JP2011137785A - Analyzer - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an analyzer allowing an insert to be efficiently washed, which is inserted into a liquid containing magnetic particles. <P>SOLUTION: This analyzer for analyzing a specimen by using a reagent containing magnetic particles, includes a reagent probe 22a inserted into a container with magnetic particles contained therein and a probe washer for washing the reagent probe 22a. The probe washer is equipped with an electromagnet 629e for supplying magnetic force to the interior of a washing tank 629a supplied with washing liquid, causing a magnetic field to be generated in the washing tank 629a together with a liquid flow of the washing liquid Wb. Since magnetic particles 51 attracted to the surface of the reagent probe 22a can be removed, it is made possible to efficiently wash the reagent probe 22a. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an analyzer for analyzing a specimen based on optical characteristics of a reaction product between a measurement object contained in the specimen and magnetic particles contained in a reagent.

  The analyzer can perform analysis processing on a large number of liquid samples such as blood samples and urine samples at the same time. In addition, it can analyze multiple components quickly and with high accuracy. It is used for inspection in various fields. Among these, in an analyzer for performing an immunological test, an analysis target in a sample is detected using an antibody-antigen reaction. That is, in such an analyzer, a reagent containing magnetic particles having an antibody or antigen that specifically binds to the analyte and a reagent containing a labeling substance having an antibody or antigen that specifically binds to the analyte. After dispensing into the sample and generating a reaction product that combines the antigen or antibody to be analyzed with magnetic particles and a labeling substance, the analyte in the sample is detected by acquiring the optical properties of the reaction product. is doing. In the analyzer, each time the analysis process is completed, the reagent probe for dispensing the reagent and the specimen is washed to prevent contamination in the analyzer.

  Here, as a cleaning mechanism for each reagent probe, the dispensed reagent probe is inserted into a cleaning tank having a drain port, and the cleaning liquid is supplied into the cleaning layer rather than the drain flow rate from the drain port. There has been proposed a cleaning mechanism that supplies the cleaning liquid into the cleaning tank so as to increase the flow rate and cleans the outside of the reagent probe (see, for example, Patent Document 1).

JP 2003-240787 A

  Here, since the reagent probe is made of metal, the magnetic particles are likely to adhere to the surface, and even after dispensing the reagent containing the magnetic particles, the magnetic particles may remain attached to the surface of the reagent probe. Many. However, in the conventional cleaning mechanism, it is difficult to efficiently remove the magnetic particles remaining on the reagent probe surface because the cleaning liquid is simply flowed to the outside of the reagent probe. In particular, in the case of the cleaning process of the reagent probe, the liquid pressure can be applied to the inside of the reagent probe by repeating the suction and discharge of the cleaning liquid. The external surface of the probe cannot be applied with a hydraulic pressure, and the magnetic material must be removed only by a liquid flow, and magnetic particles sometimes remain. For this reason, in the conventional analyzer, in order to prevent contamination in the analyzer, a disposable protective cap is attached to the tip of the reagent probe for each analysis process, and the dispensing process is performed.

  The present invention has been made in view of the above, and an object of the present invention is to provide an analyzer that enables efficient cleaning of an insertion member inserted into a liquid containing magnetic particles.

  In order to solve the above-described problems and achieve the object, an analyzer according to the present invention is inserted into a container containing magnetic particles in an analyzer that analyzes a sample using a reagent containing magnetic particles. An insertion member; and a cleaning unit that cleans the insertion member, the cleaning unit including a cleaning tank to which a cleaning liquid is supplied, and a magnetic field generation unit that generates a magnetic field in the cleaning tank. Features.

  The analyzer according to the present invention further comprises a cleaning tank magnetic field control means for controlling the generation of a magnetic field by the magnetic field generating means in the cleaning tank, and the cleaning tank magnetic field control means is configured to collect the magnetic flux by the cleaning means. When the member is cleaned, the magnetic field generating means generates a magnetic field in the cleaning layer.

  In the analyzer according to the present invention, the magnetic field generating means includes an electromagnet, and the cleaning tank magnetic field control means controls a current supplied to the electromagnet, thereby controlling the magnetic field generated by the magnetic field generating means in the cleaning tank. It is characterized by controlling the occurrence of.

  Further, in the analyzer according to the present invention, the magnetic field generating means is either a permanent magnet and a position where the permanent magnet is close to the cleaning tank or a position where the magnetic field by the permanent magnet does not reach the cleaning tank. The cleaning tank magnetic field control means for causing the magnet transfer means to transfer the permanent magnet to a position close to the cleaning tank to cause the magnetic field generating means to move into the cleaning tank. And generating the magnetic field in the cleaning tank by causing the magnetic field generating means to stop the generation of the magnetic field in the cleaning tank by moving the permanent magnet to a position where the magnetic field generated by the permanent magnet does not reach the cleaning tank.

  The present invention, in an analyzer for analyzing a sample using a reagent containing magnetic particles, comprises an insertion member inserted into a container containing magnetic particles, and a cleaning means for cleaning the insertion member, By providing a magnetic field generating means for generating a magnetic field in the cleaning tank, by generating a magnetic field in the cleaning tank along with the flow of the cleaning liquid, it is possible to remove the magnetic particles adsorbed on the surface of the insertion member from the surface of the insertion member. An efficient cleaning process of the insertion member inserted into the liquid containing magnetic particles is enabled.

FIG. 1 is a schematic diagram illustrating the configuration of the analyzer according to the first embodiment. FIG. 2 is a perspective view schematically showing the magnetic flux collecting rod transfer unit, the photometry unit, and the magnetic flux collecting rod cleaning unit shown in FIG. FIG. 3 is a diagram for explaining the measurement object in the sample, the reaction of the magnetic particles and the label particles contained in the reagent, and the measurement process by the photometry unit in the analyzer shown in FIG. FIG. 4 is a cross-sectional view of the magnetic flux collecting rod shown in FIG. FIG. 5 is a perspective view showing a tip portion of the magnetic flux collecting rod shown in FIG. FIG. 6 is a diagram for explaining the invalidation of the magnetic force during the cleaning process of the magnetic flux collecting rod shown in FIG. FIG. 7 is a flowchart showing the processing procedure from the recovery process of the complex to the magnet bar cleaning process in the main part of the analyzer shown in FIG. FIG. 8 is a perspective view showing another example of the tip portion of the magnetic flux collecting rod shown in FIG. FIG. 9 is a schematic diagram illustrating another configuration of the analyzer according to the first embodiment. 10 is a sectional view of the magnetic flux collecting rod shown in FIG. FIG. 11 is a diagram for explaining the activation of the magnetic force during the recovery process of the magnetic collecting rod shown in FIG. 9 in the reaction vessel. FIG. 12 is a diagram for explaining the invalidation of the magnetic force during the cleaning process of the magnetic flux collecting rod shown in FIG. FIG. 13 is a flowchart showing the processing procedure from the complex recovery process to the magnet bar cleaning process in the main part of the analyzer shown in FIG. FIG. 14 is a schematic diagram illustrating a configuration of the analyzer according to the second embodiment. FIG. 15 is a cross-sectional view of the cleaning tank provided in the magnetic flux collecting bar cleaning section shown in FIG. FIG. 16 is a diagram for explaining the invalidation of the magnetic force during the cleaning process of the magnetic flux collecting rod shown in FIG. FIG. 17 is a flowchart showing a processing procedure from the complex recovery process to the magnet bar cleaning process in the main part of the analyzer shown in FIG. FIG. 18 is a cross-sectional view showing another example of the cleaning tank provided in the magnetic flux collecting bar cleaning section shown in FIG. FIG. 19 is a cross-sectional view showing another example of the cleaning tank provided in the magnetic flux collecting bar cleaning section shown in FIG. FIG. 20 is a schematic diagram illustrating another configuration of the analyzer according to the second embodiment. FIG. 21 is a cross-sectional view of the cleaning tank provided in the magnetic flux collecting bar cleaning section shown in FIG. FIG. 22 is an explanatory diagram of a main part of the cleaning tank shown in FIG. FIG. 23 is a diagram for explaining the magnetic rod cleaning process in the analyzer shown in FIG. FIG. 24 is a flowchart showing the processing procedure from the complex recovery process to the magnet bar cleaning process in the main part of the analyzer shown in FIG. FIG. 25 is a diagram for explaining another example of the magnetic flux collecting rod in the analyzer shown in FIG. FIG. 26 is a flowchart showing a processing procedure from the recovery process of the complex to the cleaning process of the magnetic collecting bar in the main part of the analyzer equipped with the magnetic collecting bar shown in FIG. FIG. 27 is a diagram for explaining another example of the magnetic collecting rod in the analyzer shown in FIG. FIG. 28 is a flowchart showing a processing procedure from the recovery process of the complex to the cleaning process of the magnetic collecting rod in the main part of the analyzer equipped with the magnetic collecting rod shown in FIG. FIG. 29 is a schematic diagram illustrating the configuration of the analyzer according to the third embodiment. FIG. 30 is a cross-sectional view of a probe cleaning tank provided in the probe cleaning unit shown in FIG. FIG. 31 is a diagram for explaining the cleaning process of the reagent probe in the analyzer shown in FIG. FIG. 32 is a flowchart showing a processing procedure from the first reagent dispensing process to the probe cleaning process in the main part of the analyzer shown in FIG. 29. FIG. 33 is a cross-sectional view showing another example of the cleaning tank provided in the probe cleaning section shown in FIG. 34 is a cross-sectional view showing another example of the cleaning tank provided in the probe cleaning section shown in FIG. FIG. 35 is a schematic diagram illustrating another configuration of the analyzer according to the third embodiment. 36 is a cross-sectional view of a probe cleaning tank provided in the probe cleaning section shown in FIG. FIG. 37 is an explanatory diagram of a main part of the probe cleaning tank shown in FIG. FIG. 38 is a view for explaining the cleaning process of the reagent probe in the analyzer shown in FIG. FIG. 39 is a flowchart showing a processing procedure from the first reagent dispensing process to the probe cleaning process in the main part of the analyzer shown in FIG. FIG. 40 is a schematic diagram illustrating another configuration of the analyzer according to the first embodiment. FIG. 41 is a diagram for explaining the reaction of the measurement target in the sample, the magnetic particles contained in the reagent, and the label particles in the analyzer shown in FIG. FIG. 42 is a diagram for explaining measurement processing by the photometry unit in the analyzer shown in FIG.

  The following is an example of an analyzer that performs analysis by measuring surface-enhanced Raman scattered light (SERS) on a body fluid sample such as blood, urine, or saliva. explain. Note that the present invention is not limited to the embodiments. In the description of the drawings, the same parts are denoted by the same reference numerals.

(Embodiment 1)
First, the first embodiment will be described. FIG. 1 is a schematic diagram illustrating the configuration of the analyzer according to the first embodiment. As shown in FIG. 1, the analyzer 1 according to the first embodiment emits a laser beam to a complex of a measurement object, a magnetic particle, and a labeling substance contained in a specimen, and the surface from the complex is enhanced. A measurement mechanism 2 that measures Raman scattered light, and a control mechanism 4 that controls the entire analyzer 1 including the measurement mechanism 2 and analyzes the measurement results in the measurement mechanism 2. The analyzer 1 automatically performs analysis on a plurality of specimens by the cooperation of these two mechanisms.

  The measurement mechanism 2 will be described. The measurement mechanism 2 is roughly divided into a reaction table 10, a sample transfer unit 19, a sample dispensing unit 20, a first reagent storage 21, a first reagent dispensing unit 22, a probe cleaning unit 23, a second reagent storage 24, and a second. A reagent dispensing unit 25, a probe cleaning unit 26, a stirring unit 27, a magnetic flux collecting rod transfer unit 28, a magnetic flux collecting rod cleaning unit 29, a photometric unit 30, and a container cleaning unit 31 are provided.

  The reaction table 10 transfers the reaction container 11 to a predetermined position in order to dispense a sample or reagent into the reaction container 11, to stir and wash the reaction container 11. The reaction table 10 is rotatable about a vertical line passing through the center of the reaction table 10 as a rotation axis by driving a drive mechanism (not shown) under the control of the control unit 41 described later.

  The sample transfer unit 19 includes a plurality of sample racks 19b that hold a plurality of sample containers 19a that store liquid samples such as blood, urine, or saliva and sequentially transfer them in the direction of the arrows in the figure. The sample in the sample container 19a transferred to the sample aspiration position on the sample transfer unit 19 is dispensed by the sample dispensing unit 20 into the reaction container 11 that is arranged and transported on the reaction table 10.

  The sample dispensing unit 20 includes an arm that freely moves up and down in the vertical direction and rotates around a vertical line passing through its base end as a central axis. A sample probe for aspirating and discharging the sample is attached to the tip of the arm. The sample dispensing unit 20 includes an intake / exhaust mechanism using an unillustrated intake / exhaust syringe or piezoelectric element. The sample dispensing unit 20 sucks the sample from the sample container 19a transferred to the predetermined position on the sample transfer unit 19 with the sample probe, rotates the arm counterclockwise in the drawing, The specimen is discharged into the reaction container 11.

  The first reagent storage 21 can store a plurality of first reagent bottles 21a in which the first reagent is stored. The second reagent storage 24 can store a plurality of second reagent bottles 24a in which second reagents are stored. The first reagent in the first reagent bottle 21a and the second reagent in the second reagent bottle 24a are respectively dispensed into the reaction container 11 of the reaction table 10. The first reagent storage 21 and the second reagent storage 24 can be rotated clockwise or counterclockwise by driving a drive mechanism (not shown), and a desired reagent bottle can be moved to the first reagent dispensing unit 22 or the second reagent storage 22. 2. Transfer to the reagent aspirating position by the reagent dispensing unit 25. Here, the measurement object in the sample includes, for example, antibodies, proteins, peptides, amino acids, carbohydrates, hormones, steroids, vitamins, bacteria, DNA, RNA, cells, viruses, any antigenic substances, haptens, antibodies, and There are combinations of these. The first reagent is a reagent including magnetic particles solid-phased with an antigen or an antibody that binds to a measurement target in a sample that is an analysis target. The second reagent is a reagent containing a labeling substance that binds to the measurement target in the sample. The labeling substance is a particle containing gold or silver having an atomic surface roughness, and the surface of the particle containing gold or silver is coated with an antigen or an antibody that can bind to the measurement object.

  The first reagent dispensing unit 22 has a reagent probe for aspirating and discharging the first reagent attached to the distal end portion, and can freely move up and down in the vertical direction and rotate around a vertical line passing through its base end portion. An arm is provided. The first reagent dispensing unit 22 includes a suction / discharge mechanism using a suction / discharge syringe or a piezoelectric element (not shown). The first reagent dispensing unit 22 sucks the reagent in the first reagent bottle 21a moved to a predetermined position by the first reagent storage 21 by the reagent probe, rotates the arm, and discharges the first reagent by the reaction table 10. Dispense into the reaction container 11 conveyed to the position. The second reagent dispensing unit 25 has the same configuration as that of the first reagent dispensing unit 22, and the reagent in the second reagent bottle 24a moved to a predetermined position by the second reagent storage 24 is aspirated by the reagent probe. Then, the arm is turned and dispensed into the reaction container 11 conveyed to the second reagent discharge position by the reaction table 10.

  The probe cleaning units 23 and 26 are disposed on the locus of the reagent probe of the first reagent dispensing unit 22 and on the locus of the reagent probe of the second reagent dispensing unit 25, respectively, and clean the inside and outside of the reagent probe. Do. After the reagent dispensing is completed, the reagent probe is washed by the probe washing units 23 and 26, and then the next reagent dispensing process is performed.

  The stirring unit 27 stirs the sample dispensed into the reaction container 11 and the reagent to promote the reaction. The reaction of the sample, the first reagent, and the second reagent dispensed in the reaction container 11 is promoted by the stirring unit 27. As a result, a complex of the measurement object, magnetic particles, and labeling substance contained in the specimen is generated in the reaction container 11. This composite has magnetic particles. When the magnetic particles are located in a region to which the magnetic field extends, the magnetic particles have a magnetic force in the magnetic field and are attracted to the magnetic field generation source. As a result, the composite having magnetic particles is also attracted to the magnetic field generation source.

