JP2011093850A - Method and kit for peeling keratin - Google Patents

Abstract

<P>PROBLEM TO BE SOLVED: To provide a keratin-peeling method by which the keratin can efficiently and readily be peeled off, and to provide a kit for peeling the keratin, suitable for the execution of the method. <P>SOLUTION: The keratin-peeling method includes a sebum-removing step for removing the sebum at a part from which the keratin of the surface of the skin is to be removed by a sebum-adsorbing sheet, and a keratin-peeling step for peeling off the keratin at the surface of the skin from which the sebum has been removed by an adhesive sheet for peeling the keratin. The kit for peeling the keratin is obtained by integrating the sebum-adsorbing sheet and the adhesive sheet for peeling the keratin. <P>COPYRIGHT: (C)2011,JPO&amp;INPIT

Description

  The present invention relates to a keratin exfoliation method excellent in an exfoliation effect and a keratin exfoliation kit suitable for carrying out this method.

The stratum corneum in the outermost layer of the skin is an interface that separates the inside of the living body from the outside world, and has a barrier function that prevents biological components from leaking into the outside world and prevents harmful components from entering the living body.
In this way, the keratin has an important function for the living body.For example, active ingredients such as drugs and vaccines can be administered into the living body through the skin, or the suction exudate is reduced from the skin for the purpose of clinical examinations. It may be necessary to remove the keratin when sucking.

Conventionally, as a method of removing keratin, for example, a method of removing keratin by attaching an adhesive tape to the skin surface and peeling it after a certain time is known (Patent Documents 1 to 6 and the like).
However, conventional adhesive tapes may have insufficient exfoliation ability due to individual differences in sebum secretion, seasonal differences, etc., and the effect of these factors can be reduced to more effectively exfoliate exfoliation. Currently, there is a demand for development of a method for exfoliating keratin.

JP-A-5-123326 JP-A-3-151951 JP 2007-289672 A JP 2008-201698 A JP 2009-102304 A JP 2009-29742 A

  The present invention has been made in view of the above situation, and the problem is to provide a keratin exfoliation method capable of exfoliating keratin more efficiently and simply, and a keratin exfoliation kit suitable for carrying out this method. Is to provide.

  In order to solve the above-mentioned problems, the present inventors have intensively studied on a method for removing keratin by sticking an adhesive sheet for exfoliating keratin to the skin surface and peeling it after a predetermined time. As a result, according to the method of removing the keratin on the skin surface where the exfoliating part is removed with a sebum adsorbing sheet such as a cosmetic degreasing paper, the keratin is efficiently removed according to the method of exfoliating the keratin with the exfoliating adhesive sheet. I found that I can do it. In addition, the present inventors have devised a kit for exfoliating keratin suitable for this method, and have completed the present invention.

  Thus, according to the first aspect of the present invention, the sebum removing sheet removes the sebum in the part where the skin surface exfoliates with the sebum adsorbing sheet, and the exfoliated skin surface exfoliant with the exfoliating pressure-sensitive adhesive sheet. A keratin exfoliation method having an exfoliating step of exfoliating is provided.

According to the second aspect of the present invention, there is provided a keratin exfoliation kit in which a sebum adsorbing sheet and an exfoliating pressure-sensitive adhesive sheet are integrated.
The keratin exfoliation kit of the present invention is preferably composed of a skin immobilization site, a sebum adsorption site, and a keratin exfoliation site.

According to the keratin exfoliation method of the present invention, keratin can be exfoliated efficiently and easily.
The keratin exfoliation kit of the present invention is suitable for carrying out the keratin exfoliation method of the present invention, has excellent handleability, and can efficiently exfoliate the target keratin by a simple operation.

