JP2011136969A - Extract from saussurea involucrata, food/drink composition and basic cosmetic composition each containing the same - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide an extract from Saussurea involucrata enabling itself to be incorporated, as an active ingredient for protecting the liver, in health food or pharmaceutical compositions. <P>SOLUTION: The extract from Saussurea involucrata includes: at least, flavonoids; chlorogenic acid; and syringin; and is to be used for preventing or treating hepatopathy, articular rheumatism, hypertension, hyperglycemia or hyperlipemia. Besides, the extract can be served as an active ingredient for health food or pharmaceuticals in the form of powder, drink, capsules or tablets. Further, the extract has moisturizing anti-suntan effect simultaneously, thus enabling serving as an active ingredient for basic cosmetics, makeup cosmetics or agents for external use in the form of gel type, water-including-oil emulsified type or oil-including-water emulsified type. <P>COPYRIGHT: (C)2011,JPO&INPIT

Description

  The present invention relates to an extract of cetsurenka, and more particularly to an extract of sturlenca for preventing or treating liver disease, rheumatoid arthritis, hypertension, hyperglycemia or hyperlipidemia.

  Liver cancer is a disease in which hepatocytes change abnormally, and forms a cancerous tumor by uncontrolled abnormal division. The formation of liver cancer is associated with infection with hepatitis B and C. Taiwanese hepatitis B carrier rate is about 16%, that is, more than about 3.6 million people are at risk for potential liver disease. Scientists estimate that 10-20% of people infected with hepatitis B will have liver cancer. In Taiwan, 80-90% of liver cancer patients have been infected with hepatitis B. A reliable relationship between hepatitis C and liver cancer is under study.

  It is now known that people with certain types of liver disease suffer from primary liver cancer with a relatively high probability. For example, among patients with cirrhosis (a disease caused by progressive liver damage), 5-10% eventually suffer from liver cancer. Some studies suggest that poor lifestyle habits, such as lack of sleep, excessive drinking and malnutrition, all lead to cirrhosis and liver cancer.

  The liver is the most important detoxifying organ of the human body and the only reproducible organ in the human body. Because of lifestyle relationships, many people find that they cannot get enough rest at work when they are young, and they cannot recover their health with money even if they become wealthy after they get older. Liver cancer has a high mortality rate, and Taiwan's liver consciousness is gradually emerging. Good health foods for various livers are appearing one after another.

  In order to solve this problem in view of various problems in the known technology, the present inventor provides cetelecan extract as a realization method and a basis for improving the above-mentioned drawbacks based on many years of research and development and many practical experiences.

  In view of this, an object of the present invention is to provide a cetsurenka extract that can be added to health foods or pharmaceutical compositions as an active ingredient for protecting the liver.

  In accordance with the object of the present invention, cetulenca extract containing at least a flavonoid, chlorogenic acid and syringin, which can be used as an active ingredient for preventing or treating liver disease, rheumatoid arthritis, hypertension, hyperglycemia or hyperlipidemia. Offer things.

  In addition, the present invention further provides a food and beverage composition comprising a cetsurenka extract used for the prevention or treatment of liver disease, rheumatoid arthritis, hypertension, hyperglycemia or hyperlipidemia.

  In addition, the present invention further provides a moisturizing agent containing a cetsurenka extract applicable to basic cosmetics, makeup cosmetics, or external preparations.

As described above, the cethuren extract according to the present invention has the following advantages.
(1) This cetsurenka extract has an effect of protecting the liver, and can be used as an active ingredient of health foods or pharmaceuticals.
(2) This Ceturenka extract has a moisturizing sunscreen effect and can be used as an active ingredient in basic cosmetics, makeup cosmetics or external preparations.

  Tenzanseturen is a plant belonging to the genus Spruce genus Sausureu involukurata Kar. Et Kin, and is also called snow-capped flower. It is a perennial and the only large herbaceous plant that can grow on the snow line. Seturenka is distributed in the Tianshan Mountains, Altai Mountains, and Dunhuang Mountains in the Xinjiang Uygur Autonomous Region, grows in the crevices of snowy mountains over 3000 meters above sea level, and has the effect of warming with a spicy taste.

The certurica extract of the present invention is obtained by the following steps.
1. Provide dry cetsurenka powder.
2.1 Extract cetsurenka powder with 1-butanol.
3. Separate the cetsurenka extract from 1-butanol.

  This cetsurenka extract can be in powder or extract specifications.