  As shown in FIG. 2, the magnetic flux collecting rod transporting portion 28 has an arm 28 b that is attached to the tip of a magnetic flux collecting rod 28 a that generates a magnetic field with respect to the reaction vessel 11 and that can freely move up and down. The magnetic flux collecting rod transfer unit 28 contains a sample and a reagent and is located in a predetermined magnetic flux collecting position, a photometric position by a photometric unit 30 described later, or a cleaning position by a magnetic rod cleaning unit 29 described later. The magnetic flux collecting rod 28a is transferred to Specifically, the magnetic flux collecting rod transfer unit 28 is a reaction vessel 11 that is transferred to the reaction table 10 according to a predetermined locus L2, and is located inside the reaction vessel 11 located at a predetermined magnetic collection position on the locus L1. Then, the magnetic flux collecting rod 28 a is transferred to the photometric position inside the photometric portion 30 or the cleaning tank 29 a of the magnetic flux collecting rod cleaning portion 29.

  As shown in FIG. 2, the magnetic flux collecting rod transfer unit 28 is connected to the other end of the arm 28 b, and has a column 28 c whose vertical axis passing through the other end of the arm 28 b is the central axis. The magnetic flux collecting rod transfer unit 28 includes a rotating mechanism 28d that rotates the support column 28c and an elevating mechanism 28e that moves the support column 28c up and down. The rotation mechanism 28d is connected to a pulley 282d and is fixed to a rotation motor 281d fixed to a non-moving portion of the apparatus main body, a pulley 284d provided integrally with the column 28c, and the pulley 282d and the pulley 284d. A rotating belt 283d. When the rotation motor 281d rotates in a direction corresponding to clockwise or counterclockwise rotation, the rotation of the rotation motor 281d is sequentially transmitted to the pulley 282d, the rotation belt 283d, and the pulley 284d, whereby the column 28c rotates clockwise or counterclockwise. Rotate around. By this rotation of the column 28c, the arm 28b to which the column 28c is connected rotates along the locus L2 as indicated by an arrow Y5. The elevating mechanism 28e is connected to the pulley 282e and fixed to the immovable portion inside the analyzer 1, the elevating plate 286e provided integrally with the lower end of the column 28c, and parallel to the column 28c. The screw shaft 285e is fixed to a non-moving portion inside the analyzer 1 and provided with a pulley 284e at the lower end, and the pulley 282e and the lifting belt 283e stretched over the pulley 284e are provided. The screw shaft 285e passes through the lifting plate 286e, and the lifting plate 286e and the screw shaft 285e constitute, for example, a ball screw mechanism. When the elevating motor 281e rotates in a direction corresponding to the upward or downward direction, the rotation of the elevating motor 281e is sequentially transmitted to the pulley 282e, the elevating belt 283e, and the pulley 284e, whereby the screw shaft 285e rotates. As the screw shaft 285e rotates, the elevating plate 286e is also raised or lowered, so that the column 28c is raised or lowered. As the column 28c is moved up and down, the arm 28b connected to the column 28c is also moved up and down as indicated by an arrow Y6.

  The magnetic flux collecting rod transfer unit 28 inserts the magnetic flux collecting rod 28a into the reaction container 11 in which the specimen, the first reagent, and the second reagent are dispensed and the complex is generated. The magnetic flux collecting rod 28a inserted into the reaction vessel 11 generates a magnetic field in the reaction vessel 11 from the tip, thereby adsorbing the magnetic particles in the complex in the reaction vessel 11 on the tip surface of the magnetic flux collecting rod 28a, Magnetize the composite. Thereafter, the magnetic flux collecting rod transfer unit 28 moves the arm 28b to move the magnetic flux collecting rod 28c onto an opening 30c of the photometric unit 30 to be described later, and lowers the arm 28b to lower the photometric unit through the opening 30c. The magnetic flux collecting rod 28a is inserted up to 30 photometric positions. Then, after the photometric processing by the photometric unit 30 is completed, the magnetic flux collecting rod transfer unit 28 cleans the magnetic flux collecting rod 28a from the photometric position by the photometric unit 30 to the cleaning tank 29a in the magnetic flux collecting rod cleaning unit 29 described later. The magnetic flux collecting rod 28a having the composite adsorbed on the tip surface is transferred. As will be described later, the magnetic flux collecting rod transfer section 28 has a cylindrical shape inside the magnetic flux collecting rod 28a, and a magnetic control rod 28h that can move up and down in the cylindrical shape in the figure. And a stopper member 28j joined to the control rod 28h.

  As shown in FIG. 2, the magnetic flux collecting bar cleaning unit 29 is connected to the cleaning liquid tank on the side surface and supplies a cleaning liquid to the cleaning liquid supply pipe 29 b, and on the bottom surface is connected to the drainage tank and discharges the cleaning liquid and the like. The magnetic flux collecting rod 28a having a predetermined washing tank 29a to which the 29c is connected and having finished the photometry process by the photometry unit 30 is washed. The cleaning tank 29a has a substantially prismatic shape with an opening in the upper part, accommodates the magnetic flux collecting rod 28a, and cleans the magnetic flux collecting rod 28a. The magnetic flux collecting rod cleaning section 29 has a concave portion 29f that can be mounted on the upper portion of the control rod 28h of the magnetic flux collecting rod 28a and is positioned on the locus L2, and the stopper member 28j can be hung on the upper surface on the concave portion 29f side. It has a plate-like member 29e and a column 29d that is connected to the plate-like member 29e and fixed to a stationary part inside the analyzer 1. As shown in FIG. 2, the height of the column 29d and the connection point between the column 29d and the plate member 29e are set so that the plate member 29e is located a predetermined distance away from the upper part of the cleaning tank 29a. Has been.

  The photometry unit 30 performs photometric processing on the composite with the magnetic flux collecting rod 28a collected to measure the optical characteristics of the composite. The photometry unit 30 measures the surface-enhanced Raman scattered light of the aggregate in which the complex is aggregated, and outputs the measurement result to the control mechanism 4.

  The container cleaning unit 31 sucks and discharges the mixed liquid in the reaction container 11 from which the composite has been removed by the magnetic flux collecting process of the composite by the magnetic collecting rod 28a by means of a nozzle (not shown), as well as detergent and washing water. The reaction vessel 11 is washed by injecting and sucking the washing liquid. Although the washed reaction container 11 is reused, the reaction container 11 may be discarded after completion of one measurement depending on the contents of inspection.

  Next, the control mechanism 4 will be described. The control mechanism 4 includes a control unit 41, an input unit 42, an analysis unit 43, a storage unit 44, and an output unit 45. These units included in the measurement mechanism 2 and the control mechanism 4 are electrically connected to the control unit 41.

  The control unit 41 is configured using a CPU or the like, and controls processing and operation of each unit of the analyzer 1. The control unit 41 performs predetermined input / output control on information input / output to / from each of these components, and performs predetermined information processing on this information.

  The input unit 42 is configured using a keyboard, a mouse, and the like, and acquires various information necessary for analyzing the sample, instruction information for the analysis operation, and the like from the outside. The analysis unit 43 analyzes the sample based on the Raman spectroscopic result acquired from the photometry unit 33.

  The storage unit 44 is configured by using a hard disk that magnetically stores information and a memory that electrically loads various programs related to the process from the hard disk when the analyzer 1 executes the process, Various information including the analysis result of the sample is stored. The storage unit 44 may include an auxiliary storage device that can read information from a storage medium such as a CD-ROM, a DVD-ROM, or a PC card.

  The output unit 45 is configured using a printer, a speaker, and the like, and outputs various information including the analysis result of the sample. The output unit 45 may output information according to a predetermined format to an external device via a communication network (not shown).

  In the analyzer 1 configured as described above, the sample dispensing unit 20 dispenses the sample in the sample container 19a to the plurality of reaction containers 11 that are sequentially conveyed in a row, and the first reagent dispensing is performed. The injection part 22 dispenses the first reagent in the first reagent bottle 21a, and the second reagent dispensing part 25 dispenses the second reagent in the second reagent bottle 24a. Specifically, a sample is injected into each reaction container 11 from the sample container 19a by the sample dispensing unit 20, and as shown in FIG. 3 (1), the first reagent containing the magnetic particles 51 and the labeling substance A second reagent containing gold particles 52 is injected. The magnetic particles 51 and the gold particles 52 react with the measurement object 50 in the specimen. As a result, as shown in FIG. 3 (2), the magnetic particles 51, the gold particles 52, and the measurement object 50 are combined. A body 53 is formed. Thereafter, as shown by the arrow Y1 in FIG. 3 (2), the magnetic flux collecting rod transfer unit 28 inserts the magnetic flux collecting rod 28a into the reaction vessel 11 in which the complex 53 is formed. Then, as indicated by an arrow Y2 in FIG. 3 (3), the magnetic collecting rod 28a generates a magnetic field from the front end in the reaction vessel 11, and the magnetic particles of the composite 53 are attracted to the front surface of the magnetic collecting rod 28a. By adsorbing, an aggregate 54 in which the composite 53 is aggregated is formed on the tip surface of the magnetic collecting rod 28a. Thus, the magnetic flux collecting rod 28a collects the composite 53 on the tip surface. Thereafter, the magnetic flux collecting rod 28a is pulled up from the inside of the reaction vessel 11 as indicated by an arrow Y3 by the magnetic flux collecting rod transfer unit 28 with the aggregate 54 adsorbed on the surface, and is transferred to the photometric position of the photometric unit 30. .

  As shown in FIG. 3 (4), the photometry unit 30 includes a laser light source 30a, a condensing mechanism (not shown), and a Raman spectrometer 30b. In the photometry unit 30, the laser light Li emitted from the laser light source 30a is incident on the aggregate 54 adsorbed on the surface of the magnetic collecting rod 28a, and the Raman scattered light Lf whose surface is enhanced by the aggregate 54 is converted into the Raman spectrometer 30b. Measured by. The measurement result by the Raman spectrometer 30b is output to the control unit 41 described later. The analysis unit 43 analyzes the measurement result, so that the component analysis of the sample is automatically performed. In addition, the container cleaning unit 31 cleans the reaction container 11 that is being transported after the magnetic flux collection processing of the complex 53 by the magnetic flux collecting rod 28a has been completed and the complex 53 has been removed. Repeated continuously. Then, the magnetic flux collecting rod 28 a that has been measured by the photometric unit 30 is cleaned by the magnetic flux collecting rod cleaning unit 29, and then performs a magnetic flux collecting process for the complex 53 on the reaction vessel 11 to be measured next.

  Here, in the analyzer 1 according to the first embodiment, the magnetic collecting rod 28a does not always generate a magnetic field, but generates a magnetic field in the reaction vessel 11, and further generates this magnetic field. It is possible to stop. In other words, the magnetic flux collecting rod 28a can turn on or off the generation of a magnetic field. The control unit 41 includes a magnetic collecting bar magnetic field control unit 46 that controls generation of a magnetic field by the magnetic collecting rod 28 a in the reaction vessel 11, and this magnetic collecting rod magnetic field control unit 46 is a magnetic collecting rod in the reaction vessel 11. By controlling the generation of the magnetic field by 28a and the stop of the generation of this magnetic field, the magnetic collection of the composite 53 (aggregate 54) from the reaction vessel 11 and the magnetic collection of the aggregate 54 after the photometry is adsorbed The rod 28a is smoothly cleaned.

  Next, the magnetism collecting rod 28a will be described in detail. 4 is a cross-sectional view of the magnetic flux collecting rod 28a shown in FIG. 2 cut in the longitudinal direction, and FIG. 5 is a perspective view showing a tip portion of the magnetic flux collecting rod 28a shown in FIG. As shown in FIGS. 4 and 5, the magnetic flux collecting rod 28a includes an outer cylinder 28g. The outer cylinder 28g has a structure in which the inside is hollow, and has a cylindrical shape in which at least a tip is formed of a magnetic material and an upper surface is opened. The distal end portion of the outer cylinder 28g has a pointed shape formed by cutting out from two directions. The upper part of the outer cylinder 28g is mounted in a hole provided at the tip of the arm 28b and fixedly connected to the arm 28b.

  A control rod 28h that can move up and down in the cavity of the outer cylinder 28g is inserted into the cavity of the outer cylinder 28g. A permanent magnet 28i is connected to the lower end of the control rod 28h. The permanent magnet 28i may be a permanent magnet made of neodymium element or a ferrite magnet. The control rod 28h and the permanent magnet 28i may be joined by welding as well as by an adhesive. When the tip of the control rod 28h is formed of a magnetic material, the control rod 28h and the permanent magnet 28i can be connected by a magnetic field generated by the permanent magnet 28i. The length of the control rod 28h is such that the upper end of the control rod 28h protrudes from the arm 28b strip even when the permanent magnet 28i at the lower end of the control rod 28h contacts the bottom of the cavity inside the outer cylinder 28g. Is set to The control rod 28h is supported on the arm 28b by a bearing 28k. A stopper member 28j is provided at the top end of the control rod 28h.

  In the magnetic flux collecting rod 28a, the position of the permanent magnet 28i at the lower end of the control rod 28h is changed to a position close to the magnetic flux collecting location of the composite 53, thereby generating a magnetic field in the reaction vessel 11, and the permanent magnet By changing the position of 28i to a position away from the magnetic collection location of the composite 53 and the magnetic field of the permanent magnet 28i does not reach the magnetic collection location of the composite 53, the generation of the magnetic field in the reaction vessel 11 occurs. Stop.

  First, the case where the magnetic flux collecting rod 28a generates a magnetic field in the reaction vessel 11 will be described. As shown in FIG. 4, when the control rod 28h is inserted up to the bottom of the cavity of the outer cylinder 28g according to gravity or the like, the permanent magnet 28i is positioned close to the lower end of the outer cylinder 28g. That is, in this case, the permanent magnet 28i is positioned close to the two flat surfaces 28m cut out at the tip of the outer cylinder 28g. As a result, the magnetic field of the permanent magnet 28i is emitted from these planes 28m, and the magnetic field can be generated from the tip of the magnetic flux collecting rod 28a. When the magnetic flux collecting rod 28a in this state is inserted into the reaction vessel 11 in which the complex 53 is formed, a magnetic field can be generated in the reaction vessel 11 from the flat surface 28m at the tip of the magnetic flux collecting rod 28a. As a result, the composite 53, which is a magnetic material, is attracted to the surfaces of the two flat surfaces 28m of the outer cylinder 28g as indicated by the arrow Y2 shown in FIG. 3 (3), and the magnetic flux collecting rods 28a are aggregated 54 on the surface of the flat surface 28m. Thus, the composite 53 can be magnetized. In this way, the control rod 28h is inserted to the bottom of the cavity of the outer cylinder 28g so that the position of the permanent magnet 28i is close to the plane 28m, which is the magnetic collection location, during the magnetic collection process of the composite 53. This makes it possible to generate a magnetic field by the magnetic collecting rod 28a in the reaction vessel 11. The magnetic flux collecting rod 28a maintains this state in the magnetic flux collecting process of the composite 53 and the photometric process by the photometric unit 30. That is, the magnetic flux collecting rod magnetic field control unit 46 controls the movement process of the arm 28b, and inserts the magnetic flux collecting rod 28a with the control rod 28h inserted into the bottom of the cavity of the outer cylinder 28g into the reaction vessel 11. By maintaining the state of the magnetism collecting rod 28a until the magnetism collecting rod 28a is moved to the photometry position in the photometry section 30 by generating a magnetic field in the reaction vessel 11, Generation of a magnetic field from the tip of the magnetic flux collecting rod 28a is maintained.

  Next, a case where the magnetic field generated by the magnetic flux collecting rod 28a from the tip of the magnetic flux collecting rod 28a is stopped will be described. When the position of the permanent magnet 28i at the lower end of the control rod 28h is changed from the plane 28m, which is the magnetic collection point, to a separated position where the magnetic field of the permanent magnet 28i does not reach, the magnetism collecting rod 28a is The generation of the magnetic field stops. Then, after the photometry processing of the aggregate 54 on the surface 28 m by the photometry unit 30 is finished and the magnetism collecting rod 28 a is washed by the magnetism collecting rod cleaning unit 29, the magnetic field from the tip of the magnetism collecting rod 28 a is reduced. Occurrence stops.