It is a figure which shows an example of the kit for exfoliation of this invention. In the figure, (i) is a top view and (ii) is a cross-sectional view of the layer structure in the XY direction. It is a figure which shows an example of the kit for exfoliation of this invention. It is a figure which shows an example of the kit for exfoliation of this invention. FIG. 4 is a production process cross-sectional view of the keratin exfoliation kit of Example 1. FIG. 4 is a production process cross-sectional view of the keratin exfoliation kit of Example 1. FIG. 4 is a production process cross-sectional view of the keratin exfoliation kit of Example 1. It is the upper side figure (i) of the kit for exfoliation of Example 1, and traveling cross-sectional view (ii) of a X2-Y2 direction.

  Hereinafter, the present invention will be described in detail by dividing into 1) a keratin exfoliation method and 2) a keratin exfoliation kit.

1) Skin exfoliation method The first aspect of the present invention is a sebum removing step of removing sebum in a part where exfoliation of the skin surface is removed with a sebum adsorbing sheet; It is a keratin exfoliation method which has a keratin exfoliation process which exfoliates keratin.

(1) Sebum removing step In the keratin exfoliation method of the present invention, first, sebum is removed from the part where the keratin on the skin surface is exfoliated with a sebum adsorbing sheet (sebum removing step).

  When sebum that is an oily component is present on the stratum corneum, the amount of stratum corneum peeling of the stratum corneum peeling pressure-sensitive adhesive sheet decreases due to the effect of sebum present at the interface between the stratum corneum peeling pressure-sensitive adhesive layer and the stratum corneum. Therefore, by removing the sebum in the part that exfoliates the keratin on the skin surface in advance with the sebum adsorbing sheet, it is possible to suppress a decrease in the amount of exfoliated keratin exfoliation due to the sebum.

  The sebum adsorbing sheet used in the present invention can be used without particular limitation as long as it is in the form of a sheet capable of adsorbing sebum, and specifically described in JP-A Nos. 06-319664 and 3647909. The decorative degreasing paper that has been used can be suitably used.

  By attaching the sebum adsorbing sheet to the part of the skin surface where the keratin is peeled off, and then removing the sebum adsorbing sheet, the part of the skin surface where the keratin is peeled off can be removed. The time until the sebum adsorbing sheet is adhered to the skin surface and then removed is not particularly limited, but is usually 1 second to several minutes. Further, the operation of bringing the sebum-adsorbing sheet into close contact with the part of the skin surface where the keratin is peeled and then removing the sebum-adsorbing sheet may be repeated a plurality of times.

  Whether or not sebum remains on the skin is determined by, for example, holding the filter paper on the skin surface for 1 minute and then leaving the filter paper in osmium tetroxide vapor for 15 minutes. If the sebum remains, the filter paper develops a black color, and if the sebum does not remain, the filter paper does not develop a black color. This is because oleic acid, which is the main component of sebum, and its glycerin ester have an unsaturated double bond in the molecule, so that they undergo an addition reaction with osmium tetroxide and develop a black color.

(2) Keratin Peeling Step Next, the stratum corneum on the skin surface from which the sebum has been removed is peeled off with a keratin peeling adhesive sheet (keratin peeling step).
The stratum corneum peeling pressure-sensitive adhesive sheet used in the present invention is not particularly limited as long as it has at least a stratum corneum peeling pressure-sensitive adhesive layer containing a pressure-sensitive adhesive component on a supporting substrate.

  The supporting substrate is not particularly limited as long as it can carry the stratum corneum peeling adhesive layer. For example, polyester film such as polyethylene terephthalate (PET), polyethylene, polypropylene, ethylene / methacrylic acid copolymer, polyolefin film such as ethylene / methyl methacrylate, polyurethane film, polystyrene thermoplastic elastomer film, etc. Films: Films obtained by depositing metals such as aluminum on these resin films; Fibers such as woven fabrics, knitted fabrics, and nonwoven fabrics made of various synthetic fibers and / or natural fibers; fine papers, glassine papers, coated papers, etc. Papers; laminates thereof; and the like.

  The thickness of the support substrate is not particularly limited, but when the support substrate is a resin film, it is usually 5 to 250 μm, preferably 10 to 100 μm, and the support substrate is made of fibers or papers. Is usually 10 to 1000 μm, preferably 20 to 500 μm.