  The cetsurenka extract of the present invention contains at least a flavonoid, chlorogenic acid, and syringin, and has an effect of preventing or treating liver disease, rheumatoid arthritis, hypertension, hyperglycemia or hyperlipidemia. The basic structure of flavonoids is a structure in which 15 carbon atoms are arranged in three rings. The main difference of flavonoids is in the ring containing oxygen. Depending on the structure, flavones (Flavones), flavonols (Flavonols), It is divided into five major classifications: isoflavones, flavanones, and anthocyanins. Flavonoids are natural antioxidants and are recognized as the most powerful antioxidants in the world, with antioxidant capacity 50 times that of vitamin E and 20 times that of vitamin C. Flavonoids have a small molecular structure, water solubility, and are easily absorbed by the human body. It is not accumulative, can remove radicals in the body, and is a major component of liver protection. Chlorogenic acid is present in coffee beans, and the content in unroasted coffee beans reaches 45% or more. Chlorogenic acid not only has high antioxidant action, suppresses active oxygen, is effective in preventing cancer and lifestyle-related diseases, but can also protect capillaries and prevent thrombus. Chlorogenic acid has a very strong scavenging ability, has a very good ability to resist radicals, and can effectively remove or suppress hydroxyl radicals having the strongest destructive power. Syringin is a powerful anti-hepatotoxic drug that restores the enzyme activity of the microsomal enzyme system and suppresses lipid peroxidation, thereby promoting the metabolism of hepatotoxic substances and improving and normalizing liver function. be able to.

  The cetsurenka extract of the present invention may further comprise one or a mixture of two or more of amino acids, umbelliferone, scopoletin, apigenin, sitosterol and colchicine. Amino acids can effectively adjust the pH of the human body, enhance the immunity of the human body, and prevent fatigue. Umbelliferone has significant antibacterial, antihypertensive, sedative, and antispasmodic effects. Scopoletin has the effects of suppressing allergic reactions, anti-inflammatory, analgesic, and phlegm cutting, and has an extremely excellent effect in the treatment of chronic bronchitis. Apigenin has smooth muscle spasm and anti-gastric ulcer effects. Sitosterol has the effect of lowering blood pressure and cholesterol in the liver. Colchicine is a typical representative of cell mitosis, can suppress the growth of cancer cells, is clinically used for the treatment of cancer, and has a certain therapeutic effect especially against breast cancer Also has some effects on skin cancer and leukemia.

  A capsule of 500 ml capacity was prepared by uniformly mixing 50 grams of Selecan extract powder, 25 grams of microcrystalline cellulose and 25 grams of lactose according to the present invention. Liver function values (GOT, GPT) were too high. 15 night shift workers were given 10 tablets of Tenzan cetrene capsule per day and measured 30 days later. As a result, all the liver function values were higher than the initial values. The liver function values of 6 of them were already within the normal range. Moreover, the cetsurenka extract of this invention can be made into a powder, a drink, a capsule, or a tablet.

  A gel-like basic cosmetic product was prepared by uniformly mixing 50 grams of Selenium extract according to the present invention, 3 grams of thickener and 47 grams of water. Fifteen female office workers were applied to the face every morning and evening, measured 30 days later, and epidermis moisture was measured with a Corneometer (R) CM825 probe of skin measuring instrument MPA580. As a result of measurement after 30 days, an increase phenomenon was observed in the skin water content of all persons, and the average skin water content increased from 61.3 before use to 65.4 after use, to 6.91. % Increase.

  The contents described above are merely illustrative and not restrictive. All equivalent modifications or changes made without departing from the spirit and scope of the invention are intended to be included within the scope of the claims.

Claims (12)

A cetulenca extract containing at least a flavonoid, chlorogenic acid, and syringin and used for the prevention or treatment of liver disease, rheumatoid arthritis, hypertension, hyperglycemia or hyperlipidemia. The cetsurenka extract according to claim 1, further comprising one or a mixture of two or more of amino acids, umbelliferone, scopoletin, apigenin, sitosterol and colchicine. 3. A certurica extract according to claim 1 or 2 in powder or liquid form. The cetsurenka extract according to any one of claims 1 to 3, wherein 1-butanol is used as an extraction solvent. The food-drinks composition containing the cetsurenka extract of Claim 1. The food or beverage composition according to claim 5, further comprising one or a mixture of two or more of amino acids, umbelliferone, scopoletin, apigenin, sitosterol and colchicine. The food / beverage composition according to claim 5 or 6, wherein the food / beverage composition is in the form of powder, beverage, capsule or tablet. The food or beverage composition according to any one of claims 5 to 7, which is used for prevention or treatment of liver disease, rheumatoid arthritis, hypertension, hyperglycemia or hyperlipidemia. A basic cosmetic composition comprising the cetsurenka extract according to claim 1. The basic cosmetic composition according to claim 9, further comprising one or a mixture of two or more of amino acids, umbelliferone, scopoletin, apigenin, sitosterol and colchicine. The basic cosmetic composition according to claim 9 or 10, which is a gel, an oil-in-water emulsion, or a water-in-oil emulsion. The basic cosmetic composition according to any one of claims 9 to 11, which is used for moisturizing, sunscreen or whitening.