  FIG. 6 is a diagram for explaining the stop of the generation of the magnetic field from the tip of the magnetic flux collecting rod 28a during the cleaning process of the magnetic flux collecting rod 28a. With reference to FIG. 6 and FIG. 2, generation of a magnetic field from the tip of the magnetic flux collecting rod 28a during the magnetic flux collecting rod cleaning process will be described. First, the magnetic flux collecting bar magnetic field control unit 46 performs photometry of the magnetic flux collecting rod 28a by the photometric unit 30 with respect to the magnetic flux collecting rod transfer unit 28 when the photometry of the aggregate 54 on the surface 28m by the photometric unit 30 is completed. The position is moved from the position to the cleaning position by the magnetic flux collecting bar cleaning unit 29. Specifically, the magnetic flux collecting rod magnetic field control unit 46 raises the arm 28b and raises the magnetic flux collecting rod 28a from the photometry unit 30 with respect to the magnetic flux collecting rod transfer unit 28, and then moves to a locus L2 shown in FIG. The magnetic flux collecting rod 28a is moved onto the magnetic flux collecting rod cleaning unit 29 by rotating the arm 28b along the arm 28b.

  Then, as shown in FIG. 6, the magnetic flux collecting bar magnetic field control unit 46 controls the moving operation of the arm 28b, thereby mounting the upper part of the control rod 28h in the recess 29f of the plate-like member 29e. The stopper member 28j is hung on the upper surface of the recess 29f side. In this state, the magnetic flux collecting bar magnetic field control unit 46 lowers the arm 28b as indicated by an arrow Y8. As the arm 28b is lowered, the outer cylinder 28g of the magnetic flux collecting rod 28a fixedly connected to the arm 28b is also lowered into the cleaning tank 29a in the magnetic flux collecting rod cleaning section 29 as indicated by an arrow Y9.

  On the other hand, the control rod 28h in the magnetic flux collecting rod 28a is not lowered even if the arm 28b is lowered because the upper stopper member 28j is hung on the plate-like member 29e. Keep the height of. Therefore, as shown in FIG. 6, the position of the lower end of the control rod 28h is changed to the upper part in the cavity of the outer cylinder 28g as the outer cylinder 28g is lowered as the arm 28b is lowered. That is, the entire control rod 28h rises relative to the outer cylinder 28g. Accordingly, the position of the permanent magnet 28i connected to the lower end of the control rod 28h is also changed to a position in the upper part of the cavity of the outer cylinder 28g so that the magnetic field of the permanent magnet 28i does not reach the plane 28m. In other words, the position of the permanent magnet 28i changes from the bottom of the cavity of the outer cylinder 28g to the top of the cavity, thereby being separated from the plane 28m that is the magnetic collection position of the composite 53, and the magnetic field of the permanent magnet 28i is flat. It will change to a position that does not reach 28m. As a result, the generation of the magnetic field from the tip of the magnetic flux collecting rod 28a generated in the reaction vessel 11 in the magnetic flux collecting process and the photometric process of the composite 53 is stopped. That is, when the magnetic collecting rod 28a is cleaned by the magnetic collecting rod cleaning unit 29, the magnetic collecting rod magnetic field control unit 46 rotates the arm 28b so that the stopper member 28j of the control rod 28h is engaged with the plate member 28e. After that, by lowering the arm 28b, only the outer cylinder 28g is inserted into the cleaning tank 29a, and the generation of the magnetic field from the magnetic collecting rod 28a to the tip of the magnetic collecting rod 28a is stopped.

  The analyzer 1 supplies the cleaning liquid Wa from the cleaning liquid supply pipe 29b into the cleaning tank 29a in which the magnetic collecting bar 28a is inserted in a state where the generation of the magnetic field from the magnetic collecting bar 28a is stopped in this manner, thereby collecting the magnetic collecting bar. 28a is being washed. In this case, the aggregate 54 adsorbed on the surface 28m by the magnetic field emitted from the surface 28m should stop the generation of the magnetic field from the tip of the magnetic collecting rod 28a, which is the cause of the adsorption, and the magnetic field will not reach. Then, the adsorption to the flat surface 28m is released, and it is peeled off from the surface of the magnetic flux collecting rod 28a as shown by the arrow Y10 in FIG. Then, the aggregate 54 separated from the magnetic flux collecting rod 28a flows downward according to the water flow of the cleaning liquid Wa. The magnetic collecting rod cleaning unit 29 removes the aggregate 54 adsorbed on the surface of the magnetic collecting rod 28a by discarding the cleaning liquid Wa containing the aggregate 54 to the outside of the cleaning tank 29a through the drain pipe 29c. .

  Thus, in the analyzer 1, the magnetic collecting rod 28a collects the composite 53 from the reaction vessel 11 on the tip surface by generating a magnetic field in the reaction vessel 11, and stops the generation of this magnetic field. It is possible. For this reason, in the analyzer 1, the composite 53 (aggregate 54) can be appropriately collected by generating a magnetic field from the tip of the magnetic collecting rod 28a, and a magnetic field is generated from the tip of the magnetic collecting rod 28a. Can be removed appropriately from the surface of the magnetic flux collecting rod 28a after the photometric treatment. Therefore, according to the analyzer 1, since the complex 53 can be appropriately removed from the surface of the magnetic flux collecting rod 28a without attaching a protective cap to the magnetic flux collecting rod, both prevention of contamination in the device and reduction of waste are achieved. Is possible.

  Of course, in the analyzer 1, since the complex 53 is collected by inserting the magnetic flux collecting rod 28a directly into the reaction solution in the reaction vessel 11, the complex is collected from outside the reaction vessel. As compared with the case of performing the conventional BF (bound-free) separation process in which the unreacted substances other than those are removed to leave the complex, the complex 53 can be more efficiently magnetized. In addition, since the analysis apparatus 1 does not need to perform the conventional BF separation process, the analysis process can be performed with high accuracy without increasing the efficiency of the BF separation process. Moreover, in the analyzer 1, since SERS photometry can be performed with the aggregate 54 adsorbed on the surface of the magnetic flux collecting rod 28a, compared with the conventional method for measuring the optical characteristics of the composite in liquid. The influence of impurities contained in the liquid can be greatly reduced, and analysis processing can be performed with high accuracy.

  In the magnetic flux collecting rod cleaning unit 29 shown in FIG. 6, the cleaning liquid supply pipe 29b is provided on the side surface of the cleaning tank 29a so as to penetrate the cleaning tank 29a, and supplies the cleaning liquid or water into the cleaning tank 29a. Further, the amount of drainage from the drainage pipe 29c is controlled by opening and closing a solenoid valve (not shown) provided in the drainage pipe 29c. In the magnetic flux collecting rod cleaning process, the electromagnetic valve is kept closed until a certain amount of cleaning liquid is supplied into the cleaning tank 29a so as not to exceed the cleaning liquid height Pw. A mechanism other than the electromagnetic valve may be provided in the drainage pipe 29c to control the flow rate.

  Next, an operation process of the main part of the analyzer 1 from the magnetic flux collecting process of the composite 53 to the magnetic flux collecting bar cleaning process will be described. FIG. 7 is a flowchart showing a processing procedure from the magnetic flux collecting process to the magnetic flux collecting bar cleaning process of the complex 53 in the main part of the analyzer 1.

  As shown in FIG. 7, the magnetic flux collecting bar magnetic field control unit 46 rotates and moves the arm 28 b of the magnetic flux collecting rod transfer unit 28, whereby the magnetic flux collecting rod 28 a is stored in the reaction container 11 accommodated in the reaction table 10. Are transferred onto the reaction vessel 11 located at the magnetic collection position (step S2). Then, the magnetic flux collecting bar magnetic field control unit 46 performs a magnetic flux collecting bar lowering process for lowering the magnetic flux collecting bar 28a into the reaction vessel 11 by lowering the arm 28b (step S4). In this case, since the control rod 28h in the magnetic flux collecting rod 28a is inserted to the bottom of the hollow of the outer cylinder 28g according to gravity, the permanent magnet 28i connected to the bottom end of the control rod 28h is the magnetic collecting surface of the composite 53. Close to the plane 28m. For this reason, a magnetic field is emitted from the flat surface 28m at the tip of the magnetic flux collecting rod 28a. Therefore, when the magnetic collecting rod 28a is lowered into the reaction vessel 11 in this state, the magnetic field emitted from the tip of the magnetic collecting rod 28a is also moved into the reaction vessel 11, so that the magnetic collecting rod 28a is placed in the reaction vessel 11. Will generate a magnetic field. The composite 53 is adsorbed on the surface of the flat surface 28m at the tip of the magnetic flux collecting rod 28a, and an aggregate 54 is formed. The arm 28 b lowers the magnetic flux collecting rod 28 a into the reaction vessel 11 so that the upper end of the magnetic body portion of the outer cylinder 28 g of the magnetic flux collecting rod 28 a is positioned above the liquid level in the reaction vessel 11. When the upper end of the magnetic part of the outer cylinder 28g is positioned below the liquid level, the composite 53 is attracted to the upper end of the magnetic part of the outer cylinder 28g in addition to the flat surface 28m at the lower end of the outer cylinder 28m. This is because the magnetic flux collection efficiency in the plane 28m of the composite 53 is reduced. The descending speed of the magnetic collecting rod 28a into the reaction vessel 11 is preferably 50 m / second or less.

  Then, the magnetic flux collecting bar magnetic field control unit 46 determines whether or not a predetermined magnetic flux collecting time for forming the aggregate 54 at the tip of the magnetic flux collecting rod 28a has elapsed (step S6). This magnetic collection time needs to be 0.1 second or more, and is preferably 2 seconds or more in order to make the magnetic collection efficiency of the composite 53 constant or more. The magnetic flux collecting rod magnetic field control unit 46 repeats the determination process of step S6 until this magnetic flux collection time elapses, and when it is determined that the magnetic flux collection time has elapsed (step S6: Yes), the magnetic flux collecting rod 28a from the reaction vessel 11 is reached. In order to take out the magnetic flux collecting rod, the magnetic flux collecting rod raising process for raising the magnetic flux collecting rod 28a from the reaction vessel 11 by raising the arm 28b is performed (step S8). It is desirable that the rising speed of the magnetism collecting rod 28a from the reaction vessel 11 is set equal to or lower than the falling speed.

  Next, the magnetic flux collecting bar magnetic field control unit 46 rotates and moves the arm 28b to transfer the magnetic flux collecting rod 28a onto the photometric unit 30 (step S10), and lowers the arm 28b to move the magnetic flux collecting rod 28a to the photometric unit 30. A magnetic rod lowering process for lowering to the photometric position is performed (step S12). In this case, since the position of the permanent magnet 28i at the tip of the control rod 28h with respect to the magnetism collecting rod 28a has not changed, the generation of the magnetic field from the tip of the magnetism collecting rod 28a is maintained. Therefore, the magnetic flux collecting rod 28a is transferred into the photometry unit 30 with the aggregate 54 adsorbed on the surface of the flat surface 28m at the tip, and photometric processing is performed. Thereafter, the magnetic flux collecting rod magnetic field control unit 46 determines whether or not the photometric process for the aggregate 54 adsorbed on the tip of the magnetic flux collecting rod 28a is completed (step S14). For example, the magnetic flux collecting bar magnetic field control unit 46 determines that the photometric process is completed when a predetermined photometric time has elapsed. This photometric time varies depending on the type of detection means of the photometric unit 30, and in any case, it is 0.1 second or longer. The photometric time is preferably 1 second or longer when detecting surface-enhanced Raman scattered light.

  Then, the magnetic flux collecting rod magnetic field control unit 46 repeats the determination process of step S14 until the photometry process is completed, and when it is determined that the photometry process is completed (step S14: Yes), by raising the arm 28b, The magnetic rod raising process for raising the magnetic rod 28a from the photometry unit 30 is performed (step S16). Thereafter, the magnetic flux collecting bar magnetic field control unit 46 rotates the arm 28b to wash the magnetic flux collecting rod 28a that has been subjected to the photometric processing, thereby placing the magnetic flux collecting rod 28a on the cleaning tank 29a of the magnetic flux collecting bar cleaning unit 29. Transfer (step S18). When the transfer of the magnetic flux collecting rod 28a onto the cleaning tank 29a is completed, the stopper member 28j above the control rod 28h of the magnetic flux collecting rod 28a is moved to the upper surface on the concave portion 29f side of the plate member 29e in the magnetic flux collecting rod cleaning portion 29. It will be in the state hung on. That is, the stopper member 28j can be mounted on the upper surface on the concave portion 29f side of the plate-like member 29e which is a stopper avoiding member (step S20).

  In this state, the magnetic flux collecting bar magnetic field controller 46 lowers the magnetic flux collecting bar 28a into the cleaning tank 29a by lowering the arm 28b (step S22). In this case, since the upper stopper member 28j is hung on the plate-shaped member 29e, the control rod 28h in the magnetic flux collecting rod 28a is not lowered even if the arm 28b is lowered, and remains as it is. Hold Accordingly, the permanent magnet 28i connected to the lower end of the control rod 28h also maintains the height as it is. On the other hand, since the outer cylinder 28g descends as the arm 28b is lowered, the plane 28m at the tip of the outer cylinder 28g is separated from the permanent magnet 28i. For this reason, the generation of the magnetic field from the tip of the magnetic flux collecting rod 28a stops, and the magnetic field of the permanent magnet 28i does not reach the plane 28m. The descending speed of the magnetism collecting rod 28a in the cleaning tank 29a is 0.1 mm / second or more, and is preferably about 150 mm / second. Further, by adjusting the descending speed of the arm 28b, the relative ascending speed of the control rod 28h with respect to the outer cylinder 28g can be adjusted. Further, by adjusting the installation height of the stopper member 28j and the plate-like member 29e, the amount of relative rise of the control rod 28h with respect to the outer cylinder 28g can be adjusted.

  Thereafter, the control unit 41 starts supplying the cleaning liquid into the cleaning tank 29a (step S26), and cleans the magnetic flux collecting rod 28a. In this case, since the generation of the magnetic field from the tip of the magnetic flux collecting rod 28a is stopped, the aggregate 54 adsorbed on the flat surface 28m at the tip of the outer cylinder 28g is detached into the cleaning liquid and is passed through the drain pipe 29c. Discarded. Further, the control unit 41 controls the electromagnetic valve provided in the drainage pipe 29c so as to adjust the drainage amount so that the cleaning liquid does not exceed or falls below the cleaning liquid height Pw in the cleaning tank 29a. Further, the control unit 41 controls the electromagnetic valve to maintain the height of the cleaning liquid and to form a flow of the cleaning liquid in the cleaning tank 29a. The cleaning liquid height Pw is set to be higher than the upper end of the magnetic part of the outer cylinder 28g of the magnetic collecting rod 28a when the magnetic collecting rod 28a is inserted into the cleaning tank 29a.

  The magnetic flux collecting bar magnetic field control unit 46 determines whether or not a predetermined cleaning time has elapsed (step S28). This washing time needs to be 0.1 second or longer, and is desirably 2 seconds or longer for reliable removal of the complex 53. The magnetic flux collecting bar magnetic field control unit 46 repeats the determination process of step S28 until the cleaning time elapses, and when it is determined that the magnetic flux collection time has elapsed (step S28: Yes), the magnetic flux collecting rod 28a is removed from the cleaning tank 29a. In order to take it out, a magnet collecting bar raising process is performed in which the arm 28b is raised to raise the magnet collecting bar 28a from the cleaning tank 29a (step S30). The rising speed of the magnetism collecting rod 28a from the washing tank 29a is not until the tip surface of the outer cylinder 28g exceeds the washing liquid height Pw in order to prevent the washing liquid from adhering to the tip of the outer cylinder 28g of the magnetism collecting rod 28a. 50 mm / second or less. When the arm 28b is raised, the outer cylinder 28g is also raised, and the control rod 28h is mounted in the cavity of the outer cylinder 28g so that the permanent magnet 28i is located at the bottom of the cavity. As a result, the magnetic collecting rod 28a enters a state in which a magnetic field is emitted from the tip of the magnetic collecting rod 28a. If there is a reaction vessel to be analyzed next, the magnetic flux collecting bar magnetic field control unit 46 returns to step S2 and transfers the magnetic flux collecting rod 28a onto the reaction vessel 11.

  Thereafter, the controller 41 stops the supply of the cleaning liquid to the cleaning tank 29a (step S32). Substantially, the control unit 41 loses contact between the tip of the outer cylinder 28g and the liquid surface when the tip of the outer cylinder 28g of the magnetic collecting rod 28a moves to a position higher than the cleaning liquid height Pw. If so, stop supplying the cleaning solution. Whether or not the tip of the outer cylinder 28g is in contact with the liquid level can be determined using a capacitance type liquid level detection method or the like. And the control part 41 drains the washing | cleaning liquid which remains in the washing tank 29a (step S36), and complete | finishes the washing process of the magnetic flux collecting rod 28a. As described above, by repeating the series of processes from step S2 to step S36, the magnetic flux collection process, the photometry process, and the magnetic flux collection bar cleaning process by the magnetic flux collecting rod 28a are performed for each analysis process.