  In addition, as a support substrate, surface treatment such as primer treatment, corona treatment, plasma treatment or the like is performed in advance on the surface on which the stratum corneum peeling adhesive layer is formed in order to enhance adhesion with the stratum corneum peeling adhesive layer. It may be given. Alternatively, the surface on which the keratin peeling adhesive layer is not formed may be peeled with a silicone-based release agent, a long-chain alkyl compound, or the like.

  The stratum corneum peeling pressure-sensitive adhesive layer can be formed by applying and drying a stratum corneum peeling pressure-sensitive adhesive composition containing a pressure-sensitive adhesive component on the support substrate.

  The adhesive component to be used is not particularly limited as long as the keratin can be peeled off by the adhesive force, and examples thereof include a rubber adhesive, an acrylic adhesive, a silicone adhesive, and a urethane adhesive. Among these, an acrylic pressure-sensitive adhesive is preferable in terms of easy control of the adhesive force.

  The pressure-sensitive adhesive sheet for exfoliating used in the present invention is a pressure-sensitive adhesive force (mode: 180 ° peeling, peeling speed: 300 mm / min, sticking time) 5 minutes after the pressure-sensitive adhesive sheet for exfoliating is attached to a bakelite plate. : 5 minutes) is preferably 5 to 25 N / 25 mm, particularly preferably 7 to 20 N / 25 mm. If the adhesive force is less than 5 N / 25 mm, the stratum corneum cannot be effectively peeled off. On the other hand, when the adhesive strength exceeds 25 N / 25 mm, there is a possibility that an adhesive residue may occur on the skin.

The said stratum corneum peeling adhesive composition may further contain other components according to the intended purpose.
Examples of other components include various additives such as drugs, humectants, antioxidants, viscosity modifiers, ultraviolet absorbers, masking agents, plasticizers, waxes, colorants, inorganic fillers, and organic fillers.

  The pressure-sensitive adhesive composition for exfoliating exfoliation can be prepared by appropriately mixing the above-mentioned pressure-sensitive adhesive component and optionally other components and an organic solvent according to a conventional method.

  Examples of the organic solvent used here include aromatic hydrocarbon solvents such as toluene; ester solvents such as ethyl acetate and butyl acetate; ketone solvents such as acetone, methyl ethyl ketone, and methyl isobutyl ketone; n-pentane, n-hexane, and aliphatic hydrocarbon solvents such as n-heptane; alicyclic hydrocarbon solvents such as cyclopentane and cyclohexane; and mixed solvents composed of two or more of these solvents.

  Although the usage-amount of an organic solvent is not specifically limited, It is 5-90 mass% normally with respect to the whole adhesive composition for exfoliation, Preferably it is 10-80 mass%, More preferably, it is 20-70 mass%.

An adhesive layer for exfoliating exfoliated with excellent exfoliation ability can be formed by applying an adhering composition for exfoliating exfoliation on a supporting substrate and drying it.
Application of the pressure-sensitive adhesive composition for exfoliating exfoliation can be performed using an existing application apparatus. Examples of the coating apparatus include a gravure coater, a Mayer bar coater, a roll coater, a knife coater, a die coater, and a screen coater.

  Although there is no restriction | limiting in particular in drying temperature, Usually, 60-200 degreeC, Preferably it is 80-120 degreeC. Although depending on the drying temperature, the drying time is usually 5 seconds to 10 minutes, preferably 10 seconds to 5 minutes.

  The thickness of the pressure-sensitive adhesive layer for exfoliating exfoliation is not particularly limited, but is preferably 10 to 200 μm, and particularly preferably 15 to 100 μm, from the viewpoint of effectively exfoliating exfoliation.

A release sheet may be laminated for storage and transportation on the resulting exfoliating pressure-sensitive adhesive layer. The release sheet is peeled off when the keratin peeling adhesive sheet is used.
Examples of release sheets include paper such as fine paper, glassine paper, coated paper, polyethylene laminated paper, and polypropylene laminated paper; polyester-based films such as polyethylene terephthalate; synthetic resin films such as polyolefin-based films such as polyethylene and polypropylene; and these And a paper or synthetic resin film that has been subjected to a release treatment with a silicone-based release agent, a long-chain alkyl compound, or the like. Of these, a polyester film that has been subjected to a release treatment is preferred from the standpoint of availability and ease of handling.

