wherein the discharge port member is formed with a ridge that surrounds the opening on an opening end surface of the medicine storage chamber.   The medical multi-chamber container according to claim 3, wherein the protrusion has a stress concentration portion at least on a distal end side of the opening end face.   5. The discharge port member according to claim 1, wherein the discharge port member is bonded to a flexible film to which the peeling member is not bonded in a medicine storage chamber that can communicate with the outside of the container body by the discharge port member. The medical multi-chamber container according to any one of the above.   The medical multi-chamber container according to any one of claims 1 to 5, wherein the discharge port member and the medicine storage chamber are closed in a non-liquid-tight manner.   A medical-use multi-chamber container containing a medicine in the medical multi-chamber container according to any one of claims 1 to 6.

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