  In the first embodiment, as shown in FIG. 5, the distal end of the outer cylinder 28g has a shape in which the distal end portion is cut out from two directions. This is to make the permanent magnet 28i as close as possible to the tip of the outer cylinder 28g. As a result, a magnetic field can be efficiently generated from the two planes 28m, so that the composite 53 can be smoothly aggregated and collected on the surfaces of these two planes 28m. In addition, by making the surface on which the agglomerated points collect magnetism a flat surface, the focal length and the focal depth can be made close to constant in the photometric processing by the photometric unit 30, thereby enabling measurement with less variation and improving analysis accuracy. be able to. The magnetism collecting rod 28a only needs to have a planar shape at the tip and serve as the magnetism collecting surface of the composite 53. Therefore, the magnetism collecting rod 28a may be cut out from only one direction as shown in FIG.

  In the first embodiment, the case where the magnetism collecting rod 28a has the control rod 28h in which the permanent magnet 28i is joined only to the tip portion has been described as an example. You may form with a permanent magnet. Further, not only the tip of the control rod 28h but also the entire control rod 28h may be formed of a magnetic material, and a plurality of magnetic materials may be connected.

  In the first embodiment, the case where the permanent magnet 28i is used to generate the magnetic field from the tip of the magnetic flux collecting rod and the generation of the magnetic field can be stopped has been described as an example. It is also possible to use an electromagnet formed by a coil wound with a conducting wire formed by a body. Hereinafter, the case where the magnetic field of the magnetic collecting rod is controlled using an electromagnet will be described. FIG. 9 is a schematic diagram illustrating another configuration of the analyzer according to the first embodiment. As shown in FIG. 9, the analyzer 101, which is another configuration of the analyzer according to the first embodiment, is compared with the analyzer 1 shown in FIG. And a measuring mechanism 102 including a magnetic flux collecting bar cleaning unit 129 instead of the magnetic flux collecting bar cleaning unit 29. The control mechanism 104 of the analysis apparatus 101 includes a control unit 141 including a magnetic flux collecting bar magnetic field control unit 146 instead of the control unit 41 as compared with the analysis apparatus 1.

  The magnetic flux collecting rod transfer unit 128 has a configuration including an electromagnet instead of a permanent magnet. FIG. 10 is a view for explaining a magnetic collecting rod included in the magnetic collecting rod transfer section 128 shown in FIG. 9, and is a cross-sectional view of the magnetic collecting rod cut in the longitudinal direction.

  As shown in FIG. 10, the magnetic flux collecting rod transfer unit 128 includes a magnetic flux collecting rod 128 a attached to the tip of the arm 28 b. This magnetism collecting rod 128a includes an outer cylinder 28g having a hollow inside, like the magnetism collecting rod 28a. A control rod 128h having an electromagnet 128i connected to the lower end is fixedly disposed in the cavity of the outer cylinder 28g. Inside the control rod 128h, a connection line 128m that connects to the electromagnet 128i and supplies current to the electromagnet 128i penetrates, and this connection line 128m extends along the arm 28b from above the control rod 128h to control the magnetic flux collecting rod magnetic field. Connected to the unit 146.

  The magnetic flux collecting bar magnetic field control unit 146 controls the generation of a magnetic field by the magnetic flux collecting bar 128a in the reaction vessel 11 by controlling the current supplied to the electromagnet 128i. The magnetic flux collecting rod 128a has a configuration in which the stopper member 28j provided in the magnetic flux collecting rod 28a is omitted because the generation of the magnetic field is controlled by the current supplied to the electromagnet 128i. Accordingly, the magnetic flux collecting rod cleaning unit 129 has a configuration in which the support rod 29d and the plate-like member 29e are omitted from the magnetic flux collecting rod cleaning unit 29.

  When generating a magnetic field from the magnetic collecting rod 128a, the magnetic flux collecting rod magnetic field control unit 146 performs control so that a current is supplied to the electromagnet 128i at the tip of the control rod 128h. As a result, a current flows through the electromagnet 128i to generate a magnetic field, and a magnetic field is generated from the flat surface 28m at the tip of the outer cylinder 28g close to the electromagnet 128i.

  As shown in FIG. 11, the magnetic collecting rod 128a is inserted into the reaction vessel 11 in which the composite 53 is formed in such a state that a magnetic field is generated from the tip as described above, whereby the reaction vessel 11 A magnetic field is generated inside. As a result, the composite body 53, which is a magnetic body, is attracted to the surfaces of the two flat surfaces 28m of the outer cylinder 28g of the magnetic flux collecting rod 128a as indicated by the arrow Y12, and the aggregates 54 are formed on the surface of the flat surface 28m. 53 can be magnetized. As described above, the magnetic flux collecting rod 128a is in a state in which the magnetic field is activated in the magnetic flux collecting process of the composite 53 and the photometric process by the photometric unit 30 under the current control of the magnetic flux collecting bar magnetic field control unit 146. Hold.

  On the other hand, the magnetic flux collecting rod magnetic field control unit 146 controls the supply of current to the electromagnet 128i of the magnetic flux collecting rod 128a to be stopped when the generation of the magnetic field by the magnetic flux collecting rod 128a is stopped. As a result, no current flows through the electromagnet 128i and the magnetic field generated by the electromagnet 128i disappears, so that the generation of the magnetic field in the magnetic flux collecting rod 128a is also stopped. The magnetic flux collecting bar magnetic field control unit 146 performs the electromagnet 128i when the light collecting rod 128a is cleaned by the magnetic flux collecting bar cleaning unit 129 after the photometry of the aggregate 54 on the surface 28m by the photometry unit 30 is finished. Is stopped, and the generation of the magnetic field by the magnetic flux collecting rod 128a is stopped.

  Specifically, the magnetic flux collecting bar magnetic field control unit 146 causes the arm 28b to transfer the magnetic flux collecting bar 128a that has been subjected to photometry processing onto the cleaning tank 29a, and then, as shown by an arrow Y8 in FIG. Is lowered. As a result, the magnetic collecting rod 128a is also lowered into the cleaning tank 29a. Thereafter, the magnetic flux collecting bar magnetic field control unit 146 stops the current supply to the electromagnet 128i and stops the next generation by the magnetic flux collecting bar 128a. The analyzer 101 supplies the cleaning liquid Wa from the cleaning liquid supply pipe 29b into the cleaning tank 29a and cleans the magnetic collecting bar 128a in a state where the magnetic field from the magnetic collecting bar 128a has disappeared. In this case, the aggregate 54 that has been attracted by being attracted to the surface of the flat surface 28m by the magnetic field emitted from the tip of the magnetic flux collecting rod 128a loses the magnetic field of the magnetic flux collecting rod 128a, which was the cause of the attraction. Is released from the surface of the magnetic flux collecting rod 128a as shown by an arrow Y10 in FIG. Then, the aggregate 54 separated from the magnetic flux collecting rod 128a flows downward according to the water flow of the cleaning liquid Wa. The magnetic collecting rod cleaning unit 129 removes the aggregate 54 adsorbed on the surface of the magnetic collecting rod 128a by discarding the cleaning liquid Wa containing the aggregate 54 to the outside of the cleaning tank 29a through the drain pipe 29c. .

  As described above, in the analysis apparatus 101 as well, like the analysis apparatus 1, by controlling the current supply to the electromagnet 128i, it is possible to generate a magnetic field by the magnetic collecting rod 128a in the reaction vessel 11 or to stop the generation of the magnetic field. Therefore, since the magnetic flux collecting rod 128a can be properly cleaned together with the magnetic flux collecting of the composite 53 without attaching a protective cap to the magnetic flux collecting rod, both prevention of contamination in the apparatus and reduction of waste are possible. become.

  Next, with reference to FIG. 13, an operation process of the main part of the analyzer 101 from the magnetic flux collecting process of the complex 53 to the magnetic flux collecting bar cleaning process will be described. As shown in FIG. 13, similarly to step S2 and step S4 shown in FIG. 7, the magnetic flux collecting bar magnetic field control unit 146 controls the arm 28 b to move the magnetic flux collecting rod 128 a to a predetermined magnetic flux collection in the reaction table 10. The magnet is transferred onto the reaction vessel 11 located at the position (step S102), and the magnetic flux collecting bar lowering process for lowering the magnetic flux collecting rod 128a into the reaction vessel 11 is performed (step S104). Then, the magnetic flux collecting bar magnetic field control unit 146 starts supplying current to the electromagnet 128i of the magnetic flux collecting rod 128a for collecting the complex 53 in the reaction vessel 11 (step S105). As a result, a magnetic field is generated from the electromagnet 128 i, and the magnetic collecting rod 128 a generates a magnetic field in the reaction vessel 11. Then, similarly to step S6 and step S8, the magnetic flux collecting rod magnetic field control unit 146 determines whether or not a predetermined magnetic flux collection time has elapsed (step S106), and in step S106 until this magnetic flux collection time has elapsed. When the determination process is repeated and it is determined that the magnetism collection time has passed (step S106: Yes), the magnet 28 is raised to raise the magnet collection rod 128a from the reaction vessel 11 (step 106). S108).

  Next, the magnetic flux collecting rod magnetic field control unit 146 controls the arm 28b to transfer the magnetic flux collecting rod 128a onto the photometry unit 30 (step S110) and then moves the magnetic flux collecting rod 128a to the photometry unit 30 in the same manner as in step S10 and step S12. A magnetic rod lowering process for lowering to the photometric position of the photometric unit 30 is performed (step S112). During this time, since the magnetic flux collecting bar magnetic field control unit 146 continues to supply current to the electromagnet 128i, the magnetic flux generated by the magnetic flux collecting rod 128a is maintained. The state where the aggregate 54 is adsorbed on the surface of 28 m is maintained. Thereafter, the magnetic flux collecting bar magnetic field control unit 146 determines whether or not the photometry process by the photometry unit 30 is completed (step S114), and repeats the determination process of step S114 until the photometry process is completed, as in step S14. If it is determined that the photometry process has been completed (step S114: Yes), the magnetism bar raising process for raising the magnetism collecting bar 128a from the photometry unit 30 is performed (step S116), as in step S16.

  Then, similarly to step S18 and step S22, the magnetic flux collecting bar magnetic field control unit 146 controls the arm 28b to clean the magnetic flux collecting bar cleaning unit 129 in order to wash the magnetic flux collecting rod 128a for which the photometric processing has been completed. After the magnetism collecting bar 128a is transferred onto the tank 29a (step S118), the magnetism collecting bar 128a is lowered into the cleaning tank 29a (step S122). Next, the magnetic flux collecting rod magnetic field control unit 146 stops supplying current to the electromagnet 128i of the magnetic flux collecting rod 128a (step S124), and the magnetic field generated from the electromagnet 128i disappears. Stop. As a result, the magnetic field from the magnetic collecting rod 128a disappears. Therefore, when the supply of the cleaning liquid is started (step S126), the aggregate 54 can be detached from the surface of the magnetic collecting bar 128a into the cleaning liquid, and the magnetic collecting bar 128a is cleaned. Can be performed appropriately. Next, similarly to step S28, the magnetic flux collecting bar magnetic field control unit 146 determines whether or not a predetermined cleaning time has elapsed (step S128), and repeats the determination process of step S128 until this cleaning time has elapsed. If it is determined that the magnetism collecting time has elapsed (step S128: Yes), the magnetism collecting rod ascending process for raising the arm 28b and raising the magnetism collecting rod 128a from within the cleaning tank 29a is performed as in step S30 ( Step S130). After that, the control unit 41 stops supplying the cleaning liquid to the cleaning tank 29a (step S132), drains the cleaning liquid remaining in the cleaning tank 29a (step S136), and collects the magnetic flux, similarly to step S32 and step S36. The cleaning process for the rod 128a is terminated. As described above, by repeating the series of processing from step S102 to step S136, the magnetic flux collection processing, photometry processing, and magnetic flux collection rod cleaning processing by the magnetic flux collecting rod 128a are performed for each analysis processing.

  Further, in the first embodiment, as a magnetic flux collecting rod transfer section for transferring the magnetic flux collecting rod 28a, a support pole 28c is connected to the other end of an arm 28b provided with the magnetic flux collecting rod 28a at one end, and the support pole 28c is rotated and moved up and down. The magnetic flux collecting rod transfer unit 28 provided with the rotating mechanism 28d and the lifting mechanism 28e has been described as an example. However, the present invention is not limited to this, and the magnetic flux collecting rod 28a may be transferred using an xyz stage.

(Embodiment 2)
Next, a second embodiment will be described. In the first embodiment, the case where the generation of the magnetic field by the magnetic flux collecting rod is stopped in the cleaning process of the magnetic flux collecting rod has been described. In the second embodiment, a magnetic field is generated in the cleaning tank for washing the magnetic flux collecting rod. This further ensures the separation of the aggregates from the surface of the magnetic flux collecting rod.

  FIG. 14 is a schematic diagram illustrating a configuration of an analyzer according to the second embodiment. As shown in FIG. 14, the analyzer 201 according to the second embodiment can generate a magnetic field in the cleaning tank in place of the magnetic flux collecting bar cleaning unit 29, as compared with the analyzer 1 shown in FIG. A measurement mechanism 202 including a magnetic flux collecting rod cleaning unit 229 is provided. And the control mechanism 204 of the analyzer 201 is replaced with the control part 41 instead of the analyzer 1, and the washing tank magnetic field control part which controls generation | occurrence | production of the magnetic field in a washing tank in addition to the control part 41 The control unit 241 further includes H.246.

  FIG. 15 is a diagram for explaining the magnetic flux collecting rod cleaning unit 229 shown in FIG. 14, and is a cross-sectional view of the cleaning tank 229 a constituting the magnetic flux collecting rod cleaning unit 229 cut in the vertical direction. As shown in FIG. 15, the cleaning tank 229a has a configuration in which a concave portion is provided on a side surface, and an electromagnet 229e is attached to the concave portion. The electromagnet 229e generates a magnetic field when supplied with an electric current, and generates a magnetic field in the attached cleaning tank 229a. The cleaning tank magnetic field control unit 246 controls the generation of a magnetic field by the electromagnet 229e in the cleaning tank 229a by controlling the current supplied to the electromagnet 229e. The cleaning tank magnetic field control unit 246 causes the electromagnet 229e to generate a magnetic field in the cleaning tank 229a when the magnetic collecting rod cleaning unit 229 cleans the magnetic collecting rod 28a.

  Specifically, as shown in FIG. 16, the cleaning tank magnetic field control unit 246 supplies a current to the electromagnet 229 e to generate a magnetic field when cleaning the magnetic flux collecting rod 28 a after the photometric process. As a result, a magnetic field is generated in the cleaning tank 229a. Here, in the magnetic flux collecting rod cleaning process, as the arm 28b indicated by the arrow Y8 is lowered, only the outer cylinder 28g of the magnetic flux collecting rod 28a is lowered into the cleaning tank 229a as indicated by the arrow Y9. Since the control rod 28h hung on the plate-like member 29e maintains its position as it is, the permanent magnet 28i and the outer cylinder 28g tip are separated from each other, and the generation of the magnetic field from the magnetic collecting rod 28a is stopped. In the analyzer 201, a magnetic field from the side surface direction of the cleaning tank 229a is further generated in the cleaning tank 229a. In this state, the cleaning liquid Wa is supplied from the cleaning liquid supply pipe 29b into the cleaning tank 229a. As a result, the agglomerate 54 adsorbed by being attracted to the surface of the flat surface 28m disappears from the magnetic field of the magnetic collecting rod 28a, which is the cause of the adsorption, so that the adsorption to the flat surface 28m is released and the washing tank The magnetic field generated in the cleaning tank 229a from the side surface direction of the 229a is pulled toward the side surface side of the cleaning tank 229a as indicated by an arrow Y20, so that it is peeled off from the surface of the magnetic flux collecting rod 28a. In this case, since the cleaning liquid is supplied into the cleaning tank 229a, a force is applied so as to separate from the plane 28m by the flow of the cleaning liquid. The aggregate 54 separated from the magnetic collecting rod 28a is flowed downward according to the water flow of the cleaning liquid Wa while floating on the electromagnet 229e mounting side in the inner side surface of the cleaning tank 229a, and is cleaned through the drain pipe 29c. Discarded outside the tank 29a.