The keratin exfoliation pressure-sensitive adhesive sheet obtained as described above is applied to the keratin exfoliation pressure-sensitive adhesive layer side of the keratin exfoliation pressure-sensitive adhesive sheet, and is attached to the skin surface from which sebum has been removed. By exfoliating, the stratum corneum can be removed.
The time from the application of the exfoliating pressure-sensitive adhesive sheet to the exfoliation of the exfoliating adhesive sheet is not particularly limited, but is usually from several seconds to 10 minutes.

  Sebum is hardly confirmed on the skin after exfoliating the stratum corneum with the exfoliating pressure-sensitive adhesive sheet. According to the present invention, in order to adsorb and remove the sebum in the part where the skin surface exfoliates with the sebum adsorbing sheet in advance, there is no decrease in the exfoliating ability due to the presence of sebum, Excellent exfoliating ability.

  The fact that sebum does not remain on the skin surface after the sebum has been adsorbed and removed by the sebum adsorbing sheet is, for example, that the filter paper is fixed on the skin surface and maintained for 1 minute, and then the filter paper is placed in osmium tetroxide vapor. It can be left for a minute, and the degree of color development can be confirmed with the naked eye, and it can be confirmed by almost no color development.

Moreover, according to the keratin exfoliation method of the present invention, keratin can be efficiently and simply removed. The excellent exfoliating effect of the exfoliating substance is obtained by the exfoliating method of the present invention. For example, the exfoliating sheet is exfoliated after being applied to a human forehead for 5 minutes, and the exfoliated sheet is punched to a specified size. It can be confirmed by measuring the amount of keratin exfoliation (protein amount, μg / cm ² ) with a DC protein assay kit (Bio-Rad Laboratories).

2) Keratin exfoliation kit The second of the present invention is a keratin exfoliation kit in which a sebum adsorbing sheet and an exfoliating pressure-sensitive adhesive sheet are integrated. The keratin exfoliation kit of the invention is suitable for carrying out the keratin exfoliation method of the present invention.

  In the keratin exfoliation kit of the present invention, as the sebum adsorbing sheet and the keratin exfoliation pressure-sensitive adhesive sheet, those similar to those exemplified as those that can be used in the above-described keratin exfoliation method of the present invention can be used.

  Here, the “keratin exfoliation kit in which the sebum adsorbing sheet and the exfoliating pressure-sensitive adhesive sheet are integrated” is sebum adsorbing so that the sebum adsorbing sheet and the exfoliating adhesive sheet can be used continuously. The sheet and the exfoliating pressure-sensitive adhesive sheet are connected directly or through another sheet and integrated to form one article. For example, (α) a sebum adsorbing sheet and an exfoliating pressure-sensitive adhesive sheet are connected to each other at an end edge part thereof directly or via another sheet, (β) a sebum adsorbing sheet, Examples include those in which the keratin exfoliation pressure-sensitive adhesive sheet is detachably connected to each edge portion directly or via another sheet.

  The keratin exfoliation kit of the present invention may be formed by integrating at least one sebum adsorbing sheet and at least one exfoliating pressure-sensitive adhesive sheet. However, the sebum adsorbing sheet and / or keratin exfoliating kit may be used. A plurality of pressure-sensitive adhesive sheets may be integrated.

  In the keratin exfoliation kit of the present invention, those composed of an immobilization site on the skin, a sebum adsorption site, and a keratin exfoliation site are preferable. Here, the site immobilized on the skin corresponds to the “other sheet (adhesive sheet for fixing)”, the sebum adsorbing site corresponds to the sebum adsorbing sheet, and the keratin exfoliating site corresponds to the keratin exfoliating adhesive sheet. These sheets are integrated to form the keratin exfoliation kit of the present invention. When the stratum corneum peeling kit is configured in this way, the site to be immobilized on the skin serves as a mark. Therefore, the stratum corneum peeling adhesive sheet is accurately applied to the part from which sebum has been removed by the sebum adsorption sheet. Can be peeled off.

Specific examples of the keratin exfoliation kit of the present invention are shown in FIGS.
In the exfoliating kit 10A shown in FIG. 1, a sebum adsorbing sheet 1a having a size covering at least the opening 5 is provided at one end of a rectangular fixing adhesive sheet 2a. 42—a double-sided pressure-sensitive adhesive sheet 4a composed of three layers, that is, a bonding pressure-sensitive adhesive layer 43, is detachably connected via a bonding pressure-sensitive adhesive layer 43, and at least the opening 5 is provided at the other end of the fixing pressure-sensitive adhesive sheet 2a. A coverable keratin peeling adhesive sheet 3a is detachably connected via a bonding adhesive layer 32. 1, (i) is a top view of the keratin exfoliation kit 10A, and (ii) is a structural cross-sectional view in the XY direction of the keratin exfoliation kit 10A.

  In the keratin exfoliation kit 10 </ b> A shown in FIG. 1, an opening 5 is provided at the center of the fixing adhesive sheet 2 a so that the skin can be directly touched through the opening 5. Further, the fixing adhesive sheet 2a has a skin fixing adhesive layer 22 formed on the side opposite to the side where the sebum adsorbing sheet 1a and the exfoliating adhesive sheet 3a are provided. The skin fixing adhesive layer 22 is formed on the entire surface of the fixing adhesive sheet 2a surrounding the four sides of the opening 5 (not shown).

  In the keratin exfoliation kit 10A shown in FIG. 1, the adhesive used for the skin fixing adhesive layer 22 constituting the fixing adhesive sheet 2a is not particularly limited, but is preferably an adhesive with little irritation to the skin. For example, rubber pressure sensitive adhesive, acrylic pressure sensitive adhesive, silicone pressure sensitive adhesive, urethane pressure sensitive adhesive, and the like can be mentioned.

  In the keratin exfoliation kit 10A shown in FIG. 1, the release sheet 21 is provided on the lower surface of the skin fixing adhesive layer 22 constituting the fixing adhesive sheet 2a. Are laminated so that they come into contact with each other, and the release sheet 21 is peeled off and used at the time of use. Examples of the release sheet 21 include paper such as fine paper, glassine paper, coated paper, polyethylene laminated paper, and polypropylene laminated paper; polyester film such as polyethylene terephthalate; synthetic resin film such as polyolefin film such as polyethylene and polypropylene; and One or both surfaces of these papers or synthetic resin films are subjected to a release treatment with a silicone release agent, a long-chain alkyl compound, or the like. Of these, a polyester film that has been subjected to a release treatment is preferred from the standpoint of availability and ease of handling.

In the stratum corneum peeling kit 10 </ b> A shown in FIG. 1, a peeling sheet 23 is laminated on the upper surface of the skin fixing adhesive layer 22. The opposite side of the release sheet 23 on the side where the skin fixing adhesive layer 22 is provided is subjected to a release treatment with a silicone release agent, a long-chain alkyl compound, or the like, and the sebum-adsorbing sheet 1a and the keratin release adhesive sheet 3a are The double-sided pressure-sensitive adhesive sheet 4a or the bonding pressure-sensitive adhesive layer 32 is detachably connected. Further, the surface of the release sheet 23 that has not been subjected to the release treatment and the skin fixing adhesive layer 22 are firmly bonded. As the peeling sheet 23, the thing similar to the peeling sheet 21 mentioned above can be used.
In the above description, the sebum adsorbing sheet 1a and the exfoliating pressure-sensitive adhesive sheet 3a are described as being detachably connected to the peeling sheet 23 via the double-sided pressure-sensitive adhesive sheet 4a or the bonding pressure-sensitive adhesive layer 32. When the attachment / detachment is not required, the release sheet 23 may be replaced with a support base material such as a synthetic resin film that has not been subjected to the release treatment.