  The magnetic field generated in the cleaning tank 229a by the electromagnet 229e is equal to or stronger than the magnetic field generated from the magnetic collecting rod 28a in order to ensure the separation of the aggregate 54 from the tip surface of the magnetic collecting rod 28a. It is desirable.

  As described above, in the analyzer 201 according to the second embodiment, during the cleaning process of the magnetic collecting rod 28a, the generation of the magnetic field in the cleaning tank in the magnetic collecting rod 28a is stopped, and not only the water flow of the cleaning liquid but also the cleaning tank. By generating a magnetic field in the cleaning tank 229a from the side surface direction of the 229a, the aggregates adsorbed on the flat surface 28m at the tip of the magnetic flux collecting rod 28a can be more reliably separated from the magnetic flux collecting rod 28a than in the first embodiment. Can do. Therefore, according to the analyzer 201, as with the analyzer 1, the magnetic flux collecting rod 228 a can be appropriately washed together with the magnetic flux of the complex 53 without attaching a protective cap to the magnetic flux collecting rod. Both pollution prevention and waste reduction are possible.

  Next, with reference to FIG. 17, the operation process of the main part of the analyzer 201 from the magnetic flux collecting process of the composite 53 to the magnetic flux collecting bar cleaning process will be described. As shown in FIG. 17, similarly to step S <b> 2 and step S <b> 4 shown in FIG. 7, the magnetic flux collecting bar magnetic field control unit 46 controls the arm 28 b to move the magnetic flux collecting rod 28 a to a predetermined magnetic flux collection of the reaction table 10. The magnet is transferred onto the reaction vessel 11 located at the position (step S202), and a magnet collecting bar lowering process for lowering the magnet collecting rod 28a into the reaction vessel 11 is performed (step S204). In this case, since the control rod 28h is inserted to the bottom of the cavity of the outer cylinder 28g and the permanent magnet 28i is close to the flat surface 28m at the tip of the outer cylinder 28g, the magnetic collecting rod 28a generates a magnetic field in the reaction vessel 11. It will be. Then, similarly to step S6 and step S8, the magnetic flux collecting rod magnetic field control unit 46 determines whether or not a predetermined magnetic flux collection time has elapsed (step S206), and in step S206 until this magnetic flux collection time has elapsed. If the determination process is repeated and it is determined that the magnetism collection time has elapsed (step S206: Yes), the magnet collector rod raising process is performed to raise the arm 28b and raise the magnet rod 28a from the reaction vessel 11 (step S206). S208).

  Next, the magnetic flux collecting rod magnetic field control unit 46 controls the arm 28b to transfer the magnetic flux collecting rod 28a onto the photometry unit 30 (step S210) and then moves the magnetic flux collecting rod 28a to the photometry unit 30 in the same manner as in step S10 and step S12. A magnetic rod lowering process for lowering to the photometric position of the photometric unit 30 is performed (step S212). During this time, since the generation of the magnetic field from the tip of the magnetic flux collecting rod 28a remains maintained, the magnetic flux collecting rod 28a maintains the state in which the aggregate 54 is adsorbed on the surface of the flat surface 28m at the tip. Thereafter, the magnetic flux collecting bar magnetic field control unit 46 determines whether or not the photometry process by the photometry unit 30 is completed (step S214), and repeats the determination process of step S214 until the photometry process is completed, as in step S14. If it is determined that the photometric process has been completed (step S214: Yes), the magnetic rod raising process for raising the magnetic flux collecting rod 28a from the photometric unit 30 is performed (step S216), as in step S16.

  Then, the magnetic flux collecting bar magnetic field control unit 46 controls the arm 28b to clean the magnetic flux collecting bar cleaning unit 229 in order to wash the magnetic flux collecting rod 28a that has been subjected to the photometric processing, similarly to steps S18 to S22. The magnetism collecting rod 28a is transferred onto the tank 229a (step S218), and the stopper member 28j is mounted on the upper surface on the concave portion 29f side of the plate-like member 29e which is a stopper avoiding member (step S220). Then, the magnetic flux collecting rod magnetic field control unit 46 lowers the magnetic flux collecting rod 28a into the cleaning tank 29a (step S222). As the arm 28b is lowered, only the outer cylinder 28g of the magnetic collecting rod 28a is lowered into the cleaning tank 229a, and the control rod 28h hung on the plate-like member 29e maintains its position, so that the permanent magnet 28i It is separated from the tip of the outer cylinder 28g, and the generation of the magnetic field from the tip of the magnetic flux collecting rod 28a stops.

  And the washing tank magnetic field control part 246 starts the electric current to the electromagnet 229e in the washing tank 229a (step S225). As a result, the electromagnet 229e generates a magnetic field, and a magnetic field is generated in the cleaning tank 229a. Subsequently, supply of the cleaning liquid is started by the control unit 241 (step S226). In this case, the adsorption of the aggregate 54 on the surface of the magnetic collecting rod 28a where the generation of the magnetic field is stopped is released, and the aggregate 54 is attracted to the side surface of the cleaning tank 229a by the magnetic field emitted from the side surface direction of the cleaning tank 229a. Aggregate 54 is surely separated from the surface of magnetic flux collecting rod 28a into the cleaning liquid. As a result, the magnetic flux collecting rod 28a can be appropriately cleaned.

  Next, the magnetic flux collecting bar magnetic field control unit 46 determines whether or not a predetermined cleaning time has elapsed (step S228), and repeats the determination process of step S228 until this cleaning time has elapsed, as in step S28. If it is determined that the magnetism collecting time has elapsed (step S228: Yes), the magnet collecting rod ascending process for raising the arm 28b and raising the magnet collecting rod 28a from the cleaning tank 229a is performed in the same manner as in step S30 ( Step S230). In this case, since the magnetic field generated by the electromagnet 229e in the cleaning tank 229a remains generated, the agglomerate 54 detached into the cleaning liquid remains attracted to the side surface of the cleaning tank 229a and reattaches to the magnetic collecting rod 28a. There is no.

  Thereafter, the control unit 241 stops the supply of the cleaning liquid to the cleaning tank 229a (step S232), and then the cleaning tank magnetic field control unit 246 stops the current supply to the electromagnet 229e (step S232). S234). Then, similarly to step S36, the control unit 241 drains the cleaning liquid remaining in the cleaning tank 229a (step S236) and ends the cleaning process of the magnetic flux collecting rod 28a. As described above, by repeating the series of processing from step S202 to step S236, the magnetic flux collection processing, photometry processing, and magnetic flux collection rod cleaning processing by the magnetic flux collecting rod 28a are performed for each analysis processing.

  In addition, although the cleaning tank 229a in which the electromagnet 229e is mounted on the side surface has been described as the cleaning tank of the magnetic flux collecting bar cleaning unit 229 according to the second embodiment, the present invention is not limited to this. Since it is sufficient that a magnetic field can be generated in the cleaning tank so that the aggregate 54 separated from the magnetic flux collecting rod 28a into the cleaning liquid does not reattach to the surface of the magnetic flux collecting rod 28a, a concave portion is formed at the bottom as shown in FIG. A cleaning tank 2291a having an electromagnet 229e attached to the recess may be used. Further, the number of electromagnets 229e to be mounted is not limited to two. FIG. 19 is a cross-sectional view of another example of the cleaning tank cut in the lateral direction. As the cleaning tank of the magnetic flux collecting bar cleaning unit 229, as shown in FIG. 19, a cleaning tank 2292a having electromagnets 229e mounted on the four side surfaces may be used. Like this cleaning tank 2292a, by providing an electromagnet on each side of the cleaning tank, it is possible to generate a stronger magnetic field in the cleaning liquid in the cleaning tank as compared with the case where an electromagnet is provided on only two surfaces. In addition, a magnetic field having a more uniform strength can be generated. Of course, the electromagnet 229e provided in the washing tank may be single.

  In the second embodiment, the case where a magnetic field is generated in the cleaning tank 229a using the electromagnet 229e has been described as an example. However, a permanent magnet can be used instead of the electromagnet. Hereinafter, a case where a permanent magnet is used as means for generating a magnetic field into the cleaning tank will be described. FIG. 20 is a schematic diagram illustrating another configuration of the analyzer according to the second embodiment. As shown in FIG. 20, the analyzer 301, which is another configuration of the analyzer according to the second embodiment, is compared with the analyzer 201 shown in FIG. 14, and instead of the magnet collector cleaning unit 229, the magnet collector cleaning is performed. A measurement mechanism 302 including a unit 329 is provided. The control mechanism 304 of the analyzer 301 is provided with a magnetic flux collecting bar magnetic field controller 46 instead of the controller 41 as compared with the analyzer 1, and a cleaning tank magnetic field for controlling the generation of the magnetic field in the cleaning tank. The controller 341 further includes a controller 346.

  FIG. 21 is a diagram for explaining the magnetic flux collecting rod cleaning unit 329 shown in FIG. 20, and is a cross-sectional view in which the cleaning tank 329 a constituting the magnetic flux collecting rod cleaning unit 329 is cut in the vertical direction. As shown in FIG. 21, the cleaning tank 329a has a concave portion on the side surface, and as indicated by an arrow Y31, a permanent magnet 329e that can approach or contact the concave portion is provided. The permanent magnet 329e is a permanent magnet made of neodymium element and may be a ferrite magnet. The permanent magnets 329e are fixedly connected to the shaft columns 329f, and each shaft column 329f is connected to the magnet transfer mechanism 329u shown in FIG.

  As shown in FIG. 22, the magnet transfer mechanism 329u includes a transfer motor 329k that is connected to the pulley 329j and fixed to the stationary part of the apparatus main body, a moving plate 329g having one end fixedly connected to the right end of the shaft column 329f, And a rotating belt 329h installed so as to be parallel to the shaft column 329f. The rotating belt 329h is stretched over a pulley 239i and a pulley 329j fixed to a non-moving portion in the apparatus, and the other end of the moving plate 329g is connected. When the transfer motor 329k rotates in the direction corresponding to the left or right as indicated by an arrow Y36, the rotation of the transfer motor 329k is sequentially transmitted to the pulley 329j, the rotary belt 329h, and the pulley 329i, whereby the rotary belt 329h Rotating like Y37, the moving plate 329g to which the rotating belt 329h is connected is also moved rightward or leftward in the figure. As the moving plate 329g moves to the right or left, the shaft column 329f connected to the moving plate 329g also moves to the right or left in the drawing. As a result, the permanent magnet 329e fixedly connected to the shaft column 329f also moves rightward or leftward in the figure as indicated by an arrow Y38.

  In the cleaning tank 329a, the magnet transfer mechanism 329u transfers the permanent magnet 329e to either a position close to the cleaning tank 329a or a position where the magnetic field of the permanent magnet 329e does not reach the cleaning tank 329a. The cleaning tank magnetic field control unit 346 generates a magnetic field in the cleaning tank 329a by causing the magnet transfer mechanism 329u to transfer the permanent magnet 329e to a position close to the cleaning tank 329a. Then, the cleaning tank magnetic field control unit 346 stops the generation of the magnetic field in the cleaning tank 329a by causing the magnet transfer mechanism 329u to transfer the permanent magnet 329e to a position where the magnetic field of the permanent magnet 329e does not reach the cleaning tank 329a. Similar to the cleaning tank magnetic field control unit 246, the cleaning tank magnetic field control unit 346 supplies a magnetic field constituted by the permanent magnet 329e and the magnet transfer mechanism 329u when the magnetic collecting rod cleaning unit 329 is cleaned. The mechanism generates a magnetic field in the cleaning tank 329a to prevent the aggregates separated from the surface of the magnetic flux collecting rod 28a from reattaching to the magnetic flux collecting rod 28a.

  Specifically, as shown in FIG. 23, when the magnetic flux collecting rod 28a after the photometry process is cleaned, the outer side of the magnetic flux collecting rod 28a is moved as indicated by the arrow Y9 as the arm 28b is lowered as indicated by the arrow Y8. When only the cylinder 28g is lowered into the cleaning tank 329a, the cleaning tank magnetic field control unit 346 causes the magnet transfer mechanism 329u to move the permanent magnet 329e to a position close to the cleaning tank 329a as indicated by an arrow Y34. Thus, a magnetic field is generated in the cleaning tank 329a. In this state, the cleaning liquid Wa is supplied from the cleaning liquid supply pipe 29b into the cleaning tank 329a. As a result, the aggregate 54 adsorbed by being attracted to the surface of the flat surface 28m stops the generation of the magnetic field from the tip of the magnetic collecting rod 28a, which was the cause of the adsorption, and thus the adsorption to the flat surface 28m is released. At the same time, the magnetic field generated in the cleaning tank 329a from the side surface direction of the cleaning tank 329a is pulled toward the side surface side of the cleaning tank 329a as indicated by an arrow Y35, and is peeled off from the surface of the magnetic flux collecting rod 28a. In this case, since the cleaning liquid Wa is supplied into the cleaning tank 329a, a force is applied so as to separate from the plane 28m by the flow of the cleaning liquid Wa. Then, the aggregate 54 separated from the magnetic collecting rod 28a is flowed downward according to the water flow of the cleaning liquid Wa while floating on the permanent magnet 329e mounting side in the inner side surface of the cleaning tank 329a, and through the drain pipe 29c. Discarded outside the cleaning tank 329a. The magnetic field generated in the cleaning tank 329a by the permanent magnet 329e is compared with the magnetic field of the magnetic material provided inside the magnetic flux collecting rod 28a in order to ensure the separation of the aggregate 54 from the tip surface of the magnetic flux collecting rod 28a. Are equal or stronger.

  As described above, in the analyzer 301 as well as in the analyzer 201, during the cleaning process of the magnetic collecting rod 28a, the generation of the magnetic field in the cleaning tank in the magnetic collecting rod 28a is stopped, and not only the flow of the cleaning liquid. By generating a magnetic field in the cleaning tank 329a from the side surface direction of the cleaning tank 329a, the aggregate 54 adsorbed on the flat surface 28m at the tip of the magnetic flux collecting bar 28a is more reliably compared to the first embodiment. Can be disengaged from.

  Next, with reference to FIG. 24, the operation process of the main part of the analyzer 301 from the magnetic collection process of the complex 53 to the magnetic stick cleaning process will be described. As shown in FIG. 24, similarly to step S2 and step S4 shown in FIG. 7, the magnetic flux collecting bar magnetic field control unit 46 controls the arm 28b to move the magnetic flux collecting rod 28a to a predetermined magnetic flux collection in the reaction table 10. It moves on the reaction container 11 located at the position (step S302), and performs a magnetic flux collecting bar lowering process for lowering the magnetic flux collecting bar 28a into the reaction container 11 (step S304). In this case, since the control rod 28h is inserted to the bottom of the cavity of the outer cylinder 28g, the permanent magnet 28i is close to the flat surface 28m at the tip of the outer cylinder 28g, so that the magnetism collecting rod 28a generates a magnetic field in the reaction vessel 11. Will be allowed to. Then, similarly to step S6 and step S8, the magnetic flux collecting rod magnetic field controller 46 determines whether or not a predetermined magnetic flux collection time has elapsed (step S306), and in step S306 until this magnetic flux collection time has elapsed. When the determination process is repeated and it is determined that the magnetism collection time has elapsed (step S306: Yes), the magnet 28 is raised to raise the magnet collection rod 28a from the reaction vessel 11 (step S306). S308).

  Next, the magnetic flux collecting rod magnetic field control unit 46 controls the arm 28b to transfer the magnetic flux collecting rod 28a onto the photometry unit 30 (step S310) and then moves the magnetic flux collecting rod 28a to the photometry unit 30 in the same manner as in step S10 and step S12. A magnetic rod lowering process for lowering to the photometric position of the photometric unit 30 is performed (step S312). During this time, since the generation of the magnetic field from the tip of the magnetic flux collecting rod 28a remains maintained, the magnetic flux collecting rod 28a maintains the state where the aggregate 54 is adsorbed on the surface of the flat surface 28m at the tip. Thereafter, the magnetic flux collecting bar magnetic field control unit 46 determines whether or not the photometry process by the photometry unit 30 is completed (step S314), and repeats the determination process of step S314 until the photometry process is completed, as in step S14. If it is determined that the photometric process has been completed (step S314: Yes), the magnetic rod raising process for raising the magnetic flux collecting bar 28a from the photometric unit 30 is performed (step S316), as in step S16.