  In the keratin exfoliation kit 10A shown in FIG. 1, a double-sided pressure-sensitive adhesive sheet 4a comprising three layers of a bonding pressure-sensitive adhesive layer 41, a supporting base material 42, and a bonding pressure-sensitive adhesive layer 43 is provided on one edge of the fixing pressure-sensitive adhesive sheet 2a. Thus, the sebum adsorbing sheet 1a is detachably attached via the double-sided adhesive sheet 4a. There are no particular limitations on the bonding adhesive and the supporting base material 42 that constitute the bonding pressure-sensitive adhesive layers 41 and 43, and known materials that have been conventionally used as pressure-sensitive adhesives and supporting base materials for pressure-sensitive adhesive sheets can be used.

  In the stratum corneum peeling kit 10 </ b> A shown in FIG. 1, a bonding adhesive layer 32 is formed on the other edge portion of the fixing pressure-sensitive adhesive sheet 2 a, and a support substrate 33 -keratin peeling is formed on the bonding pressure-sensitive adhesive layer 32. An adhesive sheet 3a for exfoliating keratin made of adhesive layer 34 is attached in a detachable manner. The bonding adhesive that constitutes the bonding adhesive layer 32 is not particularly limited, and those conventionally used as pressure-sensitive adhesives can be used.

  Further, release sheets 31 and 35 are laminated on the surface of the bonding adhesive layer 32 opposite to the support substrate 33 and on the surface of the stratum corneum peeling adhesive layer 34, respectively. The sheet 35 is peeled off and used. As the release sheets 31 and 35, those similar to the release sheet 21 described above can be used.

  In the exfoliating kit 10B shown in FIG. 2, a sebum adsorbing sheet 1b having a substantially square shape is connected to two edge portions of a fixing sheet 2b having a substantially equilateral triangle shape, and a substantially square shape is connected to the remaining one edge. The exfoliating pressure-sensitive adhesive sheet 3b having the following shape is connected. The connecting method of the fixing adhesive sheet 2b, the sebum adsorbing sheet 1b, and the exfoliating adhesive sheet 3b is the same as in the case of the exfoliating kit 10A shown in FIG.

  According to the keratin exfoliation kit 10B shown in FIG. 2, after using the two sebum adsorbing sheets 1b to sufficiently remove the sebum present in the exfoliated part of the skin surface, the keratin exfoliating pressure sensitive adhesive sheet 3b is used. Therefore, an excellent exfoliating effect can be obtained.

  In the exfoliating kit 10C shown in FIG. 3, a sebum adsorbing seam 1c having the same shape as the fixing adhesive sheet 2c is connected to the three end edges of the rectangular fixing adhesive sheet 2c, and the remaining one edge In addition, the exfoliating pressure-sensitive adhesive sheet 3c having the same shape as the fixing pressure-sensitive adhesive sheet 2c is connected. The connecting method of the fixing adhesive sheet 2c, the sebum adsorbing sheet 1c and the exfoliating adhesive sheet 3c is the same as in the case of the exfoliating kit 10A shown in FIG.

  According to the keratin exfoliation kit 10C shown in FIG. 3, by using three sebum adsorbing sheets 1c, the sebum present in the keratin exfoliation part on the skin surface is sufficiently removed, and then the keratin is removed by the exfoliating pressure-sensitive adhesive sheet 3c. Therefore, an excellent exfoliating effect can be obtained.

  The keratin exfoliation kit of the present invention is not limited to the keratin exfoliation kit shown in FIGS. 1 to 3, and its shape and size, adhesive sheet for fixing, and sebum are within the scope of the present invention. It is possible to modify the connection method with the adsorbing sheet and the exfoliating sheet.

  Hereinafter, the present invention will be described in more detail with reference to Examples and Comparative Examples. However, this invention is not restrict | limited at all by these Examples.

Example 1
Hereafter, the manufacturing method of Example 1 of this invention is demonstrated using FIG.
As the release sheet 350, a PET release sheet having one side peel-treated with a 38 μm-thick silicone resin was prepared, and the average thickness after drying the ethyl acetate solution of the horny peel acrylic adhesive on the release-treated face Was applied and dried to form a keratin peeling adhesive layer 340 (keratin peeling adhesive layer forming step). Thereafter, a PET film having an average thickness of 12 μm was laminated on the stratum corneum peeling adhesive layer 340 as the support base material 330 to prepare a stratum corneum peeling kit intermediate a shown in FIG.
The keratin exfoliation kit intermediate a was removed from the PET exfoliation sheet, adhered to a bakelite plate, and after 5 minutes, the adhesive strength in accordance with JIS Z0237 (mode: 180 ° exfoliation, exfoliation rate: 300 mm / min) , Sticking time: 5 minutes) was 19.1 N / 25 mm.

  Next, as the release sheet 310, a PET release sheet having one side peel-treated with a 38 μm-thick silicone resin was prepared, and an average after drying an ethyl acetate solution of a bonding acrylic pressure-sensitive adhesive on the peel-treated surface After applying to a thickness of 20 μm, it was heated and dried to form a bonding adhesive layer 320 (bonding adhesive layer forming step). Thereafter, the non-adhesive processed surface of the support substrate 330 of the stratum corneum peeling kit intermediate a was laminated to the bonding pressure-sensitive adhesive layer 320 to prepare a stratum corneum peeling kit intermediate b shown in FIG.

  After punching out the stratum corneum peeling intermediate b to be 4 cm long × 6 cm wide, only the PET release sheet 310 is cut in parallel at a 1 cm portion from the end and peeled off, thereby removing the stratum corneum as shown in FIG. Kit intermediate A (adhesive sheet for exfoliating keratin) was prepared.

Next, as shown in FIG. 5, a PET release sheet having one side peeled off with a silicone resin having a thickness of 75 μm is prepared as the release sheet 210, and an acrylic adhesive for fixing the skin is formed on the release treated surface. The ethyl acetate solution was applied so that the average thickness after drying was 30 μm, and then dried by heating to form an adhesive layer 220 for fixing the skin. Thereafter, as the release sheet 230, a non-release treatment surface of a PET release sheet whose one side was peeled with a 38 μm thick silicone resin was laminated on the skin fixing adhesive layer 220 to form a laminate (not shown). .
Next, after punching out the obtained laminate so as to be 4 cm long × 6 cm wide, the release sheet 230 and the adhesive layer 220 for fixing the skin are punched out so that the opening 50 is formed in 2 cm long × 4 cm wide, A stratum corneum peeling kit intermediate B (fixing adhesive sheet) shown in FIGS. 5 (i) and (ii) was prepared. In FIG. 5, (i) is a top view of the intermediate body B, and (ii) is a cross-sectional view of the layer structure of the intermediate body B in the X1-Y1 direction.

  Next, as a sebum adsorbing sheet 100a, a cosmetic degreasing paper (manufactured by Mandom Co., Ltd., trade name “Gatsby oil blotting paper (film type)”) is prepared and punched out to be 4 cm long × 6 cm wide, A double-sided pressure-sensitive adhesive sheet 400a measuring 4 cm in length and 1 cm in width (bonding adhesive layers 410 and 430 (bonding acrylic pressure-sensitive adhesive having a thickness of 30 μm) formed on both surfaces of a support base material 420 (recycled paper)) in the vertical direction Affixed to produce a stratum corneum peeling kit intermediate C shown in FIG.

  Thereafter, the keratin exfoliation kit intermediates A and C were immobilized on the exfoliation surface of the exfoliation sheet 230 of the keratin exfoliation kit intermediate B, thereby producing a keratin exfoliation kit 100A shown in FIG. 7, (i) is a top view of the keratin exfoliation kit 100A, and (ii) is a cross-sectional view of the layer structure of the keratin exfoliation kit 100A in the X2-Y2 direction.