  Then, similarly to steps S18 to S22, the magnetic flux collecting bar magnetic field control unit 46 controls the arm 28b to clean the magnetic flux collecting bar cleaning unit 329 in order to wash the magnetic flux collecting rod 28a that has been subjected to the photometric processing. The magnetic flux collecting rod 28a is transferred onto the tank 329a (step S318), and the stopper member 28j is mounted on the upper surface on the concave portion 29f side of the plate-like member 29e which is a stopper avoiding member (step S220). Then, the magnetic flux collecting rod magnetic field control unit 46 lowers the magnetic flux collecting rod 28a into the cleaning tank 329a (step S322). As the arm 28b is lowered, the generation of the magnetic field from the tip of the magnetic collecting rod 28a stops.

  Then, the cleaning tank magnetic field controller 346 drives the magnet transfer mechanism 329u to bring the permanent magnet 329e close to or in contact with the cleaning tank 329a, and attaches the permanent magnet 329e to the cleaning tank 329a (step S325). As a result, a magnetic field is generated in the cleaning tank 329a. Then, when the supply of the cleaning liquid is started by the control unit 341 (step S326), the adsorption of the aggregate 54 on the surface of the magnetic collecting rod 28a where the generation of the magnetic field is stopped is released, and the cleaning liquid 329a is emitted from the side surface direction. The aggregate 54 is attracted to the side surface of the cleaning tank 329a by the applied magnetic field, and is surely separated from the surface of the magnetic flux collecting rod 28a into the cleaning liquid. As a result, the magnetic flux collecting rod 28a can be appropriately cleaned.

  Next, the magnetic flux collecting bar magnetic field control unit 46 determines whether or not a predetermined cleaning time has passed (step S328), and repeats the determination process of step S328 until this cleaning time has passed, as in step S28. If it is determined that the magnetism collecting time has elapsed (step S328: Yes), the magnet collecting rod ascending process for raising the arm 28b and raising the magnet collecting rod 28a from the cleaning tank 229a is performed in the same manner as in step S30 ( Step S330). In this case, since the magnetic field generated by the permanent magnet 329e attached to the cleaning tank 329a is still generated in the cleaning tank 329a, the aggregate 54 separated into the cleaning liquid is attracted to the side surface of the cleaning tank 329a. To the magnetic flux collecting rod 28a again.

  Thereafter, the control unit 341 stops supplying the cleaning liquid to the cleaning tank 329a (step S332), and then the cleaning tank magnetic field control unit 346 sends the permanent magnet 329e to the magnet transfer mechanism 329u as in the case of step S32. By moving the magnetic field of 329e to a position that does not reach the cleaning tank 329a, the permanent magnet 329e is removed from the cleaning tank 329a (step S334), and the generation of the magnetic field in the cleaning tank 329a is stopped. Then, similarly to step S36, the controller 341 drains the cleaning liquid remaining in the cleaning tank 329a (step S336), and ends the cleaning process of the magnetic flux collecting rod 28a. In this way, by repeating the series of processes from step S302 to step S336, the magnetic flux collection process, the photometry process, and the magnetic flux collection bar cleaning process by the magnetic flux collecting rod 28a are performed for each analysis process.

  In the second embodiment, not only the magnetic flux collecting rod transfer portion 28 having the magnetic flux collecting rod 28a provided with the permanent magnet 228i, but also the magnetic flux collecting rod transfer portion 128 having the electromagnet 128i shown in FIGS. Of course it is possible to adopt.

  FIG. 25 is a diagram illustrating a case where a magnetic flux collecting rod transfer unit 128 is employed as the magnetic flux collecting rod transfer unit in place of the magnetic flux collecting rod transfer unit 28 in the analyzer 201 shown in FIG. 14. FIG. 25 is a diagram for explaining a cleaning process in the magnetic flux collecting rod cleaning unit 229 of the magnetic flux collecting rod 128a. The control unit 241 includes a magnetic flux collecting bar magnetic field control unit 146 shown in FIG. 9 instead of the magnetic flux collecting bar magnetic field control unit 46.

  As shown in FIG. 25, similarly in this case, the cleaning tank magnetic field control unit 246 lowers the arm 28b as shown by an arrow Y8 to lower the magnetism collecting rod 128a in the cleaning tank 229a, thereby collecting the magnetism collecting rod 128a. Wash. Then, the magnetic flux collecting bar magnetic field control unit 146 stops the current supply to the electromagnet 128i of the magnetic flux collecting rod 128a to stop the generation of the magnetic field from the magnetic flux collecting rod 128a, and the cleaning tank magnetic field control unit 146 performs the cleaning tank 229a. A current is supplied to the electromagnet 229e to generate a magnetic field in the cleaning tank 229a. In this state, as a result of supplying the cleaning liquid Wa from the cleaning liquid supply pipe 29b into the cleaning tank 229a, the aggregate 54 adsorbed on the surface of the flat surface 28m is released from being adsorbed on the flat surface 28m, and the cleaning tank 229a. The magnetic field generated in the cleaning tank 229a from the side surface is pulled toward the side surface of the cleaning tank 229a as indicated by an arrow Y35, and is peeled off from the surface of the magnetism collecting rod 128a. The aggregate 54 separated from the magnetic flux collecting rod 128a is caused to flow downward according to the water flow of the cleaning liquid Wa, and is discarded outside the cleaning tank 229a via the drain pipe 29c.

  In this case as well, the generation of the magnetic field in the cleaning tank in the magnetic collecting bar 128a during the cleaning process of the magnetic collecting bar 128a is stopped, and the magnetic field is generated in the cleaning tank 229a as well as the flow of the cleaning liquid. In addition, the aggregate 54 adsorbed on the flat surface 28m at the tip of the magnetic flux collecting rod 128a can be detached from the magnetic flux collecting rod 128a.

  Next, with reference to FIG. 26, the operation process from the magnetic flux collecting process of the complex 53 to the magnetic flux collecting bar cleaning process in the analyzer having the magnetic flux collecting rod 128a and the cleaning tank 229a shown in FIG. 25 will be described. As shown in FIG. 26, similarly to step S2 and step S4 shown in FIG. 7, the magnetic flux collecting bar magnetic field control unit 146 controls the arm 28b to move the magnetic flux collecting rod 128a to a predetermined magnetic flux collection of the reaction table 10. The magnet is transferred onto the reaction vessel 11 located at the position (step S402), and the magnetic flux collecting bar lowering process is performed to lower the magnetic flux collecting rod 128a into the reaction vessel 11 (step S404). Then, similarly to step S105 in FIG. 13, the magnetic flux collecting bar magnetic field control unit 146 starts supplying current to the electromagnet 128i of the magnetic flux collecting bar 128a (step S105). Similar to step S6 and step S8, the magnetic flux collecting bar magnetic field control unit 146 determines whether or not a predetermined magnetic flux collection time has elapsed (step S406), and the determination process of step S406 until this magnetic flux collection time has elapsed. Is repeated (step S406: Yes), the arm 28b is lifted to perform the magnet collecting rod raising process for raising the magnet collecting rod 128a from the reaction vessel 11 (step S408). .

  Next, the magnetic flux collecting rod magnetic field control unit 146 controls the arm 28b to transfer the magnetic flux collecting rod 128a onto the photometry unit 30 (step S410) and then moves the magnetic flux collecting rod 128a to the photometry unit 30 in the same manner as in step S10 and step S12. A magnetic rod lowering process for lowering to the photometric position of the photometric unit 30 is performed (step S412). During this time, since the magnetic flux collecting bar magnetic field control unit 146 continues to supply current to the electromagnet 128i, the magnetic field generation from the tip of the magnetic flux collecting rod 128a remains maintained. The state where the aggregate 54 is adsorbed on the surface of 28 m is maintained. Thereafter, the magnetic flux collecting bar magnetic field control unit 146 determines whether or not the photometry process by the photometry unit 30 is completed (step S414), and repeats the determination process of step S414 until the photometry process is completed, as in step S14. If it is determined that the photometric process has been completed (step S414: Yes), the magnetic rod raising process for raising the magnetic flux collecting bar 128a from the photometric unit 30 is performed (step S416), as in step S16.

  Then, similarly to step S18 and step S22, the magnetic flux collecting bar magnetic field control unit 146 controls the arm 28b to clean the magnetic flux collecting bar cleaning unit 329 in order to wash the magnetic flux collecting bar 128a that has been subjected to the photometric processing. After the magnetism collecting rod 128a is transferred onto the tank 229a (step S418), the magnetism collecting bar 128a is lowered into the cleaning tank 229a (step S422). Next, the magnetic flux collecting rod magnetic field control unit 146 stops supplying current to the electromagnet 128i of the magnetic flux collecting rod 128a (step S424), and stops generating a magnetic field from the tip of the magnetic flux collecting rod 128a. Furthermore, the cleaning tank magnetic field control unit 146 starts a current to the electromagnet 229e in the cleaning tank 229a (step S425). In this state, the supply of the cleaning liquid is started by the control unit 241 (step S426). In this case, the aggregate 54 can be separated into the cleaning liquid from the surface of the magnetic flux collecting rod 128a from which the magnetic field has disappeared, and further, the separated aggregate 54 is formed on the side surface of the cleaning tank 229a by the magnetic field emitted from the side surface direction of the cleaning tank 229a. Since it is attracted to the side surface of the cleaning tank 229a, the magnetic flux collecting rod 128a can be appropriately cleaned.

  Next, the magnetic flux collecting bar magnetic field control unit 146 determines whether or not a predetermined cleaning time has passed (step S428), and repeats the determination process of step S428 until this cleaning time has passed, as in step S28. If it is determined that the magnetism collecting time has elapsed (step S428: Yes), the magnet collecting rod ascending process for raising the arm 28b and raising the magnet collecting rod 128a from within the cleaning tank 229a is performed as in step S30 ( Step S430). In this case, since the magnetic field generated by the electromagnet 229e on the side surface of the cleaning tank 229a is still generated in the cleaning tank 229a, the agglomerates 54 that have separated into the cleaning liquid from the surface of the magnetic collecting rod 128a are attracted to the side surface of the cleaning tank 229a. Therefore, it does not adhere again to the magnetism collecting rod 128a.

  After that, the control unit 241 stops the supply of the cleaning liquid to the cleaning tank 229a (step S432), and then the cleaning tank magnetic field control unit 146 stops the current supply to the electromagnet 229e (step S432). S434), the generation of the magnetic field in the cleaning tank 229a is stopped. Then, similarly to step S36, the control unit 241 drains the cleaning liquid remaining in the cleaning tank 229a (step S436), and ends the cleaning process of the magnetic flux collecting rod 128a. In this way, by repeating the series of processes of step S402 to step S436, the magnetic flux collection process, the photometry process, and the magnetic flux collection bar cleaning process by the magnetic flux collecting bar 128a are performed for each analysis process.

  In addition, with reference to FIG. 27, a description will be given of a case where a magnetic flux collecting rod transfer unit 128 is employed instead of the magnetic flux collecting rod transfer unit 28 in the analyzer 301 shown in FIG. In this case, the control unit 341 in FIG. 20 includes a magnetic collecting rod magnetic field control unit 146 shown in FIG. 9 instead of the magnetic collecting rod magnetic field control unit 46.

  As shown in FIG. 27, in this case as well, similarly, the cleaning tank magnetic field control unit 346 lowers the arm 28b as shown by an arrow Y8 and lowers the magnetism collecting bar 128a in the cleaning tank 329a. Wash. Then, the magnetic flux collecting bar magnetic field control unit 146 stops the current supply to the electromagnet 128i of the magnetic flux collecting rod 128a to stop the generation of the magnetic field from the magnetic flux collecting rod 128a, and the cleaning tank magnetic field control unit 346 has a magnet transfer mechanism. A magnetic field is generated in the cleaning tank 329a by transferring the permanent magnet 329e to a position close to the cleaning tank 329a. In this state, as a result of supplying the cleaning liquid Wa from the cleaning liquid supply pipe 29b into the cleaning tank 329a, the aggregate 54 adsorbed on the surface of the flat surface 28m is released from being adsorbed on the flat surface 28m, and the side surface of the cleaning tank 329a. The magnetic field generated in the cleaning tank 329a from the direction is pulled toward the side surface of the cleaning tank 329a as indicated by an arrow Y35, and is peeled off from the surface of the magnetic flux collecting rod 128a. Then, the aggregate 54 separated from the magnetic flux collecting rod 128a flows downward according to the water flow of the cleaning liquid Wa, and is discarded outside the cleaning tank 329a through the drain pipe 29c.

  Also in this case, the generation of the magnetic field in the cleaning tank in the magnetic collecting bar 128a is stopped during the cleaning process of the magnetic collecting bar 128a, and the magnetic field is generated in the cleaning tank 329a as well as the flow of the cleaning liquid. Further, the agglomerates adsorbed on the flat surface 28m at the tip of the magnetic flux collecting rod 128a can be detached from the magnetic flux collecting rod 128a.

  Next, with reference to FIG. 28, the operation process from the magnetic flux collecting process of the complex 53 to the magnetic flux collecting bar cleaning process in the analyzer having the magnetic flux collecting rod 128a and the cleaning tank 329a shown in FIG. 27 will be described. As shown in FIG. 28, similarly to step S2 and step S4 shown in FIG. 7, the magnetic flux collecting bar magnetic field control unit 146 controls the arm 28b to move the magnetic flux collecting rod 128a to a predetermined magnetic flux collection of the reaction table 10. The magnet is transferred onto the reaction container 11 located at the position (step S502), and a magnet collecting bar lowering process for lowering the magnet collecting bar 128a into the reaction container 11 is performed (step S504). Then, similarly to step S105 of FIG. 13, the magnetic flux collecting bar magnetic field control unit 146 starts supplying current to the electromagnet 128i of the magnetic flux collecting bar 128a (step S505). Similar to step S6 and step S8, the magnetic flux collecting rod magnetic field control unit 146 determines whether or not a predetermined magnetic collecting time has elapsed (step S506), and the determination process of step S506 is performed until this magnetic collecting time has elapsed. Is repeated (step S506: Yes), the arm 28b is raised to raise the magnet collecting rod 128a from the reaction vessel 11 (step S508). .

  Next, the magnetic flux collecting rod magnetic field control unit 146 controls the arm 28b to transfer the magnetic flux collecting rod 128a onto the photometry unit 30 (step S510) and then moves the magnetic flux collecting rod 128a to the photometry unit 30 in the same manner as in step S10 and step S12. A magnetic rod lowering process for lowering to the photometric position of the photometric unit 30 is performed (step S512). During this time, since the magnetic flux collecting bar magnetic field control unit 146 continues to supply current to the electromagnet 128i, the magnetic field generation from the tip of the magnetic flux collecting rod 128a is maintained. The state where the aggregate 54 is adsorbed on the surface of the flat surface 28 m is maintained. Thereafter, the magnetic flux collecting bar magnetic field control unit 146 determines whether or not the photometric process by the photometric unit 30 is completed (step S514), and repeats the determination process of step S514 until the photometric process is completed, as in step S14. If it is determined that the photometric process has been completed (step S514: Yes), the magnetic rod raising process for raising the magnetic flux collecting bar 128a from the photometric unit 30 is performed (step S516), as in step S16.

  Then, similarly to step S18 and step S22, the magnetic flux collecting bar magnetic field control unit 146 controls the arm 28b to clean the magnetic flux collecting bar cleaning unit 329 in order to wash the magnetic flux collecting bar 128a that has been subjected to the photometric processing. After the magnetism collecting bar 128a is transferred onto the tank 329a (step S518), the magnetism collecting bar 128a is lowered into the cleaning tank 329a (step S522). Next, the magnetic flux collecting rod magnetic field control unit 146 stops supplying current to the electromagnet 128i of the magnetic flux collecting rod 128a (step S524), and stops generating a magnetic field from the tip of the magnetic flux collecting rod 128a. As a result, the magnetic field from the magnetic flux collecting rod 128a disappears. Further, the cleaning tank magnetic field control unit 346 drives the magnet transfer mechanism 329u to bring the permanent magnet 329e close to or in contact with the cleaning tank 329a, and attaches the permanent magnet 329e to the cleaning tank 329a (step S525). In this state, supply of the cleaning liquid is started by the control unit 341 (step S526). In this case, the aggregate 54 can be separated into the cleaning liquid from the surface of the magnetic flux collecting rod 128a from which the magnetic field has disappeared, and is further separated to the side surface of the cleaning tank 329a by the magnetic field generated from the permanent magnet 329e attached to the side surface of the cleaning tank 329a. Since the aggregate 54 thus attracted is pulled toward the side surface of the cleaning tank 329a, the magnetic flux collecting rod 128a can be appropriately cleaned.