(Comparative Example 1)
A keratin exfoliation kit 200A (not shown) having no sebum adsorbing sheet is prepared by immobilizing the keratin exfoliation kit intermediate A on the exfoliation surface of the exfoliation sheet 230 of the exfoliation kit intermediate B. did.

(Exfoliation test)
The following experiment was conducted using the keratin exfoliation kits 100A and 200A obtained in Example 1 and Comparative Example 1.

(1) A keratin exfoliation experiment using the keratin exfoliation kit 100A First, the exfoliation sheet 210 of the exfoliation kit 100A is exfoliated, and the exposed skin fixing adhesive layer 220 is applied to a part where the exfoliation on the subject's forehead surface is exfoliated. Pasted.
Next, the sebum adsorbing sheet 100a was folded and adhered to the skin surface in the opening 50 and immediately removed.
Thereafter, the release sheet 350 was peeled off, and the exfoliated pressure-sensitive adhesive sheet 300a was folded and pasted on the skin surface in the opening 50, and peeled and removed after 5 minutes.

(2) A keratin exfoliation experiment using the keratin exfoliation kit 200A A keratin exfoliation experiment was conducted in the same manner as when the keratin exfoliation kit 100A was used, except that the sebum was not removed using the sebum adsorbing sheet.

(Evaluation test)
For the subjects who conducted the above exfoliation experiment, the remaining amount of sebum after removing sebum using the sebum adsorbing sheet and the exfoliation amount exfoliated by the exfoliating pressure-sensitive adhesive sheet were measured as follows. .

(1) Measurement of residual sebum amount A filter paper was fixed on the skin surface after removing sebum using a sebum adsorbing sheet and maintained for 1 minute. This filter paper was left in osmium tetroxide vapor for 15 minutes, the degree of color development was confirmed with the naked eye, and the amount of residual sebum on the skin was evaluated according to the following evaluation criteria. The evaluation results are shown in Table 1.

1: No color development 2: Slight color development 3: Color development (2) Measurement of keratin exfoliation amount Protein quantification method (Lowry method; F. Dreher, Colorimetric Method for Quantitative Human Stratum Connec- um Removed By Adhesive Adhesive Adhesive Adhesive Adhesives Stockh (1998) 78: 186-189).

  Each of the adhesive sheets for exfoliating used in the exfoliation experiment was punched out to a specified size, and the exfoliated amount (protein amount) was measured with a DC protein assay kit (manufactured by Bio-Rad Laboratories). The measurement results are shown in Table 1.

  From Table 1, by using the keratin exfoliation kit of Example 1, a comparative example in which exfoliating exfoliation without removing sebum when exfoliating exfoliation after exfoliating exfoliating part of exfoliating part of the skin surface It can be seen that the stratum corneum can be peeled off more reliably than 1.

1a, 1b, 1c, 100a ... Sebum adsorption sheets 2a, 2b, 2c, 200a ... Fixing adhesive sheets 3a, 3b, 3c, 300a ... Exfoliating adhesive sheets 4a, 400a ... Double-sided adhesive Sheets 5, 50... Openings 10A, 10B, 10C, 100A, 200A... Exfoliating kits 21, 23, 31, 35, 210, 230, 310, 350 ... Release sheets 32, 41, 43 320, 410, 430 ... bonding adhesive layer 22, 220 ... skin fixing adhesive layer 33, 330, 42, 420 ... support substrate 34, 340 ... stratum corneum peeling adhesive layer

Claims (3)

With the sebum adsorbing sheet, the sebum removing step of removing the sebum of the part that peels off the skin surface of the skin,
A keratin exfoliation method comprising a keratin exfoliation step of exfoliating exfoliation of the skin surface from which the sebum has been removed with an exfoliating pressure-sensitive adhesive sheet.   A stratum corneum peeling kit comprising a sebum adsorbing sheet and a stratum corneum peeling adhesive sheet.   The keratin exfoliation kit according to claim 2, comprising an immobilization site on the skin, a sebum adsorption site, and a keratin exfoliation site.

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