  Next, similarly to step S28, the magnetic flux collecting bar magnetic field control unit 146 determines whether or not a predetermined cleaning time has elapsed (step S528), and repeats the determination process of step S528 until this cleaning time has elapsed. If it is determined that the magnetism collecting time has elapsed (step S528: Yes), the magnet collecting rod ascending process for raising the arm 28b and raising the magnet collecting rod 128a from the cleaning tank 329a is performed as in step S30 ( Step S530). In this case, since the magnetic field generated by the permanent magnet 329e attached to the cleaning tank 329a is still generated in the cleaning tank 229a, the aggregate 54 separated from the surface of the magnetic flux collecting rod 128a into the cleaning liquid is attracted to the side surface of the cleaning tank 229a. Therefore, it does not adhere again to the magnetism collecting rod 128a.

  Thereafter, the controller 341 stops the supply of the cleaning liquid to the cleaning tank 329a as in Step S32 (Step S532), and then the cleaning tank magnetic field controller 346 places the permanent magnet 329e in the magnet transfer mechanism 329u as a permanent magnet. By moving the magnetic field of 329e to a position that does not reach the cleaning tank 329a, the permanent magnet 329e is removed from the cleaning tank 329a (step S534), and the generation of the magnetic field in the cleaning tank 329a is stopped. Then, similarly to step S36, the control unit 341 drains the cleaning liquid remaining in the cleaning tank 329a (step S536) and ends the cleaning process of the magnetic flux collecting rod 128a. As described above, by repeating the series of processes from step S502 to step S536, the magnetic flux collection process, the photometry process, and the magnetic flux collection bar cleaning process by the magnetic flux collecting bar 128a are performed for each analysis process.

(Embodiment 3)
Next, a third embodiment will be described. In Embodiment 1 and Embodiment 2, cleaning of the magnetic collecting rod has been described. In Embodiment 3, cleaning of the reagent probe that dispenses the first reagent containing magnetic particles will be described. In the third embodiment, a magnetic field is generated in a probe cleaning tank that cleans the reagent probe, so that the removal of magnetic particles attached to the surface of the reagent probe is made efficient.

  FIG. 29 is a schematic diagram illustrating the configuration of the analyzer according to the third embodiment. As illustrated in FIG. 29, the analysis apparatus 601 according to the third embodiment includes a measurement mechanism 602 including a probe cleaning unit 623 instead of the probe cleaning unit 23 as compared with the analysis apparatus 1 illustrated in FIG. 1. The control mechanism 604 of the analysis apparatus 601 has a control unit 641 that further includes a probe cleaning tank magnetic field control unit 647 in addition to the magnetic collecting rod magnetic field control unit 46 instead of the control unit 41 as compared with the analysis apparatus 1. .

  FIG. 30 is a view for explaining the probe cleaning unit 623 shown in FIG. 29, and is a cross-sectional view of the probe cleaning tank 623a constituting the probe cleaning unit 623 cut in the vertical direction. As shown in FIG. 30, the probe cleaning tank 623a has a configuration in which a side surface has a recess, and an electromagnet 623e is attached to the recess. The electromagnet 623e generates a magnetic field when supplied with current, and generates a magnetic field in the attached probe cleaning tank 623a. The probe cleaning tank magnetic field control unit 647 controls the generation of a magnetic field in the probe cleaning tank 623a by the electromagnet 623e by controlling the current supplied to the electromagnet 623e. When the reagent probe is cleaned by the probe cleaning unit 623, the probe cleaning tank magnetic field control unit 647 supplies a current to the electromagnet 623e to generate a magnetic field in the probe cleaning tank 623a. The probe cleaning tank 623a is connected to a cleaning liquid supply pipe 623b that is connected to the cleaning liquid tank and supplies the cleaning liquid to the side surface, and a drainage pipe 623c that is connected to the drainage tank and discharges the cleaning liquid and the like to the bottom surface.

  Specifically, as shown in FIG. 31, the probe cleaning tank magnetic field control unit 647 has been dispensed with the first reagent containing magnetic particles, and is inserted into the probe cleaning tank 623a as indicated by an arrow Y60. When cleaning the reagent probe 22a, a current is supplied to the electromagnet 623e of the probe cleaning tank 623a to generate a magnetic field. As a result, a magnetic field is generated in the probe cleaning tank 623a. In this state, the cleaning liquid Wb is supplied from the cleaning liquid supply pipe 623b into the probe cleaning tank 623a. The supply amount and the discharge amount of the cleaning liquid Wb supplied to the probe cleaning tank 623a are controlled so as not to exceed the cleaning liquid height Pw2.

  By the way, since the reagent probe 22a is made of metal, the magnetic particles 51 are easily adsorbed on the surface, and the magnetic particles remain adsorbed on the probe surface even after dispensing the reagent containing the magnetic particles 51. There are many.

  Therefore, in the analyzer 601, in the cleaning process of the reagent probe 22 a for dispensing the first reagent including the magnetic particles 51, a magnetic field is generated from the side of the probe cleaning tank 623 a in the probe cleaning tank 623 a. As a result, the magnetic particles 51, which are magnetic substances attached to the surface of the reagent probe 22a, are drawn toward the side surface of the probe cleaning tank 623a as shown by an arrow Y61 in FIG. 31, and the magnetic particles 51 are peeled off from the surface of the reagent probe 22a. I'm letting go. Furthermore, since the cleaning liquid Wb is supplied into the probe cleaning tank 623a, a force is applied so that the magnetic particles 51 are detached from the surface of the reagent probe 22a by the flow of the cleaning liquid Wb. The magnetic particles 51 detached from the reagent probe 22a are flowed downward according to the water flow of the cleaning liquid Wb while floating on the electromagnet 623e mounting side of the inner side surface of the probe cleaning tank 623a, and are probed through the drain pipe 623c. Discarded outside the cleaning tank 623a. The magnitude of the magnetic field generated by the electromagnet 623e in the cleaning tank 623a is supplied with the size of the probe cleaning tank 623a and the magnetic characteristics of the magnetic particles 51 in order to ensure the detachment of the magnetic particles 51 from the surface of the reagent probe 22a. It is set according to the flow rate of the cleaning liquid.

  As described above, the analyzer 601 according to the third embodiment generates a magnetic field in the probe cleaning tank 623a from the side surface direction of the probe cleaning tank 623a as well as the flow of the cleaning liquid. The particles 51 can be efficiently detached from the surface of the reagent probe 22a. Therefore, according to the analysis apparatus 601, the magnetic particles 51 can be appropriately removed from the surface of the reagent probe 22a without attaching a protective cap to the reagent probe 22a. Therefore, both the prevention of contamination within the apparatus and the reduction of waste can be achieved. It becomes possible.

  Next, the operation process of the main part of the analyzer 601 from the first reagent dispensing process to the cleaning process of the probe dispensed with the first reagent will be described. FIG. 32 is a flowchart showing a processing procedure from the first reagent dispensing process to the probe cleaning process in the main part of the analyzer 601.

  As shown in FIG. 32, the control unit 641 rotates the arm (not shown) of the first reagent dispensing unit 22 to move the reagent probe 22a of the first reagent bottle stored in the first reagent storage 21. Among these, it transfers on the 1st reagent bottle 21a located in a predetermined | prescribed suction position (step S602). Then, the control unit 641 performs a reagent probe lowering process for lowering the reagent probe 22a into the first reagent bottle 21a by lowering the arm (step S604). Thereafter, the controller 641 performs a reagent aspirating process for aspirating a predetermined amount of the first reagent into the reagent probe 22a by driving the suction / discharge mechanism in the first reagent dispensing unit 22 (step S606). Then, in order to take out the reagent probe 22a from the first reagent bottle 21a, the control unit 641 performs a reagent probe raising process for raising the arm and raising the reagent probe 22a from the first reagent bottle 21a (step S608).

  Next, the control unit 641 rotates the arm to transfer the reagent probe 22a onto the reaction container 11 located at a predetermined first reagent discharge position among the reaction containers 11 accommodated in the reaction table 10 (step S610). Then, a reagent probe lowering process for lowering the reagent probe 22a into the reaction container 11 by lowering the arm is performed (step S612). Thereafter, the control unit 641 performs a reagent discharge process for discharging a predetermined amount of the first reagent sucked into the probe 22a into the reaction container 11 by driving the suction / discharge mechanism in the first reagent dispensing unit 22 (Step S1). S614).

  Then, the control unit 641 performs a reagent probe raising process for raising the reagent probe 22a from the reaction container 11 by raising the arm (step S616). Thereafter, the control unit 641 moves the reagent probe 22a onto the cleaning tank 623a of the probe cleaning unit 623 by rotating the arm in order to clean the reagent probe 22a for which the first reagent dispensing process has been completed (step S618). ). Subsequently, the control unit 641 lowers the reagent probe 22a into the probe cleaning tank 623a by lowering the arm (step S622).

  Then, the probe cleaning tank magnetic field control unit 647 starts current supply to the electromagnet 623e in the probe cleaning tank 623a (step S625). As a result, a magnetic field is generated in the probe cleaning tank 623a. Subsequently, the supply of the cleaning liquid is started by the control unit 641 (step S626). In addition, the control unit 641 controls the electromagnetic valve provided in the drain pipe 623c so as to prevent the cleaning liquid from exceeding or lowering the cleaning liquid height Pw2 in the probe cleaning tank 623a, thereby adjusting the amount of drainage. Further, the control unit 641 controls the electromagnetic valve to maintain the cleaning liquid height and to form a flow of cleaning liquid in the probe cleaning tank 623a. Thus, the magnetic particles 51 adsorbed on the surface of the reagent probe 22a are removed not only by the flow of the cleaning liquid but also by the magnetic field generated in the probe cleaning tank 623a from the side of the probe cleaning tank 623a. The control unit 641 determines whether or not a predetermined cleaning time has elapsed (step S628). This cleaning time needs to be 0.1 second or more in consideration of the time for the magnetic particles 51 to move from the reagent probe 22a, and is desirably 2 seconds or more for reliable magnetic particle 51 removal. The control unit 641 repeats the determination process of step S628 until the cleaning time elapses. When it is determined that the cleaning time has elapsed (step S628: Yes), the control unit 641 uses an arm to take out the reagent probe 22a from the probe cleaning tank 623a. Is raised to raise the reagent probe 22a from the probe washing tank 623a (step S630). The rising speed of the reagent probe 22a from the probe cleaning tank 623a is set to 50 mm / second or less until the tip surface of the reagent probe 22a exceeds the cleaning liquid height Pw2 in order to prevent the cleaning liquid from adhering to the surface of the reagent probe 22a. . If there is a reaction container to be dispensed next, the control unit 641 returns to step S602 and transfers the reagent probe 22a onto the first reagent bottle 21a.

  Thereafter, the controller 641 stops the supply of the cleaning liquid to the probe cleaning tank 623a (step S632). In effect, the control unit 641 supplies the cleaning liquid when the tip of the reagent probe 22a moves to a position higher than the cleaning liquid height Pw2, that is, when the contact between the tip of the reagent probe 22a and the liquid surface is lost. To stop. Whether or not the contact between the tip of the reagent probe 22a and the liquid level is lost can be determined using a capacitive liquid level detection method or the like. Thereafter, the cleaning tank magnetic field control unit 646 stops the current supply to the electromagnet 623e (step S634), and stops the generation of the magnetic field in the probe cleaning tank 623a. Then, the control unit 641 drains the cleaning liquid remaining in the probe cleaning tank 623a (step S636), and ends the cleaning process of the reagent probe 22a. As described above, the first reagent dispensing process is performed for each analysis process by repeating a series of processes in steps S602 to S636.

  In addition, although the probe cleaning tank 623a with the electromagnet 623e attached to the side surface has been described as the cleaning tank of the probe cleaning unit 623 according to the third embodiment, the present invention is not limited to this. Since it is only necessary to generate a magnetic field in the probe cleaning tank so that the magnetic particles 51 detached from the reagent probe 22a into the cleaning liquid can be detached from the reagent probe 22a, as shown in FIG. You may use the probe washing tank 6231a by which the electromagnet 623e was mounted | worn in this recessed part. Further, the number of electromagnets 623e to be mounted is not limited to two. FIG. 34 is a cross-sectional view of another example of the probe cleaning tank cut in the lateral direction. As the cleaning tank of the probe cleaning unit 623, as shown in FIG. 34, a probe cleaning tank 6232a having electromagnets 623e attached to the four side surfaces may be used. As in this probe cleaning tank 6232a, by providing an electromagnet on each side of the probe cleaning tank, a stronger magnetic field is generated in the cleaning liquid in the probe cleaning tank than in the case where an electromagnet is provided on only two surfaces. And a magnetic field can be generated with a more uniform strength. Of course, the electromagnet 623e provided in the cleaning tank may be single.

  In the third embodiment, the case where a magnetic field is generated in the probe cleaning tank 623a using the electromagnet 623e has been described as an example. However, a permanent magnet can be used instead of the electromagnet. Hereinafter, a case where a permanent magnet is used as means for generating a magnetic field into the probe cleaning tank will be described. FIG. 35 is a schematic diagram illustrating another configuration of the analyzer according to the third embodiment. As shown in FIG. 35, the analyzer 701, which is another configuration of the analyzer according to the third embodiment, includes a probe cleaning unit 723 instead of the probe cleaning unit 623, as compared with the analyzer 601 shown in FIG. Measuring mechanism 702. The control mechanism 704 of the analyzer 701 is compared with the analyzer 601, and instead of the controller 641, the controller 741 includes a probe cleaning tank magnetic field controller 747 that controls generation of a magnetic field in the probe cleaning tank. Have

  FIG. 36 is a diagram for explaining the probe cleaning unit 723 shown in FIG. 35, and is a cross-sectional view of the probe cleaning tank 723a constituting the probe cleaning unit 723 cut in the vertical direction. As shown in FIG. 36, the probe cleaning tank 723a has a concave portion on its side surface, and as shown by an arrow Y71, a permanent magnet 723e that can approach or contact the concave portion is provided. The permanent magnet 723e may be a permanent magnet made of neodymium element or a ferrite magnet. The permanent magnets 723a are respectively fixedly connected to the shaft columns 723f, and each shaft column 723f is connected to a magnet transfer mechanism 723u shown in FIG.

  As shown in FIG. 37, the magnet transfer mechanism 723u includes a transfer motor 723k that is connected to the pulley 723j and is fixed to the stationary part of the apparatus main body, a moving plate 723g that is fixedly connected to the right end of the shaft post 723f, And a rotating belt 723h installed so as to be parallel to the shaft column 723f. The rotating belt 723h is stretched between a pulley 239i and a pulley 723j fixed to a non-moving portion in the apparatus, and the other end of the moving plate 723g is connected. When the transfer motor 723k rotates in a direction corresponding to the left or right as indicated by an arrow Y76, the rotation of the transfer motor 723k is sequentially transmitted to the pulley 723j, the rotary belt 723h, and the pulley 723i, whereby the rotary belt 723h Rotating like Y77, the moving plate 723g to which the rotating belt 723h is connected is also moved to the right or left. As the moving plate 723g moves to the right or left, the shaft column 723f connected to the moving plate 723g also moves to the right or left in the drawing. As a result, the permanent magnet 723e fixedly connected to the shaft column 723f also moves to the right or left in the figure as indicated by the arrow Y78.

  In the probe cleaning tank 723a, the magnet transfer mechanism 723u transfers the permanent magnet 723e to either a position close to the probe cleaning tank 723a or a position where the magnetic field of the permanent magnet 723e does not reach the probe cleaning tank 723a. The probe cleaning tank magnetic field controller 747 generates a magnetic field in the probe cleaning tank 723a by causing the magnet transfer mechanism 723u to transfer the permanent magnet 723e to a position close to the probe cleaning tank 723a. Then, the probe cleaning tank magnetic field control unit 747 causes the magnet transfer mechanism 723u to transfer the permanent magnet 723e to a position where the magnetic field of the permanent magnet 723e does not reach the probe cleaning tank 723a, thereby generating a magnetic field in the probe cleaning tank 723a. Stop. When the reagent probe 22a is cleaned by the probe cleaning unit 723, the probe cleaning tank magnetic field control unit 747 generates a magnetic field in the probe cleaning tank 723a by the magnetic field generation mechanism configured by the permanent magnet 723e and the magnet transfer mechanism 723u. Thus, the magnetic particles detached from the surface of the reagent probe 22a are prevented from reattaching to the reagent probe 22a.

  Specifically, as shown in FIG. 38, the probe cleaning tank magnetic field controller 747 finishes the first reagent dispensing process and cleans the reagent probe 22a inserted into the probe cleaning tank 723a as indicated by an arrow Y70. When doing so, as indicated by an arrow Y73, the permanent magnet 723e is transferred to a position close to the probe cleaning tank 723a by the magnet transfer mechanism 723u. As a result, a magnetic field is generated in the probe cleaning tank 723a. In this state, the cleaning liquid Wb is supplied from the cleaning liquid supply pipe 623b into the probe cleaning tank 723a. As a result, the magnetic particles 51 adhering to the surface of the reagent probe 22a due to the liquid flow of the cleaning liquid Wb and the magnetic field emitted from the side surface direction of the probe cleaning tank 723a, as shown by the arrow Y74 in FIG. The magnetic particles 51 are peeled off from the surface of the reagent probe 22a. The magnetic field generated by the permanent magnet 723e is set according to the size of the probe cleaning tank 723a, the magnetic characteristics of the magnetic particles 51, the flow rate of the supplied cleaning liquid, etc. in order to ensure the separation of the magnetic particles 51 from the surface of the reagent probe 22a. Is done.

  As described above, in the analyzer 701 shown in FIG. 35 as well as the analyzer 601, not only the flow of the cleaning liquid but also the magnetic field generated in the probe cleaning tank 723 a from the side surface direction can be efficiently generated. The magnetic particles 51 adsorbed on the surface of the reagent probe 22a can be detached from the surface of the reagent probe 22a.

  Next, an operation process of the main part of the analyzer 701 from the first reagent dispensing process to the cleaning process of the probe dispensed with the first reagent will be described. FIG. 39 is a flowchart showing a processing procedure from the first reagent dispensing process to the probe cleaning process in the main part of the analyzer 701.

  As shown in FIG. 39, the control unit 741 drives the arm (not shown) of the first reagent dispensing unit 22, thereby allowing the reagent probe 22 a to be contained in the first reagent container 21. The reagent probe is moved onto the first reagent bottle 21a located at a predetermined magnetic collection position (step S702), and a reagent probe lowering process for lowering the reagent probe 22a into the first reagent bottle 21a is performed (step S704). Thereafter, the control unit 741 performs a reagent aspirating process for aspirating the first reagent into the reagent probe 22a by driving the suction / discharge mechanism in the first reagent dispensing unit 22 (step S706). Then, the control unit 741 performs a reagent probe raising process for raising the arm and raising the reagent probe 22a from the first reagent bottle 21a (step S708), and takes out the reagent probe 22a from the first reagent bottle 21a.

  Next, the control unit 741 operates the arm to transfer the reagent probe 22a onto the reaction container 11 positioned at a predetermined first reagent dispensing position (step S710), and moves the reagent probe 22a to the inside of the reaction container 11. A reagent probe lowering process for lowering is performed (step S712). Thereafter, the control unit 741 performs a reagent discharge process for discharging a predetermined amount of the first reagent sucked into the probe 22a into the reaction container 11 by driving the suction / discharge mechanism in the first reagent dispensing unit 22 (step S714). ).

  Then, the controller 741 performs a reagent probe ascent process for raising the reagent probe 22a from the reaction container 11 by driving the arm (step S716), and cleans the reagent probe 22a after the first reagent dispensing process is completed. In order to do this, the reagent probe 22a is transferred onto the cleaning tank 723a of the probe cleaning unit 723 (step S718). Subsequently, the control unit 741 lowers the reagent probe 22a into the probe cleaning tank 723a by lowering the arm (step S722).

  Then, the probe cleaning tank magnetic field controller 747 drives the magnet transfer mechanism 723u to bring the permanent magnet 723e close to or in contact with the probe cleaning tank 723a, and attaches the permanent magnet 723e to the probe cleaning tank 723a (step S725). . As a result, a magnetic field is generated in the probe cleaning tank 723a. Subsequently, supply of the cleaning liquid is started by the control unit 741 (step S726). In addition, the control unit 741 controls the electromagnetic valve provided in the drain pipe 623c so that the cleaning liquid does not exceed or falls below the cleaning liquid height Pw2 in the probe cleaning tank 723a, and adjusts the amount of drainage. A flow of cleaning liquid is formed in the probe cleaning tank 723a. The control unit 741 determines whether or not a predetermined cleaning time has elapsed (step S728). The control unit 741 repeats the determination process of step S728 until the cleaning time elapses. If it is determined that the cleaning time has elapsed (step S728: Yes), the control unit 741 uses an arm to take out the reagent probe 22a from the probe cleaning tank 723a. Is raised to raise the reagent probe 22a from the probe washing tank 723a (step S730). If there is a reaction container to be analyzed next, the control unit 741 returns to step S2 and transfers the reagent probe 22a onto the first reagent bottle 21a.

  Thereafter, the controller 741 stops the supply of the cleaning liquid to the probe cleaning tank 723a (step S732). Thereafter, the probe cleaning tank magnetic field controller 747 removes the permanent magnet 723e from the probe cleaning tank 723a by causing the magnet transfer mechanism 723u to move the permanent magnet 723e to a position where the magnetic field of the permanent magnet 732e does not reach the probe cleaning tank 723a. (Step S734), the generation of the magnetic field in the probe cleaning tank 723a is stopped. Then, the control unit 741 drains the cleaning liquid remaining in the probe cleaning tank 723a (step S736), and ends the cleaning process of the reagent probe 22a. As described above, the first reagent dispensing process is performed for each analysis process by repeating a series of processes in steps S702 to S736.

  Further, in the first to third embodiments, the analysis apparatus that measures and analyzes so-called Raman scattered light (SERS) has been described as an example. However, the present invention is not limited to this, and the measurement object in the magnetic particle and the specimen is of course not limited thereto. Can be applied to any analyzer that collects the reactants based on the magnetic properties of the reactants. For example, the present invention can be applied to an analyzer for measuring the light emission characteristics of a complex in which a labeling substance that emits light by acting with an enzyme is further bound to a reaction product between a magnetic particle and a measurement target in a specimen. Therefore, among Embodiments 1 to 3, a case where the light emission characteristic of the complex is measured by the analyzer 101 described in Embodiment 1 will be described with reference to FIG. FIG. 40 is a schematic diagram illustrating another configuration of the analyzer according to the first embodiment. The analyzer 801 illustrated in FIG. 40 is compared with the analyzer 101 illustrated in FIG. A photometric unit 830 that measures light emission such as fluorescence is provided. Then, the control mechanism 804 of the analyzer 801 replaces the control unit 141 with the control unit 841 that controls each component of the measurement mechanism 802 including the photometry unit 830 and the sample based on the measurement result by the photometry unit 830. And an analysis unit 843 for analysis. The control unit 841 includes a magnetic flux collecting bar magnetic field control unit 146.

  In this analyzer 801, the sample dispensing unit 20 dispenses the sample in the sample container 19a to the plurality of reaction containers 11 that are sequentially conveyed in a row, and the first reagent dispensing unit 22 is magnetic. The reagent in the first reagent bottle 21a containing particles is dispensed, and the second reagent dispensing unit 25 dispenses the second reagent in the second reagent bottle 24a containing the labeling substance. That is, a sample is injected into each reaction container 11 from the sample container 19a by the sample dispensing unit 20, and as shown in FIG. 41 (1), the first reagent including the magnetic particles 851 and the enzyme act. Thus, the second reagent containing the labeling substance 852 that emits light is injected. The magnetic particles 851 and the labeling substance 852 react with the measurement object 850 in the specimen, and as a result, as shown in FIG. 41 (2), the magnetic particles 851, the labeling substance 852, and the measurement object 850 are combined. A body 853 is formed. Thereafter, the magnetic flux collecting rod transfer unit 128 inserts the magnetic flux collecting rod 128a into the reaction vessel 11 in which the complex 853 is formed, as indicated by an arrow Y801 in FIG. In this case, the magnetic field of the magnetic flux collecting bar 128 a is validated by the control of the magnetic flux collecting bar magnetic field control unit 146. Then, as shown in FIG. 41 (3), the composite 853 in the reaction vessel 11 is attracted and attracted to the front surface of the magnetic collecting rod 128a by the magnetic field of the magnetic collecting rod 128a. In this manner, the magnetic flux collecting rod 128a collects the composite 853 as in the first embodiment. Thereafter, the magnetic flux collecting rod 128a is pulled up from the inside of the reaction vessel 11 as indicated by an arrow Y803 by the magnetic flux collecting rod transfer portion 128 and transferred to the photometric position of the photometric portion 830.

  As shown in FIG. 42, the photometry unit 830 is provided with a measurement container 811 in which a substrate solution Ws containing an enzyme 866 that acts with a labeling substance 852 is accommodated. The complex 853 collected on the surface of the magnetic flux collecting rod 128a acts with the enzyme 866 to emit light as a reaction product 854. In order to realize this action, it is necessary to resuspend the complex 853 magnetized on the surface of the magnetism collecting rod 128a in the substrate solution Ws containing the enzyme 866. In other words, it is necessary to insert the magnetic flux collecting rod 128a having the composite 853 collected on the surface thereof into the measurement container 811 and to release the complex 853 adsorbed on the surface of the magnetic collecting rod 128a from the surface of the magnetic collecting rod 128a. . Therefore, similarly to the analyzer 101, the magnetic flux collecting bar magnetic field control unit 146 stops the generation of the magnetic field from the tip of the magnetic flux collecting rod 128a, and causes the adsorption of the composite 853 to the surface of the magnetic flux collecting rod 128a. The magnetic field of the magnetic flux collecting rod 128a is lost. As a result, the composite 853 is released from the surface of the magnetic flux collecting rod 128a and is smoothly detached from the surface of the magnetic flux collecting rod 128a. The detached complex 853 is dispersed in the substrate solution Ws, acts with the enzyme 866 in the substrate solution Ws, becomes a reaction product 854, and emits light Ls. Then, since the generation of the magnetic field from the tip of the magnetic flux collecting rod 128a remains stopped, the magnetic reactant 854 does not adhere to the surface of the magnetic flux collecting rod 128a again. As described above, in the analyzer 801, when a magnetic collecting rod made of a conventional bar magnet is used by stopping the generation of a magnetic field from the tip of the magnetic collecting rod 128a after inserting the magnetic collecting rod 128a into the measurement container 811. As compared with the above, resuspension of the complex 853 in the substrate solution Ws can be performed appropriately and efficiently.

  The photometric unit 830 is further provided with a condensing mechanism (not shown) and a spectrometer 830b, and the spectrometer emits light emitted from the reaction solution in the measurement container 811. The spectrometer 830b has, for example, a photomultiplier tube that detects weak light emission generated by chemiluminescence, and measures the light emission amount. In addition, the photometry unit 830 may include a mechanism that holds an optical filter and calculates a true light emission intensity based on a measurement value that is attenuated by the optical filter according to the light emission intensity. Note that the measurement container 811 is replaced with a new measurement container in which the substrate solution corresponding to the analysis item is accommodated for each measurement process performed by the spectrometer 830b.

  Then, the magnetic flux collecting rod 128a for which the measurement process has been completed is taken out from the measurement container 811. In this case, the magnetic flux collecting rod magnetic field control unit 146 keeps the generation of the magnetic field from the tip of the magnetic flux collecting rod 128a, and in this state, the magnetic flux collecting rod 128a is moved to the magnetic flux collecting rod transfer unit 128. In the washing tank 29a. Accordingly, since the generation of the magnetic field from the tip of the magnetic flux collecting rod 128a remains stopped, the magnetic reactant 854 does not adhere to the magnetic flux collecting rod 128a again. For this reason, the speed at which the magnetic flux collecting rod 128a is taken out from the measuring container 811 can be freely set according to the time required for each processing, and can be selected from a range of 0.1 to 50 mm / second, for example.

  Subsequently, the magnetic flux collecting bar 128a is cleaned in the magnetic flux collecting bar cleaning unit 129 in a state where the generation of the magnetic field is stopped, similarly to the magnetic flux collecting bar cleaning process in the analyzer 101 shown in FIG. Therefore, also in the analyzer 801, the magnetic collecting rod 128a that collects the composite 853 from the reaction vessel 11 by a magnetic field appropriately collects the composite 853 in the reaction vessel 11 by the generation of the magnetic field by the magnetic collecting rod 128a. In addition, the composite 853 can be appropriately removed from the surface of the magnetic flux collecting rod 128a after the photometry process by stopping the generation of the magnetic field by the magnetic flux collecting rod 128a.

  For this reason, according to the analyzer 801, the reactants can be appropriately removed from the surface of the magnetic flux collecting rod 128a without attaching a protective cap to the magnetic flux collecting rod. Therefore, both prevention of contamination in the device and reduction of waste are achieved. Is possible. Of course, in the analyzer 801, as with the analyzer 101, since the magnetic collecting rod 128 a is directly inserted into the reaction solution of the reaction vessel 11 to collect the composite 853, the composite from outside the reaction vessel is collected. As compared with the case of performing the conventional BF separation process in which the unreacted substance other than the composite is removed by removing the unreacted substance other than the composite, the composite 853 can be efficiently magnetically collected.

  Moreover, the layout of the analyzer described as the first to third embodiments is an example, and the dispensing order is not restricted by this layout.

1,101,201,301,601,701,801 Analyzing device 2,102,202,302,602,702,802 Measuring mechanism 4,104,204,304,604,704,804 Control mechanism 10 Reaction table 11 Reaction Container 19 Sample transfer unit 19a Sample container 19b Sample rack 20 Sample dispensing unit 21 First reagent storage 21a First reagent bottle 22 First reagent dispensing unit 23, 26 Probe cleaning unit 24 Second reagent storage 24a Second reagent bottle 25 Second reagent dispensing unit 27 Stirring unit 28 Magnetic collecting rod transfer unit 28a Magnetic collecting rod 28b Arm 28c Strut 28d Rotating mechanism 28e Lifting mechanism 29 Magnetic collecting rod cleaning unit 29a Cleaning tank 30 Photometric unit 31 Container cleaning unit 41, 241, 341 , 641, 741, 841 Control unit 42 Input unit 43 Analysis unit 44 Storage unit 45 Output unit 46, 146 Magnetic flux collecting bar magnetic field control unit 246, 346 Cleaning tank magnetic field control unit 647, 747 Probe cleaning tank magnetic field control unit

Claims (4)

In an analyzer for analyzing a sample using a reagent containing magnetic particles,
An insertion member inserted into a container containing the magnetic particles;
A cleaning means for cleaning the insertion member;
With
The cleaning means includes
A cleaning tank to which a cleaning liquid is supplied;
Magnetic field generating means for generating a magnetic field in the cleaning tank;
An analyzer characterized by comprising: A cleaning tank magnetic field control means for controlling generation of a magnetic field by the magnetic field generating means in the cleaning tank;
The analyzer according to claim 1, wherein the cleaning tank magnetic field control means causes the magnetic field generating means to generate a magnetic field in the cleaning layer when the magnetic collecting member is cleaned by the cleaning means. The magnetic field generating means includes an electromagnet,
The analyzer according to claim 2, wherein the cleaning tank magnetic field control means controls the generation of a magnetic field by the magnetic field generation means in the cleaning tank by controlling a current supplied to the electromagnet. The magnetic field generating means includes
With permanent magnets,
Magnet transfer means for transferring the permanent magnet to either a position close to the cleaning tank or a position where a magnetic field by the permanent magnet does not reach the cleaning tank;
With
The cleaning tank magnetic field control means causes the magnet transfer means to transfer the permanent magnet to a position close to the cleaning tank, thereby causing the magnetic field generation means to generate a magnetic field in the cleaning tank, and the permanent magnet The analyzer according to claim 2, wherein the magnetic field generation means stops the generation of the magnetic field in the cleaning tank by transferring the magnetic field generated by the permanent magnet to a position that does not reach the cleaning tank.

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